{"id":"https://openalex.org/W2034184423","doi":"https://doi.org/10.1016/s1567-5769(02)00179-0","title":"APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease","display_name":"APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W2034184423","doi":"https://doi.org/10.1016/s1567-5769(02)00179-0","mag":"2034184423","pmid":"https://pubmed.ncbi.nlm.nih.gov/12489805"},"language":"en","primary_location":{"id":"doi:10.1016/s1567-5769(02)00179-0","doi":"https://doi.org/10.1016/s1567-5769(02)00179-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1567-5769(02)00179-0","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070207434","display_name":"Michael S. Wolfe","orcid":"https://orcid.org/0000-0002-5721-9092","observed_orcids":["https://orcid.org/0000-0002-5721-9092"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael S. Wolfe","raw_affiliation_strings":["Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, H.I.M. 626, Boston, MA 02115, USA. mwolfe@rics.bwh.harvard.edu","Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, H.I.M. 626, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, H.I.M. 626, Boston, MA 02115, USA. mwolfe@rics.bwh.harvard.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, H.I.M. 626, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070207434"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":3220,"currency":"USD","value_usd":3220},"apc_paid":null,"fwci":0.1887,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.1755618,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"13-14","first_page":"1919","last_page":"1929"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9620000123977661},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9610000252723694},{"id":"https://openalex.org/keywords/presenilin","display_name":"presenilin","score":0.8679999709129333},{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.9710000157356262},{"id":"https://openalex.org/keywords/beta-secretase","display_name":"beta-secretase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8360000252723694},{"id":"https://openalex.org/keywords/gamma-secretase-inhibitors","display_name":"gamma-secretase inhibitors","score":0.7850000262260437},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.9478755593299866},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.6075126528739929},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5492791533470154},{"id":"https://openalex.org/C2780645649","wikidata":"https://www.wikidata.org/wiki/Q18252685","display_name":"Notch 1","level":4,"score":0.4803982079029083},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4154531955718994},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4086754322052002},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3738030791282654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32431650161743164},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2098732888698578},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20710352063179016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11485081911087036}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1567-5769(02)00179-0","doi":"https://doi.org/10.1016/s1567-5769(02)00179-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1567-5769(02)00179-0","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},{"id":"pmid:12489805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12489805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1480987708","https://openalex.org/W1485366536","https://openalex.org/W1491665105","https://openalex.org/W1495136850","https://openalex.org/W1524261859","https://openalex.org/W1534001036","https://openalex.org/W1574188788","https://openalex.org/W1626267121","https://openalex.org/W1652739389","https://openalex.org/W1655404681","https://openalex.org/W1660631781","https://openalex.org/W1675105744","https://openalex.org/W1763915099","https://openalex.org/W1967027232","https://openalex.org/W1972856649","https://openalex.org/W1977683347","https://openalex.org/W1978566291","https://openalex.org/W1979432217","https://openalex.org/W1979853120","https://openalex.org/W1988923764","https://openalex.org/W1995434077","https://openalex.org/W2000582255","https://openalex.org/W2000769863","https://openalex.org/W2001914338","https://openalex.org/W2004305803","https://openalex.org/W2005681172","https://openalex.org/W2007730323","https://openalex.org/W2007773692","https://openalex.org/W2016668224","https://openalex.org/W2019007505","https://openalex.org/W2019216667","https://openalex.org/W2019500453","https://openalex.org/W2022114463","https://openalex.org/W2022796225","https://openalex.org/W2023432179","https://openalex.org/W2023531011","https://openalex.org/W2029205666","https://openalex.org/W2033796514","https://openalex.org/W2036520596","https://openalex.org/W2049130898","https://openalex.org/W2056181922","https://openalex.org/W2067521893","https://openalex.org/W2075175573","https://openalex.org/W2077196279","https://openalex.org/W2077674018","https://openalex.org/W2078001656","https://openalex.org/W2081733923","https://openalex.org/W2081998222","https://openalex.org/W2082195162","https://openalex.org/W2088152552","https://openalex.org/W2095745901","https://openalex.org/W2098503611","https://openalex.org/W2101077392","https://openalex.org/W2104636742","https://openalex.org/W2113690827","https://openalex.org/W2122391469","https://openalex.org/W2128084592","https://openalex.org/W2140503956","https://openalex.org/W2146955477","https://openalex.org/W2150970420","https://openalex.org/W2154861644","https://openalex.org/W2156910937","https://openalex.org/W2157895955","https://openalex.org/W2168087300","https://openalex.org/W2605805536","https://openalex.org/W2775777157","https://openalex.org/W2833026885","https://openalex.org/W4250522654"],"related_works":["https://openalex.org/W2136902554","https://openalex.org/W7073897381","https://openalex.org/W1973130935","https://openalex.org/W4247365895","https://openalex.org/W2030657258","https://openalex.org/W1992779462","https://openalex.org/W2005249952","https://openalex.org/W71170684","https://openalex.org/W2068781633","https://openalex.org/W2093689223"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
