{"id":"https://openalex.org/W2034523637","doi":"https://doi.org/10.1172/jci118555","title":"Targeted mutagenesis: analysis of phenotype without germ line transmission.","display_name":"Targeted mutagenesis: analysis of phenotype without germ line transmission.","publication_year":1996,"publication_date":"1996-03-15","ids":{"openalex":"https://openalex.org/W2034523637","doi":"https://doi.org/10.1172/jci118555","mag":"2034523637","pmid":"https://pubmed.ncbi.nlm.nih.gov/8617866","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/507193"},"language":"en","primary_location":{"id":"doi:10.1172/jci118555","doi":"https://doi.org/10.1172/jci118555","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118555","pdf_url":"http://www.jci.org/articles/view/118555/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/118555/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011105258","display_name":"Andr\u00e1s Nagy","orcid":"https://orcid.org/0000-0003-4311-0413","observed_orcids":["https://orcid.org/0000-0003-4311-0413"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A Nagy","raw_affiliation_strings":["Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011985445","display_name":"Janet Rossant","orcid":"https://orcid.org/0000-0002-3731-5466","observed_orcids":["https://orcid.org/0000-0002-3731-5466"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J Rossant","raw_affiliation_strings":["Mount Sinai Hospital, Toronto,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai Hospital, Toronto,","institution_ids":["https://openalex.org/I1291836623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":0.9122,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.65831435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"97","issue":"6","first_page":"1360","last_page":"1365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.10639999806880951,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/targeted-mutagenesis","display_name":"targeted mutagenesis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mouse-genetics","display_name":"mouse genetics","score":0.718999981880188},{"id":"https://openalex.org/keywords/genetic-mosaicism","display_name":"genetic mosaicism","score":0.8479999899864197},{"id":"https://openalex.org/keywords/germline-transmission","display_name":"germline transmission","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mouse-mutants","display_name":"mouse mutants","score":0.5210000276565552},{"id":"https://openalex.org/keywords/gene-targeting","display_name":"gene targeting","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7737410664558411},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7292867302894592},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7080624103546143},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.7055261135101318},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.694736659526825},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.5480476021766663},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5466367602348328},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.504419207572937},{"id":"https://openalex.org/C111829913","wikidata":"https://www.wikidata.org/wiki/Q211083","display_name":"Gene targeting","level":3,"score":0.4997091293334961},{"id":"https://openalex.org/C107635520","wikidata":"https://www.wikidata.org/wiki/Q1967554","display_name":"Insertional mutagenesis","level":4,"score":0.4828910827636719},{"id":"https://openalex.org/C23085057","wikidata":"https://www.wikidata.org/wiki/Q5532877","display_name":"Genetic analysis","level":3,"score":0.47577062249183655},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47386693954467773},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.42857879400253296},{"id":"https://openalex.org/C169899063","wikidata":"https://www.wikidata.org/wiki/Q2842787","display_name":"Laboratory mouse","level":3,"score":0.4260557293891907},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3960868716239929}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005854","descriptor_name":"Germ Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci118555","doi":"https://doi.org/10.1172/jci118555","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118555","pdf_url":"http://www.jci.org/articles/view/118555/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:507193","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/507193","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:8617866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8617866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci118555","doi":"https://doi.org/10.1172/jci118555","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118555","pdf_url":"http://www.jci.org/articles/view/118555/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2034523637.pdf","grobid_xml":"https://content.openalex.org/works/W2034523637.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W135569227","https://openalex.org/W1856781683","https://openalex.org/W1894129931","https://openalex.org/W1966697925","https://openalex.org/W1967071065","https://openalex.org/W1967287827","https://openalex.org/W1984684498","https://openalex.org/W1999671240","https://openalex.org/W2002273560","https://openalex.org/W2003028861","https://openalex.org/W2005688198","https://openalex.org/W2009624062","https://openalex.org/W2011642803","https://openalex.org/W2014721239","https://openalex.org/W2021516648","https://openalex.org/W2029844184","https://openalex.org/W2038970416","https://openalex.org/W2046516822","https://openalex.org/W2048139403","https://openalex.org/W2054275704","https://openalex.org/W2058528119","https://openalex.org/W2061116292","https://openalex.org/W2063023858","https://openalex.org/W2065788477","https://openalex.org/W2067376187","https://openalex.org/W2069022895","https://openalex.org/W2072984471","https://openalex.org/W2074249987","https://openalex.org/W2079749432","https://openalex.org/W2092806325","https://openalex.org/W2093918751","https://openalex.org/W2101710059","https://openalex.org/W2118296721","https://openalex.org/W2126464081","https://openalex.org/W2140489687","https://openalex.org/W2166694150","https://openalex.org/W2403316467","https://openalex.org/W2417865499"],"related_works":["https://openalex.org/W2023028626","https://openalex.org/W346385145","https://openalex.org/W2563925955","https://openalex.org/W84936090","https://openalex.org/W1939711593","https://openalex.org/W2045985937","https://openalex.org/W2416028092","https://openalex.org/W1991875866","https://openalex.org/W2151003948","https://openalex.org/W4388466478"],"abstract_inverted_index":{"The":[0],"available":[1],"techniques":[2],"for":[3,23],"directed":[4],"gene":[5],"manipulation":[6],"in":[7,12,52,81],"the":[8,18,33,74,78],"mouse":[9,19],"are":[10,56],"unprecedented":[11],"any":[13],"multicellular":[14],"organism":[15],"and":[16,46,50,72,77,83],"make":[17],"an":[20],"invaluable":[21],"tool":[22],"unraveling":[24],"all":[25],"aspects":[26],"of":[27,35,68,87],"mammalian":[28],"biology.":[29],"To":[30],"realize":[31],"fully":[32],"potential":[34],"these":[36],"genetic":[37],"tools":[38],"requires":[39],"that":[40],"phenotypic":[41],"analysis":[42,67],"be":[43,62],"efficient,":[44],"rapid,":[45],"complete.":[47],"Genetic":[48],"chimeras":[49],"mosaics,":[51],"which":[53],"mutant":[54,70,88],"cells":[55],"mixed":[57],"with":[58],"wild-type":[59],"cells,":[60],"can":[61],"used":[63],"to":[64],"augment":[65],"standard":[66],"intact":[69],"animals":[71],"alleviate":[73],"time":[75],"required":[76],"expense":[79],"involved":[80],"generating":[82],"maintaining":[84],"multiple":[85],"strains":[86],"mice.":[89]},"counts_by_year":[{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
