{"id":"https://openalex.org/W2034420014","doi":"https://doi.org/10.1371/journal.pone.0114726","title":"Bee Venom Phospholipase A2 Protects against Acetaminophen-Induced Acute Liver Injury by Modulating Regulatory T Cells and IL-10 in Mice","display_name":"Bee Venom Phospholipase A2 Protects against Acetaminophen-Induced Acute Liver Injury by Modulating Regulatory T Cells and IL-10 in Mice","publication_year":2014,"publication_date":"2014-12-05","ids":{"openalex":"https://openalex.org/W2034420014","doi":"https://doi.org/10.1371/journal.pone.0114726","mag":"2034420014","pmid":"https://pubmed.ncbi.nlm.nih.gov/25478691","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4257707"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0114726","doi":"https://doi.org/10.1371/journal.pone.0114726","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0114726","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114726&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114726&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102172978","display_name":"Hyunseong Kim","orcid":"https://orcid.org/0009-0008-4161-5876","observed_orcids":["https://orcid.org/0009-0008-4161-5876"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyunseong Kim","raw_affiliation_strings":["Department of Physiology, College of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047593303","display_name":"Dongjune Keum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong June Keum","raw_affiliation_strings":["Department of Physiology, College of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032977924","display_name":"Jung won Kwak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung won Kwak","raw_affiliation_strings":["Department of Physiology, College of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056367866","display_name":"Hwan\u2010Suck Chung","orcid":"https://orcid.org/0000-0002-5901-0217","observed_orcids":["https://orcid.org/0000-0002-5901-0217"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hwan-Suck Chung","raw_affiliation_strings":["Department of Physiology, College of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054619950","display_name":"Hyunsu Bae","orcid":"https://orcid.org/0000-0002-0299-3582","observed_orcids":["https://orcid.org/0000-0002-0299-3582"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyunsu Bae","raw_affiliation_strings":["Department of Physiology, College of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea; Institute of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea","Department of Physiology, College of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea","Institute of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea; Institute of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Physiology, College of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Institute of Korean Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054619950","https://openalex.org/A5056367866"],"corresponding_institution_ids":["https://openalex.org/I35928602"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.3695,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.91741472,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"12","first_page":"e114726","last_page":"e114726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.19380000233650208,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bee-venom","display_name":"bee venom","score":0.9139999747276306},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acetaminophen-induced-hepatotoxicity","display_name":"acetaminophen hepatotoxicity","score":0.906000018119812},{"id":"https://openalex.org/keywords/acute-liver-injury","display_name":"acute liver injury","score":0.9459999799728394},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8849999904632568},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.9729999899864197},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7599999904632568},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9679999947547913},{"id":"https://openalex.org/keywords/treg-depletion","display_name":"Treg depletion","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.8545867204666138},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6875296235084534},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.5809773802757263},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5552986264228821},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5445953607559204},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.425339937210083},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2578349709510803}],"mesh":[{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001514","descriptor_name":"Bee Venoms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001514","descriptor_name":"Bee Venoms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D054467","descriptor_name":"Phospholipases A2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0114726","doi":"https://doi.org/10.1371/journal.pone.0114726","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0114726","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114726&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:25478691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25478691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4257707","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4257707/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.770.2982","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.770.2982","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a7/66/pone.0114726.PMC4257707.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:be6c71e77fe54ae3b2b73a47dcb07f81","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/be6c71e77fe54ae3b2b73a47dcb07f81","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 12, p e114726 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0114726","doi":"https://doi.org/10.1371/journal.pone.0114726","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0114726","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114726&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G57888267","display_name":null,"funder_award_id":"2009-0063466","funder_id":"https://openalex.org/F4320322348","funder_display_name":"Korea Science and Engineering Foundation"}],"funders":[{"id":"https://openalex.org/F4320322348","display_name":"Korea Science and Engineering Foundation","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2034420014.pdf","grobid_xml":"https://content.openalex.org/works/W2034420014.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1490356694","https://openalex.org/W1550888268","https://openalex.org/W1966556984","https://openalex.org/W1976616466","https://openalex.org/W1978244308","https://openalex.org/W1984934101","https://openalex.org/W1986337007","https://openalex.org/W1991844778","https://openalex.org/W1994840499","https://openalex.org/W1996448769","https://openalex.org/W2003833115","https://openalex.org/W2004708987","https://openalex.org/W2005930832","https://openalex.org/W2006005366","https://openalex.org/W2009609856","https://openalex.org/W2018896156","https://openalex.org/W2021760949","https://openalex.org/W2026759021","https://openalex.org/W2030284768","https://openalex.org/W2037159578","https://openalex.org/W2047082520","https://openalex.org/W2052012629","https://openalex.org/W2059565012","https://openalex.org/W2060561647","https://openalex.org/W2061126659","https://openalex.org/W2061184943","https://openalex.org/W2070647828","https://openalex.org/W2074238518","https://openalex.org/W2078422760","https://openalex.org/W2083681924","https://openalex.org/W2089671344","https://openalex.org/W2107336310","https://openalex.org/W2108290804","https://openalex.org/W2109507495","https://openalex.org/W2114667085","https://openalex.org/W2115891825","https://openalex.org/W2116459155","https://openalex.org/W2122722718","https://openalex.org/W2140494021","https://openalex.org/W2140986765","https://openalex.org/W2148226248","https://openalex.org/W2153389047","https://openalex.org/W2155970781","https://openalex.org/W2164325660","https://openalex.org/W2166539778","https://openalex.org/W2169958072","https://openalex.org/W2170920819","https://openalex.org/W2171740867","https://openalex.org/W2175221334","https://openalex.org/W2243800263","https://openalex.org/W2289456500","https://openalex.org/W2737785069"],"related_works":["https://openalex.org/W7099931070","https://openalex.org/W3014117401","https://openalex.org/W2960401100","https://openalex.org/W3189778873","https://openalex.org/W4313359368","https://openalex.org/W2011910115","https://openalex.org/W2771783191","https://openalex.org/W2007433506","https://openalex.org/W2778391567","https://openalex.org/W2134691299"],"abstract_inverted_index":{"The":[0,140],"aim":[1],"of":[2,11,43,91,114,156,169,222],"this":[3],"study":[4],"was":[5,187],"to":[6,54],"investigate":[7],"the":[8,73,88,111,154,181,191,219,232],"protective":[9,56,196,220],"effects":[10,57,113,197,221],"phospholipase":[12],"A2":[13],"(PLA2)":[14],"from":[15],"bee":[16,69,92],"venom":[17,70,93],"against":[18,103,224],"acetaminophen-induced":[19,225],"hepatotoxicity":[20,226],"through":[21],"CD4+CD25+Foxp3+":[22],"T":[23],"cells":[24],"(Treg)":[25],"in":[26,58,76,190,200,207],"mice.":[27,184,193,209],"Acetaminophen":[28],"(APAP)":[29],"is":[30,94],"a":[31,127],"widely":[32],"used":[33],"antipyretic":[34],"and":[35,62,78,132,147,160,175,206,234],"analgesic,":[36],"but":[37],"an":[38],"acute":[39],"or":[40,118],"cumulative":[41],"overdose":[42],"acetaminophen":[44,138,151],"can":[45,215,227],"cause":[46],"severe":[47],"hepatic":[48,195],"failure.":[49],"Tregs":[50],"have":[51],"been":[52],"reported":[53],"possess":[55],"various":[59],"liver":[60,104],"diseases":[61],"kidney":[63],"toxicity.":[64],"We":[65],"previously":[66],"found":[67,86],"that":[68,87,99,218],"strongly":[71],"increased":[72,189],"Treg":[74,233],"population":[75],"splenocytes":[77],"subsequently":[79],"suppressed":[80],"immune":[81],"disorders.":[82],"More":[83],"recently,":[84],"we":[85,97],"effective":[89],"component":[90],"PLA2.":[95],"Thus,":[96],"hypothesized":[98],"PLA2":[100,125,223],"could":[101],"protect":[102],"injury":[105],"induced":[106],"by":[107,203,230],"acetaminophen.":[108],"To":[109],"evaluate":[110],"hepatoprotective":[112],"PLA2,":[115],"C57BL/6":[116],"mice":[117,121,165,202],"interleukin-10-deficient":[119],"(IL-10-/-)":[120],"were":[122,143,198],"injected":[123],"with":[124,180],"once":[126],"day":[128],"for":[129,153],"five":[130],"days":[131],"sacrificed":[133],"24":[134,148],"h":[135,149],"(h)":[136],"after":[137,150],"injection.":[139],"blood":[141],"sera":[142],"collected":[144],"0,":[145],"6,":[146],"injection":[152],"analysis":[155],"aspartate":[157],"aminotransferase":[158,162],"(AST)":[159],"alanine":[161],"(ALT).":[163],"PLA2-injected":[164,192],"showed":[166],"reduced":[167],"levels":[168],"serum":[170],"AST,":[171],"ALT,":[172],"proinflammatory":[173],"cytokines,":[174],"nitric":[176],"oxide":[177],"(NO)":[178],"compared":[179],"PBS-injected":[182],"control":[183],"However,":[185],"IL-10":[186,235],"significantly":[188],"These":[194],"abolished":[199],"Treg-depleted":[201],"antibody":[204],"treatment":[205],"IL-10-/-":[208],"Based":[210],"on":[211],"these":[212],"findings,":[213],"it":[214],"be":[216,228],"concluded":[217],"mediated":[229],"modulating":[231],"production.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}