{"id":"https://openalex.org/W2033980540","doi":"https://doi.org/10.1186/1744-8069-10-2","title":"Acid Evoked Thermal Hyperalgesia Involves Peripheral P2Y1 Receptor Mediated TRPV1 Phosphorylation in a Rodent Model of Thrombus Induced Ischemic Pain","display_name":"Acid Evoked Thermal Hyperalgesia Involves Peripheral P2Y1 Receptor Mediated TRPV1 Phosphorylation in a Rodent Model of Thrombus Induced Ischemic Pain","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2033980540","doi":"https://doi.org/10.1186/1744-8069-10-2","mag":"2033980540","pmid":"https://pubmed.ncbi.nlm.nih.gov/24401144","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3895685"},"language":"en","primary_location":{"id":"doi:10.1186/1744-8069-10-2","doi":"https://doi.org/10.1186/1744-8069-10-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1744-8069-10-2","pdf_url":null,"source":{"id":"https://openalex.org/S49886757","display_name":"Molecular Pain","issn_l":"1744-8069","issn":["1744-8069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/1744-8069-10-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061028646","display_name":"Soon Gu Kwon","orcid":"https://orcid.org/0000-0003-4937-3142","observed_orcids":["https://orcid.org/0000-0003-4937-3142"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soon-Gu Kwon","raw_affiliation_strings":["Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052619724","display_name":"Dae\u2010Hyun Roh","orcid":"https://orcid.org/0000-0002-5139-5458","observed_orcids":["https://orcid.org/0000-0002-5139-5458"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I4210134882","display_name":"Kyung Hee University Dental Hospital","ror":"https://ror.org/02ss0kx69","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210112503","https://openalex.org/I4210134882","https://openalex.org/I4405258385"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dae-Hyun Roh","raw_affiliation_strings":["Department of Maxillofacial Tissue Regeneration, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Maxillofacial Tissue Regeneration, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea","institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4210134882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031988163","display_name":"Seo Yeon Yoon","orcid":"https://orcid.org/0000-0002-0365-2923","observed_orcids":["https://orcid.org/0000-0002-0365-2923"]},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seo-Yeon Yoon","raw_affiliation_strings":["Laboratory of Molecular Signal Transduction, Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul 136-791, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Signal Transduction, Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul 136-791, Republic of Korea","institution_ids":["https://openalex.org/I58716616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111870936","display_name":"Ji-Young Moon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Young Moon","raw_affiliation_strings":["Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040325440","display_name":"Sheu\u2010Ran Choi","orcid":"https://orcid.org/0000-0001-8755-2024","observed_orcids":["https://orcid.org/0000-0001-8755-2024"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sheu-Ran Choi","raw_affiliation_strings":["Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073627134","display_name":"Hoon\u2010Seong Choi","orcid":"https://orcid.org/0000-0002-8314-6683","observed_orcids":["https://orcid.org/0000-0002-8314-6683"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hoon-Seong Choi","raw_affiliation_strings":["Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019207623","display_name":"Suk-Yun Kang","orcid":"https://orcid.org/0000-0001-6812-9503","observed_orcids":["https://orcid.org/0000-0001-6812-9503"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Suk-Yun Kang","raw_affiliation_strings":["Acupuncture, Moxibustion & Meridian Research Group, Medical Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture, Moxibustion & Meridian Research Group, Medical Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100779305","display_name":"Ho Jae Han","orcid":"https://orcid.org/0000-0002-0657-1766","observed_orcids":["https://orcid.org/0000-0002-0657-1766"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ho-Jae Han","raw_affiliation_strings":["Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040912906","display_name":"Alvin James Beitz","orcid":"https://orcid.org/0000-0002-2640-2628","observed_orcids":["https://orcid.org/0000-0002-2640-2628"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alvin J Beitz","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005357174","display_name":"Seog Bae Oh","orcid":"https://orcid.org/0000-0001-7975-6895","observed_orcids":["https://orcid.org/0000-0001-7975-6895"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seog Bae Oh","raw_affiliation_strings":["Pain Cognitive Function Research Center, Dental Research Institute and Department of Neurobiology and Physiology, Department of Brain and cognitive Sciences, Seoul National University, Seoul 110-749, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pain Cognitive Function Research Center, Dental Research Institute and Department of Neurobiology and Physiology, Department of Brain and cognitive Sciences, Seoul National University, Seoul 110-749, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038375061","display_name":"Jang\u2010Hern Lee","orcid":"https://orcid.org/0000-0002-4971-4085","observed_orcids":["https://orcid.org/0000-0002-4971-4085"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jang-Hern Lee","raw_affiliation_strings":["Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5038375061"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":4.91,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.95669274,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"2","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.06629999727010727,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thermal-hyperalgesia","display_name":"thermal hyperalgesia","score":0.8659999966621399},{"id":"https://openalex.org/keywords/p2y1-receptor","display_name":"P2Y1 receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/acidosis","display_name":"acidosis","score":0.6629999876022339},{"id":"https://openalex.org/keywords/pkc-signaling","display_name":"PKC signaling","score":0.6899999976158142},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.8090000152587891},{"id":"https://openalex.org/keywords/carbonic-anhydrase-ii","display_name":"carbonic anhydrase II","score":0.996999979019165},{"id":"https://openalex.org/keywords/chelerythrine","display_name":"chelerythrine","score":0.7059999704360962},{"id":"https://openalex.org/keywords/amg9810","display_name":"AMG9810","score":0.9470000267028809},{"id":"https://openalex.org/keywords/proton-sensing-receptor","display_name":"proton-sensing receptor","score":0.5529999732971191},{"id":"https://openalex.org/keywords/ischemic-pain","display_name":"ischemic pain","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.8259569406509399},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.7474902868270874},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5573267936706543},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.47234001755714417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4633999168872833},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.45148003101348877},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41364461183547974},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3988092541694641},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39688581228256226},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3282499313354492},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.31622347235679626},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.3003714978694916},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2409205436706543},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19520816206932068},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1019544005393982}],"mesh":[{"descriptor_ui":"D000143","descriptor_name":"Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014020","descriptor_name":"Tissue Extracts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053119","descriptor_name":"Benzophenanthridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058472","descriptor_name":"Receptors, Purinergic P2Y1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/1744-8069-10-2","doi":"https://doi.org/10.1186/1744-8069-10-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1744-8069-10-2","pdf_url":null,"source":{"id":"https://openalex.org/S49886757","display_name":"Molecular Pain","issn_l":"1744-8069","issn":["1744-8069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pain","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2882382","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3895685","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24401144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24401144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pain","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3895685","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3895685/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Pain","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:05e2e6bef0cc437e9fe437caa4f01c1d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/05e2e6bef0cc437e9fe437caa4f01c1d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Pain, Vol 10 (2014)","raw_type":"article"},{"id":"mag:2185144877","doi":null,"is_oa":false,"landing_page_url":"http://molecularpain.com/content/pdf/1744-8069-10-2.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1186/1744-8069-10-2","doi":"https://doi.org/10.1186/1744-8069-10-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1744-8069-10-2","pdf_url":null,"source":{"id":"https://openalex.org/S49886757","display_name":"Molecular Pain","issn_l":"1744-8069","issn":["1744-8069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pain","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3217971587","display_name":null,"funder_award_id":"2012R1A3A2048834","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G5530307390","display_name":null,"funder_award_id":"2012R1A3A2048834","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G572945765","display_name":null,"funder_award_id":"2012-0005436","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1488245315","https://openalex.org/W1563482856","https://openalex.org/W1790023182","https://openalex.org/W1965695350","https://openalex.org/W1976621999","https://openalex.org/W1976933476","https://openalex.org/W1982934241","https://openalex.org/W1983449340","https://openalex.org/W1983602530","https://openalex.org/W1985030046","https://openalex.org/W1985703062","https://openalex.org/W1987135275","https://openalex.org/W1988224103","https://openalex.org/W1990331048","https://openalex.org/W1990923495","https://openalex.org/W2001358071","https://openalex.org/W2004728887","https://openalex.org/W2007456083","https://openalex.org/W2014760856","https://openalex.org/W2014955407","https://openalex.org/W2017124821","https://openalex.org/W2019000624","https://openalex.org/W2020340995","https://openalex.org/W2020880088","https://openalex.org/W2021252502","https://openalex.org/W2024334459","https://openalex.org/W2024420229","https://openalex.org/W2029535311","https://openalex.org/W2037235836","https://openalex.org/W2042054830","https://openalex.org/W2043142760","https://openalex.org/W2043262347","https://openalex.org/W2046955207","https://openalex.org/W2047218877","https://openalex.org/W2055765506","https://openalex.org/W2062431479","https://openalex.org/W2062480940","https://openalex.org/W2062776570","https://openalex.org/W2067477139","https://openalex.org/W2070663123","https://openalex.org/W2073327402","https://openalex.org/W2075375255","https://openalex.org/W2078879971","https://openalex.org/W2082908786","https://openalex.org/W2083457444","https://openalex.org/W2083602091","https://openalex.org/W2083910964","https://openalex.org/W2087172186","https://openalex.org/W2089178475","https://openalex.org/W2090778387","https://openalex.org/W2096621667","https://openalex.org/W2098430424","https://openalex.org/W2099489133","https://openalex.org/W2100553853","https://openalex.org/W2104675460","https://openalex.org/W2107062525","https://openalex.org/W2113139558","https://openalex.org/W2120487125","https://openalex.org/W2139389244","https://openalex.org/W2141005071","https://openalex.org/W2145740488","https://openalex.org/W2149855043","https://openalex.org/W2175961491"],"related_works":["https://openalex.org/W2185144877","https://openalex.org/W2007456083","https://openalex.org/W2043142760","https://openalex.org/W2584627952","https://openalex.org/W3007035179","https://openalex.org/W2029535311","https://openalex.org/W2045994093","https://openalex.org/W2117966992","https://openalex.org/W2000591396","https://openalex.org/W4411786025"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1],"previously":[2],"developed":[3],"a":[4,183,302,328,335],"thrombus-induced":[5],"ischemic":[6,60,158,288,317],"pain":[7],"(TIIP)":[8],"animal":[9],"model,":[10],"which":[11,39,91,223,305],"was":[12,190,268],"characterized":[13],"by":[14],"chronic":[15,316],"bilateral":[16],"mechanical":[17],"allodynia":[18],"without":[19],"thermal":[20],"hyperalgesia":[21],"(TH).":[22],"On":[23],"the":[24,43,74,78,97,125,150,165,174,216,230,251,259,264,287,296,308,340],"other":[25],"hand":[26],"we":[27],"had":[28],"shown":[29,191],"that":[30,154,280],"intraplantar":[31,104,202],"injection":[32,72,105,203],"of":[33,45,80,99,106,127,136,176,204,232,261,282,291,298,310,342],"acidic":[34,51,70,155,193,284],"saline":[35,71,132,194],"facilitated":[36],"ATP-induced":[37],"pain,":[38],"did":[40],"result":[41],"in":[42,47,82,96,124,149,173,178,186,192,271,286,295,315,331,344],"induction":[44,260],"TH":[46,81,311,343],"normal":[48],"rats.":[49],"Because":[50],"pH":[52,107,112,130,252],"and":[53,88,114,141,209,263],"increased":[54,265],"ATP":[55],"are":[56,94],"closely":[57],"associated":[58],"with":[59,160,319],"conditions,":[61],"this":[62,100,332],"study":[63],"is":[64],"designed":[65],"to:":[66],"(1)":[67],"examine":[68],"whether":[69],"into":[73],"hind":[75,179,289],"paw":[76,180,290],"causes":[77],"development":[79,98,126,231,309,341],"TIIP,":[83],"but":[84,110],"not":[85,111],"control,":[86],"animals;":[87],"(2)":[89],"determine":[90],"peripheral":[92,324,337],"mechanisms":[93],"involved":[95],"TH.":[101,128,218],"RESULTS:":[102],"Repeated":[103],"4.0":[108,131,253],"saline,":[109,116],"5.5":[113],"7.0":[115],"for":[117],"3":[118],"days":[119],"following":[120],"TIIP":[121,198,292],"surgery":[122],"resulted":[123],"After":[129],"injections,":[133],"protein":[134],"levels":[135],"hypoxia":[137],"inducible":[138],"factor-1\u03b1":[139],"(HIF-1\u03b1)":[140],"carbonic":[142],"anhydrase":[143],"II":[144],"(CA":[145],"II)":[146],"were":[147,170,248],"elevated":[148],"plantar":[151],"muscle":[152],"indicating":[153],"stimulation":[156],"intensified":[157],"insults":[159],"decreased":[161],"tissue":[162],"acidity.":[163],"At":[164],"same":[166],"time":[167],"point,":[168],"there":[169],"no":[171],"changes":[172],"expression":[175],"TRPV1":[177,187,212,299],"skin,":[181],"whereas":[182],"significant":[184],"increase":[185],"phosphorylation":[188,297],"(pTRPV1)":[189],"(pH":[195],"4.0)":[196],"injected":[197,273],"(AS-TIIP)":[199],"animals.":[200,274],"Moreover,":[201],"chelerythrine":[205],"(a":[206,211,240,245],"PKC":[207],"inhibitor)":[208],"AMG9810":[210],"antagonist)":[213,242,247],"effectively":[214],"alleviated":[215],"established":[217],"In":[219],"order":[220],"to":[221,229,307],"investigate":[222],"proton-":[224],"or":[225,243],"ATP-sensing":[226],"receptors":[227,300,326],"contributed":[228],"TH,":[233,262],"amiloride":[234],"(an":[235],"ASICs":[236],"blocker),":[237],"AMG9810,":[238],"TNP-ATP":[239],"P2Xs":[241],"MRS2179":[244,256,272],"P2Y1":[246,325],"pre-injected":[249],"before":[250],"saline.":[254],"Only":[255],"significantly":[257],"prevented":[258],"pTRPV1":[266],"ratio":[267],"also":[269],"blocked":[270],"CONCLUSION:":[275],"Collectively":[276],"these":[277,345],"data":[278],"show":[279],"maintenance":[281],"an":[283],"environment":[285],"rats":[293],"results":[294],"via":[301],"PKC-dependent":[303],"pathway,":[304],"leads":[306],"mimicking":[312],"what":[313],"occurs":[314],"patients":[318],"severe":[320],"acidosis.":[321],"More":[322],"importantly,":[323],"play":[327],"pivotal":[329],"role":[330],"process,":[333],"suggesting":[334],"novel":[336],"mechanism":[338],"underlying":[339],"patients.":[346]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}