{"id":"https://openalex.org/W2034493283","doi":"https://doi.org/10.1159/000368862","title":"Preserved Fertility in a Patient with Gynecomastia Associated with the p.Pro695Ser Mutation in the Androgen Receptor","display_name":"Preserved Fertility in a Patient with Gynecomastia Associated with the p.Pro695Ser Mutation in the Androgen Receptor","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2034493283","doi":"https://doi.org/10.1159/000368862","mag":"2034493283","pmid":"https://pubmed.ncbi.nlm.nih.gov/25401426"},"language":"en","primary_location":{"id":"doi:10.1159/000368862","doi":"https://doi.org/10.1159/000368862","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000368862","pdf_url":null,"source":{"id":"https://openalex.org/S99309566","display_name":"Sexual Development","issn_l":"1661-5425","issn":["1661-5425","1661-5433"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexual Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080634770","display_name":"Reginaldo Jos\u00e9 Petroli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Reginaldo J. Petroli","raw_affiliation_strings":["Centro de Biologia Molecular e Engenharia Gen\u00e9tica (CBMEG), Universidade Estadual de Campinas, Campinas, Brazil","Centro de Biologia Molecular e Engenharia Gen\u00e9tica (CBMEG),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biologia Molecular e Engenharia Gen\u00e9tica (CBMEG), Universidade Estadual de Campinas, Campinas, Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Centro de Biologia Molecular e Engenharia Gen\u00e9tica (CBMEG),","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018333266","display_name":"Olaf Hiort","orcid":"https://orcid.org/0000-0001-7490-4983","observed_orcids":["https://orcid.org/0000-0001-7490-4983"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olaf Hiort","raw_affiliation_strings":["Department of Paediatrics and Adolescent Medicine, Division of Experimental Paediatric Endocrinology and Diabetes, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7490-4983","affiliations":[{"raw_affiliation_string":"Department of Paediatrics and Adolescent Medicine, Division of Experimental Paediatric Endocrinology and Diabetes, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033791507","display_name":"Dagmar Struve","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dagmar Struve","raw_affiliation_strings":["Department of Paediatrics and Adolescent Medicine, Division of Experimental Paediatric Endocrinology and Diabetes, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics and Adolescent Medicine, Division of Experimental Paediatric Endocrinology and Diabetes, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024768713","display_name":"Andr\u00e9a Trevas Maciel\u2010Guerra","orcid":"https://orcid.org/0000-0001-5335-4628","observed_orcids":["https://orcid.org/0000-0001-5335-4628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andr\u00e9a T. Maciel-Guerra","raw_affiliation_strings":["Departamento de Gen\u00e9tica M\u00e9dica, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica M\u00e9dica, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071955712","display_name":"Gil Guerra\u2010J\u00fanior","orcid":"https://orcid.org/0000-0002-2991-7678","observed_orcids":["https://orcid.org/0000-0002-2991-7678"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gil Guerra-J\u00fanior","raw_affiliation_strings":["Departamento de Pediatria, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Estadual de Campinas, Campinas, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Pediatria, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Estadual de Campinas, Campinas, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074963120","display_name":"Maricilda Palandi de Mello","orcid":"https://orcid.org/0000-0003-0521-9100","observed_orcids":["https://orcid.org/0000-0003-0521-9100"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maricilda Palandi de Mello","raw_affiliation_strings":["Centro de Biologia Molecular e Engenharia Gen\u00e9tica (CBMEG),"],"raw_orcid":"https://orcid.org/0000-0003-0521-9100","affiliations":[{"raw_affiliation_string":"Centro de Biologia Molecular e Engenharia Gen\u00e9tica (CBMEG),","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005005766","display_name":"Ralf Werner","orcid":"https://orcid.org/0000-0003-3718-3595","observed_orcids":["https://orcid.org/0000-0003-3718-3595"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Werner","raw_affiliation_strings":["Department of Paediatrics and Adolescent Medicine, Division of Experimental Paediatric Endocrinology and Diabetes, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics and Adolescent Medicine, Division of Experimental Paediatric Endocrinology and Diabetes, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3079,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.79738828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"6","first_page":"350","last_page":"355"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8339999914169312},{"id":"https://openalex.org/keywords/androgen-insensitivity-syndrome","display_name":"androgen insensitivity syndrome","score":0.9089999794960022},{"id":"https://openalex.org/keywords/gynecomastia","display_name":"gynecomastia","score":0.9440000057220459},{"id":"https://openalex.org/keywords/male-fertility","display_name":"male fertility","score":0.7900000214576721},{"id":"https://openalex.org/keywords/ligand-binding-domain","display_name":"ligand-binding domain","score":0.8619999885559082},{"id":"https://openalex.org/keywords/transactivation-activity","display_name":"transactivation activity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.9369999766349792},{"id":"https://openalex.org/keywords/46-xy-disorders-of-sex-development","display_name":"46,XY disorders of sex development","score":0.7039999961853027},{"id":"https://openalex.org/keywords/hormone-resistance","display_name":"hormone resistance","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.9608222246170044},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.8402708768844604},{"id":"https://openalex.org/C2778952551","wikidata":"https://www.wikidata.org/wiki/Q512313","display_name":"Androgen insensitivity syndrome","level":5,"score":0.8259215354919434},{"id":"https://openalex.org/C2777691561","wikidata":"https://www.wikidata.org/wiki/Q339221","display_name":"Gynecomastia","level":2,"score":0.7192224264144897},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6996635794639587},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6174499988555908},{"id":"https://openalex.org/C2779881493","wikidata":"https://www.wikidata.org/wiki/Q411054","display_name":"Dihydrotestosterone","level":4,"score":0.5896213054656982},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5563336610794067},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5430958867073059},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.49707677960395813},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.483136385679245},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43882277607917786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42608487606048584},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3674575686454773},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2850181460380554},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.21615561842918396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1394347846508026},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.13350972533226013},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.05572506785392761}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006177","descriptor_name":"Gynecomastia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1159/000368862","doi":"https://doi.org/10.1159/000368862","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000368862","pdf_url":null,"source":{"id":"https://openalex.org/S99309566","display_name":"Sexual Development","issn_l":"1661-5425","issn":["1661-5425","1661-5433"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexual Development","raw_type":"journal-article"},{"id":"pmid:25401426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25401426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation","raw_type":"Case Reports"},{"id":"pmh:oai:repositorio.unifesp.br:11600/37292","doi":null,"is_oa":false,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/37292","pdf_url":null,"source":{"id":"https://openalex.org/S4377196380","display_name":"UNIFESP Institutional Repository (Universidade Federal de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88273585","host_organization_name":"Universidade Federal de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I88273585"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Artigo"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W190361340","https://openalex.org/W1598128285","https://openalex.org/W1968056809","https://openalex.org/W1979046207","https://openalex.org/W1983131802","https://openalex.org/W1987912297","https://openalex.org/W1993465691","https://openalex.org/W2018400995","https://openalex.org/W2022315433","https://openalex.org/W2050602600","https://openalex.org/W2054114642","https://openalex.org/W2054191752","https://openalex.org/W2056125291","https://openalex.org/W2056797128","https://openalex.org/W2080202166","https://openalex.org/W2084253425","https://openalex.org/W2085609235","https://openalex.org/W2127226545","https://openalex.org/W2133150634","https://openalex.org/W2133940765","https://openalex.org/W2141348275","https://openalex.org/W2144908726","https://openalex.org/W2160534562","https://openalex.org/W2160630216","https://openalex.org/W2167047231","https://openalex.org/W2167063297","https://openalex.org/W2171316518","https://openalex.org/W2172024571","https://openalex.org/W2410244497"],"related_works":["https://openalex.org/W2772846621","https://openalex.org/W1245916056","https://openalex.org/W2043146506","https://openalex.org/W2121751582","https://openalex.org/W3097041355","https://openalex.org/W2051379318","https://openalex.org/W2022864357","https://openalex.org/W2097510177","https://openalex.org/W3013417433","https://openalex.org/W1504381294"],"abstract_inverted_index":{"The":[0,59,192],"androgen":[1,12],"insensitivity":[2],"syndrome":[3],"(AIS)":[4],"is":[5,102],"described":[6,180],"as":[7],"a":[8,46,51,74,112,131,187,208],"dysfunction":[9],"of":[10,61,84,93,130,141,195,217],"the":[11,25,70,82,85,88,94,98,105,154,177,183,201,214,218],"receptor":[13],"(AR)":[14],"in":[15,24,37,69,73,127,186],"46,XY":[16],"individuals,":[17],"which":[18,115],"can":[19,29],"be":[20,30],"associated":[21,55],"with":[22,56,77,189],"mutations":[23,36,68],"AR":[26,71,89,95,106],"gene":[27,72,96,133],"or":[28],"due":[31],"to":[32,50,65,80,200],"unknown":[33],"mechanisms.":[34],"Different":[35],"AIS":[38],"generally":[39],"cause":[40],"variable":[41],"phenotypes":[42],"that":[43,207],"range":[44],"from":[45],"complete":[47],"hormone":[48],"resistance":[49],"mild":[52,190],"form":[53],"usually":[54],"male":[57],"infertility.":[58],"purpose":[60],"this":[62,171],"study":[63,172],"was":[64,116],"search":[66],"for":[67,176,182],"fertile":[75],"man":[76],"gynecomastia":[78],"and":[79,122,134,145,161,166],"evaluate":[81],"influence":[83],"mutation":[86,179],"on":[87],"transactivation":[90,120,143,159],"ability.":[91],"Sequencing":[92],"revealed":[97],"p.Pro695Ser":[99,137,178,196],"mutation.":[100],"It":[101],"located":[103],"within":[104],"ligand-binding":[107],"domain.":[108],"Bioinformatics":[109],"analysis":[110],"indicated":[111],"deleterious":[113],"role,":[114],"verified":[117],"after":[118],"testing":[119],"activity":[121,144,160],"N-/C-terminal":[123],"(N/C)":[124],"interaction":[125,147,163],"by":[126],"vitro":[128],"expression":[129,193],"reporter":[132],"2-hybrid":[135],"assays.":[136],"showed":[138],"low":[139,149],"levels":[140],"both":[142,158],"N/C":[146,162],"at":[148],"dihydrotestosterone":[150],"(DHT)":[151],"conditions.":[152],"As":[153],"ligand":[155],"concentration":[156],"increased,":[157],"also":[164,205],"increased":[165],"reached":[167],"normal":[168],"levels.":[169],"Therefore,":[170],"provides":[173],"functional":[174,215],"insights":[175],"here":[181],"first":[184],"time":[185],"patient":[188],"AIS.":[191],"profile":[194],"not":[197],"only":[198],"correlates":[199],"patient's":[202],"phenotype,":[203],"but":[204],"suggests":[206],"high-dose":[209],"DHT":[210],"therapy":[211],"may":[212],"overcome":[213],"deficit":[216],"mutant":[219],"AR.":[220]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}