{"id":"https://openalex.org/W2034499208","doi":"https://doi.org/10.1083/jcb.146.2.267","title":"Signaling to Actin Dynamics","display_name":"Signaling to Actin Dynamics","publication_year":1999,"publication_date":"1999-07-26","ids":{"openalex":"https://openalex.org/W2034499208","doi":"https://doi.org/10.1083/jcb.146.2.267","mag":"2034499208","pmid":"https://pubmed.ncbi.nlm.nih.gov/10427083","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2156183"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.146.2.267","doi":"https://doi.org/10.1083/jcb.146.2.267","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.146.2.267","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2034499208"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2156183/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012953918","display_name":"Laura M. Machesky","orcid":"https://orcid.org/0000-0002-7592-9856","observed_orcids":["https://orcid.org/0000-0002-7592-9856"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura M. Machesky","raw_affiliation_strings":["aDepartment of Biochemistry, University of Birmingham, Birmingham, B15 2TT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Biochemistry, University of Birmingham, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054741862","display_name":"Robert H. Insall","orcid":"https://orcid.org/0000-0003-4898-040X","observed_orcids":["https://orcid.org/0000-0003-4898-040X"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert H. Insall","raw_affiliation_strings":["aDepartment of Biochemistry, University of Birmingham, Birmingham, B15 2TT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Biochemistry, University of Birmingham, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79619799"],"apc_list":null,"apc_paid":null,"fwci":3.0178,"has_fulltext":true,"cited_by_count":262,"citation_normalized_percentile":{"value":0.93993994,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"146","issue":"2","first_page":"267","last_page":"272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9710000157356262},{"id":"https://openalex.org/keywords/actin-dynamics","display_name":"actin dynamics","score":0.9240000247955322},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.652999997138977},{"id":"https://openalex.org/keywords/cell-locomotion","display_name":"cell locomotion","score":0.8939999938011169},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cell-contractility","display_name":"cell contractility","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cell-morphology-changes","display_name":"cell shape changes","score":0.796999990940094},{"id":"https://openalex.org/keywords/cytokinesis","display_name":"cytokinesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"cell polarity","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9089542031288147},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5915400385856628},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5790475606918335},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.5268149375915527},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4222428798675537},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000098662","descriptor_name":"Vasodilator-Stimulated Phosphoprotein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018260","descriptor_name":"Gelsolin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051316","descriptor_name":"Wiskott-Aldrich Syndrome Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051339","descriptor_name":"Actin Depolymerizing Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051345","descriptor_name":"Destrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1083/jcb.146.2.267","doi":"https://doi.org/10.1083/jcb.146.2.267","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.146.2.267","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2156183","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2156183/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2156183/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:916340","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2156183","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:10427083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10427083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2156183","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2156183/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2156183/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2034499208.pdf","grobid_xml":"https://content.openalex.org/works/W2034499208.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1521071733","https://openalex.org/W1524475817","https://openalex.org/W1575892864","https://openalex.org/W1965234951","https://openalex.org/W1965607913","https://openalex.org/W1967345709","https://openalex.org/W1969563780","https://openalex.org/W1977290593","https://openalex.org/W1981501419","https://openalex.org/W1984030342","https://openalex.org/W1992569957","https://openalex.org/W1993016783","https://openalex.org/W1994494728","https://openalex.org/W2007586038","https://openalex.org/W2009068509","https://openalex.org/W2010604172","https://openalex.org/W2014187063","https://openalex.org/W2018317768","https://openalex.org/W2021124770","https://openalex.org/W2025459204","https://openalex.org/W2025994996","https://openalex.org/W2031123547","https://openalex.org/W2033619721","https://openalex.org/W2036123452","https://openalex.org/W2037773563","https://openalex.org/W2041098549","https://openalex.org/W2045923054","https://openalex.org/W2049811440","https://openalex.org/W2051281022","https://openalex.org/W2072837740","https://openalex.org/W2078384542","https://openalex.org/W2079099921","https://openalex.org/W2081922417","https://openalex.org/W2087220458","https://openalex.org/W2088899830","https://openalex.org/W2100990664","https://openalex.org/W2105789974","https://openalex.org/W2107625881","https://openalex.org/W2113249117","https://openalex.org/W2113905792","https://openalex.org/W2118875203","https://openalex.org/W2121889667","https://openalex.org/W2122782850","https://openalex.org/W2140617471","https://openalex.org/W2143926015","https://openalex.org/W2146457858","https://openalex.org/W2155047359","https://openalex.org/W2156700030","https://openalex.org/W2157151771","https://openalex.org/W2157815908","https://openalex.org/W2160459388","https://openalex.org/W2160503216","https://openalex.org/W2167146326","https://openalex.org/W2463797415","https://openalex.org/W6648914426"],"related_works":["https://openalex.org/W2008876767","https://openalex.org/W939069427","https://openalex.org/W2001289321","https://openalex.org/W193680572","https://openalex.org/W1956570430","https://openalex.org/W657023581","https://openalex.org/W2794173792","https://openalex.org/W2696329753","https://openalex.org/W7024447562","https://openalex.org/W7096950327"],"abstract_inverted_index":{"The":[0,20],"actin":[1,24],"cytoskeleton":[2],"of":[3,18,38],"a":[4],"eukaryotic":[5],"cell":[6],"is":[7],"central":[8],"to":[9],"locomotion,":[10],"phagocytosis,":[11],"contractility,":[12],"shape":[13],"changes,":[14],"cytokinesis":[15],"and":[16],"maintenance":[17],"polarity.":[19],"mechanisms":[21],"through":[22],"which":[23],"coordinates":[25],"these":[26],"different":[27],"activities":[28],"have":[29],"been":[30],"fascinating":[31],"for":[32],"many":[33],"years,":[34],"but":[35],"the":[36],"pace":[37],"discovery":[39],"has":[40]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}