{"id":"https://openalex.org/W2033933079","doi":"https://doi.org/10.1038/bcj.2013.64","title":"Targeting HSP90 and monoclonal protein trafficking modulates the unfolded protein response, chaperone regulation and apoptosis in myeloma cells","display_name":"Targeting HSP90 and monoclonal protein trafficking modulates the unfolded protein response, chaperone regulation and apoptosis in myeloma cells","publication_year":2013,"publication_date":"2013-12-06","ids":{"openalex":"https://openalex.org/W2033933079","doi":"https://doi.org/10.1038/bcj.2013.64","mag":"2033933079","pmid":"https://pubmed.ncbi.nlm.nih.gov/24317089","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3877421"},"language":"en","primary_location":{"id":"doi:10.1038/bcj.2013.64","doi":"https://doi.org/10.1038/bcj.2013.64","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bcj.2013.64","pdf_url":"https://www.nature.com/articles/bcj201364.pdf","source":{"id":"https://openalex.org/S2496263508","display_name":"Blood Cancer Journal","issn_l":"2044-5385","issn":["2044-5385"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/bcj201364.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040256621","display_name":"Ella J. Born","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E J Born","raw_affiliation_strings":["Department of Internal Medicine, University of Iowa, Iowa City, IA, USA","Dept. of Internal Medicine University of Iowa Iowa City IA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Iowa, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Dept. of Internal Medicine University of Iowa Iowa City IA USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017457730","display_name":"Sara V. Hartman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69230048","display_name":"Integrated DNA Technologies (United States)","ror":"https://ror.org/009jvpf03","country_code":"US","type":"company","lineage":["https://openalex.org/I69230048"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S V Hartman","raw_affiliation_strings":["Integrated DNA Technologies, Coralville, IA, USA","Integrated DNA Technologies;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated DNA Technologies, Coralville, IA, USA","institution_ids":["https://openalex.org/I69230048"]},{"raw_affiliation_string":"Integrated DNA Technologies;","institution_ids":["https://openalex.org/I69230048"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005732386","display_name":"Sarah A. Holstein","orcid":"https://orcid.org/0000-0002-9342-5635","observed_orcids":["https://orcid.org/0000-0002-9342-5635"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S A Holstein","raw_affiliation_strings":["Department of Internal Medicine, University of Iowa, Iowa City, IA, USA","Oncology/Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Iowa, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Oncology/Hematology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005732386"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":{"value":5290,"currency":"USD","value_usd":5290},"fwci":1.4353,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.83003416,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"3","issue":"12","first_page":"e167","last_page":"e167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.08179999887943268,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.8880000114440918},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9649999737739563},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8709999918937683},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.7670000195503235},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/17-aag","display_name":"17-AAG","score":0.9300000071525574},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.7360857725143433},{"id":"https://openalex.org/C2777560012","wikidata":"https://www.wikidata.org/wiki/Q5924361","display_name":"Hsp90 inhibitor","level":5,"score":0.6229621171951294},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6132860779762268},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6118447780609131},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.5536839365959167},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.5150849223136902},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.47005048394203186},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46754565834999084},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.4595017433166504},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36952126026153564},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.15480637550354004},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12471970915794373},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10611236095428467},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1038/bcj.2013.64","doi":"https://doi.org/10.1038/bcj.2013.64","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bcj.2013.64","pdf_url":"https://www.nature.com/articles/bcj201364.pdf","source":{"id":"https://openalex.org/S2496263508","display_name":"Blood Cancer Journal","issn_l":"2044-5385","issn":["2044-5385"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3877421","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3877421","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer J","raw_type":"Text"},{"id":"pmid:24317089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24317089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood cancer journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/bcj.2013.64","doi":"https://doi.org/10.1038/bcj.2013.64","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bcj.2013.64","pdf_url":"https://www.nature.com/articles/bcj201364.pdf","source":{"id":"https://openalex.org/S2496263508","display_name":"Blood Cancer Journal","issn_l":"2044-5385","issn":["2044-5385"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2827494669","display_name":"Rab Geranylgeranylation: a Novel Therapeutic Target in Multiple Myeloma","funder_award_id":"R01CA172070","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306274","display_name":"Roy J. Carver Charitable Trust","ror":"https://ror.org/01ah2ch91"},{"id":"https://openalex.org/F4320306571","display_name":"American Society of Hematology","ror":"https://ror.org/02nw48b86"},{"id":"https://openalex.org/F4320306799","display_name":"Pharmaceutical Research and Manufacturers of America Foundation","ror":"https://ror.org/01z88k350"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2033933079.pdf","grobid_xml":"https://content.openalex.org/works/W2033933079.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1496131048","https://openalex.org/W1525770659","https://openalex.org/W1550826473","https://openalex.org/W1633066991","https://openalex.org/W1970236041","https://openalex.org/W1972401702","https://openalex.org/W1973628970","https://openalex.org/W1980813154","https://openalex.org/W1988740497","https://openalex.org/W1989711933","https://openalex.org/W1991671803","https://openalex.org/W1991958238","https://openalex.org/W1992319922","https://openalex.org/W2009584325","https://openalex.org/W2011958996","https://openalex.org/W2026642838","https://openalex.org/W2028279477","https://openalex.org/W2029178634","https://openalex.org/W2032975232","https://openalex.org/W2034213169","https://openalex.org/W2045522345","https://openalex.org/W2064950130","https://openalex.org/W2077274888","https://openalex.org/W2077945404","https://openalex.org/W2078275713","https://openalex.org/W2081731224","https://openalex.org/W2088971374","https://openalex.org/W2092537575","https://openalex.org/W2099049651","https://openalex.org/W2105141857","https://openalex.org/W2109635468","https://openalex.org/W2120736516","https://openalex.org/W2133709362","https://openalex.org/W2136542058","https://openalex.org/W2144135883","https://openalex.org/W2150596051","https://openalex.org/W2162076197","https://openalex.org/W2168188385","https://openalex.org/W2168415166","https://openalex.org/W2171850804"],"related_works":["https://openalex.org/W2552534120","https://openalex.org/W2092537575","https://openalex.org/W2582043129","https://openalex.org/W1980813154","https://openalex.org/W1970236041","https://openalex.org/W2029178634","https://openalex.org/W2586156438","https://openalex.org/W2575982023","https://openalex.org/W2119260905","https://openalex.org/W2557850051"],"abstract_inverted_index":{"Multiple":[0],"myeloma":[1,29,144,154,176],"is":[2],"characterized":[3],"by":[4],"the":[5,21,46,82,123,126,141,164],"production":[6],"of":[7,10,20,28,33,39,45,70,96,125,140,167,183],"substantial":[8],"quantities":[9],"monoclonal":[11,40,79,90,131],"protein.":[12],"We":[13],"have":[14],"previously":[15],"demonstrated":[16],"that":[17,163],"select":[18],"inhibitors":[19,56,75,128],"isoprenoid":[22],"biosynthetic":[23],"pathway":[24],"(IBP)":[25],"induce":[26],"apoptosis":[27],"cells":[30],"via":[31,179],"inhibition":[32],"Rab":[34],"geranylgeranylation,":[35],"leading":[36],"to":[37],"disruption":[38],"protein":[41,48,53,58,80,132],"trafficking":[42,170],"and":[43,60,73,84,105,114,134,187],"induction":[44,95,139],"unfolded":[47],"response":[49],"(UPR)":[50],"pathway.":[51],"Heat-shock":[52],"90":[54],"(HSP90)":[55],"disrupt":[57],"folding":[59],"are":[61],"currently":[62],"under":[63],"clinical":[64],"investigation":[65],"in":[66,89,143,153,171],"myeloma.":[67],"The":[68,118],"effects":[69,124,147],"combining":[71],"IBP":[72,104,127],"HSP90":[74,106,119,174],"on":[76,129,148],"cell":[77,97,177,188],"death,":[78],"trafficking,":[81],"UPR":[83,142],"chaperone":[85,149],"regulation":[86],"were":[87,151],"investigated":[88],"protein-producing":[91],"cells.":[92,145,159],"An":[93],"enhanced":[94],"death":[98,178,189],"was":[99],"observed":[100,152],"following":[101],"treatment":[102],"with":[103,173],"inhibitors,":[107],"which":[108],"occurred":[109],"through":[110],"both":[111],"ER":[112,184],"stress":[113,116],"non-ER":[115],"pathways.":[117,190],"inhibitor":[120],"17-AAG":[121],"abrogated":[122],"intracellular":[130],"levels":[133],"localization":[135],"as":[136,138],"well":[137],"Disparate":[146],"expression":[150],"vs":[155],"amyloid":[156],"light":[157],"chain":[158],"Here":[160],"we":[161],"demonstrate":[162],"novel":[165],"strategy":[166],"targeting":[168],"MP":[169],"concert":[172],"enhances":[175],"a":[180],"complex":[181],"modulation":[182],"stress,":[185],"UPR,":[186]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
