{"id":"https://openalex.org/W2034045976","doi":"https://doi.org/10.1038/87090","title":"Identification of protein-tyrosine kinase catalytic domain conserved sequences in the ORF expressed sequence tags database","display_name":"Identification of protein-tyrosine kinase catalytic domain conserved sequences in the ORF expressed sequence tags database","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W2034045976","doi":"https://doi.org/10.1038/87090","mag":"2034045976"},"language":"en","primary_location":{"id":"doi:10.1038/87090","doi":"https://doi.org/10.1038/87090","is_oa":true,"landing_page_url":"https://doi.org/10.1038/87090","pdf_url":"https://www.nature.com/articles/ng0401supp_55c.pdf","source":{"id":"https://openalex.org/S137905309","display_name":"Nature Genetics","issn_l":"1061-4036","issn":["1061-4036","1546-1718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Genetics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/ng0401supp_55c.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081983360","display_name":"Daniel Giannella\u2010Neto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daniel Giannella-Neto","raw_affiliation_strings":["Laboratory for Human Nutrition and Metabolic Diseases (LIM-25), Hospital das Cl\u00ednicas, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Human Nutrition and Metabolic Diseases (LIM-25), Hospital das Cl\u00ednicas, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060724387","display_name":"Maria L\u00facia Corr\u00eaa\u2010Giannella","orcid":"https://orcid.org/0000-0003-3655-4446","observed_orcids":["https://orcid.org/0000-0003-3655-4446"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria L\u00facia C. Correa","raw_affiliation_strings":["Laboratory for Human Nutrition and Metabolic Diseases (LIM-25), Hospital das Cl\u00ednicas, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Human Nutrition and Metabolic Diseases (LIM-25), Hospital das Cl\u00ednicas, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038787051","display_name":"Ana Mercedes S. Cavaleiro-Luna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Mercedes S. Cavaleiro-Luna","raw_affiliation_strings":["Laboratory for Human Nutrition and Metabolic Diseases (LIM-25), Hospital das Cl\u00ednicas, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Human Nutrition and Metabolic Diseases (LIM-25), Hospital das Cl\u00ednicas, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110208334","display_name":"Maria Angela Henriques Zanella Fortes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Angela H.Z. Fortes","raw_affiliation_strings":["Laboratory for Human Nutrition and Metabolic Diseases (LIM-25), Hospital das Cl\u00ednicas, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Human Nutrition and Metabolic Diseases (LIM-25), Hospital das Cl\u00ednicas, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072295367","display_name":"Cassio Negro Coimbra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Cassio N. Coimbra","raw_affiliation_strings":["Laboratory for Human Nutrition and Metabolic Diseases (LIM-25), Hospital das Cl\u00ednicas, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Human Nutrition and Metabolic Diseases (LIM-25), Hospital das Cl\u00ednicas, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091239139","display_name":"Leonardo Scalon de Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leonardo S. Oliveira","raw_affiliation_strings":["Laboratory for Human Nutrition and Metabolic Diseases (LIM-25), Hospital das Cl\u00ednicas, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Human Nutrition and Metabolic Diseases (LIM-25), Hospital das Cl\u00ednicas, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035667949","display_name":"SANDRO JOS\u00c9 DE SOUZA","orcid":"https://orcid.org/0000-0002-1012-3237","observed_orcids":["https://orcid.org/0000-0002-1012-3237","https://orcid.org/0000-0003-2347-042X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandro J. De Souza","raw_affiliation_strings":["Ludwig Institute for Cancer Research, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113679680","display_name":"Andrew J.G. Simpson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew J.G. Simpson","raw_affiliation_strings":["Ludwig Institute for Cancer Research, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, S\u00e3o Paulo, Brazil","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"S4","first_page":"55","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/catalytic-domain","display_name":"catalytic domain","score":0.9599999785423279},{"id":"https://openalex.org/keywords/conserved-motifs","display_name":"conserved motifs","score":0.7080000042915344},{"id":"https://openalex.org/keywords/expressed-sequence-tags","display_name":"expressed sequence tags","score":0.8009999990463257},{"id":"https://openalex.org/keywords/orestes","display_name":"Orestes","score":0.6729999780654907},{"id":"https://openalex.org/keywords/kinase-families","display_name":"kinase families","score":0.6980000138282776},{"id":"https://openalex.org/keywords/eph-receptors","display_name":"Eph receptors","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pdgfr","display_name":"PDGFR","score":0.675000011920929},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.8539999723434448},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.7059999704360962},{"id":"https://openalex.org/keywords/cancer-signaling","display_name":"cancer signaling","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8643753528594971},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5508501529693604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5390638113021851},{"id":"https://openalex.org/C41584329","wikidata":"https://www.wikidata.org/wiki/Q175902","display_name":"Sequence database","level":3,"score":0.4750511646270752},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.47309568524360657},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.46674710512161255},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43744656443595886},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.42610445618629456},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.3912864625453949},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3512437343597412},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25541168451309204},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0772792398929596},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/87090","doi":"https://doi.org/10.1038/87090","is_oa":true,"landing_page_url":"https://doi.org/10.1038/87090","pdf_url":"https://www.nature.com/articles/ng0401supp_55c.pdf","source":{"id":"https://openalex.org/S137905309","display_name":"Nature Genetics","issn_l":"1061-4036","issn":["1061-4036","1546-1718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Genetics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/87090","doi":"https://doi.org/10.1038/87090","is_oa":true,"landing_page_url":"https://doi.org/10.1038/87090","pdf_url":"https://www.nature.com/articles/ng0401supp_55c.pdf","source":{"id":"https://openalex.org/S137905309","display_name":"Nature Genetics","issn_l":"1061-4036","issn":["1061-4036","1546-1718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2034045976.pdf","grobid_xml":"https://content.openalex.org/works/W2034045976.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2016188929","https://openalex.org/W2168752603","https://openalex.org/W420498017","https://openalex.org/W1014698510","https://openalex.org/W1438861743","https://openalex.org/W4253786908","https://openalex.org/W36604429","https://openalex.org/W2294734478","https://openalex.org/W4362593965","https://openalex.org/W4380244510"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}