{"id":"https://openalex.org/W2033795441","doi":"https://doi.org/10.1038/bjc.2012.85","title":"Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas","display_name":"Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas","publication_year":2012,"publication_date":"2012-03-27","ids":{"openalex":"https://openalex.org/W2033795441","doi":"https://doi.org/10.1038/bjc.2012.85","mag":"2033795441","pmid":"https://pubmed.ncbi.nlm.nih.gov/22454081","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3326683"},"language":"en","primary_location":{"id":"doi:10.1038/bjc.2012.85","doi":"https://doi.org/10.1038/bjc.2012.85","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2012.85","pdf_url":"https://www.nature.com/articles/bjc201285.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/bjc201285.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019753819","display_name":"Alberto Gallardo","orcid":"https://orcid.org/0000-0002-2514-2027","observed_orcids":["https://orcid.org/0000-0002-2514-2027"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A Gallardo","raw_affiliation_strings":["Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I2801795740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070683494","display_name":"Enrique Lerma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"E Lerma","raw_affiliation_strings":["Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avda. Sant Antoni Ma Claret 167, Barcelona, 08025, Spain","Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avda. Sant Antoni Ma Claret 167, Barcelona, 08025, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I2801795740"]},{"raw_affiliation_string":"Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I2801795740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003397614","display_name":"Daniel Escu\u00edn","orcid":"https://orcid.org/0000-0003-3538-0579","observed_orcids":["https://orcid.org/0000-0003-3538-0579"]},"institutions":[{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]},{"id":"https://openalex.org/I4387155026","display_name":"Institut de Recerca Sant Pau","ror":"https://ror.org/005teat46","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155026"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"D Escuin","raw_affiliation_strings":["Department of Clinical Oncology, Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain","institution_ids":["https://openalex.org/I2801795740","https://openalex.org/I4387155026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056336799","display_name":"Ariadna Tibau","orcid":"https://orcid.org/0000-0003-0229-6987","observed_orcids":["https://orcid.org/0000-0003-0229-6987"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A Tibau","raw_affiliation_strings":["Department of Clinical Oncology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I2801795740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111771801","display_name":"Josefina Mu\u00f1oz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J Mu\u00f1oz","raw_affiliation_strings":["Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avda. Sant Antoni Ma Claret 167, Barcelona, 08025, Spain","Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avda. Sant Antoni Ma Claret 167, Barcelona, 08025, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I2801795740"]},{"raw_affiliation_string":"Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I2801795740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112025539","display_name":"Belen Ojeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"B Ojeda","raw_affiliation_strings":["Department of Clinical Oncology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I2801795740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027875773","display_name":"Agust\u00ed Barnadas","orcid":"https://orcid.org/0000-0002-0429-1349","observed_orcids":["https://orcid.org/0000-0002-0429-1349"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A Barnadas","raw_affiliation_strings":["Department of Clinical Oncology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I2801795740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068323742","display_name":"Encarna Adrover","orcid":"https://orcid.org/0000-0001-8676-8560","observed_orcids":["https://orcid.org/0000-0001-8676-8560"]},"institutions":[{"id":"https://openalex.org/I4210137674","display_name":"Hospital General Universitario de Alicante Doctor Balmis","ror":"https://ror.org/02ybsz607","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210137674"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E Adrover","raw_affiliation_strings":["Department of Clinical Oncology, Hospital General Universitario, Alicante, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Hospital General Universitario, Alicante, Spain","institution_ids":["https://openalex.org/I4210137674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025782443","display_name":"Laura S\u00e1nchez-Tejada","orcid":"https://orcid.org/0000-0001-5563-8923","observed_orcids":["https://orcid.org/0000-0001-5563-8923"]},"institutions":[{"id":"https://openalex.org/I4210137674","display_name":"Hospital General Universitario de Alicante Doctor Balmis","ror":"https://ror.org/02ybsz607","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210137674"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"L S\u00e1nchez-Tejada","raw_affiliation_strings":["Research Unit, Hospital General Universitario, Alicante, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit, Hospital General Universitario, Alicante, Spain","institution_ids":["https://openalex.org/I4210137674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090701096","display_name":"Daniel Giner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137674","display_name":"Hospital General Universitario de Alicante Doctor Balmis","ror":"https://ror.org/02ybsz607","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210137674"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"D Giner","raw_affiliation_strings":["Research Unit, Hospital General Universitario, Alicante, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit, Hospital General Universitario, Alicante, Spain","institution_ids":["https://openalex.org/I4210137674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049547952","display_name":"Fernando Ortiz-Mart\u00ednez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137674","display_name":"Hospital General Universitario de Alicante Doctor Balmis","ror":"https://ror.org/02ybsz607","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210137674"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"F Ortiz-Mart\u00ednez","raw_affiliation_strings":["Research Unit, Hospital General Universitario, Alicante, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit, Hospital General Universitario, Alicante, Spain","institution_ids":["https://openalex.org/I4210137674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048798715","display_name":"Gloria Peir\u00f3","orcid":"https://orcid.org/0000-0002-2899-2908","observed_orcids":["https://orcid.org/0000-0002-2899-2908"]},"institutions":[{"id":"https://openalex.org/I4210137674","display_name":"Hospital General Universitario de Alicante Doctor Balmis","ror":"https://ror.org/02ybsz607","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210137674"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"G Peir\u00f3","raw_affiliation_strings":["Research Unit, Hospital General Universitario, Alicante, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit, Hospital General Universitario, Alicante, Spain","institution_ids":["https://openalex.org/I4210137674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070683494"],"corresponding_institution_ids":["https://openalex.org/I123044942","https://openalex.org/I2801795740"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":12.7629,"has_fulltext":true,"cited_by_count":234,"citation_normalized_percentile":{"value":0.99252127,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"106","issue":"8","first_page":"1367","last_page":"1373"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trastuzumab-resistance","display_name":"trastuzumab resistance","score":1.0},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/egfr-overexpression","display_name":"EGFR overexpression","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.7289999723434448},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.7789999842643738},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/p110alpha","display_name":"p110\u03b1","score":0.7049999833106995},{"id":"https://openalex.org/keywords/muc1","display_name":"MUC1","score":0.6430000066757202},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8889999985694885},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8420000076293945},{"id":"https://openalex.org/keywords/vascular-invasion","display_name":"vascular invasion","score":0.5619999766349792},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9491908550262451},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.8709579706192017},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6570079922676086},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.641543447971344},{"id":"https://openalex.org/C2779549131","wikidata":"https://www.wikidata.org/wiki/Q83167294","display_name":"Tensin","level":5,"score":0.6379812955856323},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5488763451576233},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.526660144329071},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5150756239891052},{"id":"https://openalex.org/C144174609","wikidata":"https://www.wikidata.org/wiki/Q14901457","display_name":"Insulin-like growth factor 1 receptor","level":4,"score":0.4865769147872925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4282018840312958},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3984386920928955},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3398008942604065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31058984994888306},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19580617547035217},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.18321698904037476},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.15930065512657166},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017526","descriptor_name":"Receptor, IGF Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/bjc.2012.85","doi":"https://doi.org/10.1038/bjc.2012.85","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2012.85","pdf_url":"https://www.nature.com/articles/bjc201285.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2614702","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3326683","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:22454081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22454081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3326683","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3326683/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmh:oai:ddd.uab.cat:184827","doi":null,"is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/184827","pdf_url":"https://ddd.uab.cat/record/184827","source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:recercat.cat:2072/426474","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2072/426474","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/bjc.2012.85","doi":"https://doi.org/10.1038/bjc.2012.85","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2012.85","pdf_url":"https://www.nature.com/articles/bjc201285.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320314997","display_name":"Strong","ror":"https://ror.org/041vyzr56"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2033795441.pdf","grobid_xml":"https://content.openalex.org/works/W2033795441.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W155933052","https://openalex.org/W1518116733","https://openalex.org/W1852564520","https://openalex.org/W1967226516","https://openalex.org/W1969345980","https://openalex.org/W1987961957","https://openalex.org/W1992916424","https://openalex.org/W1994025314","https://openalex.org/W1999070116","https://openalex.org/W2000079492","https://openalex.org/W2001447115","https://openalex.org/W2002931529","https://openalex.org/W2017234949","https://openalex.org/W2020372547","https://openalex.org/W2023087426","https://openalex.org/W2033595975","https://openalex.org/W2034091339","https://openalex.org/W2039193709","https://openalex.org/W2043103956","https://openalex.org/W2048910214","https://openalex.org/W2049940008","https://openalex.org/W2050747125","https://openalex.org/W2058700971","https://openalex.org/W2059411043","https://openalex.org/W2068326740","https://openalex.org/W2068819650","https://openalex.org/W2069707480","https://openalex.org/W2077325026","https://openalex.org/W2081923162","https://openalex.org/W2093865760","https://openalex.org/W2095156669","https://openalex.org/W2096008575","https://openalex.org/W2098544382","https://openalex.org/W2100181294","https://openalex.org/W2106036365","https://openalex.org/W2109189228","https://openalex.org/W2115759102","https://openalex.org/W2119060677","https://openalex.org/W2119975486","https://openalex.org/W2126620646","https://openalex.org/W2129172946","https://openalex.org/W2141346487","https://openalex.org/W2141393790","https://openalex.org/W2144124503","https://openalex.org/W2145117379","https://openalex.org/W2149908785","https://openalex.org/W2150086065","https://openalex.org/W2152654745","https://openalex.org/W2154834163","https://openalex.org/W2167523886","https://openalex.org/W2169095558","https://openalex.org/W2318605753"],"related_works":["https://openalex.org/W3029963027","https://openalex.org/W2566001673","https://openalex.org/W1086293690","https://openalex.org/W2333154093","https://openalex.org/W2058700971","https://openalex.org/W2107831804","https://openalex.org/W155933052","https://openalex.org/W2887033128","https://openalex.org/W2394229470","https://openalex.org/W2889716439"],"abstract_inverted_index":{"BACKGROUND:":[0],"Trastuzumab":[1],"resistance":[2,192],"hampers":[3],"its":[4],"well-known":[5],"efficacy":[6],"to":[7],"control":[8],"HER2-positive":[9,210],"breast":[10,211],"cancer.":[11],"The":[12],"involvement":[13],"of":[14,35,74,89,177,198,209],"PI3K/Akt":[15],"pathway":[16],"in":[17,120,206],"this":[18],"mechanism":[19],"is":[20],"still":[21],"not":[22],"definitively":[23],"confirmed.":[24],"METHODS:":[25],"We":[26,41,83],"selected":[27],"155":[28],"patients":[29,160],"treated":[30],"with":[31,130,161,167,196],"trastuzumab":[32,129,191],"after":[33],"development":[34],"metastasis":[36],"or":[37,132],"as":[38],"adjuvant/neoadjuvant":[39],"therapy.":[40],"performed":[42],"immunohistochemistry":[43],"for":[44,172],"HER2,":[45],"ER/PR,":[46],"epidermal":[47],"growth":[48,53],"factor":[49,54],"1-receptor":[50,55],"(EGFR),":[51],"\u03b1-insulin-like":[52],"(IGF1R),":[56],"phosphatase":[57],"and":[58,70,76,78,109,115,122,145,149,180,203],"tensin":[59],"homologue":[60],"(PTEN),":[61],"p110\u03b1,":[62],"pAkt,":[63],"pBad,":[64],"pmTOR,":[65],"pMAPK,":[66],"MUC1,":[67],"Ki67,":[68],"p53":[69],"p27;":[71],"mutational":[72],"analysis":[73],"PIK3CA":[75,114],"PTEN,":[77],"PTEN":[79,106,110,116],"promoter":[80,111],"hypermethylation.":[81],"RESULTS:":[82],"found":[84],"46%":[85],"ER/PR-positive":[86],"tumours,":[87,124],"overexpression":[88,205],"EGFR":[90,181,202],"(15%),":[91],"\u03b1-IGF1R":[92,131],"(25%),":[93],"p110\u03b1":[94,144,168],"(19%),":[95],"pAkt":[96],"(28%),":[97],"pBad":[98,133],"(22%),":[99],"pmTOR":[100],"(23%),":[101],"pMAPK":[102],"(24%),":[103],"MUC1":[104],"(80%),":[105],"loss":[107],"(20%),":[108],"hypermethylation":[112],"(20%).":[113],"mutations":[117],"were":[118,174],"detected":[119],"17%":[121],"26%":[123],"respectively.":[125],"Patients":[126],"receiving":[127],"adjuvant":[128],"overexpressing":[134],"tumours":[135],"presented":[136],"shorter":[137],"progression-free":[138],"survival":[139,155],"(PFS)":[140],"(all":[141,157],"P\u22640.043).":[142],"Also,":[143],"mTOR":[146],"overexpression,":[147],"liver":[148],"brain":[150],"relapses":[151],"implied":[152],"poor":[153],"overall":[154],"(OS)":[156],"P\u22640.041).":[158],"In":[159],"metastatic":[162],"disease,":[163],"decreased":[164],"PFS":[165],"correlated":[166],"expression":[169,182],"(P=0.024),":[170],"whereas":[171],"OS":[173],"the":[175],"presence":[176],"vascular":[178],"invasion":[179],"(P\u22640.019;":[183],"Cox":[184],"analysis).":[185],"CONCLUSION:":[186],"Our":[187],"results":[188],"support":[189],"that":[190],"mechanisms":[193],"are":[194],"related":[195],"deregulation":[197],"PTEN/PI3K/Akt/mTOR":[199],"pathway,":[200],"and/or":[201],"IGF1R":[204],"a":[207],"subset":[208],"carcinomas.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":32},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}