{"id":"https://openalex.org/W2034377002","doi":"https://doi.org/10.1038/nm.3327","title":"Roadblocks to translational advances on metastasis research","display_name":"Roadblocks to translational advances on metastasis research","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W2034377002","doi":"https://doi.org/10.1038/nm.3327","mag":"2034377002","pmid":"https://pubmed.ncbi.nlm.nih.gov/24013756","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3972758"},"language":"en","primary_location":{"id":"doi:10.1038/nm.3327","doi":"https://doi.org/10.1038/nm.3327","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nm.3327","pdf_url":null,"source":{"id":"https://openalex.org/S203256638","display_name":"Nature Medicine","issn_l":"1078-8956","issn":["1078-8956","1546-170X","1744-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3972758","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076332139","display_name":"Thomas Brabletz","orcid":"https://orcid.org/0000-0003-2983-9048","observed_orcids":["https://orcid.org/0000-0003-2983-9048"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas Brabletz","raw_affiliation_strings":["1] Department of General and Visceral Surgery, Comprehensive Cancer Center and BIOSS Centre for Biological Signalling Studies, University of Freiburg Medical Center, Freiburg, Germany. [2]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Department of General and Visceral Surgery, Comprehensive Cancer Center and BIOSS Centre for Biological Signalling Studies, University of Freiburg Medical Center, Freiburg, Germany. [2]","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044701800","display_name":"David C. Lyden","orcid":"https://orcid.org/0000-0003-0193-4131","observed_orcids":["https://orcid.org/0000-0003-0193-4131"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Lyden","raw_affiliation_strings":["David Lyden is at the Department of Pediatrics and the Department of Cell and Developmental Biology, Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center, New York, New York, USA.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David Lyden is at the Department of Pediatrics and the Department of Cell and Developmental Biology, Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center, New York, New York, USA.,","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035391817","display_name":"Patricia Schriver Steeg","orcid":"https://orcid.org/0000-0002-2626-0594","observed_orcids":["https://orcid.org/0000-0002-2626-0594"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patricia S Steeg","raw_affiliation_strings":["Patricia S. Steeg is in the Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, US National Cancer Institute, Bethesda, Maryland, USA.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Patricia S. Steeg is in the Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, US National Cancer Institute, Bethesda, Maryland, USA.,","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048523154","display_name":"Zena Werb","orcid":"https://orcid.org/0000-0002-6525-3872","observed_orcids":["https://orcid.org/0000-0002-6525-3872"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zena Werb","raw_affiliation_strings":["Zena Werb is at the Department of Anatomy, University of California, San Francisco, San Francisco, California, USA.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zena Werb is at the Department of Anatomy, University of California, San Francisco, San Francisco, California, USA.,","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5035391817","https://openalex.org/A5044701800","https://openalex.org/A5048523154","https://openalex.org/A5076332139"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I161046081","https://openalex.org/I180670191","https://openalex.org/I2801240073","https://openalex.org/I4210140884","https://openalex.org/I4210149717","https://openalex.org/I4387153466"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":4.5286,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.9564709,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"19","issue":"9","first_page":"1104","last_page":"1109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13656","display_name":"Science, Research, and Medicine","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.753000020980835},{"id":"https://openalex.org/keywords/metastasis-prevention","display_name":"metastasis prevention","score":0.6800000071525574},{"id":"https://openalex.org/keywords/research-barriers","display_name":"research barriers","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.7553716897964478},{"id":"https://openalex.org/C71750763","wikidata":"https://www.wikidata.org/wiki/Q646164","display_name":"General partnership","level":2,"score":0.7140506505966187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5158199667930603},{"id":"https://openalex.org/C2780966255","wikidata":"https://www.wikidata.org/wiki/Q5474306","display_name":"Foundation (evidence)","level":2,"score":0.4875566363334656},{"id":"https://openalex.org/C2992691968","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Cancer metastasis","level":4,"score":0.47623446583747864},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4676736295223236},{"id":"https://openalex.org/C162264550","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Translational medicine","level":2,"score":0.44864776730537415},{"id":"https://openalex.org/C57634137","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational science","level":2,"score":0.4478326439857483},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3933197259902954},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.3629489243030548},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.35840174555778503},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13719061017036438},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11284387111663818},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08537381887435913},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/nm.3327","doi":"https://doi.org/10.1038/nm.3327","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nm.3327","pdf_url":null,"source":{"id":"https://openalex.org/S203256638","display_name":"Nature Medicine","issn_l":"1078-8956","issn":["1078-8956","1546-170X","1744-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Medicine","raw_type":"journal-article"},{"id":"pmid:24013756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24013756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2955673","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3972758","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3972758","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3972758","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Med","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3pg12525","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3pg12525","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Medicine, vol 19, iss 9","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2955673","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3972758","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2436312130","display_name":"TRANSCRIPTIONAL REGULATION OF BREAST CANCER METASTASIS","funder_award_id":"R01CA129523","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1480706413","https://openalex.org/W1964081206","https://openalex.org/W1973471572","https://openalex.org/W1974140746","https://openalex.org/W1976446970","https://openalex.org/W1980669422","https://openalex.org/W1982402091","https://openalex.org/W1982760718","https://openalex.org/W1984622067","https://openalex.org/W1985727076","https://openalex.org/W1996534604","https://openalex.org/W2001258296","https://openalex.org/W2002689409","https://openalex.org/W2007394221","https://openalex.org/W2007893589","https://openalex.org/W2012247886","https://openalex.org/W2014691022","https://openalex.org/W2019214567","https://openalex.org/W2025491043","https://openalex.org/W2027525624","https://openalex.org/W2028593825","https://openalex.org/W2049528074","https://openalex.org/W2049820772","https://openalex.org/W2054017641","https://openalex.org/W2057841149","https://openalex.org/W2059806554","https://openalex.org/W2074754447","https://openalex.org/W2080232352","https://openalex.org/W2089370460","https://openalex.org/W2090037913","https://openalex.org/W2096636873","https://openalex.org/W2098253798","https://openalex.org/W2099819908","https://openalex.org/W2100218575","https://openalex.org/W2100303404","https://openalex.org/W2101096891","https://openalex.org/W2102707911","https://openalex.org/W2106785049","https://openalex.org/W2111564953","https://openalex.org/W2113860186","https://openalex.org/W2115792588","https://openalex.org/W2121710620","https://openalex.org/W2129913662","https://openalex.org/W2134408326","https://openalex.org/W2134987819","https://openalex.org/W2135523574","https://openalex.org/W2138885372","https://openalex.org/W2139085578","https://openalex.org/W2146530991","https://openalex.org/W2148744266","https://openalex.org/W2151832198","https://openalex.org/W2154715114","https://openalex.org/W2155869675","https://openalex.org/W2156323704","https://openalex.org/W2165200432","https://openalex.org/W2168631000","https://openalex.org/W2169281418","https://openalex.org/W2169491358","https://openalex.org/W2171549753","https://openalex.org/W4205433743"],"related_works":["https://openalex.org/W2163367650","https://openalex.org/W4206113265","https://openalex.org/W4229936834","https://openalex.org/W2014260136","https://openalex.org/W1976992968","https://openalex.org/W242341724","https://openalex.org/W4233766793","https://openalex.org/W4206990419","https://openalex.org/W2022233074","https://openalex.org/W3114903535"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}