{"id":"https://openalex.org/W2033891792","doi":"https://doi.org/10.1523/jneurosci.4773-08.2009","title":"Chronic Cocaine Enhances Corticotropin-Releasing Factor-Dependent Potentiation of Excitatory Transmission in Ventral Tegmental Area Dopamine Neurons","display_name":"Chronic Cocaine Enhances Corticotropin-Releasing Factor-Dependent Potentiation of Excitatory Transmission in Ventral Tegmental Area Dopamine Neurons","publication_year":2009,"publication_date":"2009-05-20","ids":{"openalex":"https://openalex.org/W2033891792","doi":"https://doi.org/10.1523/jneurosci.4773-08.2009","mag":"2033891792","pmid":"https://pubmed.ncbi.nlm.nih.gov/19458224","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3077990"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.4773-08.2009","doi":"https://doi.org/10.1523/jneurosci.4773-08.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4773-08.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/20/6535.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/29/20/6535.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008921727","display_name":"Junghyun Hahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157818","display_name":"Ernest Gallo Clinic and Research Center","ror":"https://ror.org/04g7y4303","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157818"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junghyun Hahn","raw_affiliation_strings":["Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA","institution_ids":["https://openalex.org/I4210157818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084996975","display_name":"Frederic Woodward Hopf","orcid":"https://orcid.org/0000-0001-9712-7566","observed_orcids":["https://orcid.org/0000-0001-9712-7566"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210157818","display_name":"Ernest Gallo Clinic and Research Center","ror":"https://ror.org/04g7y4303","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157818"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Woodward Hopf","raw_affiliation_strings":["Department of Neurology, University of California, San Francisco, San Francisco, California 94143","Ernest Gallo Clinic and Research Center, Emeryville, California 94608","Department of Neurology, University of California, San Francisco, San Francisco, California 94143, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of California, San Francisco, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Ernest Gallo Clinic and Research Center, Emeryville, California 94608","institution_ids":["https://openalex.org/I4210157818"]},{"raw_affiliation_string":"Department of Neurology, University of California, San Francisco, San Francisco, California 94143, and","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045219347","display_name":"Antonello Bonci","orcid":"https://orcid.org/0000-0003-0410-5507","observed_orcids":["https://orcid.org/0000-0003-0410-5507"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210157818","display_name":"Ernest Gallo Clinic and Research Center","ror":"https://ror.org/04g7y4303","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157818"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Antonello Bonci","raw_affiliation_strings":["Department of Neurology, University of California, San Francisco, San Francisco, California 94143, and","Ernest Gallo Clinic and Research Center, Emeryville, California 94608"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of California, San Francisco, San Francisco, California 94143, and","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Ernest Gallo Clinic and Research Center, Emeryville, California 94608","institution_ids":["https://openalex.org/I4210157818"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045219347"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210157818"],"apc_list":null,"apc_paid":null,"fwci":3.163,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.91935018,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"29","issue":"20","first_page":"6535","last_page":"6544"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.10819999873638153,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cocaine","display_name":"cocaine","score":0.7269999980926514},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.968999981880188},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.968999981880188},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.9829999804496765},{"id":"https://openalex.org/keywords/excitatory-synaptic-transmission","display_name":"excitatory synaptic transmission","score":0.7870000004768372},{"id":"https://openalex.org/keywords/nmda-receptor-potentiation","display_name":"NMDA receptor potentiation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ampa-receptor-potentiation","display_name":"AMPA receptor potentiation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/miniature-epscs","display_name":"miniature EPSCs","score":0.8619999885559082},{"id":"https://openalex.org/keywords/crf1-receptor","display_name":"CRF1 receptor","score":0.9010000228881836},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9940000176429749},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.7419999837875366},{"id":"https://openalex.org/keywords/addiction","display_name":"addiction","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.8263978958129883},{"id":"https://openalex.org/C2780948874","wikidata":"https://www.wikidata.org/wiki/Q640562","display_name":"Ventral tegmental area","level":4,"score":0.8095015287399292},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.7492834329605103},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.7138880491256714},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.658649742603302},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6299700140953064},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5979887247085571},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.49740198254585266},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.4892847239971161},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.46330907940864563},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4549131691455841},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.42949575185775757},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.42021244764328003},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3493465185165405},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.3156323730945587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26898494362831116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26790452003479004},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21460026502609253},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19145843386650085},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.16001677513122559}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003042","descriptor_name":"Cocaine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017557","descriptor_name":"Ventral Tegmental Area","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018765","descriptor_name":"Dopamine Uptake Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1523/jneurosci.4773-08.2009","doi":"https://doi.org/10.1523/jneurosci.4773-08.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4773-08.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/20/6535.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2087381","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3077990","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3077990","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3077990","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:19458224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19458224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.324.6062","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.324.6062","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jneurosci.org/content/29/20/6535.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.4773-08.2009","doi":"https://doi.org/10.1523/jneurosci.4773-08.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4773-08.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/20/6535.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7333628001","display_name":null,"funder_award_id":"R01 A016782","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G7368454574","display_name":null,"funder_award_id":"R01-DA016782","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G8904894121","display_name":"CRF Modulation of NMDA Currents and Behavior in the VTA","funder_award_id":"7r01da016782-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2033891792.pdf","grobid_xml":"https://content.openalex.org/works/W2033891792.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1598659526","https://openalex.org/W1644438397","https://openalex.org/W1662277789","https://openalex.org/W1950553701","https://openalex.org/W1965488965","https://openalex.org/W1967796877","https://openalex.org/W1970249278","https://openalex.org/W1971711780","https://openalex.org/W1974623546","https://openalex.org/W1975485560","https://openalex.org/W1976982330","https://openalex.org/W1978032763","https://openalex.org/W1984346427","https://openalex.org/W1990650114","https://openalex.org/W1992735948","https://openalex.org/W1997587984","https://openalex.org/W1998033984","https://openalex.org/W2004773604","https://openalex.org/W2007111568","https://openalex.org/W2007984040","https://openalex.org/W2008434916","https://openalex.org/W2009243814","https://openalex.org/W2009667219","https://openalex.org/W2012416101","https://openalex.org/W2019500639","https://openalex.org/W2019509403","https://openalex.org/W2026873245","https://openalex.org/W2027729485","https://openalex.org/W2029474372","https://openalex.org/W2037060024","https://openalex.org/W2039548187","https://openalex.org/W2041018266","https://openalex.org/W2042529649","https://openalex.org/W2043628322","https://openalex.org/W2050750919","https://openalex.org/W2057596402","https://openalex.org/W2058575080","https://openalex.org/W2070065061","https://openalex.org/W2072800851","https://openalex.org/W2074615095","https://openalex.org/W2075265726","https://openalex.org/W2079794722","https://openalex.org/W2083110441","https://openalex.org/W2083466345","https://openalex.org/W2098001295","https://openalex.org/W2099082558","https://openalex.org/W2102903526","https://openalex.org/W2103848983","https://openalex.org/W2107525024","https://openalex.org/W2110724392","https://openalex.org/W2111555603","https://openalex.org/W2114187641","https://openalex.org/W2114794569","https://openalex.org/W2117922300","https://openalex.org/W2118238128","https://openalex.org/W2120851461","https://openalex.org/W2123022860","https://openalex.org/W2127504265","https://openalex.org/W2139476920","https://openalex.org/W2146291241","https://openalex.org/W2146938761","https://openalex.org/W2154850432","https://openalex.org/W2162642602","https://openalex.org/W2171395693","https://openalex.org/W2272340543","https://openalex.org/W4406058881"],"related_works":["https://openalex.org/W7097301296","https://openalex.org/W2070065061","https://openalex.org/W2009516385","https://openalex.org/W1217248493","https://openalex.org/W2139476920","https://openalex.org/W2083110441","https://openalex.org/W2318073849","https://openalex.org/W2064632893","https://openalex.org/W1927677085","https://openalex.org/W2124778352"],"abstract_inverted_index":{"Current":[0],"concepts":[1],"suggest":[2,120],"that":[3,98,132],"stress-induced":[4,56],"release":[5,184],"of":[6,40,53,70,74,105,114,117,126,150,157,164,192],"neuromodulators":[7],"such":[8,33],"as":[9],"corticotropin-releasing":[10],"factor":[11],"(CRF)":[12],"can":[13,21],"drive":[14],"drug-dependent":[15],"behaviors.":[16],"Although":[17],"previous":[18],"drug":[19,34],"exposure":[20,35],"enhance":[22],"behavioral":[23],"and":[24,55,68,85,110,123,136,154,188],"neurochemical":[25],"responses":[26],"to":[27,101,177,197],"stress,":[28],"it":[29],"is":[30,175],"unclear":[31],"how":[32],"alters":[36],"the":[37,66,71,111,148,155],"CRF":[38,89,115,133],"modulation":[39],"excitatory":[41,165],"synapses":[42],"onto":[43,168],"ventral":[44],"tegmental":[45],"area":[46],"(VTA)":[47],"dopamine":[48,170,183],"neurons,":[49],"a":[50],"key":[51],"locus":[52],"drug-":[54],"neuroadaptation.":[57],"Here,":[58],"we":[59],"demonstrate":[60],"that,":[61],"after":[62,144,172],"repeated":[63,145],"cocaine":[64,146,173],"exposure,":[65],"magnitude":[67],"duration":[69],"CRF-induced":[72,151,162],"potentiation":[73,116,153,163],"NMDA":[75],"receptor":[76,92,134],"(NMDAR)-mediated":[77],"neurotransmission":[78],"was":[79],"significantly":[80],"increased":[81],"compared":[82],"with":[83],"naive":[84],"saline-treated":[86],"mice.":[87],"Furthermore,":[88],"enhanced":[90,161],"AMPA":[91],"(AMPAR)-mediated":[93],"transmission":[94,119,167],"only":[95],"in":[96,182,195],"mice":[97],"were":[99,141],"exposed":[100],"cocaine.":[102],"Increased":[103],"frequency":[104],"AMPAR-mediated":[106,118],"spontaneous":[107],"miniature":[108],"EPSCs":[109],"intracellular":[112],"blockade":[113],"both":[121],"presynaptic":[122],"postsynaptic":[124],"effects":[125],"CRF.":[127],"Importantly,":[128],"pharmacological":[129],"experiments":[130],"revealed":[131],"1":[135],"protein":[137],"kinase":[138],"A":[139],"pathways":[140],"newly":[142],"recruited":[143],"for":[147],"enhancement":[149],"NMDAR":[152],"appearance":[156],"AMPAR":[158],"potentiation.":[159],"Thus,":[160],"synaptic":[166],"VTA":[169],"neurons":[171],"preexposure":[174],"likely":[176],"produce":[178],"an":[179],"abnormal":[180],"increase":[181],"during":[185],"stressful":[186],"events":[187],"could":[189],"augment":[190],"activation":[191],"addictive":[193],"behaviors":[194],"response":[196],"stress.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}