{"id":"https://openalex.org/W2034371985","doi":"https://doi.org/10.1248/bpb.27.117","title":"Herbkines Increases Physical Stamina in Mice","display_name":"Herbkines Increases Physical Stamina in Mice","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2034371985","doi":"https://doi.org/10.1248/bpb.27.117","mag":"2034371985","pmid":"https://pubmed.ncbi.nlm.nih.gov/14709912"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.27.117","doi":"https://doi.org/10.1248/bpb.27.117","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.27.117","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/27/1/27_1_117/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/bpb/27/1/27_1_117/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036283037","display_name":"Hyun\u2010Na Koo","orcid":"https://orcid.org/0000-0003-1595-5558","observed_orcids":["https://orcid.org/0000-0003-1595-5558"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I77079311","display_name":"Wonkwang University","ror":"https://ror.org/006776986","country_code":"KR","type":"education","lineage":["https://openalex.org/I77079311"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun-Na Koo","raw_affiliation_strings":["Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University","Department of Pharmacology, College of Oriental Medicine, Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University","institution_ids":["https://openalex.org/I77079311"]},{"raw_affiliation_string":"Department of Pharmacology, College of Oriental Medicine, Kyung Hee University","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009547203","display_name":"Jai-Kyoo Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I77079311","display_name":"Wonkwang University","ror":"https://ror.org/006776986","country_code":"KR","type":"education","lineage":["https://openalex.org/I77079311"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jai-Kyoo Lee","raw_affiliation_strings":["Department of Emergency, Wonkwang University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, Wonkwang University School of Medicine","institution_ids":["https://openalex.org/I77079311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007917575","display_name":"Seung\u2010Heon Hong","orcid":"https://orcid.org/0000-0003-3275-7764","observed_orcids":["https://orcid.org/0000-0003-3275-7764"]},"institutions":[{"id":"https://openalex.org/I77079311","display_name":"Wonkwang University","ror":"https://ror.org/006776986","country_code":"KR","type":"education","lineage":["https://openalex.org/I77079311"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung-Heon Hong","raw_affiliation_strings":["Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University","institution_ids":["https://openalex.org/I77079311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113552733","display_name":"Hyung\u2010Min Kim","orcid":"https://orcid.org/0009-0001-2362-5033","observed_orcids":["https://orcid.org/0009-0001-2362-5033"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyung-Min Kim","raw_affiliation_strings":["Department of Pharmacology, College of Oriental Medicine, Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Oriental Medicine, Kyung Hee University","institution_ids":["https://openalex.org/I35928602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.1749,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.94178794,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"27","issue":"1","first_page":"117","last_page":"119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13651","display_name":"Medicinal Plants and Bioactive Compounds","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13651","display_name":"Medicinal Plants and Bioactive Compounds","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.5120000243186951},{"id":"https://openalex.org/keywords/physical-stamina","display_name":"physical stamina","score":0.9110000133514404},{"id":"https://openalex.org/keywords/anti-fatigue-effect","display_name":"anti-fatigue","score":0.7739999890327454},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.8859999775886536},{"id":"https://openalex.org/keywords/immobility-time","display_name":"immobility time","score":0.9449999928474426},{"id":"https://openalex.org/keywords/blood-urea-nitrogen","display_name":"blood urea nitrogen","score":0.972000002861023},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.7739999890327454},{"id":"https://openalex.org/keywords/total-protein","display_name":"total protein","score":0.824999988079071},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.8387782573699951},{"id":"https://openalex.org/C2993497327","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactic dehydrogenase","level":3,"score":0.8005102276802063},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.7417357563972473},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.5909852981567383},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.5356103777885437},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.47975170612335205},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.47965458035469055},{"id":"https://openalex.org/C2994390833","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Urea nitrogen","level":3,"score":0.4754640460014343},{"id":"https://openalex.org/C2909590148","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Serum urea","level":3,"score":0.465128630399704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4579983055591583},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4306371808052063},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42953476309776306},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3502620458602905},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.3103603720664978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24183085560798645},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22467616200447083},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19375735521316528},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010807","descriptor_name":"Physical Endurance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013550","descriptor_name":"Swimming","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013550","descriptor_name":"Swimming","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/bpb.27.117","doi":"https://doi.org/10.1248/bpb.27.117","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.27.117","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/27/1/27_1_117/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:14709912","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14709912","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/bpb.27.117","doi":"https://doi.org/10.1248/bpb.27.117","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.27.117","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/27/1/27_1_117/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321310","display_name":"Wonkwang University","ror":"https://ror.org/006776986"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2034371985.pdf","grobid_xml":"https://content.openalex.org/works/W2034371985.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W14821744","https://openalex.org/W29960794","https://openalex.org/W123517148","https://openalex.org/W1950780876","https://openalex.org/W1972746617","https://openalex.org/W1977711874","https://openalex.org/W1978926207","https://openalex.org/W2003547326","https://openalex.org/W2007376383","https://openalex.org/W2037565253","https://openalex.org/W2040927330","https://openalex.org/W2061188255","https://openalex.org/W2086438948","https://openalex.org/W2096247486","https://openalex.org/W2396247893"],"related_works":["https://openalex.org/W2384653961","https://openalex.org/W1997901242","https://openalex.org/W2518798104","https://openalex.org/W4381661828","https://openalex.org/W2172161740","https://openalex.org/W2357356518","https://openalex.org/W2348597827","https://openalex.org/W2462304112","https://openalex.org/W3208094871","https://openalex.org/W2381712281"],"abstract_inverted_index":{"Herbkines":[0,21,54,164],"has":[1],"been":[2],"used":[3],"for":[4,66,170],"the":[5,13,18,25,79,85,93,99,109,116,124,131,136,143],"purpose":[6],"of":[7,9,20,24,133,145,163],"development":[8],"physical":[10,172],"strength.":[11],"In":[12,129],"present":[14],"study,":[15],"we":[16],"investigated":[17],"effect":[19],"on":[22,31,77],"performance":[23],"forced":[26],"swimming":[27],"test":[28],"(FST)":[29],"and":[30,50,149,169],"blood":[32,38,137],"biochemical":[33],"parameters":[34],"related":[35],"to":[36,58],"fatigue:":[37],"urea":[39],"nitrogen":[40],"(BUN),":[41],"creatine":[42],"kinase":[43],"(CK),":[44],"lactic":[45],"dehydrogenase":[46],"(LDH),":[47],"glucose":[48],"(Glc),":[49],"total":[51],"protein":[52],"(TP).":[53],"were":[55],"orally":[56],"administered":[57],"mice,":[59],"10":[60],"ml/kg,":[61],"continuously":[62],"once":[63],"per":[64],"day":[65],"2":[67,75,107],"weeks":[68],"using":[69],"a":[70,154,160],"feeding":[71],"atraumatic":[72],"needle.":[73],"After":[74,106],"d,":[76],"FST,":[78],"immobility":[80,110],"time":[81,111],"was":[82,102,112,139],"decreased":[83,114],"in":[84,90,115,121,135],"Herbkines-fed":[86,117],"group":[87,95,118,126],"(178+/-8.2":[88],"s)":[89,120],"comparison":[91,122],"with":[92,123],"control":[94,125],"(189+/-22":[96],"s);":[97],"however,":[98],"statistical":[100],"difference":[101],"very":[103],"weak":[104],"(p=0.596).":[105],"weeks,":[108],"significantly":[113,140],"(196+/-4.5":[119],"(221+/-6.2":[127],"s).":[128],"addition,":[130],"content":[132],"BUN":[134],"serum":[138],"decreased.":[141],"However,":[142],"levels":[144],"CK,":[146],"LDH,":[147],"Glc,":[148],"TP":[150],"did":[151],"not":[152],"show":[153],"significant":[155],"change.":[156],"The":[157],"results":[158],"predict":[159],"potential":[161],"benefit":[162],"as":[165],"an":[166],"anti-fatigue":[167],"treatment":[168],"improving":[171],"stamina.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
