{"id":"https://openalex.org/W2034654416","doi":"https://doi.org/10.1097/00000539-199604000-00019","title":"Thermal Response in Acute Porcine Malignant Hyperthermia","display_name":"Thermal Response in Acute Porcine Malignant Hyperthermia","publication_year":1996,"publication_date":"1996-04-01","ids":{"openalex":"https://openalex.org/W2034654416","doi":"https://doi.org/10.1097/00000539-199604000-00019","mag":"2034654416","pmid":"https://pubmed.ncbi.nlm.nih.gov/8615498"},"language":"en","primary_location":{"id":"doi:10.1097/00000539-199604000-00019","doi":"https://doi.org/10.1097/00000539-199604000-00019","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000539-199604000-00019","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038966090","display_name":"Paul A. Iaizzo","orcid":"https://orcid.org/0000-0002-7661-352X","observed_orcids":["https://orcid.org/0000-0002-7661-352X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul A. Iaizzo","raw_affiliation_strings":["Department of Anesthesiology, University of Minnesota, Minneapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Minnesota, Minneapolis, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112420571","display_name":"C. H. Kehler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris H. Kehler","raw_affiliation_strings":["Departments of Anesthesiology (Iaizzo, Kehler, Zink, Belani) and Physiology, University of Minnesota, Minneapolis, Minnesota (Iaizzo), and Thermoregulation Research Laboratory, Department of Anesthesia, University of California, San Francisco, California (Sessler)","University of Minnesota Twin Cities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology (Iaizzo, Kehler, Zink, Belani) and Physiology, University of Minnesota, Minneapolis, Minnesota (Iaizzo), and Thermoregulation Research Laboratory, Department of Anesthesia, University of California, San Francisco, California (Sessler)","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of Minnesota Twin Cities","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080777406","display_name":"Robert S. Zink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert S. Zink","raw_affiliation_strings":["Departments of Anesthesiology (Iaizzo, Kehler, Zink, Belani) and Physiology, University of Minnesota, Minneapolis, Minnesota (Iaizzo), and Thermoregulation Research Laboratory, Department of Anesthesia, University of California, San Francisco, California (Sessler)","University of Minnesota Twin Cities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology (Iaizzo, Kehler, Zink, Belani) and Physiology, University of Minnesota, Minneapolis, Minnesota (Iaizzo), and Thermoregulation Research Laboratory, Department of Anesthesia, University of California, San Francisco, California (Sessler)","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of Minnesota Twin Cities","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024721965","display_name":"Kumar G. Belani","orcid":"https://orcid.org/0000-0003-1784-136X","observed_orcids":["https://orcid.org/0000-0003-1784-136X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210115145","display_name":"University of Minnesota, Duluth","ror":"https://ror.org/01hy4qx27","country_code":"US","type":"education","lineage":["https://openalex.org/I4210115145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kumar G. Belani","raw_affiliation_strings":["Departments of Anesthesiology (Iaizzo, Kehler, Zink, Belani) and Physiology, University of Minnesota, Minneapolis, Minnesota (Iaizzo), and Thermoregulation Research Laboratory, Department of Anesthesia, University of California, San Francisco, California (Sessler)","University of Minnesota, Duluth"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology (Iaizzo, Kehler, Zink, Belani) and Physiology, University of Minnesota, Minneapolis, Minnesota (Iaizzo), and Thermoregulation Research Laboratory, Department of Anesthesia, University of California, San Francisco, California (Sessler)","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of Minnesota, Duluth","institution_ids":["https://openalex.org/I4210115145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042996287","display_name":"Daniel I. Sessler","orcid":"https://orcid.org/0000-0001-9932-3077","observed_orcids":["https://orcid.org/0000-0001-9932-3077"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel I. Sessler","raw_affiliation_strings":["Departments of Anesthesiology (Iaizzo, Kehler, Zink, Belani) and Physiology, University of Minnesota, Minneapolis, Minnesota (Iaizzo), and Thermoregulation Research Laboratory, Department of Anesthesia, University of California, San Francisco, California (Sessler)","University of California at San Francisco,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology (Iaizzo, Kehler, Zink, Belani) and Physiology, University of Minnesota, Minneapolis, Minnesota (Iaizzo), and Thermoregulation Research Laboratory, Department of Anesthesia, University of California, San Francisco, California (Sessler)","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of California at San Francisco,","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038966090"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":6.2047,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.96897571,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"82","issue":"4","first_page":"782","last_page":"789"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-hyperthermia","display_name":"malignant hyperthermia","score":1.0},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.7620000243186951},{"id":"https://openalex.org/keywords/core-body-temperature","display_name":"core body temperature","score":0.7699999809265137},{"id":"https://openalex.org/keywords/skin-surface-temperature","display_name":"skin surface temperature","score":0.8640000224113464},{"id":"https://openalex.org/keywords/halothane","display_name":"halothane","score":0.871999979019165},{"id":"https://openalex.org/keywords/succinylcholine","display_name":"succinylcholine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pulmonary-artery-temperature","display_name":"pulmonary artery temperature","score":0.6060000061988831},{"id":"https://openalex.org/keywords/esophageal-temperature","display_name":"esophageal temperature","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9717300534248352},{"id":"https://openalex.org/C2778575482","wikidata":"https://www.wikidata.org/wiki/Q1585081","display_name":"Malignant hyperthermia","level":2,"score":0.8715808391571045},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.5931164026260376},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2990768253803253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2762128710746765}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006221","descriptor_name":"Halothane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008305","descriptor_name":"Malignant Hyperthermia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013390","descriptor_name":"Succinylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00000539-199604000-00019","doi":"https://doi.org/10.1097/00000539-199604000-00019","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000539-199604000-00019","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},{"id":"doi:10.1213/00000539-199604000-00019","doi":"https://doi.org/10.1213/00000539-199604000-00019","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-199604000-00019","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},{"id":"pmid:8615498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8615498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G322282307","display_name":"PERIANESTHETIC THERMOREGULATION AND HEAT BALANCE","funder_award_id":"R01GM049670","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W22796409","https://openalex.org/W1549003091","https://openalex.org/W1790377549","https://openalex.org/W1964897707","https://openalex.org/W1967950304","https://openalex.org/W1973308552","https://openalex.org/W1978036867","https://openalex.org/W1983731348","https://openalex.org/W1996161537","https://openalex.org/W2005123575","https://openalex.org/W2019469419","https://openalex.org/W2028621627","https://openalex.org/W2029417330","https://openalex.org/W2033902143","https://openalex.org/W2039886044","https://openalex.org/W2045299188","https://openalex.org/W2049600711","https://openalex.org/W2049666684","https://openalex.org/W2052154586","https://openalex.org/W2060773039","https://openalex.org/W2061610042","https://openalex.org/W2076824666","https://openalex.org/W2082061643","https://openalex.org/W2091166559","https://openalex.org/W2101823403","https://openalex.org/W2138405104","https://openalex.org/W2138806834","https://openalex.org/W2141271305","https://openalex.org/W2150621276","https://openalex.org/W2150763524","https://openalex.org/W2162937581","https://openalex.org/W2167604030","https://openalex.org/W2416248192","https://openalex.org/W2427386996","https://openalex.org/W4237126306","https://openalex.org/W4242400252"],"related_works":["https://openalex.org/W2041158593","https://openalex.org/W1980346275","https://openalex.org/W4248455345","https://openalex.org/W2170374946","https://openalex.org/W2092874805","https://openalex.org/W1968776699","https://openalex.org/W2058012324","https://openalex.org/W7113329525","https://openalex.org/W4223437635","https://openalex.org/W1719322897"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,53],"designed":[3],"to":[4,38,108,142,246],"evaluate":[5],"how":[6],"vital":[7],"organ":[8,86],"and":[9,30,33,83,91,95,101,110,119,156,170,182,232],"skin-surface":[10,238],"temperatures":[11,79,87,98,121,161,172,220,251],"correlate":[12],"with":[13,28,129,223],"other":[14],"clinical":[15],"signs":[16],"of":[17,62,132,145,178,229],"a":[18,43,60,237,247],"malignant":[19],"hyperthermia":[20,194],"(MH)":[21],"episode.":[22],"Six":[23],"susceptible":[24],"swine":[25],"were":[26,162,184],"anesthetized":[27],"thiopental":[29],"nitrous":[31],"oxide":[32],"kept":[34],"normothermic":[35],"(approximately":[36],"equal":[37],"38":[39],"degrees":[40,164],"C).":[41],"After":[42],"30-min":[44],"control":[45],"period,":[46],"halothane":[47,109],"(1":[48],"minimum":[49],"alveolar":[50],"anesthetic":[51],"concentration)":[52],"administered,":[54],"followed":[55],"in":[56,137,203,207,216,243],"5":[57],"min":[58,105],"by":[59],"bolus":[61],"succinylcholine":[63],"(2":[64],"mg/kg":[65],"intravenously).":[66],"Monitoring":[67],"included:":[68],"1)":[69],"ETCO2;":[70],"2)PaO2,":[71],"PaCO2,":[72],"pHa;":[73],"3)":[74],"cardiovascular":[75],"function;":[76],"4)":[77],"core":[78,193,224,261],"(esophagus,":[80],"pulmonary":[81,126,168],"artery,":[82],"rectum);":[84],"5)":[85],"(brain,":[88],"kidney,":[89,180],"liver,":[90,118,181],"four":[92],"skeletal":[93,148,208],"muscles);":[94],"6)":[96],"skin":[97,218],"(forehead,":[99],"neck,":[100],"axilla).":[102],"Within":[103],"10":[104],"after":[106],"exposure":[107],"succinylcholine,":[111],"all":[112],"animals":[113],"developed":[114],"fulminant":[115],"MH.":[116,133],"Kidney,":[117],"brain":[120,183],"increased":[122,136],"more":[123],"rapidly":[124],"than":[125,167],"artery":[127,169],"temperature":[128,225],"the":[130,138,143,174,179,185,230],"onset":[131],"Temperatures":[134],"significantly":[135],"visceral":[139],"organs":[140],"prior":[141],"detection":[144],"contractures":[146],"within":[147],"muscles.":[149],"The":[150],"masseter,":[151],"longissimus":[152],"dorsi,":[153],"quadriceps,":[154],"deltoid,":[155],"extensor":[157],"digiti":[158],"II":[159],"intramuscular":[160],"1-2":[163],"C":[165],"less":[166],"esophageal":[171],"during":[173,195],"episodes,":[175],"whereas":[176,227],"those":[177,228],"same":[186],"or":[187],"slightly":[188],"greater.":[189],"When":[190],"it":[191],"occurs,":[192],"acute":[196],"MH":[197],"results":[198],"largely":[199],"from":[200],"heat":[201],"produced":[202],"central":[204],"organs,":[205],"not":[206,253],"muscle":[209],"per":[210],"se.":[211],"In":[212],"these":[213],"swine,":[214],"changes":[215],"axilla":[217],"surface":[219],"correlated":[221],"well":[222],"trends,":[226],"neck":[231],"forehead":[233],"did":[234],"not.":[235],"Unless":[236],"probe":[239],"can":[240],"be":[241,254],"placed":[242],"close":[244],"proximity":[245],"major":[248],"vessel,":[249],"cutaneous":[250],"should":[252],"substituted":[255],"for":[256],"measurements":[257],"at":[258],"an":[259],"appropriate":[260],"site.":[262]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}