{"id":"https://openalex.org/W2034466962","doi":"https://doi.org/10.1002/dvdy.22672","title":"Discrete regulatory regions control early and late expression of D\u2010Pax2 during external sensory organ development","display_name":"Discrete regulatory regions control early and late expression of D\u2010Pax2 during external sensory organ development","publication_year":2011,"publication_date":"2011-06-03","ids":{"openalex":"https://openalex.org/W2034466962","doi":"https://doi.org/10.1002/dvdy.22672","mag":"2034466962","pmid":"https://pubmed.ncbi.nlm.nih.gov/21644243","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3289681"},"language":"en","primary_location":{"id":"doi:10.1002/dvdy.22672","doi":"https://doi.org/10.1002/dvdy.22672","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dvdy.22672","pdf_url":null,"source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3289681","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089794226","display_name":"Seth A. Johnson","orcid":"https://orcid.org/0000-0002-2524-2351","observed_orcids":["https://orcid.org/0000-0002-2524-2351"]},"institutions":[{"id":"https://openalex.org/I27504731","display_name":"Colby College","ror":"https://ror.org/00fvyjk73","country_code":"US","type":"education","lineage":["https://openalex.org/I27504731"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth A. Johnson","raw_affiliation_strings":["Department of Biology, Colby College, Waterville, Maine, USA","Department of Biology, Colby College, Waterville, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Colby College, Waterville, Maine, USA","institution_ids":["https://openalex.org/I27504731"]},{"raw_affiliation_string":"Department of Biology, Colby College, Waterville, Maine","institution_ids":["https://openalex.org/I27504731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029979894","display_name":"Katharine J. Harmon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27504731","display_name":"Colby College","ror":"https://ror.org/00fvyjk73","country_code":"US","type":"education","lineage":["https://openalex.org/I27504731"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katharine J. Harmon","raw_affiliation_strings":["Department of Biology, Colby College, Waterville, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Colby College, Waterville, Maine","institution_ids":["https://openalex.org/I27504731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030002070","display_name":"Sarah G. Smiley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27504731","display_name":"Colby College","ror":"https://ror.org/00fvyjk73","country_code":"US","type":"education","lineage":["https://openalex.org/I27504731"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah G. Smiley","raw_affiliation_strings":["Department of Biology, Colby College, Waterville, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Colby College, Waterville, Maine","institution_ids":["https://openalex.org/I27504731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050061797","display_name":"Frances Still","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27504731","display_name":"Colby College","ror":"https://ror.org/00fvyjk73","country_code":"US","type":"education","lineage":["https://openalex.org/I27504731"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frances M. Still","raw_affiliation_strings":["Department of Biology, Colby College, Waterville, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Colby College, Waterville, Maine","institution_ids":["https://openalex.org/I27504731"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079733480","display_name":"Joshua Kavaler","orcid":"https://orcid.org/0000-0002-4603-5781","observed_orcids":["https://orcid.org/0000-0002-4603-5781"]},"institutions":[{"id":"https://openalex.org/I27504731","display_name":"Colby College","ror":"https://ror.org/00fvyjk73","country_code":"US","type":"education","lineage":["https://openalex.org/I27504731"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua Kavaler","raw_affiliation_strings":["Department of Biology, Colby College, Waterville, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Colby College, Waterville, Maine","institution_ids":["https://openalex.org/I27504731"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079733480"],"corresponding_institution_ids":["https://openalex.org/I27504731"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":0.2595,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.55504769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"240","issue":"7","first_page":"1769","last_page":"1778"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trichogen-cells","display_name":"trichogen cells","score":0.6489999890327454},{"id":"https://openalex.org/keywords/enhancer-regulation","display_name":"enhancer regulation","score":0.718999981880188},{"id":"https://openalex.org/keywords/positive-feedback-loop","display_name":"positive feedback loop","score":0.9750000238418579},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9109435677528381},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.8123555779457092},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7626305818557739},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.6343721151351929},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6119322180747986},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4953135550022125},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4896247982978821},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.45084691047668457},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.43995437026023865},{"id":"https://openalex.org/C2777620950","wikidata":"https://www.wikidata.org/wiki/Q189105","display_name":"Cell lineage","level":4,"score":0.43025630712509155},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31486570835113525},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30027148127555847},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25124794244766235},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051762","descriptor_name":"PAX2 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051762","descriptor_name":"PAX2 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/dvdy.22672","doi":"https://doi.org/10.1002/dvdy.22672","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dvdy.22672","pdf_url":null,"source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},{"id":"pmid:21644243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21644243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental dynamics : an official publication of the American Association of Anatomists","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3289681","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3289681","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Dev Dyn","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3289681","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3289681","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Dev Dyn","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1853204378","display_name":null,"funder_award_id":"R15-HD04369-01A1","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3576481674","display_name":"Comparative Functional Genomics INBRE in Maine","funder_award_id":"5p20rr016463-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G634933097","display_name":null,"funder_award_id":"P20 RR-016463","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W947309","https://openalex.org/W1506982435","https://openalex.org/W1589317498","https://openalex.org/W1676377677","https://openalex.org/W1765030823","https://openalex.org/W1790815665","https://openalex.org/W1921966622","https://openalex.org/W1934988433","https://openalex.org/W1959340887","https://openalex.org/W1966828612","https://openalex.org/W1969862105","https://openalex.org/W1994142801","https://openalex.org/W1996205689","https://openalex.org/W1997955636","https://openalex.org/W2008493001","https://openalex.org/W2021181211","https://openalex.org/W2043655216","https://openalex.org/W2047578520","https://openalex.org/W2052364465","https://openalex.org/W2059857046","https://openalex.org/W2067981810","https://openalex.org/W2083723382","https://openalex.org/W2089988218","https://openalex.org/W2096387363","https://openalex.org/W2102468789","https://openalex.org/W2113178878","https://openalex.org/W2127427593","https://openalex.org/W2128016314","https://openalex.org/W2129708593","https://openalex.org/W2152611630","https://openalex.org/W2155825305","https://openalex.org/W2163412206","https://openalex.org/W2187370769"],"related_works":["https://openalex.org/W1568879783","https://openalex.org/W2085584791","https://openalex.org/W2911771815","https://openalex.org/W6929715906","https://openalex.org/W2051338749","https://openalex.org/W2107465253","https://openalex.org/W1996205689","https://openalex.org/W2096387363","https://openalex.org/W2058031617","https://openalex.org/W4226031254"],"abstract_inverted_index":{"The":[0],"transcription":[1],"factor":[2],"D-Pax2":[3,44,60],"is":[4,33,51,84,96],"required":[5],"for":[6],"the":[7,19,25,36,40,47,62,70,81,92],"correct":[8],"differentiation":[9],"of":[10,21,43,59],"several":[11],"cell":[12],"types":[13],"in":[14,24,46,61,69,86],"Drosophila":[15],"sensory":[16,49,63],"systems.":[17],"While":[18],"regulation":[20],"its":[22,67],"expression":[23,45,95],"developing":[26],"eye":[27],"has":[28],"been":[29],"well":[30],"studied,":[31],"little":[32],"known":[34],"about":[35],"mechanisms":[37],"by":[38,77,88,98],"which":[39],"dynamic":[41],"pattern":[42],"external":[48],"organs":[50],"achieved.":[52],"Here":[53],"we":[54],"demonstrate":[55],"that":[56],"early":[57],"activation":[58,83],"organ":[64],"lineage":[65],"and":[66,72],"maintenance":[68,94],"trichogen":[71],"thecogen":[73],"cells":[74],"are":[75],"governed":[76],"separate":[78],"enhancers.":[79],"Furthermore,":[80],"initial":[82],"controlled":[85],"part":[87],"proneural":[89],"proteins":[90],"whereas":[91],"later":[93],"regulated":[97],"a":[99],"positive":[100],"feedback":[101],"loop.":[102]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
