{"id":"https://openalex.org/W2034490685","doi":"https://doi.org/10.1073/pnas.95.25.14693","title":"Protein phosphatase 2A is required for the initiation of chromosomal DNA replication","display_name":"Protein phosphatase 2A is required for the initiation of chromosomal DNA replication","publication_year":1998,"publication_date":"1998-12-08","ids":{"openalex":"https://openalex.org/W2034490685","doi":"https://doi.org/10.1073/pnas.95.25.14693","mag":"2034490685","pmid":"https://pubmed.ncbi.nlm.nih.gov/9843951","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/24511"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.95.25.14693","doi":"https://doi.org/10.1073/pnas.95.25.14693","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.95.25.14693","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/24511","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xiao-Hong Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Xiao-Hong Lin","raw_affiliation_strings":["Departments of Pathology and Biology, University of California at San Diego, La Jolla, CA 92093; and Institut f\u00fcr Genetik, Universit\u00e4t Bonn, Bonn D-53117, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Biology, University of California at San Diego, La Jolla, CA 92093; and Institut f\u00fcr Genetik, Universit\u00e4t Bonn, Bonn D-53117, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080203458","display_name":"Johannes C. Walter","orcid":"https://orcid.org/0000-0002-4186-7570","observed_orcids":["https://orcid.org/0000-0002-4186-7570"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Johannes Walter","raw_affiliation_strings":["Departments of Pathology and Biology, University of California at San Diego, La Jolla, CA 92093; and Institut f\u00fcr Genetik, Universit\u00e4t Bonn, Bonn D-53117, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Biology, University of California at San Diego, La Jolla, CA 92093; and Institut f\u00fcr Genetik, Universit\u00e4t Bonn, Bonn D-53117, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111486571","display_name":"Karl Heinz Scheidtmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Karl Scheidtmann","raw_affiliation_strings":["Departments of Pathology and Biology, University of California at San Diego, La Jolla, CA 92093; and Institut f\u00fcr Genetik, Universit\u00e4t Bonn, Bonn D-53117, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Biology, University of California at San Diego, La Jolla, CA 92093; and Institut f\u00fcr Genetik, Universit\u00e4t Bonn, Bonn D-53117, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035368997","display_name":"Kim Ohst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Kim Ohst","raw_affiliation_strings":["Departments of Pathology and Biology, University of California at San Diego, La Jolla, CA 92093; and Institut f\u00fcr Genetik, Universit\u00e4t Bonn, Bonn D-53117, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Biology, University of California at San Diego, La Jolla, CA 92093; and Institut f\u00fcr Genetik, Universit\u00e4t Bonn, Bonn D-53117, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018892772","display_name":"John W. Newport","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"John Newport","raw_affiliation_strings":["Departments of Pathology and Biology, University of California at San Diego, La Jolla, CA 92093; and Institut f\u00fcr Genetik, Universit\u00e4t Bonn, Bonn D-53117, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Biology, University of California at San Diego, La Jolla, CA 92093; and Institut f\u00fcr Genetik, Universit\u00e4t Bonn, Bonn D-53117, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005736421","display_name":"Gernot Walter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Gernot Walter","raw_affiliation_strings":["Departments of Pathology and Biology, University of California at San Diego, La Jolla, CA 92093; and Institut f\u00fcr Genetik, Universit\u00e4t Bonn, Bonn D-53117, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Biology, University of California at San Diego, La Jolla, CA 92093; and Institut f\u00fcr Genetik, Universit\u00e4t Bonn, Bonn D-53117, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080203458"],"corresponding_institution_ids":["https://openalex.org/I135140700","https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":1.8409,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.85394799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"95","issue":"25","first_page":"14693","last_page":"14698"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.2551000118255615,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.2551000118255615,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.19089999794960022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.15199999511241913,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dna-replication-initiation","display_name":"DNA replication initiation","score":0.890999972820282},{"id":"https://openalex.org/keywords/chromosome-replication","display_name":"chromosome replication","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dephosphorylation","display_name":"dephosphorylation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/protein-kinase-phosphorylation","display_name":"protein kinase phosphorylation","score":0.656000018119812},{"id":"https://openalex.org/keywords/xenopus-egg-extracts","display_name":"Xenopus egg extracts","score":0.8489999771118164},{"id":"https://openalex.org/keywords/serine-threonine-protein-phosphatase","display_name":"serine/threonine phosphatase","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C188036394","wikidata":"https://www.wikidata.org/wiki/Q14902224","display_name":"Replication factor C","level":5,"score":0.7388391494750977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.729641318321228},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.7034844160079956},{"id":"https://openalex.org/C151158763","wikidata":"https://www.wikidata.org/wiki/Q1626856","display_name":"Origin recognition complex","level":5,"score":0.7021334767341614},{"id":"https://openalex.org/C98086919","wikidata":"https://www.wikidata.org/wiki/Q118019","display_name":"Eukaryotic DNA replication","level":4,"score":0.6956266164779663},{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.6930969953536987},{"id":"https://openalex.org/C104690221","wikidata":"https://www.wikidata.org/wiki/Q5165872","display_name":"Control of chromosome duplication","level":4,"score":0.6813643574714661},{"id":"https://openalex.org/C41141232","wikidata":"https://www.wikidata.org/wiki/Q3685229","display_name":"Pre-replication complex","level":5,"score":0.6060399413108826},{"id":"https://openalex.org/C175193931","wikidata":"https://www.wikidata.org/wiki/Q18047065","display_name":"DNA replication factor CDT1","level":5,"score":0.5000627040863037},{"id":"https://openalex.org/C22840021","wikidata":"https://www.wikidata.org/wiki/Q7701454","display_name":"Ter protein","level":5,"score":0.4814835786819458},{"id":"https://openalex.org/C113271649","wikidata":"https://www.wikidata.org/wiki/Q2565234","display_name":"Replication protein A","level":5,"score":0.4788084626197815},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4529506266117096},{"id":"https://openalex.org/C54266558","wikidata":"https://www.wikidata.org/wiki/Q6543075","display_name":"Licensing factor","level":5,"score":0.4385336935520172},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4085419774055481},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.32078057527542114},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29612165689468384},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.2755216956138611},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.2652038335800171},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.18744418025016785},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08605393767356873},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054648","descriptor_name":"Protein Phosphatase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.95.25.14693","doi":"https://doi.org/10.1073/pnas.95.25.14693","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.95.25.14693","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:24511","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/24511","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:9843951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9843951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:24511","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/24511","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2768036480","display_name":"PROTEIN PHOSPHATASE 2A AND TUMOR ANTIGENS IN CELL GROWTH","funder_award_id":"R01CA036111","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3693898079","display_name":null,"funder_award_id":"1F32GM17980-01","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3932702246","display_name":"MECHANISM OF DNA REPLICATION IN XENOPUS EXTRACTS","funder_award_id":"F32GM017980","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7670387824","display_name":"BIOCHEMICAL ANALYSIS OF NUCLEAR STRUCTURE","funder_award_id":"R01GM033523","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W61032353","https://openalex.org/W80901980","https://openalex.org/W175043000","https://openalex.org/W1496421860","https://openalex.org/W1503356528","https://openalex.org/W1772887764","https://openalex.org/W1796183786","https://openalex.org/W1954432597","https://openalex.org/W1958101689","https://openalex.org/W1964499404","https://openalex.org/W1981117368","https://openalex.org/W1985710832","https://openalex.org/W1993935814","https://openalex.org/W2001165707","https://openalex.org/W2001922379","https://openalex.org/W2018782003","https://openalex.org/W2022077088","https://openalex.org/W2030923676","https://openalex.org/W2041705004","https://openalex.org/W2046707499","https://openalex.org/W2059347018","https://openalex.org/W2062712010","https://openalex.org/W2063123880","https://openalex.org/W2065231473","https://openalex.org/W2070127489","https://openalex.org/W2074350638","https://openalex.org/W2077580885","https://openalex.org/W2079711691","https://openalex.org/W2080087666","https://openalex.org/W2085266985","https://openalex.org/W2091989106","https://openalex.org/W2096251302","https://openalex.org/W2113575427","https://openalex.org/W2116808406","https://openalex.org/W2118188822","https://openalex.org/W2137221055","https://openalex.org/W2145924416","https://openalex.org/W2166270104","https://openalex.org/W2170085122","https://openalex.org/W2275430962","https://openalex.org/W2288796536","https://openalex.org/W2342265972","https://openalex.org/W2413800071"],"related_works":["https://openalex.org/W7095497772","https://openalex.org/W1958101689","https://openalex.org/W2161626628","https://openalex.org/W80901980","https://openalex.org/W2976524863","https://openalex.org/W2486229405","https://openalex.org/W7099500805","https://openalex.org/W7100343335","https://openalex.org/W2116092803","https://openalex.org/W2153574810"],"abstract_inverted_index":{"Protein":[0],"phosphatase":[1,9],"2A":[2],"(PP2A)":[3],"is":[4],"an":[5],"abundant,":[6],"multifunctional":[7],"serine/threonine-specific":[8],"that":[10],"stimulates":[11],"simian":[12],"virus":[13],"40":[14],"DNA":[15,23,54,79],"replication.":[16,55],"The":[17],"question":[18],"as":[19],"to":[20],"whether":[21],"chromosomal":[22,78],"replication":[24,35,63,72,80],"also":[25,90],"depends":[26,81],"on":[27,84,91],"PP2A":[28,44,56],"was":[29,57],"addressed":[30],"by":[31,86,93],"using":[32],"a":[33],"cell-free":[34],"system":[36],"derived":[37],"from":[38,45],"Xenopus":[39,46],"laevis":[40],"eggs.":[41],"Immunodepletion":[42],"of":[43,53,62,69,77],"egg":[47],"extract":[48],"resulted":[49],"in":[50],"strong":[51],"inhibition":[52],"required":[58],"for":[59,66],"the":[60,67,75],"initiation":[61,76],"but":[64,89],"not":[65,82],"elongation":[68],"previously":[70],"engaged":[71],"forks.":[73],"Therefore,":[74],"only":[83],"phosphorylation":[85],"protein":[87],"kinases":[88],"dephosphorylation":[92],"PP2A.":[94]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}