{"id":"https://openalex.org/W2033820571","doi":"https://doi.org/10.1073/pnas.86.24.9662","title":"Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus.","display_name":"Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus.","publication_year":1989,"publication_date":"1989-12-01","ids":{"openalex":"https://openalex.org/W2033820571","doi":"https://doi.org/10.1073/pnas.86.24.9662","mag":"2033820571","pmid":"https://pubmed.ncbi.nlm.nih.gov/2690069","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/298561"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.86.24.9662","doi":"https://doi.org/10.1073/pnas.86.24.9662","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.86.24.9662","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC298561","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023725497","display_name":"Anne N. Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A N Roberts","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091261306","display_name":"Brendan Leighton","orcid":"https://orcid.org/0000-0001-8282-6735","observed_orcids":["https://orcid.org/0000-0001-8282-6735"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B Leighton","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001453089","display_name":"John A. Todd","orcid":"https://orcid.org/0000-0003-2740-8148","observed_orcids":["https://orcid.org/0000-0003-2740-8148"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J A Todd","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025143732","display_name":"D.J. Cockburn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D Cockburn","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059588755","display_name":"Paul N. Schofield","orcid":"https://orcid.org/0000-0002-5111-7263","observed_orcids":["https://orcid.org/0000-0002-5111-7263","https://orcid.org/0000-0003-0902-0588"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P N Schofield","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R Sutton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R Sutton","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Holt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Holt","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112781419","display_name":"Yvonne Boyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Y Boyd","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006588214","display_name":"Anthony J. Day","orcid":"https://orcid.org/0000-0002-1415-3134","observed_orcids":["https://orcid.org/0000-0002-1415-3134"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A J Day","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007569147","display_name":"ELIZABETH A. FOOT","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E A Foot","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":null,"apc_paid":null,"fwci":3.5586,"has_fulltext":false,"cited_by_count":147,"citation_normalized_percentile":{"value":0.92680104,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"86","issue":"24","first_page":"9662","last_page":"9666"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.08659999817609787,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amylin","display_name":"amylin","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.953000009059906},{"id":"https://openalex.org/keywords/islet-amyloid","display_name":"islet amyloid","score":0.9670000076293945},{"id":"https://openalex.org/keywords/chromosome-12","display_name":"chromosome 12","score":0.8479999899864197},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.9010000228881836},{"id":"https://openalex.org/keywords/calcitonin-gene-related-peptide","display_name":"calcitonin gene-related peptide","score":0.9100000262260437},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.8809999823570251},{"id":"https://openalex.org/keywords/amidation","display_name":"amidation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.609000027179718},{"id":"https://openalex.org/keywords/gene-structure","display_name":"gene structure","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C2780705028","wikidata":"https://www.wikidata.org/wiki/Q424643","display_name":"Amylin","level":4,"score":0.9804365634918213},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5594198107719421},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5518315434455872},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5242833495140076},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5177196860313416},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.44469428062438965},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.42209959030151367},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3904052674770355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3359171748161316},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.2910340428352356},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12403514981269836},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.10446837544441223}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002881","descriptor_name":"Chromosomes, Human, Pair 12","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015345","descriptor_name":"Oligonucleotide Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015740","descriptor_name":"Calcitonin Gene-Related Peptide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1073/pnas.86.24.9662","doi":"https://doi.org/10.1073/pnas.86.24.9662","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.86.24.9662","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:238721","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC298561","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:298561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/298561","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:2690069","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2690069","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Comparative Study"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/8669a403-de94-4ab6-afc2-29d78aad39c2","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/8669a403-de94-4ab6-afc2-29d78aad39c2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Roberts, A N, Leighton, B, Todd, J A, Cockburn, D, Schofield, P N, Sutton, R, Holt, S, Boyd, Y, Day, A J, Foot, E A, Willis, A C, Reid, K B M & Cooper, G J S 1989, 'Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus', Proceedings of the National Academy of Sciences of the United States of America, vol. 86, no. 24, pp. 9662-9666. https://doi.org/10.1073/pnas.86.24.9662","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2189103535","doi":null,"is_oa":false,"landing_page_url":"https://www.pnas.org/content/86/24/9662.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:238721","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC298561","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W210045494","https://openalex.org/W1491106180","https://openalex.org/W1555021163","https://openalex.org/W1557198624","https://openalex.org/W1600871831","https://openalex.org/W1970627065","https://openalex.org/W1973857041","https://openalex.org/W1989584462","https://openalex.org/W2006544477","https://openalex.org/W2021315061","https://openalex.org/W2023850224","https://openalex.org/W2032118018","https://openalex.org/W2033066280","https://openalex.org/W2034109892","https://openalex.org/W2045466835","https://openalex.org/W2050717506","https://openalex.org/W2053095574","https://openalex.org/W2054468433","https://openalex.org/W2060333964","https://openalex.org/W2063950583","https://openalex.org/W2067820229","https://openalex.org/W2070114315","https://openalex.org/W2070184994","https://openalex.org/W2079490247","https://openalex.org/W2085632182","https://openalex.org/W2091239909","https://openalex.org/W2093487114","https://openalex.org/W2095869073","https://openalex.org/W2103705495","https://openalex.org/W2106470915","https://openalex.org/W2109390566","https://openalex.org/W2145525161","https://openalex.org/W2152848856","https://openalex.org/W2168972923","https://openalex.org/W2268957452"],"related_works":["https://openalex.org/W2147844096","https://openalex.org/W1970296714","https://openalex.org/W2023850224","https://openalex.org/W2122505662","https://openalex.org/W4243466441","https://openalex.org/W2046976652","https://openalex.org/W2067820229","https://openalex.org/W2411809362","https://openalex.org/W2134125578","https://openalex.org/W2083469971"],"abstract_inverted_index":{"The":[0,48,108],"37-amino":[1],"acid":[2],"peptide":[3],"called":[4],"amylin":[5,46,59,72,90,114,180],"is":[6,73,92,100,165],"a":[7,30,35,52,79,134,150],"major":[8],"component":[9],"of":[10,18,29,40,44,58,106,110,149,159,163,172,179,209,212],"the":[11,16,27,41,45,62,66,89,104,111,116,147,156,169,176,185,206,213],"islet":[12],"amyloid":[13,63],"deposited":[14],"in":[15,65,103],"pancreases":[17],"persons":[19],"with":[20,182],"type":[21],"2":[22],"diabetes":[23],"mellitus.":[24],"We":[25,85],"report":[26],"isolation":[28],"partial":[31],"cDNA":[32],"clone":[33,39],"and":[34,69,97,115,139,222],"phage":[36],"lambda":[37],"genomic":[38],"coding":[42,128,144],"region":[43],"gene.":[47],"DNA":[49],"sequence":[50,54],"encodes":[51],"protein":[53,221],"identical":[55],"to":[56,75],"that":[57,71,88,98,155,162,195],"isolated":[60],"from":[61],"found":[64,194],"diabetic":[67],"pancreas":[68],"shows":[70],"likely":[74],"be":[76],"synthesized":[77,181],"as":[78],"precursor":[80],"peptide,":[81],"now":[82],"named":[83],"proamylin.":[84],"have":[86,133],"demonstrated":[87],"gene":[91],"present":[93],"on":[94],"chromosome":[95],"12":[96],"it":[99],"probably":[101],"transcribed":[102],"islets":[105],"Langerhans.":[107],"sequences":[109,216],"genes":[112],"for":[113,200],"calcitonin":[117],"gene-related":[118],"peptides":[119,132],"(CGRPs)":[120],"show":[121],"strong":[122],"similarity,":[123],"especially":[124],"over":[125,141],"their":[126,142],"5'":[127],"regions,":[129,145],"where":[130,146],"both":[131,196,220],"conserved":[135,218],"intramolecular":[136],"disulfide":[137,186],"bridge,":[138],"also":[140],"3'":[143],"presence":[148],"glycine":[151],"codon":[152],"strongly":[153],"suggests":[154],"carboxyl-terminal":[157],"residue":[158],"amylin,":[160],"like":[161],"CGRP,":[164],"amidated.":[166],"To":[167],"examine":[168],"functional":[170,207],"relevance":[171],"these":[173],"posttranslational":[174],"modifications,":[175],"biological":[177,202],"activity":[178],"or":[183],"without":[184],"bridge":[187],"and/or":[188],"amidation":[189],"was":[190,193],"measured.":[191],"It":[192],"features":[197],"are":[198,217],"necessary":[199],"full":[201],"activity,":[203],"thereby":[204],"confirming":[205],"importance":[208],"those":[210],"regions":[211],"molecule":[214],"whose":[215],"at":[219],"genetic":[223],"levels.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
