{"id":"https://openalex.org/W2033797134","doi":"https://doi.org/10.1007/s11745-999-0407-3","title":"Excess vitamin E decreases canthaxanthin absorption in the rat","display_name":"Excess vitamin E decreases canthaxanthin absorption in the rat","publication_year":1999,"publication_date":"1999-06-01","ids":{"openalex":"https://openalex.org/W2033797134","doi":"https://doi.org/10.1007/s11745-999-0407-3","mag":"2033797134","pmid":"https://pubmed.ncbi.nlm.nih.gov/10405977"},"language":"en","primary_location":{"id":"doi:10.1007/s11745-999-0407-3","doi":"https://doi.org/10.1007/s11745-999-0407-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11745-999-0407-3","pdf_url":null,"source":{"id":"https://openalex.org/S115623499","display_name":"Lipids","issn_l":"0024-4201","issn":["0024-4201","1558-9307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082782318","display_name":"Susan H. Hageman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan H. Hageman","raw_affiliation_strings":["Department of Nutritional Sciences\u2019 U\u201017 The University of Connecticut Storrs CT 06269\u20104017"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences\u2019 U\u201017 The University of Connecticut Storrs CT 06269\u20104017","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034847024","display_name":"Li She","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li She","raw_affiliation_strings":["Department of Nutritional Sciences\u2019 U\u201017 The University of Connecticut Storrs CT 06269\u20104017"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences\u2019 U\u201017 The University of Connecticut Storrs CT 06269\u20104017","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108605954","display_name":"Harold C. Furr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold C. Furr","raw_affiliation_strings":["Department of Nutritional Sciences\u2019 U\u201017 The University of Connecticut Storrs CT 06269\u20104017"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences\u2019 U\u201017 The University of Connecticut Storrs CT 06269\u20104017","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037531376","display_name":"Richard M. Clark","orcid":"https://orcid.org/0000-0002-1470-301X","observed_orcids":["https://orcid.org/0000-0002-1470-301X"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard M. Clark","raw_affiliation_strings":["Department of Nutritional Sciences\u2019 U\u201017 The University of Connecticut Storrs CT 06269\u20104017"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences\u2019 U\u201017 The University of Connecticut Storrs CT 06269\u20104017","institution_ids":["https://openalex.org/I140172145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037531376"],"corresponding_institution_ids":["https://openalex.org/I140172145"],"apc_list":{"value":3589,"currency":"USD","value_usd":3589},"apc_paid":null,"fwci":0.862,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.71236641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"34","issue":"6","first_page":"627","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canthaxanthin","display_name":"canthaxanthin","score":0.8550000190734863},{"id":"https://openalex.org/keywords/alpha-tocopherol","display_name":"alpha-tocopherol","score":0.9940000176429749},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.9160000085830688},{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":0.8840000033378601},{"id":"https://openalex.org/keywords/nutrient-absorption","display_name":"nutrient absorption","score":0.6240000128746033},{"id":"https://openalex.org/keywords/dietary-interactions","display_name":"dietary interactions","score":0.44699999690055847},{"id":"https://openalex.org/keywords/mesenteric-lymph","display_name":"mesenteric lymph","score":0.7889999747276306},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.6480000019073486},{"id":"https://openalex.org/keywords/intraduodenal-infusion","display_name":"duodenal infusion","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7446050047874451},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.706606388092041},{"id":"https://openalex.org/C2778584577","wikidata":"https://www.wikidata.org/wiki/Q385657","display_name":"Canthaxanthin","level":4,"score":0.6899900436401367},{"id":"https://openalex.org/C28781525","wikidata":"https://www.wikidata.org/wiki/Q191907","display_name":"Carotenoid","level":2,"score":0.633980929851532},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6200277209281921},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.5511061549186707},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5031775832176208},{"id":"https://openalex.org/C2776809568","wikidata":"https://www.wikidata.org/wiki/Q134955","display_name":"Duodenum","level":2,"score":0.48539647459983826},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.4807148277759552},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.4445447623729706},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4334806799888611},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3838605284690857},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.34926849603652954},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2964346408843994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24204567074775696},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1664958894252777},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10487332940101624},{"id":"https://openalex.org/C2780962900","wikidata":"https://www.wikidata.org/wiki/Q413740","display_name":"Astaxanthin","level":3,"score":0.07478600740432739},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008196","descriptor_name":"Lymph","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008196","descriptor_name":"Lymph","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008196","descriptor_name":"Lymph","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016644","descriptor_name":"Canthaxanthin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016644","descriptor_name":"Canthaxanthin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016644","descriptor_name":"Canthaxanthin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016644","descriptor_name":"Canthaxanthin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016644","descriptor_name":"Canthaxanthin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016644","descriptor_name":"Canthaxanthin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11745-999-0407-3","doi":"https://doi.org/10.1007/s11745-999-0407-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11745-999-0407-3","pdf_url":null,"source":{"id":"https://openalex.org/S115623499","display_name":"Lipids","issn_l":"0024-4201","issn":["0024-4201","1558-9307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids","raw_type":"journal-article"},{"id":"pmid:10405977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10405977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W23329912","https://openalex.org/W128294993","https://openalex.org/W615715220","https://openalex.org/W1006555201","https://openalex.org/W1590237349","https://openalex.org/W1598777337","https://openalex.org/W1867444741","https://openalex.org/W1900037177","https://openalex.org/W1908751631","https://openalex.org/W1932447330","https://openalex.org/W1937294600","https://openalex.org/W1966594957","https://openalex.org/W1966992204","https://openalex.org/W1983748680","https://openalex.org/W1985707064","https://openalex.org/W1997004738","https://openalex.org/W2012019027","https://openalex.org/W2018648636","https://openalex.org/W2020971868","https://openalex.org/W2050772413","https://openalex.org/W2053261371","https://openalex.org/W2064999725","https://openalex.org/W2068103674","https://openalex.org/W2072390840","https://openalex.org/W2077096051","https://openalex.org/W2079488673","https://openalex.org/W2083177045","https://openalex.org/W2095646811","https://openalex.org/W2129305215","https://openalex.org/W2142955914","https://openalex.org/W2152404127","https://openalex.org/W2157073178","https://openalex.org/W2158257036","https://openalex.org/W2163428935","https://openalex.org/W2168526937","https://openalex.org/W2188820569","https://openalex.org/W2319359834","https://openalex.org/W2413542352","https://openalex.org/W4250176059","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1970154233","https://openalex.org/W2064999725","https://openalex.org/W2018648636","https://openalex.org/W2413668261","https://openalex.org/W166440752","https://openalex.org/W39235358","https://openalex.org/W2398460091","https://openalex.org/W2060420141","https://openalex.org/W2008305579","https://openalex.org/W2076588346"],"abstract_inverted_index":{"The":[0,60,122,138],"recent":[1],"attention":[2],"given":[3],"to":[4,42,66,158,166,177],"the":[5,14,27,44,71,119,127,132,136,178,181,195],"possible":[6],"role":[7],"of":[8,18,21,26,32,62,88,114,124,141,156,161,168,183,192,212,216],"alpha-tocopherol":[9],"(alpha-Toc)":[10],"and":[11,16,38,48,70,94,116,200],"carotenoids":[12,39],"in":[13,24,57,101,118,126,194],"prevention":[15],"treatment":[17],"a":[19,102,154,213],"variety":[20],"illnesses":[22],"resulted":[23],"segments":[25],"population":[28],"increasing":[29],"their":[30],"consumption":[31,211],"these":[33],"nutrient/antioxidants.":[34],"Once":[35],"consumed,":[36],"alpha-Toc":[37,69,89,117,147,172,193,217],"are":[40],"thought":[41],"follow":[43],"same":[45],"absorptive":[46],"pathway":[47],"may":[49,218],"influence":[50,219],"each":[51],"other's":[52],"absorption,":[53],"particularly":[54],"when":[55],"taken":[56],"large":[58,214],"doses.":[59],"purpose":[61],"this":[63],"study":[64],"was":[65,109,163,175,185,201],"determine":[67],"if":[68],"carotenoid,":[72],"canthaxanthin":[73],"(CTX),":[74],"interact":[75],"during":[76],"absorption.":[77],"Rats":[78],"were":[79],"intraduodenally":[80],"infused":[81,134],"with":[82,131,150],"corn":[83],"oil":[84,179],"emulsions":[85,145],"containing":[86],"combinations":[87],"(0":[90],"or":[91],"300":[92],"mumol/L)":[93,100,174],"CTX":[95,115,125,142,169,184],"(5,":[96],"10,":[97],"15,":[98],"20":[99],"2":[103],"x":[104],"4":[105],"factorial":[106],"arrangement.":[107],"Absorption":[108],"determined":[110],"by":[111,187,204],"measuring":[112],"recovery":[113],"mesenteric":[120],"lymph.":[121],"amount":[123,133],"lymph":[128,196],"increased":[129],"significantly":[130],"into":[135],"duodenum.":[137],"overall":[139],"efficiency":[140],"absorption":[143,162,182],"from":[144],"without":[146],"averaged":[148,197],"12%":[149],"individual":[151],"animals":[152],"having":[153],"range":[155],"8":[157],"18%.":[159],"Efficiency":[160],"not":[164,202],"related":[165],"concentration":[167],"infused.":[170],"When":[171],"(300":[173],"added":[176],"emulsion,":[180],"decreased":[186],"at":[188],"least":[189],"50%.":[190],"Recovery":[191],"ca.":[198],"10%":[199],"affected":[203],"CTX.":[205],"These":[206],"results":[207],"suggest":[208],"that":[209],"concurrent":[210],"dose":[215],"carotenoid":[220],"bioavailability.":[221]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}