{"id":"https://openalex.org/W2033772834","doi":"https://doi.org/10.1111/ijlh.12057","title":"Myeloid neoplasms associated with eosinophilia and rearrangement of PDGFRA , PDGFRB , and FGFR 1: a review","display_name":"Myeloid neoplasms associated with eosinophilia and rearrangement of PDGFRA , PDGFRB , and FGFR 1: a review","publication_year":2013,"publication_date":"2013-03-13","ids":{"openalex":"https://openalex.org/W2033772834","doi":"https://doi.org/10.1111/ijlh.12057","mag":"2033772834","pmid":"https://pubmed.ncbi.nlm.nih.gov/23489324"},"language":"en","primary_location":{"id":"doi:10.1111/ijlh.12057","doi":"https://doi.org/10.1111/ijlh.12057","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ijlh.12057","pdf_url":null,"source":{"id":"https://openalex.org/S66208518","display_name":"International Journal of Laboratory Hematology","issn_l":"1751-5521","issn":["1751-5521","1751-553X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Laboratory Hematology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034471031","display_name":"Natasha M. Savage","orcid":"https://orcid.org/0000-0003-1474-9568","observed_orcids":["https://orcid.org/0000-0003-1474-9568"]},"institutions":[{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"N. Savage","raw_affiliation_strings":["Department of Pathology, Charlie Norwood VA Medical Center, Augusta, GA, USA","Department of Pathology Georgia Health Sciences University Augusta GA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Charlie Norwood VA Medical Center, Augusta, GA, USA","institution_ids":["https://openalex.org/I2799702486"]},{"raw_affiliation_string":"Department of Pathology Georgia Health Sciences University Augusta GA USA","institution_ids":["https://openalex.org/I4210087454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015788207","display_name":"Tracy I. George","orcid":"https://orcid.org/0000-0001-5478-7847","observed_orcids":["https://orcid.org/0000-0001-5478-7847"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. I. George","raw_affiliation_strings":["Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA;","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065621786","display_name":"Jason R. Gotlib","orcid":"https://orcid.org/0000-0001-8253-6156","observed_orcids":["https://orcid.org/0000-0001-8253-6156"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Gotlib","raw_affiliation_strings":["Department of Medicine (Hematology) Stanford University School of Medicine Stanford CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Hematology) Stanford University School of Medicine Stanford CA USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034471031"],"corresponding_institution_ids":["https://openalex.org/I2799702486","https://openalex.org/I4210087454"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":1.3721,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.77022059,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"35","issue":"5","first_page":"491","last_page":"500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.09260000288486481,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdgfra-rearrangement","display_name":"PDGFRA rearrangement","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pdgfrb-rearrangement","display_name":"PDGFRB rearrangement","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fgfr1-rearrangement","display_name":"FGFR1 rearrangement","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fip1l1-pdgfra-fusion","display_name":"FIP1L1-PDGFRA fusion","score":0.9430000185966492},{"id":"https://openalex.org/keywords/imatinib-resistance","display_name":"imatinib resistance","score":0.890999972820282},{"id":"https://openalex.org/keywords/imatinib-mesylate","display_name":"imatinib mesylate","score":0.843999981880188},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5950000286102295},{"id":"https://openalex.org/keywords/small-molecule-kinase-inhibitors","display_name":"small-molecule kinase inhibitors","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C78221974","wikidata":"https://www.wikidata.org/wiki/Q18030425","display_name":"PDGFRB","level":3,"score":0.9747365117073059},{"id":"https://openalex.org/C37307934","wikidata":"https://www.wikidata.org/wiki/Q18030422","display_name":"PDGFRA","level":4,"score":0.8948416709899902},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6624007225036621},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.618633508682251},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.6174017786979675},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.5736469030380249},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5406017899513245},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.517792820930481},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.49058595299720764},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.4682289958000183},{"id":"https://openalex.org/C49418065","wikidata":"https://www.wikidata.org/wiki/Q14914258","display_name":"Fibroblast growth factor receptor 1","level":4,"score":0.46593278646469116},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.4561542570590973},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.44012871384620667},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.4338516891002655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42345988750457764},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.3868335783481598},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37573307752609253},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.35653287172317505},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.3510677218437195},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3023717999458313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27132558822631836},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22422346472740173},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1534806191921234},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.14987152814865112},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10022446513175964},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.09331494569778442},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0755273699760437}],"mesh":[{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020796","descriptor_name":"Receptor, Platelet-Derived Growth Factor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020797","descriptor_name":"Receptor, Platelet-Derived Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051496","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/ijlh.12057","doi":"https://doi.org/10.1111/ijlh.12057","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ijlh.12057","pdf_url":null,"source":{"id":"https://openalex.org/S66208518","display_name":"International Journal of Laboratory Hematology","issn_l":"1751-5521","issn":["1751-5521","1751-553X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Laboratory Hematology","raw_type":"journal-article"},{"id":"pmid:23489324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23489324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of laboratory hematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W39467412","https://openalex.org/W40765902","https://openalex.org/W197540547","https://openalex.org/W1498616452","https://openalex.org/W1523217489","https://openalex.org/W1527623537","https://openalex.org/W1554784620","https://openalex.org/W1575487317","https://openalex.org/W1580535447","https://openalex.org/W1595867794","https://openalex.org/W1663457857","https://openalex.org/W1731209109","https://openalex.org/W1963557114","https://openalex.org/W1964738883","https://openalex.org/W1965679846","https://openalex.org/W1972627918","https://openalex.org/W1977394892","https://openalex.org/W1981266856","https://openalex.org/W1989691606","https://openalex.org/W1994171871","https://openalex.org/W1995038616","https://openalex.org/W2000893535","https://openalex.org/W2001737705","https://openalex.org/W2002209196","https://openalex.org/W2006236202","https://openalex.org/W2006432362","https://openalex.org/W2012952884","https://openalex.org/W2014433287","https://openalex.org/W2015663870","https://openalex.org/W2016396075","https://openalex.org/W2018110102","https://openalex.org/W2019186253","https://openalex.org/W2019866017","https://openalex.org/W2019952415","https://openalex.org/W2025690484","https://openalex.org/W2033319140","https://openalex.org/W2033967066","https://openalex.org/W2036180570","https://openalex.org/W2053343706","https://openalex.org/W2054602580","https://openalex.org/W2057723561","https://openalex.org/W2058240442","https://openalex.org/W2062829972","https://openalex.org/W2063548996","https://openalex.org/W2064244980","https://openalex.org/W2070494106","https://openalex.org/W2072681676","https://openalex.org/W2075213943","https://openalex.org/W2076844908","https://openalex.org/W2077187679","https://openalex.org/W2077992590","https://openalex.org/W2078398386","https://openalex.org/W2080251370","https://openalex.org/W2081157104","https://openalex.org/W2086449120","https://openalex.org/W2095532864","https://openalex.org/W2097289227","https://openalex.org/W2102879987","https://openalex.org/W2111914345","https://openalex.org/W2113793740","https://openalex.org/W2121727047","https://openalex.org/W2122334306","https://openalex.org/W2134085362","https://openalex.org/W2140710807","https://openalex.org/W2141949848","https://openalex.org/W2142161829","https://openalex.org/W2144198294","https://openalex.org/W2144997552","https://openalex.org/W2147029510","https://openalex.org/W2147896253","https://openalex.org/W2148698815","https://openalex.org/W2152486214","https://openalex.org/W2155591233","https://openalex.org/W2169084046","https://openalex.org/W2170354886","https://openalex.org/W2172112558","https://openalex.org/W2281850830","https://openalex.org/W2342251757","https://openalex.org/W2917035343","https://openalex.org/W4254008500"],"related_works":["https://openalex.org/W3115444543","https://openalex.org/W2949164954","https://openalex.org/W1979259616","https://openalex.org/W4292182049","https://openalex.org/W2810615447","https://openalex.org/W2975197125","https://openalex.org/W2510547464","https://openalex.org/W2561476835","https://openalex.org/W2332034944","https://openalex.org/W3114834172"],"abstract_inverted_index":{"Myeloid":[0],"and":[1,6,21,94,143,169],"lymphoid":[2],"neoplasms":[3,32],"with":[4,109,129,135,155],"eosinophilia":[5,68,156],"abnormalities":[7,91,130],"of":[8,30,37,64,71,77,90,131,150,162,166,174],"platelet-derived":[9,15],"growth":[10,16,23],"factor":[11,17,24,107],"receptor":[12,18],"alpha":[13],"(PDGFRA),":[14],"beta":[19],"(PDGFRB),":[20],"fibroblast":[22],"receptor-1":[25],"(FGFR1)":[26],"are":[27,49,103,138],"a":[28,145],"group":[29],"hematologic":[31],"resulting":[33],"from":[34],"the":[35,58,74,78,88,113,124,163,172],"formation":[36],"abnormal":[38],"fusion":[39],"genes":[40],"that":[41,177],"encode":[42],"constitutively":[43],"activated":[44],"tyrosine":[45],"kinases.":[46],"These":[47],"entities":[48,80],"now":[50],"separated":[51],"into":[52],"their":[53],"own":[54],"major":[55],"category":[56],"in":[57,98,171],"2008":[59],"World":[60],"Health":[61],"Organization":[62],"classification":[63],"hematolymphoid":[65],"tumors.":[66],"Although":[67],"is":[69,81,118,123],"characteristic":[70,114],"these":[72,167],"diseases,":[73],"clinical":[75],"presentation":[76],"three":[79],"variable.":[82],"Conventional":[83],"cytogenetics":[84],"(karyotyping)":[85],"will":[86,157],"detect":[87,106],"majority":[89],"involving":[92],"PDGFRB":[93],"FGFR1,":[95],"but":[96],"florescence":[97],"situ":[99],"hybridization":[100],"(FISH)/molecular":[101],"studies":[102],"required":[104],"to":[105,140],"interacting":[108],"PAP":[110],"(FIP1L1)-PDGFRA":[111],"as":[112],"4q12":[115],"interstitial":[116],"deletion":[117],"cryptic.":[119],"Imatinib":[120],"mesylate":[121],"(imatinib)":[122],"first-line":[125],"therapy":[126,142],"for":[127],"patients":[128,134],"PDGFRA/B,":[132],"whereas":[133],"FGFR1":[136],"fusions":[137],"resistant":[139],"this":[141],"carry":[144],"poor":[146],"prognosis.":[147],"The":[148],"discovery":[149],"novel":[151],"gene":[152],"rearrangements":[153],"associated":[154],"further":[158],"guide":[159],"our":[160],"understanding":[161],"molecular":[164],"pathobiology":[165],"diseases":[168],"aid":[170],"development":[173],"small-molecule":[175],"inhibitors":[176],"inhibit":[178],"deregulated":[179],"hematopoiesis.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
