{"id":"https://openalex.org/W2033893741","doi":"https://doi.org/10.1002/hep.510230647","title":"Evidence That Interference With Binding to Hepatic Cytosol Binders Can Inhibit Bile Acid Excretion in Rats","display_name":"Evidence That Interference With Binding to Hepatic Cytosol Binders Can Inhibit Bile Acid Excretion in Rats","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W2033893741","doi":"https://doi.org/10.1002/hep.510230647","mag":"2033893741","pmid":"https://pubmed.ncbi.nlm.nih.gov/8675188"},"language":"en","primary_location":{"id":"doi:10.1002/hep.510230647","doi":"https://doi.org/10.1002/hep.510230647","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.510230647","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.510230647","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.510230647","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041744856","display_name":"Hajime Takikawa","orcid":"https://orcid.org/0000-0002-6231-6786","observed_orcids":["https://orcid.org/0000-0002-6231-6786"]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Takikawa","raw_affiliation_strings":["Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y Sugiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Sugiyama","raw_affiliation_strings":["Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019266732","display_name":"Jos\u00e9 Carlos Fern\u00e1ndez-Checa","orcid":"https://orcid.org/0000-0003-3422-2990","observed_orcids":["https://orcid.org/0000-0003-3422-2990"]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J C Fernandez-Checa","raw_affiliation_strings":["Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021988197","display_name":"J Kuhlenkamp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J Kuhlenkamp","raw_affiliation_strings":["Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029888033","display_name":"Murad Ookhtens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Ookhtens","raw_affiliation_strings":["Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043356624","display_name":"Neil Kaplowitz","orcid":"https://orcid.org/0000-0002-9424-393X","observed_orcids":["https://orcid.org/0000-0002-9424-393X"]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Kaplowitz","raw_affiliation_strings":["Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I87531838"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I87531838"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":0.5982,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.69687605,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"23","issue":"6","first_page":"1642","last_page":"1649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bile-acid-excretion","display_name":"bile acid excretion","score":0.9259999990463257},{"id":"https://openalex.org/keywords/3alpha-hydroxysteroid-dehydrogenase","display_name":"3\u03b1-hydroxysteroid dehydrogenase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/canalicular-transport","display_name":"canalicular transport","score":0.6010000109672546},{"id":"https://openalex.org/keywords/biliary-excretion","display_name":"biliary excretion","score":0.7279999852180481},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.7646869421005249},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.6555728912353516},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.5787474513053894},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4809828996658325},{"id":"https://openalex.org/C32022120","wikidata":"https://www.wikidata.org/wiki/Q797225","display_name":"Interference (communication)","level":3,"score":0.4458313584327698},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44341588020324707},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37735849618911743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31504595279693604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2847859561443329},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10013619065284729},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06443291902542114},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006000","descriptor_name":"Glycocholic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015096","descriptor_name":"3-Hydroxysteroid Dehydrogenases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045002","descriptor_name":"3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/hep.510230647","doi":"https://doi.org/10.1002/hep.510230647","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.510230647","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.510230647","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"doi:10.1053/jhep.1996.v23.pm0008675188","doi":"https://doi.org/10.1053/jhep.1996.v23.pm0008675188","is_oa":true,"landing_page_url":"https://doi.org/10.1053/jhep.1996.v23.pm0008675188","pdf_url":"https://aasldpubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.510230647","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:8675188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8675188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006723090","doi":null,"is_oa":true,"landing_page_url":"https://teikyo-u.repo.nii.ac.jp/records/2007699","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hepatology","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1002/hep.510230647","doi":"https://doi.org/10.1002/hep.510230647","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.510230647","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.510230647","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2033893741.pdf"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W1557322059"],"related_works":["https://openalex.org/W4251133342","https://openalex.org/W7145472739","https://openalex.org/W1996181492","https://openalex.org/W2083410427","https://openalex.org/W4248416026","https://openalex.org/W1986437312","https://openalex.org/W7145378603","https://openalex.org/W7096089274","https://openalex.org/W2040184210","https://openalex.org/W203271825"],"abstract_inverted_index":{"We":[0],"previously":[1],"identified":[2],"that":[3,23,117,181],"Y'":[4],"bile":[5,12,37,44,170,193],"acid":[6,45],"binders":[7],"(3alpha-hydroxysteroid":[8],"dehydrogenases)":[9],"interact":[10],"with":[11,184,189],"acids":[13,21,38,171],"in":[14,61,68,80,87,110,175],"intact":[15],"rat":[16,72],"hepatocytes":[17,89],"using":[18],"[3beta-3H,":[19],"C24-14C]bile":[20],"and":[22,47,64,90,103,179],"indomethacin,":[24],"a":[25],"competitive":[26],"inhibitor":[27],"of":[28,36,53,66,108,120,169,192],"3alpha-hydroxysteroid":[29],"dehydrogenase,":[30],"inhibits":[31,42],"3H-loss":[32],"from":[33],"the":[34,51,62,69,81,100,105,111,118,160,190],"C3-position":[35],"as":[39,41],"well":[40],"hepatic":[43,77,177],"removal":[46],"excretion.":[48],"To":[49],"study":[50],"kinetics":[52],"these":[54],"inhibitory":[55],"effects,":[56],"glycocholate":[57,78,109,125,134,151],"transport":[58,178],"was":[59,85],"studied":[60],"absence":[63],"presence":[65],"indomethacin":[67,97,121,142],"single-pass":[70],"perfused":[71,82,112],"liver.":[73,113],"Indomethacin":[74],"decreased":[75,104],"net":[76],"uptake":[79,152],"liver,":[83],"which":[84],"confirmed":[86],"isolated":[88],"basolateral":[91],"liver":[92,155],"plasma":[93,156],"membrane":[94,157],"vesicles.":[95,158],"However,":[96],"markedly":[98],"increased":[99],"sinusoidal":[101],"efflux":[102],"biliary":[106,124],"excretion":[107,126,191],"These":[114],"observations":[115],"indicate":[116],"effect":[119],"to":[122,129,172],"delay":[123],"is":[127],"related":[128],"either":[130],"intracellular":[131],"or":[132,147],"canalicular":[133,154],"transport.":[135],"The":[136],"latter":[137],"possibility":[138],"seemed":[139],"unlikely":[140],"because":[141],"did":[143],"not":[144],"inhibit":[145],"electrogenic":[146],"adenosine":[148],"triphosphate":[149],"(ATP)-dependent":[150],"by":[153],"Thus,":[159],"current":[161],"data":[162],"support":[163],"an":[164],"important":[165],"role":[166],"for":[167],"binding":[168,186],"cytosolic":[173,185],"proteins":[174],"overall":[176],"suggest":[180],"specific":[182],"interference":[183],"can":[187],"interfere":[188],"acids.":[194]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}