{"id":"https://openalex.org/W2034437838","doi":"https://doi.org/10.1038/sj.jcbfm.9600065","title":"Preferred Stereoselective Transport of the D-isomer of cis-4-[18F]fluoro-proline at the Blood\u2013Brain Barrier","display_name":"Preferred Stereoselective Transport of the D-isomer of cis-4-[18F]fluoro-proline at the Blood\u2013Brain Barrier","publication_year":2005,"publication_date":"2005-03-02","ids":{"openalex":"https://openalex.org/W2034437838","doi":"https://doi.org/10.1038/sj.jcbfm.9600065","mag":"2034437838","pmid":"https://pubmed.ncbi.nlm.nih.gov/15744252"},"language":"en","primary_location":{"id":"doi:10.1038/sj.jcbfm.9600065","doi":"https://doi.org/10.1038/sj.jcbfm.9600065","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.jcbfm.9600065","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/sj.jcbfm.9600065","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1038/sj.jcbfm.9600065","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062516261","display_name":"Karl\u2010Josef Langen","orcid":"https://orcid.org/0000-0003-1101-5075","observed_orcids":["https://orcid.org/0000-0003-1101-5075"]},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Karl-Josef Langen","raw_affiliation_strings":["Brain Imaging Centre West (BICW), J\u00fclich, Germany","Institute of Medicine, Research Centre J\u00fclich, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Imaging Centre West (BICW), J\u00fclich, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Medicine, Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111854639","display_name":"Kurt Hamacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kurt Hamacher","raw_affiliation_strings":["Brain Imaging Centre West (BICW), J\u00fclich, Germany","Institute of Nuclear Chemistry, Research Centre J\u00fclich, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Imaging Centre West (BICW), J\u00fclich, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Nuclear Chemistry, Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113572672","display_name":"Dagmar Bauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dagmar Bauer","raw_affiliation_strings":["Brain Imaging Centre West (BICW), J\u00fclich, Germany","Institute of Medicine, Research Centre J\u00fclich, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Imaging Centre West (BICW), J\u00fclich, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Medicine, Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074021013","display_name":"Stefan Br\u00f6er","orcid":"https://orcid.org/0000-0002-8040-1634","observed_orcids":["https://orcid.org/0000-0002-8040-1634"]},"institutions":[{"id":"https://openalex.org/I118347636","display_name":"Australian National University","ror":"https://ror.org/019wvm592","country_code":"AU","type":"education","lineage":["https://openalex.org/I118347636"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stefan Br\u00f6er","raw_affiliation_strings":["School of Biochemistry & Molecular Biology, Faculty of Science, Australian National University, Canberra, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biochemistry & Molecular Biology, Faculty of Science, Australian National University, Canberra, Australia","institution_ids":["https://openalex.org/I118347636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110542982","display_name":"Dirk O. Pauleit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk Pauleit","raw_affiliation_strings":["Brain Imaging Centre West (BICW), J\u00fclich, Germany","Institute of Medicine, Research Centre J\u00fclich, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Imaging Centre West (BICW), J\u00fclich, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Medicine, Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006033207","display_name":"Hans R Herzog","orcid":"https://orcid.org/0000-0002-6751-7165","observed_orcids":["https://orcid.org/0000-0002-6751-7165"]},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans Herzog","raw_affiliation_strings":["Brain Imaging Centre West (BICW), J\u00fclich, Germany","Institute of Medicine, Research Centre J\u00fclich, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Imaging Centre West (BICW), J\u00fclich, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Medicine, Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108197450","display_name":"Frank Willi Floeth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Floeth","raw_affiliation_strings":["Clinic of Neurosurgery, University Clinic of D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Neurosurgery, University Clinic of D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210089242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087646992","display_name":"Karl Zilles","orcid":"https://orcid.org/0000-0002-4705-4175","observed_orcids":["https://orcid.org/0000-0002-4705-4175"]},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl Zilles","raw_affiliation_strings":["Brain Imaging Centre West (BICW), J\u00fclich, Germany","Institute of Medicine, Research Centre J\u00fclich, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Imaging Centre West (BICW), J\u00fclich, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Medicine, Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106234784","display_name":"Heinz Hubert Coenen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heinz H Coenen","raw_affiliation_strings":["Brain Imaging Centre West (BICW), J\u00fclich, Germany","Institute of Nuclear Chemistry, Research Centre J\u00fclich, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Imaging Centre West (BICW), J\u00fclich, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Nuclear Chemistry, Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062516261"],"corresponding_institution_ids":["https://openalex.org/I171892758"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":1.7315,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.81203566,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"5","first_page":"607","last_page":"616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.6640999913215637,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.6640999913215637,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.21289999783039093,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/d-proline","display_name":"D-proline","score":0.8109999895095825},{"id":"https://openalex.org/keywords/proline","display_name":"proline","score":0.8769999742507935},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9789999723434448},{"id":"https://openalex.org/keywords/amino-acid-transport","display_name":"amino acid transport","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pet-radiotracer","display_name":"PET radiotracer","score":0.7059999704360962},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.5339999794960022},{"id":"https://openalex.org/keywords/excitatory-neurotransmission","display_name":"excitatory neurotransmission","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.6983324289321899},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.6552591323852539},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.36569803953170776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35146015882492065},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3339931070804596},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2755165696144104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17072004079818726},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1519705057144165},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14815884828567505},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/sj.jcbfm.9600065","doi":"https://doi.org/10.1038/sj.jcbfm.9600065","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.jcbfm.9600065","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/sj.jcbfm.9600065","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:15744252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15744252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","raw_type":"Comparative Study"},{"id":"pmh:oai:juser.fz-juelich.de:45401","doi":null,"is_oa":false,"landing_page_url":"https://juser.fz-juelich.de/search?p=id:%22PreJuSER-45401%22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401090","display_name":"JuSER (Forschungszentrum J\u00fclich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I171892758","host_organization_name":"Forschungszentrum J\u00fclich","host_organization_lineage":["https://openalex.org/I171892758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of cerebral blood flow &amp; metabolism 25, 607 - 616 (2005). doi:10.1038/sj.jcbfm.9600065","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:openresearch-repository.anu.edu.au:1885/84148","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1885/84148","pdf_url":null,"source":{"id":"https://openalex.org/S4306402539","display_name":"ANU Open Research (Australian National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118347636","host_organization_name":"Australian National University","host_organization_lineage":["https://openalex.org/I118347636"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cerebral Blood Flow and Metabolism","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1038/sj.jcbfm.9600065","doi":"https://doi.org/10.1038/sj.jcbfm.9600065","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.jcbfm.9600065","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/sj.jcbfm.9600065","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2034437838.pdf","grobid_xml":"https://content.openalex.org/works/W2034437838.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W11956919","https://openalex.org/W16603568","https://openalex.org/W1559213768","https://openalex.org/W1924226790","https://openalex.org/W1967228743","https://openalex.org/W1973143170","https://openalex.org/W1976696624","https://openalex.org/W1979452879","https://openalex.org/W1980263219","https://openalex.org/W1986791806","https://openalex.org/W1991155811","https://openalex.org/W1995643379","https://openalex.org/W2002322242","https://openalex.org/W2003198568","https://openalex.org/W2006712669","https://openalex.org/W2010735507","https://openalex.org/W2019617917","https://openalex.org/W2023658000","https://openalex.org/W2031849543","https://openalex.org/W2041557110","https://openalex.org/W2046370585","https://openalex.org/W2063236748","https://openalex.org/W2068524525","https://openalex.org/W2072576878","https://openalex.org/W2075384280","https://openalex.org/W2076121967","https://openalex.org/W2081489286","https://openalex.org/W2087824576","https://openalex.org/W2088334587","https://openalex.org/W2092078486","https://openalex.org/W2092540307","https://openalex.org/W2095023183","https://openalex.org/W2101494517","https://openalex.org/W2150598634","https://openalex.org/W2154263373","https://openalex.org/W2156130516","https://openalex.org/W2156658337","https://openalex.org/W2166070786","https://openalex.org/W2172132512","https://openalex.org/W2219978756","https://openalex.org/W2313757943","https://openalex.org/W2338515527","https://openalex.org/W2403687361","https://openalex.org/W2408886053"],"related_works":["https://openalex.org/W6995947977","https://openalex.org/W7209012478","https://openalex.org/W7061196329","https://openalex.org/W7006075672","https://openalex.org/W7014647309","https://openalex.org/W1967228743","https://openalex.org/W7043551595","https://openalex.org/W2091989219","https://openalex.org/W3024892511","https://openalex.org/W2076121967"],"abstract_inverted_index":{"Generally,":[0],"L-amino":[1,15],"acids":[2,16],"are":[3,17,169],"preferably":[4,170],"transported":[5,171],"into":[6,19],"mammalian":[7],"cells":[8],"compared":[9,176],"with":[10,177],"their":[11,178],"D-isomers,":[12],"and":[13,49,57,67,103,150,167,180],"only":[14],"incorporated":[18],"proteins.":[20],"Former":[21],"studies,":[22],"however,":[23],"indicated":[24],"that":[25,165],"D-[H]proline":[26],"is":[27,38],"accumulated":[28],"in":[29,61,72,85,128,135,154,190],"the":[30,42,47,52,68,86,116,129,136,155,173,183,186,191],"brain":[31,118],"of":[32,46,51,58,70,83,89,115,122,138,197,209],"mice":[33],"after":[34,120],"injection,":[35],"while":[36],"L-[3H]proline":[37],"not.":[39],"We":[40,163],"investigated":[41],"differential":[43],"cerebral":[44,87],"uptake":[45,69,80],"D-":[48],"L-isomers":[50,179],"PET":[53,141],"tracer":[54,65],"cis-4-[18F]fluoroproline":[55],"(D-/L-cis-FPro)":[56],"D-/L-[3H]proline":[59],"(D-/L-Pro)":[60],"rats":[62,90],"by":[63,76],"dual":[64],"autoradiography":[66],"D-cis-FPro":[71,84,123,159,166],"two":[73],"human":[74,156],"subjects":[75],"PET.":[77],"The":[78,140],"standardized":[79],"value":[81],"(SUV)":[82],"cortex":[88,157],"2":[91],"h":[92],"p.i.":[93],"was":[94],"3.05+/-1.18":[95],"(n=9)":[96,110],"versus":[97,108],"0.06+/-0.01":[98],"(n=4)":[99,105],"for":[100,106,111,158,161],"L-cis-FPro":[101],"(P<0.001)":[102],"1.29+/-0.27":[104],"D-Pro":[107,168,189],"0.30+/-0.14":[109],"L-Pro":[112],"(P<0.001).":[113],"Analysis":[114],"rat":[117],"tissue":[119],"injection":[121],"(n=3)":[124],"revealed":[125],"no":[126],"radioactivity":[127],"proteins":[130],"but":[131],"a":[132,144,195,207],"relevant":[133],"part":[134],"form":[137],"L-trans-FPro.":[139],"studies":[142],"yielded":[143],"four-":[145],"to":[146,182,204],"five-fold":[147],"higher":[148],"SUV":[149],"influx":[151],"rate":[152],"constant":[153],"than":[160],"L-cis-FPro.":[162],"conclude":[164],"at":[172],"blood-brain":[174],"barrier":[175],"isomerized":[181],"L-form":[184],"within":[185],"brain.":[187],"Thus,":[188],"plasma":[192],"might":[193],"be":[194],"source":[196],"intracerebral":[198],"L-proline,":[199],"which":[200],"has":[201],"been":[202],"shown":[203],"act":[205],"as":[206],"modulator":[208],"excitatory":[210],"neurotransmission.":[211]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
