{"id":"https://openalex.org/W2033988932","doi":"https://doi.org/10.1007/bf00315849","title":"Optimization of non-radioactive in situ hybridization: image analysis of varying pretreatment, hybridization and probe labelling conditions","display_name":"Optimization of non-radioactive in situ hybridization: image analysis of varying pretreatment, hybridization and probe labelling conditions","publication_year":1990,"publication_date":"1990-02-01","ids":{"openalex":"https://openalex.org/W2033988932","doi":"https://doi.org/10.1007/bf00315849","mag":"2033988932","pmid":"https://pubmed.ncbi.nlm.nih.gov/1969856"},"language":"en","primary_location":{"id":"doi:10.1007/bf00315849","doi":"https://doi.org/10.1007/bf00315849","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00315849","pdf_url":null,"source":{"id":"https://openalex.org/S78725770","display_name":"Histochemistry and Cell Biology","issn_l":"0948-6143","issn":["0948-6143","1432-119X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059674225","display_name":"Lars Larsson","orcid":"https://orcid.org/0000-0003-3722-035X","observed_orcids":["https://orcid.org/0000-0003-3722-035X"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"L. -I. Larsson","raw_affiliation_strings":["Department of Molecular Cell Biology, State Serum Institute, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, State Serum Institute, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081337637","display_name":"DAVID MICHAEL HOUGAARD","orcid":"https://orcid.org/0000-0001-5928-3517","observed_orcids":["https://orcid.org/0000-0001-5928-3517"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"D. M. Hougaard","raw_affiliation_strings":["Department of Molecular Cell Biology, State Serum Institute, Amager Boulevard 80, Building 81, DK-2300, Copenhagen S, Denmark","Department of Molecular Cell Biology, State Serum Institute, Copenhagen S, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, State Serum Institute, Amager Boulevard 80, Building 81, DK-2300, Copenhagen S, Denmark","institution_ids":["https://openalex.org/I101527212"]},{"raw_affiliation_string":"Department of Molecular Cell Biology, State Serum Institute, Copenhagen S, Denmark","institution_ids":["https://openalex.org/I101527212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I101527212"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":null,"fwci":2.8822,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.91631865,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"93","issue":"4","first_page":"347","last_page":"354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14134","display_name":"Classical Anatomy and Histology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2702","display_name":"Anatomy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.7799999713897705},{"id":"https://openalex.org/keywords/tissue-pretreatment","display_name":"tissue pretreatment","score":0.6499999761581421},{"id":"https://openalex.org/keywords/hybridization-temperature","display_name":"hybridization temperature","score":0.8650000095367432},{"id":"https://openalex.org/keywords/terminal-deoxynucleotidyl-transferase","display_name":"terminal deoxynucleotidyl transferase","score":0.8610000014305115},{"id":"https://openalex.org/keywords/signal-to-noise-ratio","display_name":"signal-to-noise ratio","score":0.765999972820282},{"id":"https://openalex.org/keywords/dynorphin-b","display_name":"dynorphin B","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C204628709","wikidata":"https://www.wikidata.org/wiki/Q864854","display_name":"Biotinylation","level":2,"score":0.7585076093673706},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.6342247724533081},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6276561617851257},{"id":"https://openalex.org/C2780523633","wikidata":"https://www.wikidata.org/wiki/Q380709","display_name":"Labelling","level":2,"score":0.5838525295257568},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.5112814903259277},{"id":"https://openalex.org/C54871578","wikidata":"https://www.wikidata.org/wiki/Q2074275","display_name":"Nucleic acid thermodynamics","level":4,"score":0.489165335893631},{"id":"https://openalex.org/C145169222","wikidata":"https://www.wikidata.org/wiki/Q9339485","display_name":"Molecular probe","level":3,"score":0.4633159637451172},{"id":"https://openalex.org/C2778270854","wikidata":"https://www.wikidata.org/wiki/Q283917","display_name":"Formamide","level":2,"score":0.4576806426048279},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4389124810695648},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4184887409210205},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.36536911129951477},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.324233740568161},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2915685474872589},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.24496260285377502},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.16547691822052002},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07993042469024658},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003845","descriptor_name":"Deoxycytosine Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003856","descriptor_name":"Deoxyuracil Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004399","descriptor_name":"Dynorphins","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004399","descriptor_name":"Dynorphins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005069","descriptor_name":"Evaluation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005404","descriptor_name":"Fixatives","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005559","descriptor_name":"Formamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008722","descriptor_name":"Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00315849","doi":"https://doi.org/10.1007/bf00315849","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00315849","pdf_url":null,"source":{"id":"https://openalex.org/S78725770","display_name":"Histochemistry and Cell Biology","issn_l":"0948-6143","issn":["0948-6143","1432-119X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histochemistry","raw_type":"journal-article"},{"id":"pmid:1969856","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1969856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histochemistry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W613699236","https://openalex.org/W1966341306","https://openalex.org/W1997867640","https://openalex.org/W2000850714","https://openalex.org/W2003606976","https://openalex.org/W2008354532","https://openalex.org/W2010998911","https://openalex.org/W2026469349","https://openalex.org/W2037373352","https://openalex.org/W2041638247","https://openalex.org/W2063273614","https://openalex.org/W2065671011","https://openalex.org/W2074453811","https://openalex.org/W2109458990","https://openalex.org/W2124314287","https://openalex.org/W2165992479","https://openalex.org/W2404112123","https://openalex.org/W4239664624"],"related_works":["https://openalex.org/W2065671011","https://openalex.org/W2318424079","https://openalex.org/W2057645202","https://openalex.org/W1614814996","https://openalex.org/W2058584798","https://openalex.org/W2088139568","https://openalex.org/W2077906501","https://openalex.org/W2409456883","https://openalex.org/W2009462086","https://openalex.org/W2397448734"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
