{"id":"https://openalex.org/W2033958784","doi":"https://doi.org/10.1006/cimm.2000.1643","title":"The Epithelial Mucin, MUC1, Is Expressed on Resting T Lymphocytes and Can Function as a Negative Regulator of T Cell Activation","display_name":"The Epithelial Mucin, MUC1, Is Expressed on Resting T Lymphocytes and Can Function as a Negative Regulator of T Cell Activation","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2033958784","doi":"https://doi.org/10.1006/cimm.2000.1643","mag":"2033958784","pmid":"https://pubmed.ncbi.nlm.nih.gov/10831317"},"language":"en","primary_location":{"id":"doi:10.1006/cimm.2000.1643","doi":"https://doi.org/10.1006/cimm.2000.1643","is_oa":false,"landing_page_url":"https://doi.org/10.1006/cimm.2000.1643","pdf_url":null,"source":{"id":"https://openalex.org/S193466101","display_name":"Cellular Immunology","issn_l":"0008-8749","issn":["0008-8749","1090-2163"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109145925","display_name":"Ju-Fay Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ju-Fay Chang","raw_affiliation_strings":["Cell Genesys Inc., Foster City, CA 94404, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Genesys Inc., Foster City, CA 94404, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hui-Ling Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802871645","display_name":"Genesys (United States)","ror":"https://ror.org/00f975e16","country_code":"US","type":"company","lineage":["https://openalex.org/I2802871645"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui-Ling Zhao","raw_affiliation_strings":["Cell Genesys Inc. 324 Lakeside Drive, Foster City, California, 94404"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Genesys Inc. 324 Lakeside Drive, Foster City, California, 94404","institution_ids":["https://openalex.org/I2802871645"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802871645","display_name":"Genesys (United States)","ror":"https://ror.org/00f975e16","country_code":"US","type":"company","lineage":["https://openalex.org/I2802871645"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Phillips","raw_affiliation_strings":["Cell Genesys Inc. 324 Lakeside Drive, Foster City, California, 94404"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Genesys Inc. 324 Lakeside Drive, Foster City, California, 94404","institution_ids":["https://openalex.org/I2802871645"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108410219","display_name":"Gary Greenburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802871645","display_name":"Genesys (United States)","ror":"https://ror.org/00f975e16","country_code":"US","type":"company","lineage":["https://openalex.org/I2802871645"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Greenburg","raw_affiliation_strings":["Cell Genesys Inc. 324 Lakeside Drive, Foster City, California, 94404"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Genesys Inc. 324 Lakeside Drive, Foster City, California, 94404","institution_ids":["https://openalex.org/I2802871645"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":1.1944,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.76105248,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"201","issue":"2","first_page":"83","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.5253999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.5253999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4553000032901764,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muc1","display_name":"MUC1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/epithelial-mucins","display_name":"epithelial mucins","score":0.9340000152587891},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/negative-regulation","display_name":"negative regulation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/il-2-production","display_name":"IL-2 production","score":0.7620000243186951},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.7919999957084656},{"id":"https://openalex.org/keywords/anti-muc1-antibodies","display_name":"anti-MUC1 antibodies","score":0.7599999904632568},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hut-78-cells","display_name":"HUT-78 cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/t-cell-leukemia","display_name":"T-cell leukemia","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cd3-stimulation","display_name":"CD3 stimulation","score":0.5849999785423279},{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.9349935054779053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7514663934707642},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.7392457723617554},{"id":"https://openalex.org/C2777421810","wikidata":"https://www.wikidata.org/wiki/Q21145188","display_name":"MUC1","level":3,"score":0.7093122005462646},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.6814939379692078},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5993381142616272},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5772901177406311},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5041550397872925},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.45245277881622314},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4448619782924652},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4240458011627197},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4193716049194336},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4152663052082062},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34190839529037476},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.31972140073776245},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24288508296012878},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1716185212135315},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.16538512706756592},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10438045859336853},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007152","descriptor_name":"Immunologic Capping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015458","descriptor_name":"Leukemia, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018106","descriptor_name":"CD28 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018396","descriptor_name":"Mucin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018396","descriptor_name":"Mucin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1006/cimm.2000.1643","doi":"https://doi.org/10.1006/cimm.2000.1643","is_oa":false,"landing_page_url":"https://doi.org/10.1006/cimm.2000.1643","pdf_url":null,"source":{"id":"https://openalex.org/S193466101","display_name":"Cellular Immunology","issn_l":"0008-8749","issn":["0008-8749","1090-2163"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Immunology","raw_type":"journal-article"},{"id":"pmid:10831317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10831317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W133140336","https://openalex.org/W1493034773","https://openalex.org/W1526736180","https://openalex.org/W1617102100","https://openalex.org/W1877148728","https://openalex.org/W1984684956","https://openalex.org/W2010571201","https://openalex.org/W2037053580","https://openalex.org/W2042527277","https://openalex.org/W2060358477","https://openalex.org/W2073016683","https://openalex.org/W2076870798","https://openalex.org/W2095623135","https://openalex.org/W2096186216","https://openalex.org/W2119031040","https://openalex.org/W2122534065","https://openalex.org/W2132932170","https://openalex.org/W2139104516","https://openalex.org/W2463547549","https://openalex.org/W6629694344","https://openalex.org/W6631584342","https://openalex.org/W6674259730","https://openalex.org/W6678538670"],"related_works":["https://openalex.org/W17188698","https://openalex.org/W1998030770","https://openalex.org/W2122534065","https://openalex.org/W2050033446","https://openalex.org/W2129384532","https://openalex.org/W2121582733","https://openalex.org/W2896378740","https://openalex.org/W2802600930","https://openalex.org/W69258018","https://openalex.org/W2005936795"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
