{"id":"https://openalex.org/W2033771997","doi":"https://doi.org/10.1016/0091-6749(84)90128-3","title":"Arachidonate 5-lipoxygenase and its new inhibitors","display_name":"Arachidonate 5-lipoxygenase and its new inhibitors","publication_year":1984,"publication_date":"1984-09-01","ids":{"openalex":"https://openalex.org/W2033771997","doi":"https://doi.org/10.1016/0091-6749(84)90128-3","mag":"2033771997","pmid":"https://pubmed.ncbi.nlm.nih.gov/6432877"},"language":"en","primary_location":{"id":"doi:10.1016/0091-6749(84)90128-3","doi":"https://doi.org/10.1016/0091-6749(84)90128-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0091-6749(84)90128-3","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111462363","display_name":"Shozo Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shozo Yamamoto","raw_affiliation_strings":["Department of Biochemistry,","Department of Biochemistry, School of Medicine, and the Department of Applied Chemistry, Technical College, To-kushima University, Tokushima;","Department of Phar-macology, Kyoto College of Pharmacy, Kyoto, Japan","School of Medicine, Tokushima University, Kuramoto-cho, To-kushima 770, Japan","Tokushima and Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, School of Medicine, and the Department of Applied Chemistry, Technical College, To-kushima University, Tokushima;","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Department of Phar-macology, Kyoto College of Pharmacy, Kyoto, Japan","institution_ids":[]},{"raw_affiliation_string":"School of Medicine, Tokushima University, Kuramoto-cho, To-kushima 770, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Tokushima and Kyoto, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110070901","display_name":"Tanihiro Yoshimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tanihiro Yoshimoto","raw_affiliation_strings":["Department of Biochemistry,","Department of Biochemistry, School of Medicine, and the Department of Applied Chemistry, Technical College, To-kushima University, Tokushima;","Department of Phar-macology, Kyoto College of Pharmacy, Kyoto, Japan","School of Medicine, Tokushima University, Kuramoto-cho, To-kushima 770, Japan","Tokushima and Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, School of Medicine, and the Department of Applied Chemistry, Technical College, To-kushima University, Tokushima;","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Department of Phar-macology, Kyoto College of Pharmacy, Kyoto, Japan","institution_ids":[]},{"raw_affiliation_string":"School of Medicine, Tokushima University, Kuramoto-cho, To-kushima 770, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Tokushima and Kyoto, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masayuki Furukawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Furukawa","raw_affiliation_strings":["Department of Biochemistry,","Department of Biochemistry, School of Medicine, and the Department of Applied Chemistry, Technical College, To-kushima University, Tokushima;","Department of Phar-macology, Kyoto College of Pharmacy, Kyoto, Japan","School of Medicine, Tokushima University, Kuramoto-cho, To-kushima 770, Japan","Tokushima and Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, School of Medicine, and the Department of Applied Chemistry, Technical College, To-kushima University, Tokushima;","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Department of Phar-macology, Kyoto College of Pharmacy, Kyoto, Japan","institution_ids":[]},{"raw_affiliation_string":"School of Medicine, Tokushima University, Kuramoto-cho, To-kushima 770, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Tokushima and Kyoto, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111632552","display_name":"Tokunaru H\u00f2rie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tokunaru Horie","raw_affiliation_strings":["Department of Biochemistry,","Department of Biochemistry, School of Medicine, and the Department of Applied Chemistry, Technical College, To-kushima University, Tokushima;","Department of Phar-macology, Kyoto College of Pharmacy, Kyoto, Japan","School of Medicine, Tokushima University, Kuramoto-cho, To-kushima 770, Japan","Tokushima and Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, School of Medicine, and the Department of Applied Chemistry, Technical College, To-kushima University, Tokushima;","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Department of Phar-macology, Kyoto College of Pharmacy, Kyoto, Japan","institution_ids":[]},{"raw_affiliation_string":"School of Medicine, Tokushima University, Kuramoto-cho, To-kushima 770, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Tokushima and Kyoto, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089610801","display_name":"Shigekatsu Watanabe-Kohno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigekatsu Watanabe-Kohno","raw_affiliation_strings":["Department of Biochemistry,","Department of Biochemistry, School of Medicine, and the Department of Applied Chemistry, Technical College, To-kushima University, Tokushima;","Department of Phar-macology, Kyoto College of Pharmacy, Kyoto, Japan","School of Medicine, Tokushima University, Kuramoto-cho, To-kushima 770, Japan","Tokushima and Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, School of Medicine, and the Department of Applied Chemistry, Technical College, To-kushima University, Tokushima;","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Department of Phar-macology, Kyoto College of Pharmacy, Kyoto, Japan","institution_ids":[]},{"raw_affiliation_string":"School of Medicine, Tokushima University, Kuramoto-cho, To-kushima 770, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Tokushima and Kyoto, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I922474255"],"apc_list":{"value":4900,"currency":"USD","value_usd":4900},"apc_paid":null,"fwci":2.1494,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.86537718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"74","issue":"3","first_page":"349","last_page":"352"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.5435000061988831,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.5435000061988831,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.4133000075817108,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-lipoxygenase","display_name":"5-lipoxygenase","score":0.9020000100135803},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.8859999775886536},{"id":"https://openalex.org/keywords/leukotriene-biosynthesis","display_name":"leukotriene biosynthesis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/lipoxygenase-inhibitors","display_name":"lipoxygenase inhibitors","score":0.8830000162124634},{"id":"https://openalex.org/keywords/flavonoid-inhibitors","display_name":"flavonoid inhibitors","score":0.9929999709129333},{"id":"https://openalex.org/keywords/calcium-dependent-enzyme-activity","display_name":"calcium-dependent enzyme activity","score":0.7950000166893005},{"id":"https://openalex.org/keywords/atp-stimulation","display_name":"ATP stimulation","score":0.3499999940395355},{"id":"https://openalex.org/keywords/rbl-cells","display_name":"RBL cells","score":0.7580000162124634},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6603582501411438},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.6329803466796875},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.6258948445320129},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.6148780584335327},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6004336476325989},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5486406683921814},{"id":"https://openalex.org/C90342290","wikidata":"https://www.wikidata.org/wiki/Q94234745","display_name":"Arachidonate 5-lipoxygenase","level":4,"score":0.5240935683250427},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4666424095630646},{"id":"https://openalex.org/C2779543280","wikidata":"https://www.wikidata.org/wiki/Q2704310","display_name":"Leukotriene C4","level":4,"score":0.44550809264183044},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.41222649812698364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2586390972137451},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1147882342338562},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06560355424880981},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001091","descriptor_name":"Arachidonate Lipoxygenases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007942","descriptor_name":"Leukemia, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008084","descriptor_name":"Lipoxygenase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013189","descriptor_name":"SRS-A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016227","descriptor_name":"Benzoquinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047309","descriptor_name":"Flavones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0091-6749(84)90128-3","doi":"https://doi.org/10.1016/0091-6749(84)90128-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0091-6749(84)90128-3","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:6432877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6432877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of allergy and clinical immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309791","display_name":"Suzuken Memorial Foundation","ror":"https://ror.org/03yvcwz92"},{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"},{"id":"https://openalex.org/F4320328054","display_name":"Japan Heart Foundation","ror":"https://ror.org/008qgm855"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1567023633","https://openalex.org/W1659584317","https://openalex.org/W1974172774","https://openalex.org/W1986305114","https://openalex.org/W1994214516","https://openalex.org/W1994421907","https://openalex.org/W1995194389","https://openalex.org/W1997787821","https://openalex.org/W2005186266","https://openalex.org/W2021554688","https://openalex.org/W2037981980","https://openalex.org/W2047206656","https://openalex.org/W2066720230","https://openalex.org/W2071421932","https://openalex.org/W2078720424","https://openalex.org/W2438601235"],"related_works":["https://openalex.org/W1567023633","https://openalex.org/W2068261691","https://openalex.org/W1668867309","https://openalex.org/W205448491","https://openalex.org/W2051058593","https://openalex.org/W4211231247","https://openalex.org/W2052501719","https://openalex.org/W2335169562","https://openalex.org/W2015097584","https://openalex.org/W2021554688"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}