{"id":"https://openalex.org/W2034401388","doi":"https://doi.org/10.1002/aja.1001340105","title":"Intracellular channels as a route for protein passage in the capillary endothelium of the shark brain","display_name":"Intracellular channels as a route for protein passage in the capillary endothelium of the shark brain","publication_year":1972,"publication_date":"1972-05-01","ids":{"openalex":"https://openalex.org/W2034401388","doi":"https://doi.org/10.1002/aja.1001340105","mag":"2034401388","pmid":"https://pubmed.ncbi.nlm.nih.gov/5031975"},"language":"en","primary_location":{"id":"doi:10.1002/aja.1001340105","doi":"https://doi.org/10.1002/aja.1001340105","is_oa":false,"landing_page_url":"https://doi.org/10.1002/aja.1001340105","pdf_url":null,"source":{"id":"https://openalex.org/S69635808","display_name":"American Journal of Anatomy","issn_l":"0002-9106","issn":["0002-9106","1553-0795"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Anatomy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110024876","display_name":"Paulo Hitonari Hashimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Paulo H. Hashimoto","raw_affiliation_strings":["Department of Anatomy, Osaka University Medical School, Osaka 530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Osaka University Medical School, Osaka 530, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110024876"],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":null,"apc_paid":null,"fwci":4.0825,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.93176074,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"134","issue":"1","first_page":"41","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13100","display_name":"Comparative Animal Anatomy Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2702","display_name":"Anatomy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/capillary-endothelium","display_name":"capillary endothelium","score":0.9549999833106995},{"id":"https://openalex.org/keywords/area-postrema","display_name":"area postrema","score":0.7210000157356262},{"id":"https://openalex.org/keywords/horseradish-peroxidase","display_name":"horseradish peroxidase","score":0.7639999985694885},{"id":"https://openalex.org/keywords/endothelial-fenestrations","display_name":"endothelial fenestrations","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.8259999752044678},{"id":"https://openalex.org/keywords/perivascular-spaces","display_name":"perivascular spaces","score":0.8289999961853027},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2776459250","wikidata":"https://www.wikidata.org/wiki/Q640532","display_name":"Area postrema","level":3,"score":0.7550606727600098},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.7053259611129761},{"id":"https://openalex.org/C2777799939","wikidata":"https://www.wikidata.org/wiki/Q1711381","display_name":"Perivascular space","level":2,"score":0.688223123550415},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.6654180288314819},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.5298445224761963},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5120134949684143},{"id":"https://openalex.org/C2777942826","wikidata":"https://www.wikidata.org/wiki/Q5443357","display_name":"Fenestration","level":2,"score":0.4945466220378876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4737095236778259},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.4703894853591919},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.44901323318481445},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4246165454387665},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42189744114875793},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.356056272983551},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3145027160644531},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2861698269844055},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1622696816921234},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14982134103775024},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1451592743396759},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10211390256881714},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012754","descriptor_name":"Sharks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/aja.1001340105","doi":"https://doi.org/10.1002/aja.1001340105","is_oa":false,"landing_page_url":"https://doi.org/10.1002/aja.1001340105","pdf_url":null,"source":{"id":"https://openalex.org/S69635808","display_name":"American Journal of Anatomy","issn_l":"0002-9106","issn":["0002-9106","1553-0795"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Anatomy","raw_type":"journal-article"},{"id":"pmid:5031975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5031975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of anatomy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1513425511","https://openalex.org/W1977940746","https://openalex.org/W1983949401","https://openalex.org/W2006095108","https://openalex.org/W2008438167","https://openalex.org/W2017480358","https://openalex.org/W2021303778","https://openalex.org/W2021708418","https://openalex.org/W2024177840","https://openalex.org/W2026813799","https://openalex.org/W2026826762","https://openalex.org/W2029265259","https://openalex.org/W2036127937","https://openalex.org/W2039392601","https://openalex.org/W2045194716","https://openalex.org/W2082363445","https://openalex.org/W2087666006","https://openalex.org/W2103321800","https://openalex.org/W2107604859","https://openalex.org/W2129179416","https://openalex.org/W2149460441","https://openalex.org/W2334041161","https://openalex.org/W2489426604","https://openalex.org/W4366065134"],"related_works":["https://openalex.org/W1996385747","https://openalex.org/W2008438167","https://openalex.org/W34649544","https://openalex.org/W2093717273","https://openalex.org/W2012165303","https://openalex.org/W1979604911","https://openalex.org/W1964949439","https://openalex.org/W2883821930","https://openalex.org/W1980930532","https://openalex.org/W2027689868"],"abstract_inverted_index":{"Abstract":[0],"Capillaries":[1],"in":[2,18,58,74,132,149],"the":[3,11,14,22,65,90,99,103,112,150],"area":[4],"postrema":[5],"and":[6,33,60,67,76,83],"other":[7,87],"brain":[8,88],"regions":[9],"at":[10],"level":[12],"of":[13,30,111,128,145,154],"obex":[15],"were":[16,39,69,116],"examined":[17],"Japanese":[19],"sharks":[20],"under":[21],"electron":[23],"microscope":[24],"with":[25,48,102],"or":[26],"without":[27],"intravascular":[28],"injection":[29],"horse\u2010radish":[31],"peroxidase":[32,108],"histochemical":[34],"incubation.":[35],"The":[36],"postremal":[37],"capillaries":[38],"characterized":[40],"by":[41,61,118],"a":[42,139],"relatively":[43],"wide":[44],"perivascular":[45],"space":[46,66],"filled":[47],"connective":[49],"tissue":[50],"elements":[51],"including":[52],"fine":[53],"fibrils":[54],"about":[55,129],"100":[56],"\u00c5":[57,131],"diameter,":[59],"endothelial":[62,114,141],"fenestration;":[63],"however,":[64],"fenestration":[68],"apparently":[70],"less":[71],"extensive":[72],"than":[73],"rats":[75],"cats":[77],"(Hashimoto,":[78],"'66;":[79,81],"Rivera\u2010Pomar,":[80],"Hashimoto":[82],"Hama,":[84],"'68).":[85],"In":[86],"regions,":[89],"capillary":[91],"endothelium":[92],"showed":[93],"peroxidase\u2010filled":[94],"intracellular":[95],"channels":[96],"that":[97],"connected":[98],"luminal":[100],"surface":[101],"basement":[104],"membrane":[105],"soon":[106],"after":[107],"injection.":[109],"Many":[110],"adjoining":[113],"cells":[115],"linked":[117],"tight":[119,126],"junctions.":[120],"Perivascular":[121],"astrocytic":[122],"processes":[123],"had":[124],"long,":[125],"contacts":[127],"125":[130],"overall":[133],"thickness.":[134],"Discussion":[135],"was":[136],"focused":[137],"on":[138],"possible":[140],"route":[142],"for":[143],"passage":[144],"so\u2010called":[146],"barrier\u2010free":[147],"substances":[148],"central":[151],"nervous":[152],"system":[153],"higher":[155],"vertebrates.":[156]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
