{"id":"https://openalex.org/W2034154258","doi":"https://doi.org/10.1006/bbrc.1997.7133","title":"Sphingomyelinase Activity Is Enhanced in Cerebral Cortex of Senescence-Accelerated Mouse-P/10 with Advancing Age","display_name":"Sphingomyelinase Activity Is Enhanced in Cerebral Cortex of Senescence-Accelerated Mouse-P/10 with Advancing Age","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W2034154258","doi":"https://doi.org/10.1006/bbrc.1997.7133","mag":"2034154258","pmid":"https://pubmed.ncbi.nlm.nih.gov/9299408"},"language":"en","primary_location":{"id":"doi:10.1006/bbrc.1997.7133","doi":"https://doi.org/10.1006/bbrc.1997.7133","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1997.7133","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100337398","display_name":"Sung Soo Kim","orcid":"https://orcid.org/0000-0002-6817-7668","observed_orcids":["https://orcid.org/0000-0002-6817-7668"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Su Kim","raw_affiliation_strings":["Department of Pharmacology, College of Medicine, Seoul National University, South Korea","Department of Pharmacology, College of Medicine & Department of Molecular Biology, Neuroscience Research Institute, Seoul National University, 28 Yongon-dong, Chongno-ku, Seoul, 110-799"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, Seoul National University, South Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Pharmacology, College of Medicine & Department of Molecular Biology, Neuroscience Research Institute, Seoul National University, 28 Yongon-dong, Chongno-ku, Seoul, 110-799","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101562790","display_name":"Mi Sun Kang","orcid":"https://orcid.org/0000-0003-4784-1424","observed_orcids":["https://orcid.org/0000-0003-4784-1424"]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mi Sun Kang","raw_affiliation_strings":["Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, 221 Huksuk-dong, Dongjak-ku, Seoul, 156-756, South Korea","Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University, 221 Huksuk-dong, Dongjak-Ku, Seoul 156-756, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, 221 Huksuk-dong, Dongjak-ku, Seoul, 156-756, South Korea","institution_ids":["https://openalex.org/I67900169"]},{"raw_affiliation_string":"Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University, 221 Huksuk-dong, Dongjak-Ku, Seoul 156-756, South Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111954288","display_name":"Yoo Mi Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoo Mi Choi","raw_affiliation_strings":["Department of Pharmacology, College of Medicine & Department of Molecular Biology, Neuroscience Research Institute, Seoul National University, 28 Yongon-dong, Chongno-ku, Seoul, 110-799"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine & Department of Molecular Biology, Neuroscience Research Institute, Seoul National University, 28 Yongon-dong, Chongno-ku, Seoul, 110-799","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110230176","display_name":"Yoo Hun Suh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoo Hun Suh","raw_affiliation_strings":["Department of Pharmacology, College of Medicine & Department of Molecular Biology, Neuroscience Research Institute, Seoul National University, 28 Yongon-dong, Chongno-ku, Seoul, 110-799"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine & Department of Molecular Biology, Neuroscience Research Institute, Seoul National University, 28 Yongon-dong, Chongno-ku, Seoul, 110-799","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016543873","display_name":"Dae Kyong Kim","orcid":"https://orcid.org/0009-0000-0388-7303","observed_orcids":["https://orcid.org/0009-0000-0388-7303"]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Dae Kyong Kim","raw_affiliation_strings":["Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, 221 Huksuk-dong, Dongjak-ku, Seoul, 156-756, South Korea","Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University, 221 Huksuk-dong, Dongjak-Ku, Seoul 156-756, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University, 221 Huksuk-dong, Dongjak-ku, Seoul, 156-756, South Korea","institution_ids":["https://openalex.org/I67900169"]},{"raw_affiliation_string":"Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University, 221 Huksuk-dong, Dongjak-Ku, Seoul 156-756, South Korea","institution_ids":["https://openalex.org/I67900169"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016543873"],"corresponding_institution_ids":["https://openalex.org/I67900169"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.7938,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.68384673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"237","issue":"3","first_page":"583","last_page":"587"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.044599998742341995,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingomyelinase","display_name":"sphingomyelinase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.8209999799728394},{"id":"https://openalex.org/keywords/senescence-accelerated-mouse","display_name":"senescence-accelerated mice","score":0.9039999842643738},{"id":"https://openalex.org/keywords/accelerated-senescence","display_name":"accelerated senescence","score":0.7110000252723694},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6380000114440918},{"id":"https://openalex.org/keywords/membrane-bound-enzyme","display_name":"membrane-bound enzyme","score":0.7409999966621399},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.6380000114440918},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.8679999709129333},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.7978546619415283},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.791290283203125},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.6637763977050781},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.6116948127746582},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5584323406219482},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49303051829338074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4651103615760803},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.46318718791007996},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.45379602909088135},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44844773411750793},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.44228243827819824},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.41055455803871155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3964017331600189},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37760141491889954},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.34942108392715454},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2748439908027649},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.21631211042404175},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2135903239250183},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15458592772483826}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013108","descriptor_name":"Sphingomyelin Phosphodiesterase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013108","descriptor_name":"Sphingomyelin Phosphodiesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013108","descriptor_name":"Sphingomyelin Phosphodiesterase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/bbrc.1997.7133","doi":"https://doi.org/10.1006/bbrc.1997.7133","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1997.7133","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:9299408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9299408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1530348463","display_name":null,"funder_award_id":"1993-1996","funder_id":"https://openalex.org/F4320322348","funder_display_name":"Korea Science and Engineering Foundation"},{"id":"https://openalex.org/G3089158846","display_name":null,"funder_award_id":"961-0719-118-2","funder_id":"https://openalex.org/F4320322348","funder_display_name":"Korea Science and Engineering Foundation"}],"funders":[{"id":"https://openalex.org/F4320321408","display_name":"Ministry of Education","ror":"https://ror.org/01p262204"},{"id":"https://openalex.org/F4320322348","display_name":"Korea Science and Engineering Foundation","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1487704738","https://openalex.org/W1514523032","https://openalex.org/W1966097252","https://openalex.org/W1968537977","https://openalex.org/W1972090215","https://openalex.org/W1976178063","https://openalex.org/W1994392702","https://openalex.org/W1995221636","https://openalex.org/W1999511974","https://openalex.org/W2002304595","https://openalex.org/W2005622032","https://openalex.org/W2007604755","https://openalex.org/W2011495375","https://openalex.org/W2016470388","https://openalex.org/W2023677185","https://openalex.org/W2027590812","https://openalex.org/W2028652974","https://openalex.org/W2049108649","https://openalex.org/W2070005836","https://openalex.org/W2118385360","https://openalex.org/W2135687585"],"related_works":["https://openalex.org/W1984086828","https://openalex.org/W2090978702","https://openalex.org/W2031581424","https://openalex.org/W1975182086","https://openalex.org/W2025843329","https://openalex.org/W1975160117","https://openalex.org/W2029045984","https://openalex.org/W2920295400","https://openalex.org/W1983726308","https://openalex.org/W2067682476"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}