{"id":"https://openalex.org/W2033800730","doi":"https://doi.org/10.1016/0005-2787(65)90109-7","title":"The effects of actinomycin D and puromycin on the formation of ribosomes in HeLa cells","display_name":"The effects of actinomycin D and puromycin on the formation of ribosomes in HeLa cells","publication_year":1965,"publication_date":"1965-09-06","ids":{"openalex":"https://openalex.org/W2033800730","doi":"https://doi.org/10.1016/0005-2787(65)90109-7","mag":"2033800730","pmid":"https://pubmed.ncbi.nlm.nih.gov/5862244"},"language":"en","primary_location":{"id":"doi:10.1016/0005-2787(65)90109-7","doi":"https://doi.org/10.1016/0005-2787(65)90109-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0005-2787(65)90109-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210217209","display_name":"Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis","issn_l":"0005-2787","issn":["0005-2787","1879-3002"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5096864328","display_name":"T TAMOKI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T TAMOKI","raw_affiliation_strings":["McArdle Laboratory, University of Wisconsin School of Medicine, Madison, Wisc. U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McArdle Laboratory, University of Wisconsin School of Medicine, Madison, Wisc. U.S.A","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105457112","display_name":"Geoffrey A. Mueller","orcid":"https://orcid.org/0000-0001-8361-5323","observed_orcids":["https://orcid.org/0000-0001-8361-5323"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G MUELLER","raw_affiliation_strings":["McArdle Laboratory, University of Wisconsin School of Medicine, Madison, Wisc. U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McArdle Laboratory, University of Wisconsin School of Medicine, Madison, Wisc. U.S.A","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":4.1699,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.94518608,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"108","issue":"1","first_page":"73","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7602999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7602999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.22349999845027924,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"ribosome biogenesis","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dactinomycin","display_name":"actinomycin D","score":0.9549999833106995},{"id":"https://openalex.org/keywords/puromycin","display_name":"puromycin","score":1.0},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/nuclear-ribosomes","display_name":"nuclear ribosomes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/rrna-synthesis","display_name":"ribosomal RNA synthesis","score":0.5550000071525574},{"id":"https://openalex.org/keywords/cytoplasmic-ribosomes","display_name":"cytoplasmic ribosomes","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C2779200571","wikidata":"https://www.wikidata.org/wiki/Q424696","display_name":"Puromycin","level":3,"score":0.9050535559654236},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.8190294504165649},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.6216499209403992},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5755083560943604},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5465878248214722},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.5217174887657166},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.5130282640457153},{"id":"https://openalex.org/C2776695378","wikidata":"https://www.wikidata.org/wiki/Q186127","display_name":"Dactinomycin","level":4,"score":0.5002174377441406},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4765494465827942},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4740576148033142},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.4735507071018219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46058765053749084},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.44867515563964844},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.12742742896080017},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10815563797950745},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011691","descriptor_name":"Puromycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014461","descriptor_name":"Ultracentrifugation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0005-2787(65)90109-7","doi":"https://doi.org/10.1016/0005-2787(65)90109-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0005-2787(65)90109-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210217209","display_name":"Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis","issn_l":"0005-2787","issn":["0005-2787","1879-3002"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis","raw_type":"journal-article"},{"id":"pmid:5862244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5862244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1608536846","https://openalex.org/W1970273330","https://openalex.org/W2011382641","https://openalex.org/W2012158275","https://openalex.org/W2024149575","https://openalex.org/W2048871497","https://openalex.org/W2055372449","https://openalex.org/W2057814407","https://openalex.org/W2060144244","https://openalex.org/W2069587943","https://openalex.org/W2072462424","https://openalex.org/W2074388428","https://openalex.org/W2085899829","https://openalex.org/W2086253427"],"related_works":["https://openalex.org/W2086253427","https://openalex.org/W2115410001","https://openalex.org/W2038131753","https://openalex.org/W2066922610","https://openalex.org/W2019053382","https://openalex.org/W2415879763","https://openalex.org/W2076338757","https://openalex.org/W1586843893","https://openalex.org/W2020657883","https://openalex.org/W1971687773"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}