{"id":"https://openalex.org/W2033924601","doi":"https://doi.org/10.1182/blood-2014-04-565309","title":"p57Kip2 regulates T-cell development and lymphoma","display_name":"p57Kip2 regulates T-cell development and lymphoma","publication_year":2014,"publication_date":"2014-05-29","ids":{"openalex":"https://openalex.org/W2033924601","doi":"https://doi.org/10.1182/blood-2014-04-565309","mag":"2033924601","pmid":"https://pubmed.ncbi.nlm.nih.gov/24876523"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2014-04-565309","doi":"https://doi.org/10.1182/blood-2014-04-565309","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2014-04-565309","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050714629","display_name":"Senthil Raja Jayapal","orcid":"https://orcid.org/0000-0002-0670-7766","observed_orcids":["https://orcid.org/0000-0002-0670-7766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Senthil Raja Jayapal","raw_affiliation_strings":["INSTITUTE OF MOLECULAR AND CELL BIOLOGY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSTITUTE OF MOLECULAR AND CELL BIOLOGY;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055174616","display_name":"Philipp Kaldis","orcid":"https://orcid.org/0000-0002-7247-7591","observed_orcids":["https://orcid.org/0000-0002-7247-7591"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Philipp Kaldis","raw_affiliation_strings":["INSTITUTE OF MOLECULAR AND CELL BIOLOGY;","NATIONAL UNIVERSITY OF SINGAPORE"],"raw_orcid":"https://orcid.org/0000-0002-7247-7591","affiliations":[{"raw_affiliation_string":"INSTITUTE OF MOLECULAR AND CELL BIOLOGY;","institution_ids":[]},{"raw_affiliation_string":"NATIONAL UNIVERSITY OF SINGAPORE","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.12410905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"123","issue":"22","first_page":"3370","last_page":"3371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0421999990940094,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p57kip2","display_name":"p57KIP2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.8519999980926514},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7910000085830688},{"id":"https://openalex.org/keywords/lymphomagenesis","display_name":"lymphomagenesis","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2778366672","wikidata":"https://www.wikidata.org/wiki/Q5957687","display_name":"Hyperactivation","level":2,"score":0.7173720598220825},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6188663244247437},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5440674424171448},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4895680844783783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41354259848594666},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3705372214317322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3595793545246124},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3318484127521515}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050761","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p57","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2014-04-565309","doi":"https://doi.org/10.1182/blood-2014-04-565309","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2014-04-565309","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:24876523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24876523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:lup.lub.lu.se:190df657-a11d-42fa-b661-ae00ed9cc991","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/190df657-a11d-42fa-b661-ae00ed9cc991","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood; 123(22), pp 3370-3371 (2014)","raw_type":"contributiontojournal/systematicreview"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1963792373","https://openalex.org/W1968813488","https://openalex.org/W1985139403","https://openalex.org/W2008223253","https://openalex.org/W2036933482","https://openalex.org/W2059141256","https://openalex.org/W2094111999","https://openalex.org/W2094697218","https://openalex.org/W2121619780","https://openalex.org/W2141942711"],"related_works":["https://openalex.org/W2036933482","https://openalex.org/W1972650056","https://openalex.org/W2112844917","https://openalex.org/W2992640452","https://openalex.org/W2010731453","https://openalex.org/W2254361048","https://openalex.org/W2161508972","https://openalex.org/W1922805298","https://openalex.org/W1986884551","https://openalex.org/W2123433818"],"abstract_inverted_index":{"In":[0],"this":[1],"issue":[2],"of":[3,13,31,33,42,49],"Blood,":[4],"Matsumoto":[5],"et":[6],"al":[7],"report":[8],"that":[9,39],"T":[10],"cell-specific":[11],"deletion":[12],"the":[14,34,40,47],"cyclin-dependent":[15],"kinase":[16],"inhibitor":[17],"p57Kip2(p57)":[18],"in":[19,25,46],"mice":[20],"leads":[21],"to":[22],"a":[23,29],"block":[24],"T-cell":[26],"development":[27],"as":[28],"result":[30],"hyperactivation":[32],"E2F-p53":[35],"pathway":[36],"and":[37],"demonstrate":[38],"loss":[41],"p57":[43],"accelerates":[44],"lymphomagenesis":[45],"absence":[48],"p53.":[50]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}