{"id":"https://openalex.org/W2033794850","doi":"https://doi.org/10.1089/cbr.2000.15.645","title":"Biodistribution and Dosimetry of an Aqueous Solution Containing Sodium 3-( 125 I)iodo-4-hydroxybenzenesulfonate (IotrexTM) for Brachytherapy of Resected Malignant Brain Tumors","display_name":"Biodistribution and Dosimetry of an Aqueous Solution Containing Sodium 3-( 125 I)iodo-4-hydroxybenzenesulfonate (IotrexTM) for Brachytherapy of Resected Malignant Brain Tumors","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2033794850","doi":"https://doi.org/10.1089/cbr.2000.15.645","mag":"2033794850","pmid":"https://pubmed.ncbi.nlm.nih.gov/11190496"},"language":"en","primary_location":{"id":"doi:10.1089/cbr.2000.15.645","doi":"https://doi.org/10.1089/cbr.2000.15.645","is_oa":false,"landing_page_url":"https://doi.org/10.1089/cbr.2000.15.645","pdf_url":null,"source":{"id":"https://openalex.org/S87235987","display_name":"Cancer Biotherapy and Radiopharmaceuticals","issn_l":"1084-9785","issn":["1084-9785","1557-8852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biotherapy and Radiopharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078685289","display_name":"James B. Stubbs","orcid":"https://orcid.org/0000-0002-0885-5244","observed_orcids":["https://orcid.org/0000-0002-0885-5244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James B. Stubbs","raw_affiliation_strings":["Proxima Therapeutics, Inc., 2555 Marconi Drive, Suite 220, Alpharetta, GA 30005, USA. jstubbs@proximatherapeutics.com","Proxima Therapeutics, Inc., 2555 Marconi Drive, Suite 220, Alpharetta, GA 30005, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proxima Therapeutics, Inc., 2555 Marconi Drive, Suite 220, Alpharetta, GA 30005, USA. jstubbs@proximatherapeutics.com","institution_ids":[]},{"raw_affiliation_string":"Proxima Therapeutics, Inc., 2555 Marconi Drive, Suite 220, Alpharetta, GA 30005, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111708570","display_name":"Alan D. Strickland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan D. Strickland","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108675199","display_name":"R. Keith Frank","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Keith Frank","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108574012","display_name":"Jaime Sim\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaime Sim\u00f3n","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112194679","display_name":"Kenneth McMillan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth McMillan","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113464176","display_name":"Jeffery A. Williams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffery A. Williams","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9433,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.75269878,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"15","issue":"6","first_page":"645","last_page":"656"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.03790000081062317,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iodine-125","display_name":"iodine-125","score":0.7979999780654907},{"id":"https://openalex.org/keywords/brachytherapy","display_name":"brachytherapy","score":0.777999997138977},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.5550000071525574},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7179999947547913},{"id":"https://openalex.org/keywords/dosimetry","display_name":"dosimetry","score":0.7799999713897705},{"id":"https://openalex.org/keywords/urinary-clearance","display_name":"urinary clearance","score":0.6019999980926514},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.3240000009536743},{"id":"https://openalex.org/keywords/deterministic-effects","display_name":"deterministic effects","score":0.6069999933242798},{"id":"https://openalex.org/keywords/phantoms","display_name":"phantoms","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.7512283325195312},{"id":"https://openalex.org/C2777416452","wikidata":"https://www.wikidata.org/wiki/Q896687","display_name":"Brachytherapy","level":3,"score":0.7357730865478516},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6906259059906006},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.6342088580131531},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.57914799451828},{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.45767495036125183},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4531344771385193},{"id":"https://openalex.org/C139059822","wikidata":"https://www.wikidata.org/wiki/Q183951","display_name":"Balloon","level":2,"score":0.4525749087333679},{"id":"https://openalex.org/C2993470428","wikidata":"https://www.wikidata.org/wiki/Q1106192","display_name":"Balloon catheter","level":3,"score":0.4260060489177704},{"id":"https://openalex.org/C2781267111","wikidata":"https://www.wikidata.org/wiki/Q652297","display_name":"Catheter","level":2,"score":0.38667818903923035},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3010061979293823},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2698814868927002},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.20729288458824158},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19250822067260742},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001557","descriptor_name":"Benzenesulfonates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001557","descriptor_name":"Benzenesulfonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001918","descriptor_name":"Brachytherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011874","descriptor_name":"Radiometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/cbr.2000.15.645","doi":"https://doi.org/10.1089/cbr.2000.15.645","is_oa":false,"landing_page_url":"https://doi.org/10.1089/cbr.2000.15.645","pdf_url":null,"source":{"id":"https://openalex.org/S87235987","display_name":"Cancer Biotherapy and Radiopharmaceuticals","issn_l":"1084-9785","issn":["1084-9785","1557-8852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biotherapy and Radiopharmaceuticals","raw_type":"journal-article"},{"id":"pmid:11190496","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11190496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biotherapy & radiopharmaceuticals","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.4699999988079071,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1987836896","https://openalex.org/W1998094473","https://openalex.org/W2022561368","https://openalex.org/W2037795557","https://openalex.org/W2042703635","https://openalex.org/W2063231374","https://openalex.org/W2093920455","https://openalex.org/W2289534699","https://openalex.org/W2473809807"],"related_works":["https://openalex.org/W2097246373","https://openalex.org/W1984770267","https://openalex.org/W1998554409","https://openalex.org/W2139203672","https://openalex.org/W2005055583","https://openalex.org/W2152795081","https://openalex.org/W1984431128","https://openalex.org/W2042216661","https://openalex.org/W2611859089","https://openalex.org/W2043895354"],"abstract_inverted_index":{"UNLABELLED:":[0],"Iotrex":[1,48,255],"is":[2,12],"an":[3,82],"aqueous":[4],"radiotherapy":[5,183],"solution":[6,84,184],"containing":[7],"sodium":[8],"3-(125I)iodo-4-hydroxybenzenesulfonate":[9],"(125I-HBS),":[10],"which":[11],"used":[13,86,129],"as":[14,87],"the":[15,19,29,46,52,60,71,93,138,153,173,182,186,202,241,250,263,272],"radiation":[16,41,61,132,242,264],"source":[17],"for":[18,90,274],"brachytherapy":[20,38],"of":[21,23,36,45,70,76,81,95,137,172,181,254,258],"resected":[22],"brain":[24,154],"tumor":[25],"cavity":[26],"margins":[27],"with":[28,97],"GliaSite":[30,53],"catheter.":[31],"During":[32],"routine":[33,67,238],"clinical":[34,68,239,252],"use":[35,69],"this":[37],"applicator":[39],"and":[40,110,117,142,149,160,214],"source,":[42],"approximately":[43],"0.1%":[44],"afterloaded":[47],"will":[49],"diffuse":[50],"through":[51],"balloon.":[54],"Our":[55],"purpose":[56],"was":[57,115,123,147],"to":[58,63,130,134,244,266],"assess":[59],"doses":[62,133,226,243,265],"normal":[64,135,222,245],"organs":[65,122,136,192,246,268],"under":[66],"GliaSite.":[72],"METHODS:":[73],"Five":[74],"groups":[75],"rats":[77],"received":[78],"intracerebral":[79],"injections":[80],"131I-HBS":[83],"(131I":[85],"a":[88],"surrogate":[89],"125I":[91],"in":[92,120],"synthesis":[94],"125I-HBS)":[96],"one":[98],"group":[99],"sacrificed":[100],"at":[101,175],"15":[102],"minutes,":[103,105],"30":[104],"1":[106],"hour,":[107],"2":[108,158],"hours":[109,112],"4":[111,176],"post-administration.":[113],"Urine":[114],"collected":[116],"activity":[118],"retention":[119],"numerous":[121],"measured.":[124],"The":[125],"biodistribution":[126],"data":[127],"were":[128],"estimate":[131],"Reference":[139],"Adult":[140],"Male":[141],"Female":[143],"phantoms.":[144],"RESULTS:":[145],"Radioactivity":[146],"rapidly":[148],"completely":[150],"cleared":[151,156],"from":[152,185],"(98%":[155],"by":[157],"hours)":[159],"total":[161],"body":[162],"(urinary":[163],"clearance;":[164],"93%@2":[165],"hours).":[166],"No":[167],"organ":[168,225],"retained":[169],">":[170],"0.7%":[171],"radioactivity":[174],"hours.":[177],"For":[178],"100%":[179],"loss":[180],"balloon":[187],"catheter":[188],"(device":[189],"failure),":[190],"all":[191,224,267],"would":[193,269],"receive":[194],"less":[195],"than":[196],"100":[197],"mGy":[198,232],"(10":[199],"rad),":[200,208],"except":[201],"bladder":[203],"wall":[204],"(2800":[205],"mGy,":[206,211,218],"280":[207],"uterus":[209],"(130":[210],"13":[212],"rad)":[213],"distal":[215],"colon":[216],"(270":[217],"27":[219],"rad).":[220,235],"Under":[221,237],"conditions,":[223,240],"are":[227,247],"1000-fold":[228],"lower":[229],"(<":[230],"3":[231],"or":[233],"0.3":[234],"CONCLUSIONS:":[236],"inconsequential.":[248],"Should":[249],"maximum":[251],"load":[253],"(16.7":[256],"GBq":[257],"125I)":[259],"be":[260,270],"released":[261],"intracerebrally,":[262],"below":[271],"thresholds":[273],"deterministic":[275],"effects.":[276]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}