{"id":"https://openalex.org/W2033771600","doi":"https://doi.org/10.1111/j.1464-410x.1991.tb15142.x","title":"Severe Hepatocellular Dysfunction following Cyproterone Acetate Therapy","display_name":"Severe Hepatocellular Dysfunction following Cyproterone Acetate Therapy","publication_year":1991,"publication_date":"1991-03-01","ids":{"openalex":"https://openalex.org/W2033771600","doi":"https://doi.org/10.1111/j.1464-410x.1991.tb15142.x","mag":"2033771600","pmid":"https://pubmed.ncbi.nlm.nih.gov/1827039"},"language":"en","primary_location":{"id":"doi:10.1111/j.1464-410x.1991.tb15142.x","doi":"https://doi.org/10.1111/j.1464-410x.1991.tb15142.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1464-410x.1991.tb15142.x","pdf_url":null,"source":{"id":"https://openalex.org/S191188855","display_name":"British Journal of Urology","issn_l":"1464-4096","issn":["1464-4096","1464-410X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018722481","display_name":"B. T. PARYS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154214","display_name":"Royal Preston Hospital","ror":"https://ror.org/05kpx1157","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1293129422","https://openalex.org/I4210154214"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"B. T. PARYS","raw_affiliation_strings":["Department of Urology, Royal Preston Hospital, Preston","MCh, FRCSE, Registrar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Royal Preston Hospital, Preston","institution_ids":["https://openalex.org/I4210154214"]},{"raw_affiliation_string":"MCh, FRCSE, Registrar","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008698250","display_name":"Saeed Sadiq Hamid","orcid":"https://orcid.org/0000-0001-7218-6885","observed_orcids":["https://orcid.org/0000-0001-7218-6885"]},"institutions":[{"id":"https://openalex.org/I4210154214","display_name":"Royal Preston Hospital","ror":"https://ror.org/05kpx1157","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1293129422","https://openalex.org/I4210154214"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. HAMID","raw_affiliation_strings":["Department of Urology. Royal Preston Hospital, Preston","FRCSE, Registrar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology. Royal Preston Hospital, Preston","institution_ids":["https://openalex.org/I4210154214"]},{"raw_affiliation_string":"FRCSE, Registrar","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032802469","display_name":"R. G. Thomson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154214","display_name":"Royal Preston Hospital","ror":"https://ror.org/05kpx1157","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1293129422","https://openalex.org/I4210154214"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. G. N. THOMSON","raw_affiliation_strings":["Department of Urology. Royal Preston Hospital, Preston","R. G. N. Thomson, FRCS, Consultant Urologist"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology. Royal Preston Hospital, Preston","institution_ids":["https://openalex.org/I4210154214"]},{"raw_affiliation_string":"R. G. N. Thomson, FRCS, Consultant Urologist","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018722481"],"corresponding_institution_ids":["https://openalex.org/I4210154214"],"apc_list":{"value":4770,"currency":"USD","value_usd":4770},"apc_paid":null,"fwci":1.3372,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.73490025,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"67","issue":"3","first_page":"312","last_page":"313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyproterone-acetate","display_name":"cyproterone acetate","score":1.0},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hepatocellular-dysfunction","display_name":"hepatocellular dysfunction","score":0.7919999957084656},{"id":"https://openalex.org/keywords/fulminant-hepatitis","display_name":"fulminant hepatitis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/advanced-prostate-cancer","display_name":"advanced prostate cancer","score":0.7590000033378601},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.8100000023841858},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2777155358","wikidata":"https://www.wikidata.org/wiki/Q426185","display_name":"Cyproterone acetate","level":4,"score":0.9470025300979614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7509384155273438},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7279514670372009},{"id":"https://openalex.org/C2776306840","wikidata":"https://www.wikidata.org/wiki/Q7381206","display_name":"Cyproterone","level":5,"score":0.6560873985290527},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6061431169509888},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.5751473903656006},{"id":"https://openalex.org/C2994395758","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Fulminant hepatitis","level":3,"score":0.5324296355247498},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4754238426685333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4588521122932434},{"id":"https://openalex.org/C2778351090","wikidata":"https://www.wikidata.org/wiki/Q1349821","display_name":"Toxic hepatitis","level":3,"score":0.4502227008342743},{"id":"https://openalex.org/C2781107259","wikidata":"https://www.wikidata.org/wiki/Q5508364","display_name":"Fulminant","level":2,"score":0.4501221477985382},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.40044939517974854},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3362005949020386},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.13307315111160278},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.069623202085495}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003534","descriptor_name":"Cyproterone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003534","descriptor_name":"Cyproterone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017373","descriptor_name":"Cyproterone Acetate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1464-410x.1991.tb15142.x","doi":"https://doi.org/10.1111/j.1464-410x.1991.tb15142.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1464-410x.1991.tb15142.x","pdf_url":null,"source":{"id":"https://openalex.org/S191188855","display_name":"British Journal of Urology","issn_l":"1464-4096","issn":["1464-4096","1464-410X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Urology","raw_type":"journal-article"},{"id":"pmid:1827039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1827039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of urology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2001724257","https://openalex.org/W2108955823","https://openalex.org/W2141237313","https://openalex.org/W2211265528","https://openalex.org/W6652705693"],"related_works":["https://openalex.org/W3140624381","https://openalex.org/W1966575378","https://openalex.org/W2113580688","https://openalex.org/W2413118598","https://openalex.org/W1907135","https://openalex.org/W2319347578","https://openalex.org/W1971833438","https://openalex.org/W175742718","https://openalex.org/W2767835776","https://openalex.org/W3121670536"],"abstract_inverted_index":{"Cyproterone":[0],"acetate":[1],"(CPA)":[2],"is":[3,17],"a":[4,27],"widely":[5],"used":[6],"drug":[7],"in":[8],"the":[9],"treatment":[10],"of":[11,29],"advanced":[12],"prostatic":[13],"carcinoma.":[14],"Although":[15],"it":[16],"generally":[18],"well":[19],"tolerated,":[20],"liver":[21],"toxicity":[22],"has":[23],"been":[24],"recognised":[25],"as":[26],"complication":[28],"long-term":[30],"use.":[31],"We":[32],"report":[33],"3":[34],"patients":[35],"with":[36,45],"severe":[37],"hepatocellular":[38],"damage":[39],"due":[40],"to":[41],"CPA":[42],"therapy,":[43],"2":[44],"fatal":[46],"fulminant":[47],"hepatitis.":[48]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
