{"id":"https://openalex.org/W2034356265","doi":"https://doi.org/10.1007/s11357-008-9069-9","title":"Age-dependent Wnt gene expression in bone and during the course of osteoblast differentiation","display_name":"Age-dependent Wnt gene expression in bone and during the course of osteoblast differentiation","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W2034356265","doi":"https://doi.org/10.1007/s11357-008-9069-9","mag":"2034356265","pmid":"https://pubmed.ncbi.nlm.nih.gov/19424851","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2585653"},"language":"en","primary_location":{"id":"doi:10.1007/s11357-008-9069-9","doi":"https://doi.org/10.1007/s11357-008-9069-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-008-9069-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-008-9069-9.pdf","source":{"id":"https://openalex.org/S4210202800","display_name":"AGE","issn_l":"0161-9152","issn":["0161-9152","1574-4647","2331-3765","2452-0756"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-class-a","anvur-scientific","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AGE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1007/s11357-008-9069-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056597436","display_name":"Martina Rauner","orcid":"https://orcid.org/0000-0002-4067-6799","observed_orcids":["https://orcid.org/0000-0002-4067-6799","https://orcid.org/0009-0001-9754-1334"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Martina Rauner","raw_affiliation_strings":["Institute of Pathophysiology, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria. martina.rauner@meduniwien.ac.at","Institute of Pathophysiology, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathophysiology, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria. martina.rauner@meduniwien.ac.at","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Institute of Pathophysiology, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065747422","display_name":"Wolfgang Sipos","orcid":"https://orcid.org/0000-0001-8209-1804","observed_orcids":["https://orcid.org/0000-0001-8209-1804"]},"institutions":[{"id":"https://openalex.org/I150540706","display_name":"University of Veterinary Medicine Vienna","ror":"https://ror.org/01w6qp003","country_code":"AT","type":"education","lineage":["https://openalex.org/I150540706"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Wolfgang Sipos","raw_affiliation_strings":["II. Medical Clinic, University of Veterinary Medicine, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"II. Medical Clinic, University of Veterinary Medicine, Vienna, Austria","institution_ids":["https://openalex.org/I150540706"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025576392","display_name":"Peter Pietschmann","orcid":"https://orcid.org/0000-0002-6966-2892","observed_orcids":["https://orcid.org/0000-0002-6966-2892"]},"institutions":[{"id":"https://openalex.org/I4210101869","display_name":"Ludwig Boltzmann Institute for Age Research","ror":"https://ror.org/017faj253","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210101869"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Peter Pietschmann","raw_affiliation_strings":["Institute of Pathophysiology, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria","Ludwig Boltzmann Institute of Aging Research, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathophysiology, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute of Aging Research, Vienna, Austria","institution_ids":["https://openalex.org/I4210101869"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025576392"],"corresponding_institution_ids":["https://openalex.org/I4210101869","https://openalex.org/I76134821"],"apc_list":null,"apc_paid":null,"fwci":1.0982,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.74910806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"30","issue":"4","first_page":"273","last_page":"282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.663100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.663100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.30219998955726624,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.753000020980835},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/osteoblastogenesis","display_name":"osteoblastogenesis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/age-related-bone-loss","display_name":"age-related bone loss","score":0.8510000109672546},{"id":"https://openalex.org/keywords/bone-marrow-cells","display_name":"bone marrow cells","score":0.6629999876022339},{"id":"https://openalex.org/keywords/wnt9b","display_name":"Wnt9b","score":0.7879999876022339},{"id":"https://openalex.org/keywords/dkk1","display_name":"DKK1","score":0.8889999985694885},{"id":"https://openalex.org/keywords/sclerostin","display_name":"sclerostin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/sfrp1","display_name":"SFRP1","score":0.9269999861717224},{"id":"https://openalex.org/keywords/wnt5a","display_name":"Wnt5a","score":0.7390000224113464},{"id":"https://openalex.org/keywords/wnt7b","display_name":"Wnt7b","score":0.8820000290870667},{"id":"https://openalex.org/keywords/wnt1","display_name":"Wnt1","score":0.6060000061988831},{"id":"https://openalex.org/keywords/wnt3a","display_name":"Wnt3a","score":0.8809999823570251},{"id":"https://openalex.org/keywords/wnt4","display_name":"Wnt4","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2779277721","wikidata":"https://www.wikidata.org/wiki/Q14887295","display_name":"Sclerostin","level":4,"score":0.8611053228378296},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.8483617305755615},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8414080739021301},{"id":"https://openalex.org/C2779131293","wikidata":"https://www.wikidata.org/wiki/Q18048098","display_name":"WNT3A","level":4,"score":0.7405919432640076},{"id":"https://openalex.org/C2780176071","wikidata":"https://www.wikidata.org/wiki/Q18032361","display_name":"WNT5A","level":4,"score":0.6735408902168274},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6310795545578003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5802159309387207},{"id":"https://openalex.org/C107300179","wikidata":"https://www.wikidata.org/wiki/Q41797887","display_name":"Frizzled","level":4,"score":0.514670193195343},{"id":"https://openalex.org/C182819311","wikidata":"https://www.wikidata.org/wiki/Q18028670","display_name":"LRP5","level":4,"score":0.4679369330406189},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.4402490556240082},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.429232656955719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41710522770881653},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3665611743927002},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3334782123565674},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27600473165512085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2727407217025757},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06525194644927979},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06142750382423401}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s11357-008-9069-9","doi":"https://doi.org/10.1007/s11357-008-9069-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-008-9069-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-008-9069-9.pdf","source":{"id":"https://openalex.org/S4210202800","display_name":"AGE","issn_l":"0161-9152","issn":["0161-9152","1574-4647","2331-3765","2452-0756"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-class-a","anvur-scientific","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AGE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2585653","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2585653","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Age (Dordr)","raw_type":"Text"},{"id":"pmid:19424851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19424851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Age (Dordrecht, Netherlands)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s11357-008-9069-9","doi":"https://doi.org/10.1007/s11357-008-9069-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-008-9069-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-008-9069-9.pdf","source":{"id":"https://openalex.org/S4210202800","display_name":"AGE","issn_l":"0161-9152","issn":["0161-9152","1574-4647","2331-3765","2452-0756"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-class-a","anvur-scientific","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AGE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5949439062","display_name":"Cathepsin S: Modulating Osteoimmunology","funder_award_id":"P 20239","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"}],"funders":[{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2034356265.pdf","grobid_xml":"https://content.openalex.org/works/W2034356265.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1970864109","https://openalex.org/W1984199402","https://openalex.org/W1987695360","https://openalex.org/W1991162692","https://openalex.org/W1997339787","https://openalex.org/W2001750225","https://openalex.org/W2005644023","https://openalex.org/W2010221831","https://openalex.org/W2025991178","https://openalex.org/W2030746292","https://openalex.org/W2040213656","https://openalex.org/W2043622469","https://openalex.org/W2061443387","https://openalex.org/W2065942289","https://openalex.org/W2077510301","https://openalex.org/W2105054202","https://openalex.org/W2118387749","https://openalex.org/W2119962765","https://openalex.org/W2122364340","https://openalex.org/W2122803804","https://openalex.org/W2123760898","https://openalex.org/W2124153237","https://openalex.org/W2125725130","https://openalex.org/W2125916510","https://openalex.org/W2135671879","https://openalex.org/W2169373397","https://openalex.org/W2169742299"],"related_works":["https://openalex.org/W2464280382","https://openalex.org/W2019149948","https://openalex.org/W2070675159","https://openalex.org/W2096730291","https://openalex.org/W1987695360","https://openalex.org/W1989306241","https://openalex.org/W2135356141","https://openalex.org/W6943896639","https://openalex.org/W3115597996","https://openalex.org/W2015536677"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}