{"id":"https://openalex.org/W2033799417","doi":"https://doi.org/10.1006/bbrc.1999.1375","title":"The Mode of Action of Taxol: Apoptosis at Low Concentration and Necrosis at High Concentration","display_name":"The Mode of Action of Taxol: Apoptosis at Low Concentration and Necrosis at High Concentration","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W2033799417","doi":"https://doi.org/10.1006/bbrc.1999.1375","mag":"2033799417","pmid":"https://pubmed.ncbi.nlm.nih.gov/10491305"},"language":"en","primary_location":{"id":"doi:10.1006/bbrc.1999.1375","doi":"https://doi.org/10.1006/bbrc.1999.1375","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1999.1375","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110237133","display_name":"T.K. Yeung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108270","display_name":"Northeast Cancer Centre","ror":"https://ror.org/01g1qg816","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802851750","https://openalex.org/I4210108270"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tai K. Yeung","raw_affiliation_strings":["Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, P3E 5J1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, P3E 5J1, Canada","institution_ids":["https://openalex.org/I4210108270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076680110","display_name":"Colin J. Germond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108270","display_name":"Northeast Cancer Centre","ror":"https://ror.org/01g1qg816","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802851750","https://openalex.org/I4210108270"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Colin Germond","raw_affiliation_strings":["Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, P3E 5J1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, P3E 5J1, Canada","institution_ids":["https://openalex.org/I4210108270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042339709","display_name":"Xinmei Chen","orcid":"https://orcid.org/0000-0002-7047-8996","observed_orcids":["https://orcid.org/0000-0002-7047-8996"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Xinmei Chen","raw_affiliation_strings":["Department of Cell Biology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100700405","display_name":"Zhixiang Wang","orcid":"https://orcid.org/0000-0002-6364-6891","observed_orcids":["https://orcid.org/0000-0002-6364-6891"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Zhixiang Wang","raw_affiliation_strings":["Department of Cell Biology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada","institution_ids":["https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100700405"],"corresponding_institution_ids":["https://openalex.org/I154425047"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.8521,"has_fulltext":false,"cited_by_count":160,"citation_normalized_percentile":{"value":0.66868077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"263","issue":"2","first_page":"398","last_page":"404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.26809999346733093,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.7170000076293945},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-cancer-cell-lines","display_name":"breast cancer cell lines","score":0.8230000138282776},{"id":"https://openalex.org/keywords/microtubule-polymerization","display_name":"microtubule assembly","score":0.878000020980835},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.7979999780654907},{"id":"https://openalex.org/keywords/s-phase-inhibition","display_name":"S-phase inhibition","score":0.847000002861023},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7703421115875244},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.7492223381996155},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7423796057701111},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6801726222038269},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6201567053794861},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5456351637840271},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.49954915046691895},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.49004924297332764},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47867852449417114},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4560028314590454},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4552234411239624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4499243497848511},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.4194461405277252},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3747645616531372},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.27006906270980835},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.244276225566864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1006/bbrc.1999.1375","doi":"https://doi.org/10.1006/bbrc.1999.1375","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1999.1375","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:10491305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10491305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W57954726","https://openalex.org/W1480509123","https://openalex.org/W1568104635","https://openalex.org/W1616592835","https://openalex.org/W1797447800","https://openalex.org/W1854639282","https://openalex.org/W1911989431","https://openalex.org/W1976033985","https://openalex.org/W1980923728","https://openalex.org/W1983914017","https://openalex.org/W1996250373","https://openalex.org/W1996522179","https://openalex.org/W2025691233","https://openalex.org/W2045862609","https://openalex.org/W2054361195","https://openalex.org/W2067299834","https://openalex.org/W2080155235","https://openalex.org/W2081406767","https://openalex.org/W2084505512","https://openalex.org/W2098612597","https://openalex.org/W2117931147","https://openalex.org/W2118873545","https://openalex.org/W2145978772","https://openalex.org/W2154094988","https://openalex.org/W2161008625","https://openalex.org/W2165101837"],"related_works":["https://openalex.org/W2057023866","https://openalex.org/W1482686649","https://openalex.org/W2053026268","https://openalex.org/W3038307504","https://openalex.org/W7096802210","https://openalex.org/W2065948575","https://openalex.org/W2017668985","https://openalex.org/W2143051140","https://openalex.org/W1989367285","https://openalex.org/W92949666"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}