{"id":"https://openalex.org/W2034400422","doi":"https://doi.org/10.1080/20028091057358","title":"Issues in Exposure and Dose Assessment for Epidemiology and Risk Assessment","display_name":"Issues in Exposure and Dose Assessment for Epidemiology and Risk Assessment","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2034400422","doi":"https://doi.org/10.1080/20028091057358","mag":"2034400422"},"language":"en","primary_location":{"id":"doi:10.1080/20028091057358","doi":"https://doi.org/10.1080/20028091057358","is_oa":false,"landing_page_url":"https://doi.org/10.1080/20028091057358","pdf_url":null,"source":{"id":"https://openalex.org/S72772346","display_name":"Human and Ecological Risk Assessment An International Journal","issn_l":"1080-7039","issn":["1080-7039","1549-7860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human and Ecological Risk Assessment: An International Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Thomas J. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas J. Smith","raw_affiliation_strings":["Environmental Science and Engineering Program, Harvard School of Public Health, Landmark Center, 404F, P.O. Box 15677, Boston, MA 02215, USA; Tel(voice):617-384-8804, Tel(fax): 617-384-8859; tsmith@hohp.harvard.edu","Environmental Science and Engineering Program, Harvard School of Public Health, Landmark Center, 404F, P.O. Box 15677, Boston, MA 02215, USA","Tel(voice):617-384-8804, Tel(fax): 617-384-8859"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Science and Engineering Program, Harvard School of Public Health, Landmark Center, 404F, P.O. Box 15677, Boston, MA 02215, USA; Tel(voice):617-384-8804, Tel(fax): 617-384-8859; tsmith@hohp.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Environmental Science and Engineering Program, Harvard School of Public Health, Landmark Center, 404F, P.O. Box 15677, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Tel(voice):617-384-8804, Tel(fax): 617-384-8859","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":0.5091,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.64544665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"8","issue":"6","first_page":"1267","last_page":"1293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.3131999969482422,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.3131999969482422,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.21629999577999115,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14374","display_name":"Statistical Methods in Epidemiology","score":0.1534000039100647,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exposure-assessment","display_name":"exposure assessment","score":0.8920000195503235},{"id":"https://openalex.org/keywords/dose-assessment","display_name":"dose estimation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/physiologically-based-pharmacokinetic-model","display_name":"physiologically based pharmacokinetic modeling","score":0.8889999985694885},{"id":"https://openalex.org/keywords/dose-metrics","display_name":"dose metrics","score":0.5120000243186951},{"id":"https://openalex.org/keywords/cross-species-extrapolation","display_name":"interspecies extrapolation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/animal-to-human-extrapolation","display_name":"animal-to-human extrapolation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.800000011920929},{"id":"https://openalex.org/keywords/tissue-concentration","display_name":"tissue concentration","score":0.640999972820282},{"id":"https://openalex.org/keywords/misclassification","display_name":"misclassification","score":0.5820000171661377},{"id":"https://openalex.org/keywords/quantitative-risk-assessment","display_name":"quantitative risk assessment","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.8641698360443115},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.7338091135025024},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.5860960483551025},{"id":"https://openalex.org/C198408306","wikidata":"https://www.wikidata.org/wiki/Q4008388","display_name":"Exposure assessment","level":2,"score":0.5544751882553101},{"id":"https://openalex.org/C2991839081","wikidata":"https://www.wikidata.org/wiki/Q413306","display_name":"Internal dose","level":2,"score":0.5531005859375},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.45195430517196655},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.4388972222805023},{"id":"https://openalex.org/C132459708","wikidata":"https://www.wikidata.org/wiki/Q744069","display_name":"Extrapolation","level":2,"score":0.43711918592453003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4309226870536804},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.40815168619155884},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.37302833795547485},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33150598406791687},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2337324619293213},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.22605803608894348},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20190680027008057},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18500608205795288},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.1823645532131195},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17912325263023376},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1679791510105133},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08275550603866577},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/20028091057358","doi":"https://doi.org/10.1080/20028091057358","is_oa":false,"landing_page_url":"https://doi.org/10.1080/20028091057358","pdf_url":null,"source":{"id":"https://openalex.org/S72772346","display_name":"Human and Ecological Risk Assessment An International Journal","issn_l":"1080-7039","issn":["1080-7039","1549-7860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human and Ecological Risk Assessment: An International Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7599999904632568}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W101436764","https://openalex.org/W135787123","https://openalex.org/W582320332","https://openalex.org/W1894519883","https://openalex.org/W1965375621","https://openalex.org/W1965578110","https://openalex.org/W1975258180","https://openalex.org/W1989712487","https://openalex.org/W1999146343","https://openalex.org/W2002106625","https://openalex.org/W2002622098","https://openalex.org/W2005426927","https://openalex.org/W2009324335","https://openalex.org/W2019714743","https://openalex.org/W2032995180","https://openalex.org/W2034432162","https://openalex.org/W2035223684","https://openalex.org/W2042160722","https://openalex.org/W2060201297","https://openalex.org/W2060681446","https://openalex.org/W2061049779","https://openalex.org/W2070618117","https://openalex.org/W2074244433","https://openalex.org/W2075869620","https://openalex.org/W2087588634","https://openalex.org/W2088579287","https://openalex.org/W2092122828","https://openalex.org/W2098787999","https://openalex.org/W2122656085","https://openalex.org/W2131201748","https://openalex.org/W2159687614","https://openalex.org/W2163262376","https://openalex.org/W2417161954","https://openalex.org/W2799114041","https://openalex.org/W2971300015","https://openalex.org/W4249389212"],"related_works":["https://openalex.org/W2004199171","https://openalex.org/W7001886595","https://openalex.org/W2504504509","https://openalex.org/W2077283851","https://openalex.org/W159315746","https://openalex.org/W2007541997","https://openalex.org/W7099250102","https://openalex.org/W2070618117","https://openalex.org/W3029248303","https://openalex.org/W2494777962"],"abstract_inverted_index":{"Epidemiologic":[0],"studies":[1,36,148],"have":[2,37],"been":[3,17,67,125],"effective":[4],"in":[5,21,62,71,90,116,144],"identifying":[6],"human":[7,63,101,138],"environmental":[8],"and":[9,32,48,122,168],"occupational":[10],"hazards.":[11],"However,":[12,56],"most":[13],"epidemiologic":[14,147,182],"data":[15,61],"has":[16,66,124],"difficult":[18],"to":[19,53,132,149,160],"use":[20,58,89],"quantitative":[22,197],"risk":[23,64,198],"assessments":[24],"because":[25,96],"of":[26,30,59,78,97,100,113,171,181],"the":[27,72,98,110,166,179],"vague":[28],"specification":[29],"exposure":[31],"dose.":[33],"Toxicologic":[34],"animal":[35,60],"used":[38,126,143,159],"applied":[39,75],"doses":[40],"(quantities":[41],"administered,":[42],"or":[43],"exposures":[44],"with":[45],"fixed":[46],"duration)":[47],"well":[49],"characterized":[50],"end":[51],"points":[52],"determine":[54],"effects.":[55,173],"direct":[57],"assessment":[65],"limited":[68],"by":[69,185],"uncertainties":[70],"extrapolation.":[73],"The":[74],"dose":[76,94,162,175],"paradigm":[77],"toxicology":[79],"is":[80,135],"not":[81],"suited":[82],"for":[83,88,127],"cross":[84],"species":[85],"extrapolation,":[86],"nor":[87],"epidemiology":[91],"as":[92],"a":[93],"metric":[95],"complexity":[99],"exposures.":[102],"Physiologically":[103],"based":[104,164],"pharmacokinetic":[105],"(PBPK)":[106],"modeling":[107,140],"can":[108,141,157,192],"estimate":[109,150],"time":[111,155,169],"course":[112,170],"tissue":[114,151,154],"concentrations":[115],"humans,":[117],"given":[118],"an":[119],"exposure-time":[120],"profile,":[121],"it":[123],"extrapolating":[128],"findings":[129],"from":[130,189],"animals":[131],"humans.":[133],"It":[134],"proposed":[136],"that":[137],"PBPK":[139],"be":[142,158,193],"appropriately":[145],"designed":[146],"concentrations.":[152],"Secondly,":[153],"courses":[156],"form":[161],"metrics":[163,176],"on":[165],"type":[167],"adverse":[172],"These":[174],"will":[177],"strengthen":[178],"determination":[180],"dose-response":[183],"relationships":[184],"reducing":[186],"misclassification.":[187],"Findings":[188],"this":[190],"approach":[191],"readily":[194],"integrated":[195],"into":[196],"assessment.":[199]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
