{"id":"https://openalex.org/W2034413738","doi":"https://doi.org/10.1016/j.cardiores.2004.11.013","title":"Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly","display_name":"Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly","publication_year":2004,"publication_date":"2004-12-13","ids":{"openalex":"https://openalex.org/W2034413738","doi":"https://doi.org/10.1016/j.cardiores.2004.11.013","mag":"2034413738","pmid":"https://pubmed.ncbi.nlm.nih.gov/15820196"},"language":"en","primary_location":{"id":"doi:10.1016/j.cardiores.2004.11.013","doi":"https://doi.org/10.1016/j.cardiores.2004.11.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cardiores.2004.11.013","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080124007","display_name":"Koichi I. Yamamoto","orcid":"https://orcid.org/0000-0003-0107-9315","observed_orcids":["https://orcid.org/0000-0003-0107-9315"]},"institutions":[{"id":"https://openalex.org/I4210090647","display_name":"Nagoya University Hospital","ror":"https://ror.org/008zz8m46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090647"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"K YAMAMOTO","raw_affiliation_strings":["Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466-8550, Japan. kojiy@med.nagoya-u.ac.jp","Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466-8550, Japan. kojiy@med.nagoya-u.ac.jp","institution_ids":["https://openalex.org/I4210090647"]},{"raw_affiliation_string":"Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466-8550, Japan","institution_ids":["https://openalex.org/I4210090647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038777997","display_name":"Kyosuke Takeshita","orcid":"https://orcid.org/0000-0002-8283-3799","observed_orcids":["https://orcid.org/0000-0002-8283-3799"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K TAKESHITA","raw_affiliation_strings":["b Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan","Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T KOJIMA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T KOJIMA","raw_affiliation_strings":["c Department of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan","Department of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"c Department of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"Department of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108748329","display_name":"Junki Takamatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090647","display_name":"Nagoya University Hospital","ror":"https://ror.org/008zz8m46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090647"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J TAKAMATSU","raw_affiliation_strings":["a Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466-8550, Japan","Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466-8550, Japan","institution_ids":["https://openalex.org/I4210090647"]},{"raw_affiliation_string":"Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466-8550, Japan","institution_ids":["https://openalex.org/I4210090647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101664787","display_name":"Hideyuki Saito","orcid":"https://orcid.org/0000-0001-6522-7300","observed_orcids":["https://orcid.org/0000-0001-6522-7300"]},"institutions":[{"id":"https://openalex.org/I4210152596","display_name":"Nagoya Medical Center","ror":"https://ror.org/04ftw3n55","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210152596"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H SAITO","raw_affiliation_strings":["d Nagoya Medical Center, Nagoya, Japan","Nagoya Medical Center, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"d Nagoya Medical Center, Nagoya, Japan","institution_ids":["https://openalex.org/I4210152596"]},{"raw_affiliation_string":"Nagoya Medical Center, Nagoya, Japan","institution_ids":["https://openalex.org/I4210152596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080124007"],"corresponding_institution_ids":["https://openalex.org/I4210090647"],"apc_list":{"value":4715,"currency":"EUR","value_usd":5329},"apc_paid":null,"fwci":2.7727,"has_fulltext":false,"cited_by_count":222,"citation_normalized_percentile":{"value":0.90013732,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"66","issue":"2","first_page":"276","last_page":"285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8080000281333923},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cardiovascular-aging","display_name":"cardiovascular aging","score":0.6850000023841858},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.8970000147819519},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/vascular-sclerosis","display_name":"vascular sclerosis","score":0.828000009059906},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9150000214576721},{"id":"https://openalex.org/keywords/emotional-stress","display_name":"emotional stress","score":0.7049999833106995},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9340000152587891},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8920000195503235},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.4729999899864197},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6878790259361267},{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.6587901711463928},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.5786514282226562},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.5355062484741211},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5283002853393555},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47430992126464844},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4282929599285126},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41657042503356934},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36215701699256897},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.29099366068840027}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005342","descriptor_name":"Fibrinolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cardiores.2004.11.013","doi":"https://doi.org/10.1016/j.cardiores.2004.11.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cardiores.2004.11.013","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},{"id":"pmid:15820196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15820196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":125,"referenced_works":["https://openalex.org/W2707883","https://openalex.org/W3171197","https://openalex.org/W8205485","https://openalex.org/W84118062","https://openalex.org/W91310628","https://openalex.org/W151540657","https://openalex.org/W157079418","https://openalex.org/W290790285","https://openalex.org/W293711590","https://openalex.org/W1533523963","https://openalex.org/W1557058411","https://openalex.org/W1589444833","https://openalex.org/W1590967073","https://openalex.org/W1607100760","https://openalex.org/W1612519001","https://openalex.org/W1651383390","https://openalex.org/W1957375239","https://openalex.org/W1965430426","https://openalex.org/W1967933537","https://openalex.org/W1974033843","https://openalex.org/W1977887439","https://openalex.org/W1978926805","https://openalex.org/W1980840278","https://openalex.org/W1981594756","https://openalex.org/W1984679591","https://openalex.org/W1985953874","https://openalex.org/W1990107586","https://openalex.org/W1992644897","https://openalex.org/W1993376880","https://openalex.org/W1995626607","https://openalex.org/W1995786546","https://openalex.org/W1998234914","https://openalex.org/W2000733622","https://openalex.org/W2002833122","https://openalex.org/W2005572060","https://openalex.org/W2005714515","https://openalex.org/W2009383527","https://openalex.org/W2010102081","https://openalex.org/W2012464351","https://openalex.org/W2013522024","https://openalex.org/W2017221955","https://openalex.org/W2017700181","https://openalex.org/W2028510530","https://openalex.org/W2029157767","https://openalex.org/W2031575410","https://openalex.org/W2032102036","https://openalex.org/W2033389086","https://openalex.org/W2033538734","https://openalex.org/W2034888656","https://openalex.org/W2035615840","https://openalex.org/W2036684875","https://openalex.org/W2038728613","https://openalex.org/W2039831544","https://openalex.org/W2041075406","https://openalex.org/W2041227327","https://openalex.org/W2042947495","https://openalex.org/W2050018002","https://openalex.org/W2051442033","https://openalex.org/W2054442750","https://openalex.org/W2057043822","https://openalex.org/W2060899732","https://openalex.org/W2061437860","https://openalex.org/W2062478697","https://openalex.org/W2063612962","https://openalex.org/W2065699955","https://openalex.org/W2066160102","https://openalex.org/W2068924987","https://openalex.org/W2070577792","https://openalex.org/W2070627144","https://openalex.org/W2075582632","https://openalex.org/W2076066102","https://openalex.org/W2076507560","https://openalex.org/W2079845152","https://openalex.org/W2080613214","https://openalex.org/W2081377369","https://openalex.org/W2082807624","https://openalex.org/W2084383114","https://openalex.org/W2088471683","https://openalex.org/W2091181219","https://openalex.org/W2096814647","https://openalex.org/W2097160762","https://openalex.org/W2100312221","https://openalex.org/W2100398674","https://openalex.org/W2101960519","https://openalex.org/W2110474655","https://openalex.org/W2111924468","https://openalex.org/W2113199324","https://openalex.org/W2113684546","https://openalex.org/W2114360920","https://openalex.org/W2117931787","https://openalex.org/W2117965404","https://openalex.org/W2118292856","https://openalex.org/W2120670639","https://openalex.org/W2124671503","https://openalex.org/W2127474796","https://openalex.org/W2128142528","https://openalex.org/W2129149737","https://openalex.org/W2133272697","https://openalex.org/W2145647935","https://openalex.org/W2148688310","https://openalex.org/W2150261004","https://openalex.org/W2152090961","https://openalex.org/W2156558755","https://openalex.org/W2163510728","https://openalex.org/W2166501331","https://openalex.org/W2170525485","https://openalex.org/W2175197632","https://openalex.org/W2272780287","https://openalex.org/W2281293425","https://openalex.org/W2285939748","https://openalex.org/W2319712662","https://openalex.org/W2320466672","https://openalex.org/W2321045931","https://openalex.org/W2331879659","https://openalex.org/W2336672206","https://openalex.org/W2403230088","https://openalex.org/W2407089473","https://openalex.org/W2409004490","https://openalex.org/W2412473816","https://openalex.org/W2415291499","https://openalex.org/W2416753060","https://openalex.org/W2442219235","https://openalex.org/W4239396299","https://openalex.org/W4285719527","https://openalex.org/W4299439003"],"related_works":["https://openalex.org/W2039901162","https://openalex.org/W2010102081","https://openalex.org/W1608726413","https://openalex.org/W1993376880","https://openalex.org/W7124969810","https://openalex.org/W4409693050","https://openalex.org/W2061379276","https://openalex.org/W2156558755","https://openalex.org/W2009383527","https://openalex.org/W1972440424"],"abstract_inverted_index":{"Thrombotic":[0],"cardiovascular":[1,153,194,220],"diseases":[2],"increase":[3],"in":[4,6,16,31,41,53,83,90,139,143,179,190,222],"incidence":[5,50],"the":[7,13,32,42,48,54,58,84,97,131,144,149,174,191,205,217],"elderly,":[8],"a":[9,70,91,159,187],"tendency":[10],"dependent":[11],"on":[12,204],"age-related":[14],"changes":[15,40],"vascular":[17,43,112,200],"and":[18,25,37,111,116,127,164,170,199],"hemostatic":[19],"systems":[20],"that":[21],"include":[22,103],"platelets,":[23],"coagulation,":[24],"fibrinolytic":[26],"factors":[27],"as":[28,30],"well":[29],"endothelium.":[33],"The":[34,75,136],"hypercoagulability":[35],"of":[36,51,57,73,77,93,99,134,162,177,193,208],"advanced":[38],"sclerotic":[39],"wall":[44],"may":[45,147],"contribute":[46],"to":[47,215,224],"increased":[49],"thrombosis":[52,64,198],"elderly.":[55],"One":[56],"important":[59],"key":[60,188],"genes":[61],"for":[62,151,219],"aging-associated":[63,209],"is":[65,79,158],"plasminogen":[66],"activator":[67],"inhibitor-1":[68],"(PAI-1),":[69],"principal":[71],"inhibitor":[72],"fibrinolysis.":[74],"expression":[76,133,176],"PAI-1":[78,163,178,184,210],"not":[80],"only":[81],"elevated":[82,175],"elderly":[85],"but":[86],"also":[87,172],"significantly":[88],"induced":[89],"variety":[92],"pathologies":[94],"associated":[95],"with":[96,141],"process":[98],"aging.":[100],"These":[101],"conditions":[102],"obesity,":[104],"insulin":[105],"resistance,":[106],"emotional":[107],"stress,":[108],"immune":[109],"responses,":[110],"sclerosis/remodeling.":[113],"Several":[114],"cytokines":[115],"hormones,":[117],"including":[118],"tumor":[119],"necrosis":[120],"factor-alpha,":[121],"transforming":[122],"growth":[123],"factor-beta,":[124],"angiotensin":[125],"II,":[126],"insulin,":[128],"positively":[129],"regulate":[130],"gene":[132],"PAI-1.":[135],"recent":[137],"epidemic":[138],"obesity":[140],"aging":[142,195,221],"industrialized":[145],"society":[146],"heighten":[148],"risk":[150],"thrombotic":[152],"disease":[154],"because":[155],"adipose":[156],"tissue":[157],"primary":[160],"source":[161],"cytokines.":[165],"Emotional":[166],"or":[167],"psychosocial":[168],"stress":[169],"inflammation":[171],"cause":[173],"an":[180],"age-specific":[181],"pattern.":[182],"Thus,":[183],"could":[185],"play":[186],"role":[189],"progression":[192],"by":[196],"promoting":[197],"(athero)sclerosis.":[201],"Further":[202],"studies":[203],"genetic":[206],"mechanism":[207],"induction":[211],"will":[212],"be":[213],"necessary":[214],"define":[216],"basis":[218],"relation":[223],"thrombosis.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}