{"id":"https://openalex.org/W2034435918","doi":"https://doi.org/10.1111/j.1600-0765.1983.tb00342.x","title":"Effect of indomethacin on bone destruction during experimental periodontal disease in the hamster","display_name":"Effect of indomethacin on bone destruction during experimental periodontal disease in the hamster","publication_year":1983,"publication_date":"1983-02-01","ids":{"openalex":"https://openalex.org/W2034435918","doi":"https://doi.org/10.1111/j.1600-0765.1983.tb00342.x","mag":"2034435918","pmid":"https://pubmed.ncbi.nlm.nih.gov/6222171"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0765.1983.tb00342.x","doi":"https://doi.org/10.1111/j.1600-0765.1983.tb00342.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0765.1983.tb00342.x","pdf_url":null,"source":{"id":"https://openalex.org/S195000414","display_name":"Journal of Periodontal Research","issn_l":"0022-3484","issn":["0022-3484","1600-0765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontal Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111884816","display_name":"Jean\u2010Jacques Lasfargues","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean\u2010Jacques Lasfargues","raw_affiliation_strings":["Laboratoire de Physiopathologie Osseuse, De\u0301partement de Parodontologie, Faculte\u0301 de Chirurgie Dentaire, Universite\u0301 Rene\u0301 Descartes (Paris-V), Montrouge, France","Laboratoire de Physiopathologie Osseuse, D\u00e9partement de Parodontologie, Facult\u00e9 de Chirurgie Dentaire, Universit\u00e9 Ren\u00e9 Descartes (Paris-V), Montrouge, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiopathologie Osseuse, De\u0301partement de Parodontologie, Faculte\u0301 de Chirurgie Dentaire, Universite\u0301 Rene\u0301 Descartes (Paris-V), Montrouge, France","institution_ids":["https://openalex.org/I4387156284"]},{"raw_affiliation_string":"Laboratoire de Physiopathologie Osseuse, D\u00e9partement de Parodontologie, Facult\u00e9 de Chirurgie Dentaire, Universit\u00e9 Ren\u00e9 Descartes (Paris-V), Montrouge, France","institution_ids":["https://openalex.org/I4387156284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088878837","display_name":"Saffar Jl","orcid":"https://orcid.org/0000-0001-6288-9325","observed_orcids":["https://orcid.org/0000-0001-6288-9325"]},"institutions":[{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jean\u2010Louis Saffar","raw_affiliation_strings":["Laboratoire de Physiopathologie Osseuse, De\u0301partement de Parodontologie, Faculte\u0301 de Chirurgie Dentaire, Universite\u0301 Rene\u0301 Descartes (Paris-V), Montrouge, France","Laboratoire de Physiopathologie Osseuse, D\u00e9partement de Parodontologie, Facult\u00e9 de Chirurgie Dentaire, Universit\u00e9 Ren\u00e9 Descartes (Paris-V), Montrouge, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiopathologie Osseuse, De\u0301partement de Parodontologie, Faculte\u0301 de Chirurgie Dentaire, Universite\u0301 Rene\u0301 Descartes (Paris-V), Montrouge, France","institution_ids":["https://openalex.org/I4387156284"]},{"raw_affiliation_string":"Laboratoire de Physiopathologie Osseuse, D\u00e9partement de Parodontologie, Facult\u00e9 de Chirurgie Dentaire, Universit\u00e9 Ren\u00e9 Descartes (Paris-V), Montrouge, France","institution_ids":["https://openalex.org/I4387156284"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088878837"],"corresponding_institution_ids":["https://openalex.org/I4387156284"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":1.3701,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.78832117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":"18","issue":"1","first_page":"110","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9077000021934509,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9077000021934509,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.08829999715089798,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":1.0},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.7829999923706055},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.8230000138282776},{"id":"https://openalex.org/keywords/prostaglandin-synthesis-inhibition","display_name":"prostaglandin synthesis inhibition","score":0.8180000185966492},{"id":"https://openalex.org/keywords/calcitonin","display_name":"calcitonin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/alveolar-bone-loss","display_name":"alveolar bone loss","score":0.925000011920929},{"id":"https://openalex.org/keywords/hamster-model","display_name":"hamster model","score":0.6800000071525574},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C151279780","wikidata":"https://www.wikidata.org/wiki/Q143588","display_name":"Dental alveolus","level":2,"score":0.7875998020172119},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.7654420137405396},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.7305989265441895},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.6667087078094482},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.6487252116203308},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.5940442085266113},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.574891984462738},{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.5598101615905762},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.521056592464447},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5054583549499512},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5032047629356384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5019853115081787},{"id":"https://openalex.org/C2777198256","wikidata":"https://www.wikidata.org/wiki/Q4860325","display_name":"Prostaglandin E","level":2,"score":0.44255274534225464},{"id":"https://openalex.org/C2992452445","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontal disease","level":2,"score":0.44009605050086975},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4243055284023285},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39807209372520447},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.30778801441192627},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10095462203025818},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07391762733459473}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010510","descriptor_name":"Periodontal Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010510","descriptor_name":"Periodontal Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0765.1983.tb00342.x","doi":"https://doi.org/10.1111/j.1600-0765.1983.tb00342.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0765.1983.tb00342.x","pdf_url":null,"source":{"id":"https://openalex.org/S195000414","display_name":"Journal of Periodontal Research","issn_l":"0022-3484","issn":["0022-3484","1600-0765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontal Research","raw_type":"journal-article"},{"id":"pmid:6222171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6222171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of periodontal research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W127691036","https://openalex.org/W1570561206","https://openalex.org/W1969046399","https://openalex.org/W1972261336","https://openalex.org/W1978958326","https://openalex.org/W1991799498","https://openalex.org/W1996212166","https://openalex.org/W1996318486","https://openalex.org/W2003402083","https://openalex.org/W2004954990","https://openalex.org/W2008574207","https://openalex.org/W2008763094","https://openalex.org/W2022053554","https://openalex.org/W2031677004","https://openalex.org/W2038042263","https://openalex.org/W2038454151","https://openalex.org/W2041663445","https://openalex.org/W2041690368","https://openalex.org/W2042408524","https://openalex.org/W2046731741","https://openalex.org/W2046878594","https://openalex.org/W2049307267","https://openalex.org/W2051613281","https://openalex.org/W2091394826","https://openalex.org/W2092252818","https://openalex.org/W2101357889","https://openalex.org/W2152306761","https://openalex.org/W2416750766","https://openalex.org/W2417752836","https://openalex.org/W2418922595","https://openalex.org/W2470848501","https://openalex.org/W2606653020"],"related_works":["https://openalex.org/W1973745058","https://openalex.org/W2008763094","https://openalex.org/W2413739670","https://openalex.org/W2015176256","https://openalex.org/W2165435958","https://openalex.org/W2124765369","https://openalex.org/W2780255387","https://openalex.org/W2037867723","https://openalex.org/W2041663445","https://openalex.org/W2101571060"],"abstract_inverted_index":{"A":[0],"major":[1],"event":[2],"in":[3,26,43,76],"periodontitis":[4,142],"is":[5,12],"the":[6,36,61,68,91,96,103,107,114],"destruction":[7,42,126],"of":[8,19,30,38,56,70,93,102,122,141],"alveolar":[9],"processes.":[10],"It":[11],"demonstrated":[13],"that":[14],"indomethacin":[15],"(IND),":[16],"an":[17,54,120,128],"inhibitor":[18,55],"prostaglandin":[20,132],"synthesis,":[21],"can":[22,134],"inhibit":[23],"bone":[24,41,63,86,125],"resorption":[25],"vitro.":[27],"The":[28,100],"aim":[29],"this":[31,139],"study":[32],"was":[33,49],"to":[34,51,95],"test":[35],"effect":[37,109,121],"IND":[39,59,123],"on":[40,113,124,131],"hamster":[44],"periodontal":[45],"disease.":[46],"Its":[47],"action":[48,130],"compared":[50],"calcitonin":[52],"(CT),":[53],"osteoclastic":[57],"resorption.":[58],"decreased":[60,90],"macroscopic":[62],"loss":[64,87],"by":[65,74],"28%":[66],"and":[67,89],"number":[69,92],"osteoclasts":[71,94],"per":[72],"mm":[73],"55%":[75],"diseased":[77],"animals":[78],"but":[79,127],"not":[80],"significantly.":[81],"Conversely":[82],"CT":[83,111,143],"reduced":[84],"significantly":[85],"(p<0.05)":[88],"control":[97],"level":[98],"(p<0.01).":[99],"combination":[101],"two":[104,115],"drugs":[105],"had":[106],"same":[108],"than":[110,147],"alone":[112],"parameters.":[116],"These":[117],"results":[118],"show":[119],"inhibitory":[129],"synthesis":[133],"only":[135],"be":[136],"hypothesized.":[137],"In":[138],"model":[140],"appears":[144],"more":[145],"effective":[146],"IND.":[148]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}