{"id":"https://openalex.org/W203395373","doi":null,"title":"Induction of endothelial RAGE expression in pterygium.","display_name":"Induction of endothelial RAGE expression in pterygium.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W203395373","mag":"203395373","pmid":"https://pubmed.ncbi.nlm.nih.gov/25593504","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4279753"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3262496","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4279753","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4279753","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066758104","display_name":"Samar A. Al-Swailem","orcid":"https://orcid.org/0000-0002-1070-7232","observed_orcids":["https://orcid.org/0000-0002-1070-7232"]},"institutions":[{"id":"https://openalex.org/I4210098844","display_name":"King Khaled Eye Specialist Hospital","ror":"https://ror.org/00zrhbg82","country_code":"SA","type":"funder","lineage":["https://openalex.org/I4210098844"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Samar Al-Swailem","raw_affiliation_strings":["King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I4210098844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101880743","display_name":"Zhenhua Xu","orcid":"https://orcid.org/0000-0002-9279-0147","observed_orcids":["https://orcid.org/0000-0002-9279-0147","https://orcid.org/0009-0009-8135-3484"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhenhua Xu","raw_affiliation_strings":["Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058133767","display_name":"Lijuan Wu","orcid":"https://orcid.org/0000-0002-5761-5140","observed_orcids":["https://orcid.org/0000-0002-5761-5140"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lijuan Wu","raw_affiliation_strings":["Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084774470","display_name":"Matthew J. Hartsock","orcid":"https://orcid.org/0000-0002-1077-2448","observed_orcids":["https://orcid.org/0000-0002-1077-2448"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J Hartsock","raw_affiliation_strings":["Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113688977","display_name":"Samuel C. Yiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel C Yiu","raw_affiliation_strings":["Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016107456","display_name":"Elia J. Duh","orcid":"https://orcid.org/0000-0003-1917-373X","observed_orcids":["https://orcid.org/0000-0003-1917-373X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elia J Duh","raw_affiliation_strings":["Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8519,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.66605572,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"20","issue":null,"first_page":"1740","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.030400000512599945,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pterygium","display_name":"pterygium","score":0.984000027179718},{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.9279999732971191},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.9800000190734863},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/conjunctiva","display_name":"conjunctiva","score":0.9449999928474426},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.8445183634757996},{"id":"https://openalex.org/C2775984611","wikidata":"https://www.wikidata.org/wiki/Q273554","display_name":"Conjunctiva","level":2,"score":0.7428845167160034},{"id":"https://openalex.org/C2778266423","wikidata":"https://www.wikidata.org/wiki/Q17142318","display_name":"Pterygium","level":2,"score":0.6785117387771606},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6585054397583008},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6104022264480591},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5914296507835388},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.558355450630188},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5553240776062012},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5448122620582581},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.46755897998809814},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3787424564361572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3412381410598755},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3404954671859741},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.323732852935791},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12532952427864075},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.08496454358100891},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067759","descriptor_name":"Receptor for Advanced Glycation End Products","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003228","descriptor_name":"Conjunctiva","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D003228","descriptor_name":"Conjunctiva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003228","descriptor_name":"Conjunctiva","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011625","descriptor_name":"Pterygium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011625","descriptor_name":"Pterygium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3262496","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4279753","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4279753","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4279753","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmid:25593504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25593504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"mag:203395373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25593504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3262496","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4279753","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1495929737","https://openalex.org/W1831226188","https://openalex.org/W1968550787","https://openalex.org/W1972979395","https://openalex.org/W1983011227","https://openalex.org/W1988677073","https://openalex.org/W1996767155","https://openalex.org/W1999908383","https://openalex.org/W2035755932","https://openalex.org/W2041912456","https://openalex.org/W2046667238","https://openalex.org/W2057715638","https://openalex.org/W2073083940","https://openalex.org/W2080093199","https://openalex.org/W2088749707","https://openalex.org/W2105327109","https://openalex.org/W2106949373","https://openalex.org/W2110964957","https://openalex.org/W2121704563","https://openalex.org/W2140389725","https://openalex.org/W2144254003","https://openalex.org/W2152209587","https://openalex.org/W2166359305","https://openalex.org/W2171783221"],"related_works":["https://openalex.org/W852364319","https://openalex.org/W2361942848","https://openalex.org/W4387470402","https://openalex.org/W2320006483","https://openalex.org/W297918424","https://openalex.org/W2982225441","https://openalex.org/W7066576814","https://openalex.org/W1810313476","https://openalex.org/W2314107410","https://openalex.org/W2430768330"],"abstract_inverted_index":{"PURPOSE:":[0],"Chronic":[1],"inflammation":[2],"is":[3,65,82,225,235,275],"a":[4,52,66,105],"critical":[5],"process":[6],"in":[7,22,57,84,86,97,108,164,174,178,205,227,231,264,279,288],"pterygium":[8,99,165,180,209],"development":[9],"and":[10,23,61,95,100,146,158,166,183,196,248],"progression,":[11],"including":[12],"promotion":[13],"of":[14,69,160,207,250,259,272],"angiogenesis.":[15],"Vascular":[16],"endothelial":[17,70,110,200,229,241],"cells":[18,230,242],"(ECs)":[19],"actively":[20],"participate":[21],"regulate":[24],"inflammation.":[25],"Pterygium":[26,113],"research":[27],"has":[28,38,252],"uncovered":[29],"multiple":[30],"inflammatory":[31,246],"cytokines":[32],"that":[33,80,222,269],"are":[34],"upregulated,":[35],"but":[36],"there":[37],"been":[39,253],"minimal":[40],"focus":[41],"on":[42],"EC":[43],"activation.":[44,72],"The":[45],"Receptor":[46],"for":[47,282],"Advanced":[48],"Glycation":[49],"Endproducts":[50],"(RAGE),":[51],"major":[53,67],"proinflammatory":[54],"molecule":[55],"expressed":[56],"the":[58,78,123,131,138,175,214,244,257],"vascular":[59,176,228],"endothelium":[60,177],"other":[62],"cell":[63,71,188],"types,":[64],"instigator":[68],"In":[73,130],"this":[74,89],"study,":[75],"we":[76,91],"explored":[77],"hypothesis":[79],"RAGE":[81,93,161,170,201,223,233,251],"upregulated":[83,226],"ECs":[85],"pterygium.":[87,232,290],"To":[88],"end,":[90],"examined":[92],"expression":[94,171,202,224],"immunolocalization":[96],"human":[98],"normal":[101],"conjunctival":[102,185],"tissue,":[103],"with":[104,152,154],"particular":[106],"interest":[107],"assessing":[109],"RAGE.":[111],"METHODS:":[112],"specimens":[114,143,182],"were":[115,135,144,150,162],"obtained":[116,136],"from":[117,137],"25":[118,208],"patients":[119],"during":[120,140],"surgery":[121],"at":[122],"King":[124],"Khaled":[125],"Eye":[126],"Specialist":[127],"Hospital":[128],"(KKESH).":[129],"same":[132],"patients,":[133],"conjunctiva":[134],"autograft":[139],"surgery.":[141],"Tissue":[142,148],"formalin-fixed":[145],"paraffin-embedded.":[147],"sections":[149],"analyzed":[151],"immunohistochemistry":[153],"anti-RAGE":[155],"antibody.":[156],"Expression":[157],"localization":[159],"evaluated":[163],"corresponding":[167,215],"conjunctiva.":[168,217],"RESULTS:":[169],"was":[172,203],"detected":[173],"all":[179],"tissue":[181,210],"most":[184],"specimens.":[186],"Other":[187],"types":[189],"exhibited":[190],"expression,":[191],"notably":[192],"epithelial":[193],"cells,":[194],"fibroblasts,":[195],"possibly":[197],"macrophages.":[198],"Strikingly,":[199],"increased":[204],"19":[206],"specimens,":[211],"compared":[212],"to":[213,255],"control":[216],"CONCLUSIONS:":[218],"Our":[219],"data":[220],"reveal":[221],"upregulation":[234],"an":[236],"important":[237],"mechanism":[238],"by":[239],"which":[240,274],"amplify":[243],"overall":[245],"response,":[247],"suppression":[249],"shown":[254],"prevent":[256],"progression":[258],"some":[260,283],"systemic":[261],"disease":[262],"processes":[263],"experimental":[265],"models.":[266],"This":[267],"suggests":[268],"pharmacologic":[270],"targeting":[271],"RAGE,":[273],"already":[276],"being":[277],"attempted":[278],"clinical":[280],"trials":[281],"diseases,":[284],"could":[285],"be":[286],"useful":[287],"treating":[289]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
