{"id":"https://openalex.org/W2034470191","doi":"https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1143>3.0.co;2-o","title":"The MEK1-ERK MAP kinase pathway and the PI 3-kinase-Akt pathway independently mediate anti-apoptotic signals in HepG2 liver cancer cells","display_name":"The MEK1-ERK MAP kinase pathway and the PI 3-kinase-Akt pathway independently mediate anti-apoptotic signals in HepG2 liver cancer cells","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W2034470191","doi":"https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1143>3.0.co;2-o","mag":"2034470191","pmid":"https://pubmed.ncbi.nlm.nih.gov/11279606"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0215(200102)9999:9999<::aid-ijc1143>3.0.co;2-o","doi":"https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1143>3.0.co;2-o","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1143>3.0.co;2-o","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0215%28200102%299999%3A9999%3C%3A%3AAID-IJC1143%3E3.0.CO%3B2-O","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hiroshi Mitsui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroshi Mitsui","raw_affiliation_strings":["","First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016838749","display_name":"Noriko Takuwa","orcid":"https://orcid.org/0000-0002-4278-2704","observed_orcids":["https://orcid.org/0000-0002-4278-2704"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriko Takuwa","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, Kanazawa University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, Kanazawa University, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113790569","display_name":"Toshiyuki Maruyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Maruyama","raw_affiliation_strings":["First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103404280","display_name":"Hisato Maekawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisato Maekawa","raw_affiliation_strings":["First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111557885","display_name":"Miki Hirayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miki Hirayama","raw_affiliation_strings":["First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006753919","display_name":"Takashi Sawatari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Sawatari","raw_affiliation_strings":["First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003339273","display_name":"Naoaki Hashimoto","orcid":"https://orcid.org/0000-0001-6264-1346","observed_orcids":["https://orcid.org/0000-0001-6264-1346"]},"institutions":[{"id":"https://openalex.org/I4210141191","display_name":"Tokyo Teishin Hospital","ror":"https://ror.org/04j339g17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141191"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoaki Hashimoto","raw_affiliation_strings":["Tokyo Teishin Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Teishin Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4210141191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058121331","display_name":"Yoh Takuwa","orcid":"https://orcid.org/0000-0001-5840-6044","observed_orcids":["https://orcid.org/0000-0001-5840-6044"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoh Takuwa","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, Kanazawa University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, Kanazawa University, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056761543","display_name":"Satoshi Kimura","orcid":"https://orcid.org/0000-0003-3555-5877","observed_orcids":["https://orcid.org/0000-0003-3555-5877"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Kimura","raw_affiliation_strings":["First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":2.1158,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.87116377,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"92","issue":"1","first_page":"55","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8970000147819519},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.796999990940094},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8690000176429749},{"id":"https://openalex.org/keywords/serum-deprivation","display_name":"serum deprivation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cell-survival-signaling","display_name":"cell survival signaling","score":0.7870000004768372},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.9700000286102295},{"id":"https://openalex.org/keywords/wortmannin","display_name":"wortmannin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.4690000116825104},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.8109999895095825},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7127801775932312},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6708563566207886},{"id":"https://openalex.org/C2778308172","wikidata":"https://www.wikidata.org/wiki/Q423565","display_name":"Wortmannin","level":4,"score":0.6698319315910339},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6035984754562378},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5735288858413696},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.516688346862793},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.504871666431427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49985575675964355},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48141714930534363},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4512559175491333},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.44110938906669617},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3916738033294678},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37936198711395264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35619863867759705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33876466751098633},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26647713780403137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10542985796928406}],"mesh":[{"descriptor_ui":"D001769","descriptor_name":"Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016895","descriptor_name":"Culture Media, Serum-Free","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048369","descriptor_name":"MAP Kinase Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/1097-0215(200102)9999:9999<::aid-ijc1143>3.0.co;2-o","doi":"https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1143>3.0.co;2-o","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1143>3.0.co;2-o","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"doi:10.1002/1097-0215(200102)9999:9999<::aid-ijc1143>3.3.co;2-f","doi":"https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1143>3.3.co;2-f","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1143>3.3.co;2-f","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0215%28200102%299999%3A9999%3C%3A%3AAID-IJC1143%3E3.0.CO%3B2-O","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:11279606","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11279606","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/1097-0215(200102)9999:9999<::aid-ijc1143>3.3.co;2-f","doi":"https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1143>3.3.co;2-f","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1143>3.3.co;2-f","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0215%28200102%299999%3A9999%3C%3A%3AAID-IJC1143%3E3.0.CO%3B2-O","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2034470191.pdf","grobid_xml":"https://content.openalex.org/works/W2034470191.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1490480018","https://openalex.org/W1541026894","https://openalex.org/W1583862506","https://openalex.org/W1947863214","https://openalex.org/W1976385326","https://openalex.org/W1994606814","https://openalex.org/W1999012962","https://openalex.org/W1999090128","https://openalex.org/W1999920274","https://openalex.org/W2000352412","https://openalex.org/W2000552194","https://openalex.org/W2002503549","https://openalex.org/W2003688815","https://openalex.org/W2004078164","https://openalex.org/W2005638713","https://openalex.org/W2008461201","https://openalex.org/W2026338728","https://openalex.org/W2029546962","https://openalex.org/W2030573603","https://openalex.org/W2032383673","https://openalex.org/W2042584344","https://openalex.org/W2046111632","https://openalex.org/W2047263793","https://openalex.org/W2048121649","https://openalex.org/W2052479142","https://openalex.org/W2061497413","https://openalex.org/W2062306067","https://openalex.org/W2062903823","https://openalex.org/W2073730363","https://openalex.org/W2074562878","https://openalex.org/W2076231007","https://openalex.org/W2088165891","https://openalex.org/W2091545748","https://openalex.org/W2093571366","https://openalex.org/W2111714805","https://openalex.org/W2142113094","https://openalex.org/W2168413006","https://openalex.org/W2225269395","https://openalex.org/W2280846418","https://openalex.org/W2399583730","https://openalex.org/W2410556791","https://openalex.org/W6644552140"],"related_works":["https://openalex.org/W2071447700","https://openalex.org/W1838206574","https://openalex.org/W2017682426","https://openalex.org/W2046111632","https://openalex.org/W2078818685","https://openalex.org/W2001270137","https://openalex.org/W2063976456","https://openalex.org/W7099631122","https://openalex.org/W2166245070","https://openalex.org/W2078353782"],"abstract_inverted_index":{"Primary":[0],"liver":[1,23,44,55,121,214],"cancers,":[2],"which":[3,43,69,176],"are":[4,17,177,230],"generally":[5],"hypervascular":[6],"in":[7,63,124,155],"nature,":[8],"depend":[9],"highly":[10],"on":[11,20],"blood":[12],"supply.":[13],"So":[14],"far":[15],"there":[16],"few":[18],"reports":[19],"apoptosis":[21,118,154,168],"of":[22,28,34,51,66,74,83,119,127,140,150,165,180,186,190,197,212],"cancer":[24,45,56,122,215],"cells":[25,46,123,216],"upon":[26,204,218],"deprivation":[27,59,196],"serum-derived":[29],"survival":[30,139,211,233],"factors.":[31],"The":[32,81,184],"aim":[33],"our":[35],"study":[36],"is":[37,135],"to":[38,235],"clarify":[39],"molecular":[40],"mechanisms":[41],"by":[42,72,172],"survive":[47],"with":[48,145],"the":[49,64,105,111,120,125,131,162,178,188,223,226,236],"aid":[50],"serum.":[52],"In":[53,143],"HepG2":[54,141,213],"cells,":[57,68],"serum":[58,93,99,166,205,219],"induced":[60,117],"time-dependent":[61],"increase":[62],"number":[65],"apoptotic":[67],"was":[70,169,201],"detected":[71],"fragmentation":[73],"genomic":[75],"DNA":[76],"and":[77,220,225],"fluorescent":[78],"nuclear":[79],"staining.":[80],"activity":[82,185],"extracellular":[84],"signal-regulated":[85],"kinase":[86,113],"(ERK)":[87],"did":[88],"not":[89,110],"decrease":[90],"considerably":[91],"after":[92,98,195],"deprivation,":[94],"although":[95],"it":[96,200],"increased":[97],"stimulation.":[100,206],"However,":[101],"we":[102],"found":[103,160],"that":[104,130,161,210,221],"MEK1":[106,152],"inhibitor":[107,114],"PD98059,":[108],"but":[109],"p38":[112],"SB203580,":[115],"potently":[116],"presence":[126],"serum,":[128,198],"indicating":[129],"MEK-ERK":[132],"signaling":[133,234],"pathway":[134],"required":[136,231],"for":[137,232],"serum-dependent":[138],"cells.":[142],"agreement":[144],"this":[146],"notion,":[147],"transient":[148],"expression":[149],"active":[151],"prevented":[153],"serum-deprived":[156],"condition.":[157],"We":[158],"also":[159],"protective":[163],"effect":[164],"against":[167],"totally":[170],"abrogated":[171],"LY294002":[173],"or":[174],"wortmannin,":[175],"inhibitors":[179],"phosphatidylinositol":[181],"(PI)":[182],"3-kinase.":[183],"Akt,":[187],"target":[189],"PI":[191,227],"3-kinase,":[192],"decreased":[193],"gradually":[194],"whereas":[199],"rapidly":[202],"reactivated":[203],"These":[207],"data":[208],"indicate":[209],"depends":[217],"both":[222],"MEK1-ERK-":[224],"3-kinase-Akt-":[228],"pathways":[229],"nucleus.":[237]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
