{"id":"https://openalex.org/W2034429582","doi":"https://doi.org/10.7326/0003-4819-88-2-176","title":"Hereditary Nephritis: A Re-examination of its Clinical and Genetic Features","display_name":"Hereditary Nephritis: A Re-examination of its Clinical and Genetic Features","publication_year":1978,"publication_date":"1978-02-01","ids":{"openalex":"https://openalex.org/W2034429582","doi":"https://doi.org/10.7326/0003-4819-88-2-176","mag":"2034429582","pmid":"https://pubmed.ncbi.nlm.nih.gov/626446"},"language":"en","primary_location":{"id":"doi:10.7326/0003-4819-88-2-176","doi":"https://doi.org/10.7326/0003-4819-88-2-176","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-88-2-176","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112133662","display_name":"William M. O\u02bcNeill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"WILLIAM M. O'NEILL","raw_affiliation_strings":["Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salt Lake City, Utah","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"CURTIS L. ATKIN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CURTIS L. ATKIN","raw_affiliation_strings":["Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salt Lake City, Utah","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"H. ALLAN BLOOMER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. ALLAN BLOOMER","raw_affiliation_strings":["Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salt Lake City, Utah","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112133662"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9311,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.9265461,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"88","issue":"2","first_page":"176","last_page":"182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alport-syndrome","display_name":"Alport syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/x-linked-dominant-inheritance","display_name":"X-linked dominant inheritance","score":0.6710000038146973},{"id":"https://openalex.org/keywords/microscopic-hematuria","display_name":"microscopic hematuria","score":0.8659999966621399},{"id":"https://openalex.org/keywords/glomerulitis","display_name":"glomerulitis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/sex-differences-in-disease-severity","display_name":"sex differences in disease severity","score":0.9179999828338623},{"id":"https://openalex.org/keywords/variable-expressivity","display_name":"variable expressivity","score":0.5830000042915344},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.7590000033378601},{"id":"https://openalex.org/keywords/uremia","display_name":"uremia","score":0.7620000243186951},{"id":"https://openalex.org/keywords/pedigree-analysis","display_name":"pedigree analysis","score":0.5929999947547913},{"id":"https://openalex.org/keywords/urinary-abnormalities","display_name":"urinary abnormalities","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8788868188858032},{"id":"https://openalex.org/C2777058396","wikidata":"https://www.wikidata.org/wiki/Q401402","display_name":"Nephritis","level":2,"score":0.7975782155990601},{"id":"https://openalex.org/C22593422","wikidata":"https://www.wikidata.org/wiki/Q3242583","display_name":"Pedigree chart","level":3,"score":0.7903244495391846},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.6707961559295654},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4831397235393524},{"id":"https://openalex.org/C2780888721","wikidata":"https://www.wikidata.org/wiki/Q1424106","display_name":"Interstitial nephritis","level":3,"score":0.4389207065105438},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3613779842853546},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35247164964675903},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.257714182138443},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1487564742565155},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07576528191566467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.04939180612564087}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006417","descriptor_name":"Hematuria","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009394","descriptor_name":"Nephritis, Hereditary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009394","descriptor_name":"Nephritis, Hereditary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009394","descriptor_name":"Nephritis, Hereditary","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.7326/0003-4819-88-2-176","doi":"https://doi.org/10.7326/0003-4819-88-2-176","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-88-2-176","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:626446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/626446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.903.176","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.903.176","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://annals.org/data/Journals/AIM/19530/AIME197802010-00005.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W157488374","https://openalex.org/W179590266","https://openalex.org/W1508871760","https://openalex.org/W1837489600","https://openalex.org/W1838284740","https://openalex.org/W1870569278","https://openalex.org/W1935156906","https://openalex.org/W1974107596","https://openalex.org/W2011938115","https://openalex.org/W2029146706","https://openalex.org/W2034506022","https://openalex.org/W2045279508","https://openalex.org/W2067056664","https://openalex.org/W2078899838","https://openalex.org/W2081412246","https://openalex.org/W2081765983","https://openalex.org/W2086243664","https://openalex.org/W2088356242","https://openalex.org/W2109297796","https://openalex.org/W2163611005","https://openalex.org/W2299125579","https://openalex.org/W2317862874","https://openalex.org/W2341418152","https://openalex.org/W2402059958","https://openalex.org/W2408900188","https://openalex.org/W2415804276","https://openalex.org/W2418414463","https://openalex.org/W2425335688","https://openalex.org/W2464001886","https://openalex.org/W2994319011","https://openalex.org/W4205495752"],"related_works":["https://openalex.org/W1508871760","https://openalex.org/W2127634362","https://openalex.org/W2399475818","https://openalex.org/W2467648317","https://openalex.org/W55821138","https://openalex.org/W2409701698","https://openalex.org/W2034944592","https://openalex.org/W2367389708","https://openalex.org/W2160317967","https://openalex.org/W2410211124"],"abstract_inverted_index":{"In":[0,110],"order":[1],"to":[2,93,136],"re-evaluate":[3],"current":[4],"concepts":[5],"of":[6,16,118],"hereditary":[7,32,48,126],"nephritis":[8,49,127],"we":[9],"studied":[10],"the":[11,14,17,41,66,138,147],"urinary":[12,44,82,104],"findings,":[13],"course":[15],"disease,":[18],"and":[19,53,90,106,144,146],"its":[20],"genetic":[21,119],"transmission":[22,120],"in":[23,50,87,96,132,140],"two":[24,112],"large":[25],"pedigrees.":[26],"We":[27],"identified":[28],"150":[29],"patients":[30],"with":[31],"nephritis.":[33],"Our":[34],"data":[35],"show":[36],"that":[37,65,125],"microscopic":[38],"hematuria":[39,57],"is":[40,58,69,128],"most":[42],"reliable":[43],"criterion":[45],"for":[46],"diagnosing":[47],"both":[51],"male":[52],"female":[54],"patients.":[55],"The":[56,123],"frequently":[59],"accompanied":[60],"by":[61],"erythrocyte":[62],"casts":[63],"indicating":[64],"renal":[67,94],"lesion":[68],"a":[70,114],"glomerulitis.":[71],"Men":[72],"are":[73,85],"more":[74],"severely":[75],"affected":[76,151],"than":[77],"women.":[78,152],"They":[79],"have":[80,101],"striking":[81],"abnormalities,":[83],"which":[84],"present":[86],"early":[88],"childhood,":[89],"they":[91],"progress":[92],"failure":[95],"adult":[97],"life.":[98],"Affected":[99],"women":[100,145],"less":[102],"obvious":[103],"abnormalities":[105],"rarely":[107],"develop":[108],"uremia.":[109],"these":[111],"families":[113],"sex-linked":[115],"dominant":[116],"mode":[117],"was":[121],"present.":[122],"demonstration":[124],"X-linked,":[129],"at":[130],"least":[131],"some":[133],"families,":[134],"helps":[135],"explain":[137],"difference":[139],"severity":[141],"between":[142],"men":[143],"variable":[148],"expression":[149],"among":[150]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}