{"id":"https://openalex.org/W2034215575","doi":"https://doi.org/10.1016/j.bpj.2011.11.1983","title":"Null Mutations for Triadin and Junctin Reveal Triadin Anchors and the Requirement for Triadin-Junctin-CASQ Complexes in Stablizing RyR Resting Leak","display_name":"Null Mutations for Triadin and Junctin Reveal Triadin Anchors and the Requirement for Triadin-Junctin-CASQ Complexes in Stablizing RyR Resting Leak","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2034215575","doi":"https://doi.org/10.1016/j.bpj.2011.11.1983","mag":"2034215575"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2011.11.1983","doi":"https://doi.org/10.1016/j.bpj.2011.11.1983","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2011.11.1983","pdf_url":"http://www.cell.com/article/S0006349511033315/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349511033315/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064460348","display_name":"Simona Boncompagni","orcid":"https://orcid.org/0000-0001-5308-5069","observed_orcids":["https://orcid.org/0000-0001-5308-5069"]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Boncompagni","raw_affiliation_strings":["University of G. d'Annunzio, Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of G. d'Annunzio, Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Monique Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monique Thomas","raw_affiliation_strings":["Dept. Anesthesia Brigham and Women Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Anesthesia Brigham and Women Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101498681","display_name":"Jose Rafael Lopez","orcid":"https://orcid.org/0000-0003-1211-2432","observed_orcids":["https://orcid.org/0000-0003-1211-2432"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose R. Lopez","raw_affiliation_strings":["Dept. Anesthesia Brigham and Women Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Anesthesia Brigham and Women Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013306631","display_name":"Paul Denney Allen","orcid":"https://orcid.org/0000-0001-6915-1390","observed_orcids":["https://orcid.org/0000-0001-6915-1390"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul D. Allen","raw_affiliation_strings":["Dept. Anesthesia Brigham and Women Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Anesthesia Brigham and Women Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080329479","display_name":"Evangelia Galani Kranias","orcid":"https://orcid.org/0000-0002-4621-6179","observed_orcids":["https://orcid.org/0000-0002-4621-6179"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evangelia G. Kranias","raw_affiliation_strings":["Dept. Pharmacology and Cell Biophysics Univ. of Cincinnati, Cincinnati, OH, USA","Dept. Pharmacology & Cell Biophysics, University of Cincinnati, Cincinnati, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Pharmacology and Cell Biophysics Univ. of Cincinnati, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Dept. Pharmacology & Cell Biophysics, University of Cincinnati, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034394771","display_name":"Clara Franzini\u2010Armstrong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clara Franzini-Armstrong","raw_affiliation_strings":["Dept. Cell Dev Biol., University of Pennsylvania, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Cell Dev Biol., University of Pennsylvania, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073523096","display_name":"Claudio F. P\u00e9rez","orcid":"https://orcid.org/0000-0002-7808-5062","observed_orcids":["https://orcid.org/0000-0002-7808-5062"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudio F. Perez","raw_affiliation_strings":["Dept. Anesthesia Brigham and Women Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Anesthesia Brigham and Women Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14042812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"102","issue":"3","first_page":"363a","last_page":"363a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7773000001907349,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7773000001907349,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.210099995136261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triadin","display_name":"triadin","score":1.0},{"id":"https://openalex.org/keywords/junctin","display_name":"junctin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ryanodine-receptor","display_name":"ryanodine receptor","score":0.9819999933242798},{"id":"https://openalex.org/keywords/calsequestrin","display_name":"calsequestrin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/junctional-sarcoplasmic-reticulum","display_name":"junctional sarcoplasmic reticulum","score":0.9480000138282776},{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":0.8309999704360962},{"id":"https://openalex.org/keywords/sr-calcium-content","display_name":"SR calcium content","score":0.4410000145435333},{"id":"https://openalex.org/keywords/calcium-transients","display_name":"calcium transients","score":0.6539999842643738},{"id":"https://openalex.org/keywords/null-mutations","display_name":"null mutations","score":0.44699999690055847},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C2775953344","wikidata":"https://www.wikidata.org/wiki/Q24774223","display_name":"Calsequestrin","level":4,"score":0.8834248781204224},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.7463061809539795},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6693211197853088},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5855210423469543},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4190014898777008},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38657572865486145},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37777578830718994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2839539349079132}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bpj.2011.11.1983","doi":"https://doi.org/10.1016/j.bpj.2011.11.1983","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2011.11.1983","pdf_url":"http://www.cell.com/article/S0006349511033315/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},{"id":"pmh:oai:zenodo.org:147888","doi":null,"is_oa":true,"landing_page_url":"https://www.openaccessrepository.it/record/147888","pdf_url":null,"source":{"id":"https://openalex.org/S4306402478","display_name":"INFM-OAR (INFN Catania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210116497","host_organization_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Catania","host_organization_lineage":["https://openalex.org/I4210116497"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2011.11.1983","doi":"https://doi.org/10.1016/j.bpj.2011.11.1983","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2011.11.1983","pdf_url":"http://www.cell.com/article/S0006349511033315/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2034215575.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2062486525","https://openalex.org/W2318733299","https://openalex.org/W2053330560","https://openalex.org/W1985175596","https://openalex.org/W2086972392","https://openalex.org/W2046262815","https://openalex.org/W2006221479","https://openalex.org/W2069769813","https://openalex.org/W2042801405","https://openalex.org/W2039697219"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}