{"id":"https://openalex.org/W203404653","doi":"https://doi.org/10.1016/s0188-4409(01)00292-2","title":"Folate Levels and N 5, N 10-Methylenetetrahydrofolate Reductase Genotype (MTHFR) in Mothers of Offspring with Neural Tube Defects","display_name":"Folate Levels and N 5, N 10-Methylenetetrahydrofolate Reductase Genotype (MTHFR) in Mothers of Offspring with Neural Tube Defects","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W203404653","doi":"https://doi.org/10.1016/s0188-4409(01)00292-2","mag":"203404653","pmid":"https://pubmed.ncbi.nlm.nih.gov/11440783"},"language":"en","primary_location":{"id":"doi:10.1016/s0188-4409(01)00292-2","doi":"https://doi.org/10.1016/s0188-4409(01)00292-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0188-4409(01)00292-2","pdf_url":null,"source":{"id":"https://openalex.org/S157833918","display_name":"Archives of Medical Research","issn_l":"0066-6769","issn":["0066-6769","0188-0128","0188-4409","1873-5487"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Medical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017600116","display_name":"L. Villarreal","orcid":"https://orcid.org/0000-0003-1442-9089","observed_orcids":["https://orcid.org/0000-0003-1442-9089"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Laura E.Mart\u0131\u0301nez de Villarreal","raw_affiliation_strings":["Departamento de Patolog\u00eda, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico. laurmart@ccr.dsi.uanl.mx","Departamento de Patolog\u00eda, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Patolog\u00eda, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico. laurmart@ccr.dsi.uanl.mx","institution_ids":["https://openalex.org/I169046204"]},{"raw_affiliation_string":"Departamento de Patolog\u00eda, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020368412","display_name":"Iv\u00e1n Delgado\u2010Enciso","orcid":"https://orcid.org/0000-0001-9848-862X","observed_orcids":["https://orcid.org/0000-0001-9848-862X"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Iv\u00e1n Delgado-Enciso","raw_affiliation_strings":["Departamento de Bioqu\u0131\u0301mica, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u0131\u0301mica, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079448879","display_name":"Ram\u00f3n Vald\u00e9z-Leal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095685","display_name":"Secretaria de Salud","ror":"https://ror.org/0082wq496","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ram\u00f3n Vald\u00e9z-Leal","raw_affiliation_strings":["Secretar\u0131\u0301a de Salud, Estado de Nuevo Le\u00f3n, Monterrey, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Secretar\u0131\u0301a de Salud, Estado de Nuevo Le\u00f3n, Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I4210095685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018050764","display_name":"Rocio Ort\u00edz-L\u00f3pez","orcid":"https://orcid.org/0000-0002-7783-026X","observed_orcids":["https://orcid.org/0000-0002-7783-026X"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Rocio Ort\u0131\u0301z-L\u00f3pez","raw_affiliation_strings":["Departamento de Bioqu\u0131\u0301mica, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u0131\u0301mica, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019119640","display_name":"Augusto Rojas\u2010Mart\u00ednez","orcid":"https://orcid.org/0000-0003-3765-6778","observed_orcids":["https://orcid.org/0000-0003-3765-6778"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Augusto Rojas-Mart\u0131\u0301nez","raw_affiliation_strings":["Departamento de Bioqu\u0131\u0301mica, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u0131\u0301mica, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072528337","display_name":"Carmen Lim\u00f3n-Benavides","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Carmen Lim\u00f3n-Benavides","raw_affiliation_strings":["Departamento de Patolog\u0131\u0301a, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico","Departamento de Patolog\u00eda, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Patolog\u0131\u0301a, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I169046204"]},{"raw_affiliation_string":"Departamento de Patolog\u00eda, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064217284","display_name":"Mar\u00eda Alejandra S\u00e1nchez-Pe\u00f1a","orcid":"https://orcid.org/0000-0001-7680-8805","observed_orcids":["https://orcid.org/0000-0001-7680-8805"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mar\u0131\u0301a A S\u00e1nchez-Pe\u00f1a","raw_affiliation_strings":["Departamento de Patolog\u0131\u0301a, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico","Departamento de Patolog\u00eda, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Patolog\u0131\u0301a, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I169046204"]},{"raw_affiliation_string":"Departamento de Patolog\u00eda, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058602978","display_name":"Jes\u00fas \u00c1ncer\u2010Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-1835-315X","observed_orcids":["https://orcid.org/0000-0002-1835-315X"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Ancer-Rodr\u0131\u0301guez","raw_affiliation_strings":["Departamento de Patolog\u0131\u0301a, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico","Departamento de Patolog\u00eda, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Patolog\u0131\u0301a, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I169046204"]},{"raw_affiliation_string":"Departamento de Patolog\u00eda, Unidad de Gen\u00e9tica y Defectos Cong\u00e9nitos, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029652952","display_name":"Hugo Alberto Barrera-Salda\u00f1a","orcid":"https://orcid.org/0000-0003-1587-4571","observed_orcids":["https://orcid.org/0000-0003-1587-4571"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Hugo A Barrera-Salda\u00f1a","raw_affiliation_strings":["Departamento de Bioqu\u0131\u0301mica, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u0131\u0301mica, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL), Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053254539","display_name":"Jes\u00fas Zacar\u00edas Villarreal\u2010P\u00e9rez","orcid":"https://orcid.org/0000-0002-6814-062X","observed_orcids":["https://orcid.org/0000-0002-6814-062X"]},"institutions":[{"id":"https://openalex.org/I4210095685","display_name":"Secretaria de Salud","ror":"https://ror.org/0082wq496","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Z Villarreal-P\u00e9rez","raw_affiliation_strings":["Secretar\u0131\u0301a de Salud, Estado de Nuevo Le\u00f3n, Monterrey, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Secretar\u0131\u0301a de Salud, Estado de Nuevo Le\u00f3n, Monterrey, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I4210095685"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017600116"],"corresponding_institution_ids":["https://openalex.org/I169046204"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":4.2775,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.93398008,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"32","issue":"4","first_page":"277","last_page":"282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-tube-defects","display_name":"neural tube defects","score":0.9990000128746033},{"id":"https://openalex.org/keywords/folate-deficiency","display_name":"folate deficiency","score":0.8600000143051147},{"id":"https://openalex.org/keywords/red-blood-cell-folate","display_name":"red blood cell folate","score":0.8410000205039978},{"id":"https://openalex.org/keywords/plasma-folate","display_name":"plasma folate","score":0.9919999837875366},{"id":"https://openalex.org/keywords/maternal-genotype","display_name":"maternal genotype","score":0.5910000205039978},{"id":"https://openalex.org/keywords/homocysteine-metabolism","display_name":"homocysteine metabolism","score":0.8069999814033508},{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.6389999985694885},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.9708840847015381},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7851436138153076},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.6730810403823853},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.626996636390686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6082155108451843},{"id":"https://openalex.org/C2780594696","wikidata":"https://www.wikidata.org/wiki/Q1127402","display_name":"Neural tube","level":3,"score":0.5865195989608765},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5457815527915955},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5279535055160522},{"id":"https://openalex.org/C153471976","wikidata":"https://www.wikidata.org/wiki/Q2873354","display_name":"Heterozygote advantage","level":4,"score":0.5106309056282043},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.48561301827430725},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.4549420177936554},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.41461992263793945},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4083820581436157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38513004779815674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32409292459487915},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2966401278972626},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21927708387374878},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18456336855888367},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17382973432540894},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.05337423086166382},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000587","descriptor_name":"Oxidoreductases Acting on CH-NH Group Donors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000757","descriptor_name":"Anencephaly","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000757","descriptor_name":"Anencephaly","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008431","descriptor_name":"Maternal-Fetal Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008800","descriptor_name":"Mexico","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009436","descriptor_name":"Neural Tube Defects","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009436","descriptor_name":"Neural Tube Defects","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011256","descriptor_name":"Pregnancy Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016135","descriptor_name":"Spinal Dysraphism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016135","descriptor_name":"Spinal Dysraphism","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0188-4409(01)00292-2","doi":"https://doi.org/10.1016/s0188-4409(01)00292-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0188-4409(01)00292-2","pdf_url":null,"source":{"id":"https://openalex.org/S157833918","display_name":"Archives of Medical Research","issn_l":"0066-6769","issn":["0066-6769","0188-0128","0188-4409","1873-5487"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Medical Research","raw_type":"journal-article"},{"id":"pmid:11440783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11440783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of medical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/2","score":0.40450000762939453,"display_name":"Zero hunger"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W52585057","https://openalex.org/W582595557","https://openalex.org/W1967898508","https://openalex.org/W1975308624","https://openalex.org/W1982144770","https://openalex.org/W1985307436","https://openalex.org/W2004895380","https://openalex.org/W2004934259","https://openalex.org/W2010365111","https://openalex.org/W2014730499","https://openalex.org/W2023172570","https://openalex.org/W2026993409","https://openalex.org/W2031262735","https://openalex.org/W2035750013","https://openalex.org/W2035815331","https://openalex.org/W2036493913","https://openalex.org/W2038331014","https://openalex.org/W2038653103","https://openalex.org/W2039569970","https://openalex.org/W2044877979","https://openalex.org/W2048151432","https://openalex.org/W2058241761","https://openalex.org/W2062399862","https://openalex.org/W2069065010","https://openalex.org/W2070236076","https://openalex.org/W2077243611","https://openalex.org/W2077689608","https://openalex.org/W2092730526","https://openalex.org/W2103043059","https://openalex.org/W2115286393","https://openalex.org/W2139158679","https://openalex.org/W2141080425","https://openalex.org/W2143268844","https://openalex.org/W2144062723","https://openalex.org/W2153330367","https://openalex.org/W2160165018","https://openalex.org/W2165715420","https://openalex.org/W2316683487","https://openalex.org/W2322037963","https://openalex.org/W2412090825","https://openalex.org/W4237533794","https://openalex.org/W4249597039","https://openalex.org/W4252789112","https://openalex.org/W4300479806","https://openalex.org/W6680727048","https://openalex.org/W6858100315"],"related_works":["https://openalex.org/W4249597039","https://openalex.org/W7220601046","https://openalex.org/W20736914","https://openalex.org/W2023172570","https://openalex.org/W1979539710","https://openalex.org/W4312336025","https://openalex.org/W2785548091","https://openalex.org/W1817730472","https://openalex.org/W1999565580","https://openalex.org/W4280594366"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}