{"id":"https://openalex.org/W2034224976","doi":"https://doi.org/10.4158/ep.7.6.480","title":"Acquired Immunodeficiency Syndrome-Related Insulin Resistance and Lipodystrophy: A Multifactorial Viral and Iatrogenic Condition","display_name":"Acquired Immunodeficiency Syndrome-Related Insulin Resistance and Lipodystrophy: A Multifactorial Viral and Iatrogenic Condition","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W2034224976","doi":"https://doi.org/10.4158/ep.7.6.480","mag":"2034224976","pmid":"https://pubmed.ncbi.nlm.nih.gov/11747288"},"language":"en","primary_location":{"id":"doi:10.4158/ep.7.6.480","doi":"https://doi.org/10.4158/ep.7.6.480","is_oa":false,"landing_page_url":"https://doi.org/10.4158/ep.7.6.480","pdf_url":null,"source":{"id":"https://openalex.org/S165390330","display_name":"Endocrine Practice","issn_l":"1530-891X","issn":["1530-891X","1934-2403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Practice","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060665424","display_name":"Tomoshige Kino","orcid":"https://orcid.org/0000-0003-0220-9396","observed_orcids":["https://orcid.org/0000-0003-0220-9396"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomoshige Kino","raw_affiliation_strings":["Pediatric and Reproductive Endocrinology Branch National Institute of Child Health and Human Development National Institutes of Health Building 10, Room 9D42 10 Center Drive MSC 1583, Bethesda, MD 20892-1583"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric and Reproductive Endocrinology Branch National Institute of Child Health and Human Development National Institutes of Health Building 10, Room 9D42 10 Center Drive MSC 1583, Bethesda, MD 20892-1583","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046164327","display_name":"George Panagiotis Chrousos","orcid":"https://orcid.org/0000-0002-3098-5264","observed_orcids":["https://orcid.org/0000-0002-3098-5264"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George P. Chrousos","raw_affiliation_strings":["Pediatric and Reproductive Endocrinology Branch National Institute of Child Health and Human Development National Institutes of Health Building 10, Room 9D42 10 Center Drive MSC 1583, Bethesda, MD 20892-1583"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric and Reproductive Endocrinology Branch National Institute of Child Health and Human Development National Institutes of Health Building 10, Room 9D42 10 Center Drive MSC 1583, Bethesda, MD 20892-1583","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3480,"currency":"USD","value_usd":3480},"apc_paid":null,"fwci":1.364,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.83365605,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":"6","first_page":"480","last_page":"484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.8240000009536743},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lipodystrophy","display_name":"lipodystrophy","score":0.9179999828338623},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.9049999713897705},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.6389999985694885},{"id":"https://openalex.org/keywords/nucleoside-reverse-transcriptase-inhibitors","display_name":"nucleoside reverse transcriptase inhibitors","score":0.8259999752044678},{"id":"https://openalex.org/keywords/iatrogenic-complications","display_name":"iatrogenic complications","score":0.5820000171661377},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.4339999854564667},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6589999794960022},{"id":"https://openalex.org/keywords/long-term-antiviral-therapy","display_name":"long-term antiviral therapy","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.768968939781189},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.6233161687850952},{"id":"https://openalex.org/C2780941825","wikidata":"https://www.wikidata.org/wiki/Q1538213","display_name":"Lipodystrophy","level":5,"score":0.5720806121826172},{"id":"https://openalex.org/C83867959","wikidata":"https://www.wikidata.org/wiki/Q371467","display_name":"Scopus","level":3,"score":0.5391590595245361},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4335521161556244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3919731378555298},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37407857179641724},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.350881963968277},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3434363603591919},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.2816276550292969},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.108440101146698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008060","descriptor_name":"Lipodystrophy","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008060","descriptor_name":"Lipodystrophy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008060","descriptor_name":"Lipodystrophy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012191","descriptor_name":"Retroviridae Proteins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4158/ep.7.6.480","doi":"https://doi.org/10.4158/ep.7.6.480","is_oa":false,"landing_page_url":"https://doi.org/10.4158/ep.7.6.480","pdf_url":null,"source":{"id":"https://openalex.org/S165390330","display_name":"Endocrine Practice","issn_l":"1530-891X","issn":["1530-891X","1934-2403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Practice","raw_type":"journal-article"},{"id":"pmid:11747288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11747288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1575318746","https://openalex.org/W1969287961","https://openalex.org/W1969304309","https://openalex.org/W1973208298","https://openalex.org/W1977902784","https://openalex.org/W1981634406","https://openalex.org/W1984621096","https://openalex.org/W1994569822","https://openalex.org/W1998660799","https://openalex.org/W1999605002","https://openalex.org/W2001582257","https://openalex.org/W2003403009","https://openalex.org/W2017506602","https://openalex.org/W2022139094","https://openalex.org/W2046854154","https://openalex.org/W2058217770","https://openalex.org/W2063054564","https://openalex.org/W2063089952","https://openalex.org/W2083184256","https://openalex.org/W2089040602","https://openalex.org/W2089695993","https://openalex.org/W2093185845","https://openalex.org/W2099011266","https://openalex.org/W2107664641","https://openalex.org/W2122204312","https://openalex.org/W2126440764","https://openalex.org/W2137035181","https://openalex.org/W2137811810","https://openalex.org/W2159436809","https://openalex.org/W2163617802","https://openalex.org/W2171030070","https://openalex.org/W2185425092","https://openalex.org/W2403587095","https://openalex.org/W2495233357","https://openalex.org/W3146045613","https://openalex.org/W4246700626"],"related_works":["https://openalex.org/W2075117075","https://openalex.org/W1995537119","https://openalex.org/W2015592292","https://openalex.org/W2317444253","https://openalex.org/W2152214945","https://openalex.org/W1521955098","https://openalex.org/W7099425972","https://openalex.org/W1964016905","https://openalex.org/W2160911126","https://openalex.org/W1970529551"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}