{"id":"https://openalex.org/W2034447711","doi":"https://doi.org/10.1002/eji.201041040","title":"PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I\u2010binding peptides in vivo","display_name":"PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I\u2010binding peptides in vivo","publication_year":2011,"publication_date":"2011-01-14","ids":{"openalex":"https://openalex.org/W2034447711","doi":"https://doi.org/10.1002/eji.201041040","mag":"2034447711","pmid":"https://pubmed.ncbi.nlm.nih.gov/21360704","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3100532"},"language":"en","primary_location":{"id":"doi:10.1002/eji.201041040","doi":"https://doi.org/10.1002/eji.201041040","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.201041040","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3100532/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048998579","display_name":"Natascha de Graaf","orcid":"https://orcid.org/0009-0003-6182-2868","observed_orcids":["https://orcid.org/0009-0003-6182-2868","https://orcid.org/0009-0005-0924-7346"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Natascha de Graaf","raw_affiliation_strings":["Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049280888","display_name":"Mary J. G. van Helden","orcid":"https://orcid.org/0000-0002-4506-4943","observed_orcids":["https://orcid.org/0000-0002-4506-4943"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mary J. G. van Helden","raw_affiliation_strings":["Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022648899","display_name":"Kathrin Textoris\u2010Taube","orcid":"https://orcid.org/0000-0002-1224-8236","observed_orcids":["https://orcid.org/0000-0002-1224-8236"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kathrin Textoris\u2010Taube","raw_affiliation_strings":["Institute of Biochemistry, Charite\u0301, Humboldt University Berlin, Berlin, Germany","Institute of Biochemistry, Charit\u00e9, Humboldt University Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Charite\u0301, Humboldt University Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institute of Biochemistry, Charit\u00e9, Humboldt University Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072809750","display_name":"Tomoki Chiba","orcid":"https://orcid.org/0000-0001-5472-9030","observed_orcids":["https://orcid.org/0000-0001-5472-9030"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoki Chiba","raw_affiliation_strings":["Department of Molecular Biology, University of Tsukuba, Tsukuba City, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, University of Tsukuba, Tsukuba City, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005429562","display_name":"David J. Topham","orcid":"https://orcid.org/0000-0002-9435-8673","observed_orcids":["https://orcid.org/0000-0002-9435-8673"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Topham","raw_affiliation_strings":["D. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055648538","display_name":"Peter\u2010Michael Kloetzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter\u2010Michael Kloetzel","raw_affiliation_strings":["Institute of Biochemistry, Charite\u0301, Humboldt University Berlin, Berlin, Germany","Institute of Biochemistry, Charit\u00e9, Humboldt University Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Charite\u0301, Humboldt University Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institute of Biochemistry, Charit\u00e9, Humboldt University Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046453229","display_name":"Dietmar M. W. Zaiss","orcid":"https://orcid.org/0000-0003-3596-7062","observed_orcids":["https://orcid.org/0000-0003-3596-7062"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dietmar M. W. Zaiss","raw_affiliation_strings":["Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051046495","display_name":"Alice J.A.M. Sijts","orcid":"https://orcid.org/0000-0003-3815-4788","observed_orcids":["https://orcid.org/0000-0003-3815-4788"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Alice J. A. M. Sijts","raw_affiliation_strings":["Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5051046495"],"corresponding_institution_ids":["https://openalex.org/I193662353"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":2.3162,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.88909383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"41","issue":"4","first_page":"926","last_page":"935"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.3075999915599823,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.3075999915599823,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.305400013923645,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.30250000953674316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pa28","display_name":"PA28","score":0.9300000071525574},{"id":"https://openalex.org/keywords/immunoproteasome","display_name":"immunoproteasome","score":0.9480000138282776},{"id":"https://openalex.org/keywords/lmp7","display_name":"LMP7","score":0.7710000276565552},{"id":"https://openalex.org/keywords/mecl-1","display_name":"MECL-1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mhc-class-i-binding-peptides","display_name":"MHC class I binding peptides","score":0.7919999957084656},{"id":"https://openalex.org/keywords/antigen-processing","display_name":"antigen processing","score":0.9819999933242798},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6159999966621399},{"id":"https://openalex.org/keywords/cd8-t-cell-responses","display_name":"CD8+ T cell responses","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mhc-class-i-antigen-presentation","display_name":"MHC class I antigen presentation","score":0.5849999785423279},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8293823003768921},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.7554018497467041},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7021157145500183},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.6937204003334045},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.5906533002853394},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5316444039344788},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.4691183865070343},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.372515469789505},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3560580313205719},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3014198839664459},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22963440418243408},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12739965319633484},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/eji.201041040","doi":"https://doi.org/10.1002/eji.201041040","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.201041040","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:21360704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21360704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3100532","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3100532/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Eur J Immunol","raw_type":"Text"},{"id":"pmh:oai:dspace.library.uu.nl:1874/234181","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/234181","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/234181","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/234181","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Immunology, 41, 926. Wiley-VCH Verlag","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3100532","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3100532/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Eur J Immunol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2072771861","display_name":"Immunogenicity of Listeria-derived antigens","funder_award_id":"R01AI064576","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W180494696","https://openalex.org/W1481440696","https://openalex.org/W1522511455","https://openalex.org/W1540017909","https://openalex.org/W1578706288","https://openalex.org/W1640850494","https://openalex.org/W1755125321","https://openalex.org/W1803459716","https://openalex.org/W1839456870","https://openalex.org/W1892909481","https://openalex.org/W1931750338","https://openalex.org/W1951894072","https://openalex.org/W1960514362","https://openalex.org/W1987011447","https://openalex.org/W2008664859","https://openalex.org/W2020442063","https://openalex.org/W2021289499","https://openalex.org/W2028699526","https://openalex.org/W2051352279","https://openalex.org/W2057976601","https://openalex.org/W2059844048","https://openalex.org/W2066013797","https://openalex.org/W2069457695","https://openalex.org/W2070854456","https://openalex.org/W2077147012","https://openalex.org/W2083155294","https://openalex.org/W2084487512","https://openalex.org/W2093270469","https://openalex.org/W2102683915","https://openalex.org/W2103460528","https://openalex.org/W2104710873","https://openalex.org/W2107198699","https://openalex.org/W2107426217","https://openalex.org/W2109962315","https://openalex.org/W2110038702","https://openalex.org/W2114163044","https://openalex.org/W2124007511","https://openalex.org/W2129443680","https://openalex.org/W2129607888","https://openalex.org/W2143746835","https://openalex.org/W2143959810","https://openalex.org/W2144318866","https://openalex.org/W2149050070","https://openalex.org/W2156277550","https://openalex.org/W2156491198","https://openalex.org/W2157579823","https://openalex.org/W2172280727","https://openalex.org/W2178503716"],"related_works":["https://openalex.org/W2108408391","https://openalex.org/W2143746835","https://openalex.org/W1525140626","https://openalex.org/W7099311894","https://openalex.org/W2031623763","https://openalex.org/W2010239849","https://openalex.org/W7014626740","https://openalex.org/W2044578540","https://openalex.org/W2144318866","https://openalex.org/W2103465870"],"abstract_inverted_index":{"Proteasomes":[0],"play":[1,60],"a":[2,45,61],"fundamental":[3],"role":[4,63],"in":[5,64,100,106,119],"the":[6,21,35,42,92,107,120,126,138,159,168,177,190],"processing":[7,183],"of":[8,23,44,47,79,94,116,122,134,140,170,192],"intracellular":[9],"antigens":[10],"into":[11],"peptides":[12,98],"that":[13,88,156],"bind":[14],"to":[15,132,144,166,185],"MHC":[16,48,80,95,117,171],"class":[17,49,81,96,172],"I":[18,82],"molecules":[19],"for":[20,137],"presentation":[22],"CD8(+)":[24,141,194],"T":[25],"cells.":[26],"Three":[27],"IFN-\u03b3-inducible":[28,36,57],"catalytic":[29],"proteasome":[30,37,58,160],"(immuno)subunits":[31],"as":[32,34],"well":[33],"activator":[38],"PA28":[39,72,89,130,157],"dramatically":[40],"accelerate":[41],"generation":[43],"subset":[46],"I-presented":[50],"antigenic":[51],"peptides.":[52],"To":[53],"determine":[54],"whether":[55],"these":[56],"components":[59],"compounded":[62],"antigen":[65],"processing,":[66],"we":[67],"generated":[68],"mice":[69],"lacking":[70],"both":[71,99],"and":[73,76,103,148,158],"immunosubunits":[74,127,161],"\u03b25i/LMP7":[75],"\u03b22i/MECL-1.":[77],"Analyses":[78],"cell-surface":[83],"levels":[84],"ex":[85],"vivo":[86],"demonstrated":[87],"deficiency":[90],"reduced":[91],"production":[93,115],"I-binding":[97,173],"cells":[101,109],"with":[102],"without":[104],"immunosubunits,":[105],"latter":[108],"further":[110],"decreasing":[111],"an":[112],"already":[113],"diminished":[114],"ligands":[118],"absence":[121],"immunoproteasomes.":[123],"In":[124],"contrast,":[125],"but":[128],"not":[129],"appeared":[131],"be":[133],"critical":[135],"importance":[136],"induction":[139],"T-cell":[142,195],"responses":[143],"multiple":[145],"dominant":[146],"Influenza":[147],"Listeria-derived":[149],"epitopes.":[150],"Taken":[151],"together,":[152],"our":[153],"data":[154],"demonstrate":[155],"use":[162],"fundamentally":[163],"different":[164],"mechanisms":[165],"enhance":[167],"supply":[169],"peptides;":[174],"however,":[175],"only":[176],"immunosubunit-imposed":[178],"effects":[179],"on":[180,189],"proteolytic":[181],"epitope":[182],"appear":[184],"have":[186],"substantial":[187],"influence":[188],"specificity":[191],"pathogen-specific":[193],"responses.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}