{"id":"https://openalex.org/W2033978652","doi":"https://doi.org/10.1006/exmp.1999.2288","title":"Swelling of Free-Radical-Induced Megamitochondria Causes Apoptosis","display_name":"Swelling of Free-Radical-Induced Megamitochondria Causes Apoptosis","publication_year":2000,"publication_date":"2000-04-01","ids":{"openalex":"https://openalex.org/W2033978652","doi":"https://doi.org/10.1006/exmp.1999.2288","mag":"2033978652","pmid":"https://pubmed.ncbi.nlm.nih.gov/10716914"},"language":"en","primary_location":{"id":"doi:10.1006/exmp.1999.2288","doi":"https://doi.org/10.1006/exmp.1999.2288","is_oa":false,"landing_page_url":"https://doi.org/10.1006/exmp.1999.2288","pdf_url":null,"source":{"id":"https://openalex.org/S111757857","display_name":"Experimental and Molecular Pathology","issn_l":"0014-4800","issn":["0014-4800","1096-0945"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Molecular Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110974660","display_name":"Masaaki Teranishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masa-aki Teranishi","raw_affiliation_strings":["Department of Cell Biology and Molecular Pathology, Nagoya University School of Medicine, Nagoya, 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Molecular Pathology, Nagoya University School of Medicine, Nagoya, 466-8550, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110062835","display_name":"Jan H. Spodonik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jan H. Spodonik","raw_affiliation_strings":["Department of Cell Biology and Molecular Pathology, Nagoya University School of Medicine, Nagoya, 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Molecular Pathology, Nagoya University School of Medicine, Nagoya, 466-8550, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035955535","display_name":"Mariusz Karbowski","orcid":"https://orcid.org/0000-0002-4336-5187","observed_orcids":["https://orcid.org/0000-0002-4336-5187"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mariusz Karbowski","raw_affiliation_strings":["Department of Cell Biology and Molecular Pathology, Nagoya University School of Medicine, Nagoya, 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Molecular Pathology, Nagoya University School of Medicine, Nagoya, 466-8550, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049858652","display_name":"Chieko Kurono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chieko Kurono","raw_affiliation_strings":["Department of Anatomy, Nagoya City University Medical School, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Nagoya City University Medical School, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006267470","display_name":"T\u015buyoshi Soji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Soji","raw_affiliation_strings":["Department of Anatomy, Nagoya City University Medical School, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Nagoya City University Medical School, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016645141","display_name":"Takashi Wakabayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Wakabayashi","raw_affiliation_strings":["Department of Cell Biology and Molecular Pathology, Nagoya University School of Medicine, Nagoya, 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Molecular Pathology, Nagoya University School of Medicine, Nagoya, 466-8550, Japan","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2640,"currency":"USD","value_usd":2640},"apc_paid":null,"fwci":1.0949,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.74172196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"68","issue":"2","first_page":"104","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.7279999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.7279999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.26510000228881836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/megamitochondria","display_name":"megamitochondria","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mitochondrial-swelling","display_name":"mitochondrial swelling","score":0.8840000033378601},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hydrazine","display_name":"hydrazine","score":0.7829999923706055},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition","display_name":"mitochondrial permeability transition","score":0.7089999914169312},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.984000027179718},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mitochondrial-fractionation","display_name":"mitochondrial fractionation","score":0.5910000205039978},{"id":"https://openalex.org/keywords/liver-mitochondria","display_name":"liver mitochondria","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.897752046585083},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.7111212611198425},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.675063967704773},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4774787425994873},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.41348662972450256},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3906245231628418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38547319173812866},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3442365527153015},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22606387734413147},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.113055020570755}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002701","descriptor_name":"Chloramphenicol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003580","descriptor_name":"Cytochromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008933","descriptor_name":"Mitochondrial Swelling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/exmp.1999.2288","doi":"https://doi.org/10.1006/exmp.1999.2288","is_oa":false,"landing_page_url":"https://doi.org/10.1006/exmp.1999.2288","pdf_url":null,"source":{"id":"https://openalex.org/S111757857","display_name":"Experimental and Molecular Pathology","issn_l":"0014-4800","issn":["0014-4800","1096-0945"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Molecular Pathology","raw_type":"journal-article"},{"id":"pmid:10716914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10716914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and molecular pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1683233246","https://openalex.org/W1775749144","https://openalex.org/W1813230101","https://openalex.org/W1950610522","https://openalex.org/W1964421556","https://openalex.org/W1965570825","https://openalex.org/W1970544699","https://openalex.org/W1972331889","https://openalex.org/W1976226379","https://openalex.org/W1981474649","https://openalex.org/W1986729958","https://openalex.org/W1989828941","https://openalex.org/W1991137272","https://openalex.org/W1993137461","https://openalex.org/W1993774828","https://openalex.org/W1999672324","https://openalex.org/W1999887864","https://openalex.org/W2009921185","https://openalex.org/W2011594284","https://openalex.org/W2011925577","https://openalex.org/W2013234576","https://openalex.org/W2013339580","https://openalex.org/W2015387867","https://openalex.org/W2016163301","https://openalex.org/W2020844325","https://openalex.org/W2028343730","https://openalex.org/W2028968359","https://openalex.org/W2029577458","https://openalex.org/W2031328970","https://openalex.org/W2035858790","https://openalex.org/W2036564526","https://openalex.org/W2038723095","https://openalex.org/W2039445898","https://openalex.org/W2050357506","https://openalex.org/W2051653292","https://openalex.org/W2057821723","https://openalex.org/W2060363769","https://openalex.org/W2061115935","https://openalex.org/W2061354386","https://openalex.org/W2061374162","https://openalex.org/W2068435297","https://openalex.org/W2068991037","https://openalex.org/W2072559373","https://openalex.org/W2087232531","https://openalex.org/W2135800090","https://openalex.org/W2149429457","https://openalex.org/W2154326047","https://openalex.org/W2161877652","https://openalex.org/W2162547399","https://openalex.org/W2271272206","https://openalex.org/W3017178498"],"related_works":["https://openalex.org/W2029577458","https://openalex.org/W2089476085","https://openalex.org/W2028343730","https://openalex.org/W2044366575","https://openalex.org/W1974302922","https://openalex.org/W2101579112","https://openalex.org/W2053972273","https://openalex.org/W2010954029","https://openalex.org/W258698817","https://openalex.org/W2065883532"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
