{"id":"https://openalex.org/W2034091561","doi":"https://doi.org/10.1155/s1110724304306017","title":"Adhesion to Vitronectin and Collagen I Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells","display_name":"Adhesion to Vitronectin and Collagen I Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2034091561","doi":"https://doi.org/10.1155/s1110724304306017","mag":"2034091561","pmid":"https://pubmed.ncbi.nlm.nih.gov/15123885","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/545655"},"language":"en","primary_location":{"id":"doi:10.1155/s1110724304306017","doi":"https://doi.org/10.1155/s1110724304306017","is_oa":true,"landing_page_url":"https://doi.org/10.1155/s1110724304306017","pdf_url":"https://downloads.hindawi.com/journals/bmri/2004/169212.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/bmri/2004/169212.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043106201","display_name":"Roman M. Salasznyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roman M. Salasznyk","raw_affiliation_strings":["Department of Biology, Rensselaer Polytechnic Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Rensselaer Polytechnic Institute","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William A. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Williams","raw_affiliation_strings":["Department of Biology, Rensselaer Polytechnic Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Rensselaer Polytechnic Institute","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052236028","display_name":"Adele L. Boskey","orcid":"https://orcid.org/0000-0002-6181-2219","observed_orcids":["https://orcid.org/0000-0002-6181-2219"]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adele Boskey","raw_affiliation_strings":["Hospital for Special Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Special Surgery","institution_ids":["https://openalex.org/I1281539108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048443006","display_name":"Anna Batorsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Batorsky","raw_affiliation_strings":["Department of Biology, Rensselaer Polytechnic Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Rensselaer Polytechnic Institute","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015163321","display_name":"George E. Plopper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George E. Plopper","raw_affiliation_strings":["Department of Biology, Rensselaer Polytechnic Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Rensselaer Polytechnic Institute","institution_ids":["https://openalex.org/I165799507"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015163321"],"corresponding_institution_ids":["https://openalex.org/I165799507"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":7.5331,"has_fulltext":true,"cited_by_count":419,"citation_normalized_percentile":{"value":0.97320006,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"2004","issue":"1","first_page":"24","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.02889999933540821,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-mesenchymal-stem-cells","display_name":"human mesenchymal stem cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":1.0},{"id":"https://openalex.org/keywords/vitronectin","display_name":"vitronectin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.996999979019165},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.800000011920929},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9269999861717224},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.9120000004768372},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/laminin-1","display_name":"laminin-1","score":0.8870000243186951},{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":0.7559999823570251},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.5690000057220459},{"id":"https://openalex.org/keywords/mineralized-matrix","display_name":"mineralized matrix","score":0.7369999885559082},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.8849999904632568},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.8695859909057617},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8245524168014526},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6550257205963135},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.6381725072860718},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4921044707298279},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4807896018028259},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.41565099358558655},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.26968926191329956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21984973549842834},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.19213047623634338},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1155/s1110724304306017","doi":"https://doi.org/10.1155/s1110724304306017","is_oa":true,"landing_page_url":"https://doi.org/10.1155/s1110724304306017","pdf_url":"https://downloads.hindawi.com/journals/bmri/2004/169212.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:545655","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/545655","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biomed Biotechnol","raw_type":"Text"},{"id":"pmid:15123885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15123885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedicine & biotechnology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1155/s1110724304306017","doi":"https://doi.org/10.1155/s1110724304306017","is_oa":true,"landing_page_url":"https://doi.org/10.1155/s1110724304306017","pdf_url":"https://downloads.hindawi.com/journals/bmri/2004/169212.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2034091561.pdf","grobid_xml":"https://content.openalex.org/works/W2034091561.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W126207357","https://openalex.org/W1918240731","https://openalex.org/W1963756782","https://openalex.org/W1967402039","https://openalex.org/W1977950302","https://openalex.org/W1979657364","https://openalex.org/W1991415492","https://openalex.org/W1992328264","https://openalex.org/W1998777645","https://openalex.org/W2003348948","https://openalex.org/W2010409614","https://openalex.org/W2013417615","https://openalex.org/W2014673628","https://openalex.org/W2023565549","https://openalex.org/W2026056871","https://openalex.org/W2026180273","https://openalex.org/W2027074656","https://openalex.org/W2033391292","https://openalex.org/W2041487686","https://openalex.org/W2051165362","https://openalex.org/W2058766023","https://openalex.org/W2060960690","https://openalex.org/W2063633164","https://openalex.org/W2070466054","https://openalex.org/W2084293556","https://openalex.org/W2089454086","https://openalex.org/W2096590593","https://openalex.org/W2097767628","https://openalex.org/W2105646619","https://openalex.org/W2112619023","https://openalex.org/W2129611079","https://openalex.org/W2142184860","https://openalex.org/W2143334477","https://openalex.org/W2150446998","https://openalex.org/W2152169709","https://openalex.org/W2159999899","https://openalex.org/W2165253648","https://openalex.org/W2396827028","https://openalex.org/W2409336843","https://openalex.org/W4231964769"],"related_works":["https://openalex.org/W7095116997","https://openalex.org/W2006344735","https://openalex.org/W2116753613","https://openalex.org/W1981549657","https://openalex.org/W2021053451","https://openalex.org/W2130527791","https://openalex.org/W2057902108","https://openalex.org/W2041179972","https://openalex.org/W2802615612","https://openalex.org/W2339079073"],"abstract_inverted_index":{"The":[0],"mechanisms":[1],"controlling":[2],"human":[3],"mesenchymal":[4],"stem":[5],"cells":[6,116],"(hMSC)":[7],"differentiation":[8,31,63,113,126,147,160],"are":[9],"not":[10],"entirely":[11],"understood.":[12],"We":[13,82,134],"hypothesized":[14],"that":[15,84,136,151],"the":[16,48,59,110,137,145],"contact":[17,138,153],"with":[18,90,139],"extracellular":[19],"matrix":[20],"(ECM)":[21],"proteins":[22,46,89],"normally":[23],"found":[24,83],"in":[25,34,47,115,161],"bone":[26],"marrow":[27],"would":[28],"promote":[29],"osteogenic":[30,54,112,146],"of":[32,52,61,66,148],"hMSC":[33,42,85],"vitro.":[35],"To":[36],"test":[37],"this":[38],"hypothesis,":[39],"we":[40],"cultured":[41],"on":[43,118,129],"purified":[44],"ECM":[45,88,152],"presence":[49,60],"or":[50,131],"absence":[51],"soluble":[53],"supplements,":[55],"and":[56,73,104,120,123,141,150],"assayed":[57],"for":[58],"well-established":[62],"markers":[64],"(production":[65],"mineralized":[67],"matrix,":[68],"osteopontin,":[69],"osteocalcin,":[70],"collagen":[71,95,98,121,142],"I,":[72],"alkaline":[74],"phosphatase":[75],"expression)":[76],"over":[77],"a":[78],"16-day":[79],"time":[80],"course.":[81],"adhere":[86],"to":[87,158],"varying":[91],"affinity":[92],"(fibronectin":[93],">":[94,102],"I":[96,122,143],">/=":[97,100],"IV":[99],"vitronectin":[101,119,140],"laminin-1)":[103],"through":[105],"distinct":[106],"integrin":[107],"receptors.":[108],"Importantly,":[109],"greatest":[111],"occurred":[114],"plated":[117],"almost":[124],"no":[125],"took":[127],"place":[128],"fibronectin":[130],"uncoated":[132],"plates.":[133],"conclude":[135],"promotes":[144],"hMSC,":[149],"alone":[154],"may":[155],"be":[156],"sufficient":[157],"induce":[159],"these":[162],"cells.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":25},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":38}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}