{"id":"https://openalex.org/W2033765375","doi":"https://doi.org/10.1038/ajg.2012.137","title":"Reduction in Hepatic Inflammation Is Associated With Less Fibrosis Progression and Fewer Clinical Outcomes in Advanced Hepatitis C","display_name":"Reduction in Hepatic Inflammation Is Associated With Less Fibrosis Progression and Fewer Clinical Outcomes in Advanced Hepatitis C","publication_year":2012,"publication_date":"2012-06-12","ids":{"openalex":"https://openalex.org/W2033765375","doi":"https://doi.org/10.1038/ajg.2012.137","mag":"2033765375","pmid":"https://pubmed.ncbi.nlm.nih.gov/22688849"},"language":"en","primary_location":{"id":"doi:10.1038/ajg.2012.137","doi":"https://doi.org/10.1038/ajg.2012.137","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ajg.2012.137","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3865099","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086380045","display_name":"Chihiro Morishima","orcid":"https://orcid.org/0000-0001-5330-9464","observed_orcids":["https://orcid.org/0000-0001-5330-9464"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chihiro Morishima","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA. chihiro@u.washington.edu","University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA. chihiro@u.washington.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010968373","display_name":"Mitchell L. Shiffman","orcid":"https://orcid.org/0000-0002-3575-6516","observed_orcids":["https://orcid.org/0000-0002-3575-6516"]},"institutions":[{"id":"https://openalex.org/I160713005","display_name":"Bon Secours Health System","ror":"https://ror.org/00baer621","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I160713005"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell L Shiffman","raw_affiliation_strings":["Liver Institute of Virginia, Bon Secours Health System, Newport News, Virginia, USA","Bon Secours Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Institute of Virginia, Bon Secours Health System, Newport News, Virginia, USA","institution_ids":["https://openalex.org/I160713005"]},{"raw_affiliation_string":"Bon Secours Health System","institution_ids":["https://openalex.org/I160713005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051411123","display_name":"Jules L. Dienstag","orcid":"https://orcid.org/0000-0001-7024-0980","observed_orcids":["https://orcid.org/0000-0001-7024-0980"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jules L Dienstag","raw_affiliation_strings":["Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA","Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018098715","display_name":"Karen L. Lindsay","orcid":"https://orcid.org/0000-0002-4481-9363","observed_orcids":["https://orcid.org/0000-0002-4481-9363"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen L Lindsay","raw_affiliation_strings":["Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California, USA","University of Southern California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006482005","display_name":"Gy\u00f6ngyi Szab\u00f3","orcid":"https://orcid.org/0000-0003-0836-2527","observed_orcids":["https://orcid.org/0000-0003-0836-2527"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gyongyi Szabo","raw_affiliation_strings":["Department of Medicine, Division of Gastroenterology, Hepatology and Liver Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA","University of Massachusetts Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, Hepatology and Liver Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"University of Massachusetts Medical School","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056557259","display_name":"Gregory T. Everson","orcid":"https://orcid.org/0000-0003-0454-3566","observed_orcids":["https://orcid.org/0000-0003-0454-3566"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory T Everson","raw_affiliation_strings":["Section of Hepatology, Division of Gastroenterology and Hepatology, University of Colorado Denver School of Medicine, Aurora, Colorado, USA","University of Colorado, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hepatology, Division of Gastroenterology and Hepatology, University of Colorado Denver School of Medicine, Aurora, Colorado, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"University of Colorado, Denver","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077140895","display_name":"Anna Suk-Fong Lok","orcid":"https://orcid.org/0000-0002-5811-6845","observed_orcids":["https://orcid.org/0000-0002-5811-6845"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna S Lok","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan, USA","(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022731052","display_name":"Adrian M. Di Bisceglie","orcid":"https://orcid.org/0000-0002-6075-9305","observed_orcids":["https://orcid.org/0000-0002-6075-9305"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian M Di Bisceglie","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St. Louis, Missouri, USA",", Saint Louis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":", Saint Louis University","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013138122","display_name":"Marc G. Ghany","orcid":"https://orcid.org/0000-0003-2837-0188","observed_orcids":["https://orcid.org/0000-0003-2837-0188"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc G Ghany","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037691277","display_name":"Deepa Naishadham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210098573","display_name":"New England Research Institutes","ror":"https://ror.org/01655nh08","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210098573"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepa Naishadham","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA","New England Research Institutes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"New England Research Institutes","institution_ids":["https://openalex.org/I4210098573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077980742","display_name":"Timothy R.M. Morgan","orcid":"https://orcid.org/0000-0003-1328-0307","observed_orcids":["https://orcid.org/0000-0003-1328-0307"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210154430","display_name":"VA Long Beach Healthcare System","ror":"https://ror.org/058p1kn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210154430"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy R Morgan","raw_affiliation_strings":["Division of Gastroenterology, University of California\u2014Irvine, Irvine, California, USA","Gastroenterology Service, VA Long Beach Healthcare System, Long Beach, California, USA","University of California at Irvine","VA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of California\u2014Irvine, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Gastroenterology Service, VA Long Beach Healthcare System, Long Beach, California, USA","institution_ids":["https://openalex.org/I4210154430"]},{"raw_affiliation_string":"University of California at Irvine","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"VA Medical Center","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005769736","display_name":"Elizabeth C. Wright","orcid":"https://orcid.org/0000-0002-9841-3879","observed_orcids":["https://orcid.org/0000-0002-9841-3879"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"id":"https://openalex.org/I4210091794","display_name":"Office of the Director","ror":"https://ror.org/00fj8a872","country_code":"US","type":"other","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210091794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth C Wright","raw_affiliation_strings":["December 2011; accepted 17 April 2012","Department of Health and Human Services, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA","Department of Health and Human Services, Office of the Director, National Institutes of Health, Bethesda, Maryland, USA","SUPPLEMENTARY MATERIAL accompanies this paper at https://links.lww.com/AJG/A500","published online 12 June 2012","National Institutes of Health, Bethesda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"December 2011; accepted 17 April 2012","institution_ids":[]},{"raw_affiliation_string":"Department of Health and Human Services, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"raw_affiliation_string":"Department of Health and Human Services, Office of the Director, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210091794"]},{"raw_affiliation_string":"SUPPLEMENTARY MATERIAL accompanies this paper at https://links.lww.com/AJG/A500","institution_ids":[]},{"raw_affiliation_string":"published online 12 June 2012","institution_ids":[]},{"raw_affiliation_string":"National Institutes of Health, Bethesda","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5086380045"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":1.2422,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.79560801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"107","issue":"9","first_page":"1388","last_page":"1398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c","display_name":"hepatitis C","score":0.8320000171661377},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/liver-fibrosis-progression","display_name":"liver fibrosis progression","score":0.9760000109672546},{"id":"https://openalex.org/keywords/peginterferon-alfa-2a","display_name":"peginterferon alfa-2a","score":0.8740000128746033},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hcv-rna-suppression","display_name":"HCV RNA suppression","score":0.7940000295639038},{"id":"https://openalex.org/keywords/ishak-fibrosis-score","display_name":"Ishak fibrosis score","score":0.7960000038146973},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7120000123977661},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.6230000257492065},{"id":"https://openalex.org/keywords/interferon-non-responders","display_name":"interferon non-responders","score":0.6610000133514404},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9756425619125366},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7336434721946716},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6615815162658691},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5421105623245239},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.5332037806510925},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.49232804775238037},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4921268820762634},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.46829384565353394},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.4534686505794525},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24090799689292908},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.05108785629272461}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/ajg.2012.137","doi":"https://doi.org/10.1038/ajg.2012.137","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ajg.2012.137","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:22688849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22688849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2848646","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3865099","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3865099","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3865099","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Am J Gastroenterol","raw_type":"Text"},{"id":"pmh:oai:escholarship.umassmed.edu:gastroenterology_pp-1109","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/gastroenterology_pp/110","pdf_url":null,"source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gastroenterology Publications","raw_type":"text"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt4k36q96g","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/4k36q96g","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The American Journal of Gastroenterology, vol 107, iss 9","raw_type":"article"},{"id":"pmh:qt4k36q96g","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/4k36q96g","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Morishima, Chihiro; Shiffman, Mitchell L; Dienstag, Jules L; Lindsay, Karen L; Szabo, Gyongyi; Everson, Gregory T; \u00c2\u00a0et al.(2012). Reduction in Hepatic Inflammation Is Associated With Less Fibrosis Progression and Fewer Clinical Outcomes in Advanced Hepatitis C. The American Journal of Gastroenterology, 107(9), 1388 - 1398. doi: 10.1038/ajg.2012.137. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/4k36q96g","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3865099","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3865099","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Am J Gastroenterol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1016094800","display_name":null,"funder_award_id":"M01-RR-00065","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1046845233","display_name":"Hepatitis C Clinical Trials-Clinical Center","funder_award_id":"n01dk92321-22-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1093595823","display_name":null,"funder_award_id":"UL1 RR 025780-01","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1217208902","display_name":null,"funder_award_id":"N01 DK092325","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1500039052","display_name":null,"funder_award_id":"N01-DK9-2322","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1555420984","display_name":"HEPATITIS C CLINICAL TRIAL-CLINICAL CENTERS","funder_award_id":"n01dk92325-24-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1608726392","display_name":null,"funder_award_id":"N01 DK092320","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1638345366","display_name":null,"funder_award_id":"N01-DK-9-2324","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1663837155","display_name":null,"funder_award_id":"UL1-TR-000451","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G1682733868","display_name":"Hepatitis C Clinical Trial-Data Coordinating Center","funder_award_id":"n01dk92328-26-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1740463284","display_name":null,"funder_award_id":"M01 RR-00043","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1789861183","display_name":null,"funder_award_id":"M01-RR001066","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1867400065","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR000633","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1952602728","display_name":null,"funder_award_id":"M-01RR00827","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2095852620","display_name":null,"funder_award_id":"N01 DK092327","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G220748524","display_name":null,"funder_award_id":"M01RR-00051","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2224345100","display_name":null,"funder_award_id":"U01 DK082871","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2383253098","display_name":null,"funder_award_id":"N01 DK 92321","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G239052087","display_name":null,"funder_award_id":"UL1-RR-024986","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2605231874","display_name":null,"funder_award_id":"N01 DK092321","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2626298412","display_name":"Hepatitis C Clinical Trial-Clinical Center","funder_award_id":"n01dk92319-17-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2911770245","display_name":"Hepatitis C Clinical Trial-Clinical Center","funder_award_id":"n01dk92323-29-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3277324657","display_name":null,"funder_award_id":"N01-DK-9-2320","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3350686849","display_name":null,"funder_award_id":"N01 DK92325","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3447108572","display_name":"Harvard Clinical and Translational Science Center (UL1)","funder_award_id":"UL1RR025758","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3482496003","display_name":"General Clinical Research Center","funder_award_id":"M01RR000051","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3493866547","display_name":"General Clinical Research Center","funder_award_id":"2m01rr001066-31","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3994153766","display_name":null,"funder_award_id":"N01 DK092323","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G417964966","display_name":null,"funder_award_id":"N01 DK092326","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4310905822","display_name":null,"funder_award_id":"N01 DK 92323","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4607014242","display_name":"Hepatitis C Clinical Trial-Clinical Center","funder_award_id":"n01dk92327-8-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4627513917","display_name":null,"funder_award_id":"N01 DK 92327","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4749549782","display_name":null,"funder_award_id":"1 UL1 RR024986","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G475936976","display_name":null,"funder_award_id":"#UL1 RR025780","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5013305198","display_name":"North and Central Texas Clinical and Translational Science Initiative (UL1)","funder_award_id":"UL1RR024982","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5685827725","display_name":null,"funder_award_id":"N01 DK092318","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5712003114","display_name":"UT-Southwestern Clinical and Translational Alliance for Research (UT-STAR) (TL1)","funder_award_id":"2ul1tr000451-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G57319417","display_name":null,"funder_award_id":"M-01RR00042","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5900184332","display_name":"General Clinical Research Center","funder_award_id":"5m01rr000043-50","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5966678231","display_name":"General Clinical Research Center","funder_award_id":"M01RR000065","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6007395664","display_name":"Hepatitis C Clinical Trial-Clinical Center","funder_award_id":"n01dk92324-24-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6062035232","display_name":null,"funder_award_id":"M01 RR006192","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6063195862","display_name":null,"funder_award_id":"N01 DK092319","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G627358779","display_name":"HEPATITIS C CLINICAL TRIALS- CLINICAL CENTERS","funder_award_id":"n01dk092320-001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G635792350","display_name":null,"funder_award_id":"N01 DK 92318","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G645260498","display_name":null,"funder_award_id":"N01 DK 92328","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6740196381","display_name":"HEPATITIS C CLINICAL TRIAL- CLINICAL CENTERS","funder_award_id":"n01dk92322-25-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6793902845","display_name":null,"funder_award_id":"N01 DK092328","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G692954999","display_name":"Hepatitis C Clinical Trial-Clinical Center","funder_award_id":"n01dk92318-15-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6998970483","display_name":null,"funder_award_id":"N01 DK092324","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G769717368","display_name":null,"funder_award_id":"N01 DK 92326","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8297551062","display_name":"General Clinical Research Center","funder_award_id":"M01RR000042","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G838905924","display_name":null,"funder_award_id":"N01-DK-92319","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G848270291","display_name":null,"funder_award_id":"M01 RR00633","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8737339525","display_name":null,"funder_award_id":"N01 DK092322","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G881343144","display_name":null,"funder_award_id":"M01-RR01066","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8878637015","display_name":"General Clinical Research Center","funder_award_id":"M01RR000827","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G903953877","display_name":null,"funder_award_id":"M01-RR-000043","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G937870883","display_name":null,"funder_award_id":"M01 RR 06192","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G986165676","display_name":"Hepatitis C Clinical Trial-Clinical Center","funder_award_id":"n01dk92326-28-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W200886538","https://openalex.org/W1978783755","https://openalex.org/W1980095859","https://openalex.org/W1981900811","https://openalex.org/W2013010588","https://openalex.org/W2015533723","https://openalex.org/W2016409892","https://openalex.org/W2029323175","https://openalex.org/W2067435274","https://openalex.org/W2069633422","https://openalex.org/W2085261733","https://openalex.org/W2090439540","https://openalex.org/W2097388257","https://openalex.org/W2097556922","https://openalex.org/W2131221081","https://openalex.org/W2160029914","https://openalex.org/W2163882915","https://openalex.org/W2168076454","https://openalex.org/W4285719527","https://openalex.org/W7008161984"],"related_works":["https://openalex.org/W3031464869","https://openalex.org/W4389552665","https://openalex.org/W2415819220","https://openalex.org/W2323242679","https://openalex.org/W2359836703","https://openalex.org/W2357095842","https://openalex.org/W141913022","https://openalex.org/W2370541698","https://openalex.org/W2018512112","https://openalex.org/W438509232"],"abstract_inverted_index":{"OBJECTIVES:":[0],"During":[1],"the":[2,142,152,165,202,233],"Hepatitis":[3],"C":[4,90],"Antiviral":[5],"Long-term":[6],"Treatment":[7],"against":[8],"Cirrhosis":[9],"Trial,":[10],"3.5":[11,162,247],"years":[12,57,248],"of":[13,154,179,272],"maintenance":[14],"peginterferon-alfa-2a":[15],"therapy":[16,127],"did":[17],"not":[18],"affect":[19],"liver":[20],"fibrosis":[21,33,81,114,214,226,266],"progression":[22,82,227,267],"or":[23,34,62,112],"clinical":[24,45,84,183,269],"outcomes":[25,85,184],"among":[26],"1,050":[27],"previous":[28],"interferon":[29],"nonresponders":[30],"with":[31,44,50,135,188,195,211,218,253,260,264],"advanced":[32],"cirrhosis.":[35],"We":[36],"investigated":[37],"whether":[38],"reduced":[39],"hepatic":[40,69,72,242],"inflammation":[41,70,243],"was":[42,103,133,251],"associated":[43,134,252],"benefit":[46],"in":[47,68,110,140,151,163,186,200,231],"834":[48,173],"patients":[49,121,174,187,210],"a":[51,106,177],"baseline":[52],"and":[53,76,83,88,96,146,168,205,236,246,263,268],"follow-up":[54],"biopsy":[55],"1.5":[56,193,223,230,245],"after":[58,86,97,249],"randomization":[59,98],"to":[60],"peginterferon":[61],"observation.":[63],"METHODS:":[64],"Relationships":[65],"between":[66,116],"change":[67,102],"(Ishak":[71],"activity":[73],"index,":[74],"(HAI))":[75],"serum":[77],"alanine":[78],"aminotransferase":[79],"level,":[80],"randomization,":[87,129],"hepatitis":[89],"virus":[91],"(HCV)":[92],"RNA":[93,138],"decline":[94],"before":[95,128],"were":[99],"evaluated.":[100],"Histological":[101],"defined":[104],"as":[105],"\u2265":[107],"2-point":[108],"difference":[109],"HAI":[111,131,190,220],"Ishak":[113,212],"score":[115],"biopsies.":[117],"RESULTS:":[118],"Among":[119,172,209],"657":[120],"who":[122],"received":[123],"full-dose":[124,261],"peginterferon/ribavirin":[125,262],"\"lead-in\"":[126],"year-1.5":[130],"improvement":[132,199],"lead-in":[136,258],"HCV":[137],"suppression":[139,256],"both":[141,164,201,232],"randomized":[143,273],"treated":[144,166,203,234],"(P<0.0001)":[145],"control":[147,169,206,237],"(P=0.0001)":[148],"groups,":[149],"even":[150],"presence":[153],"recurrent":[155],"viremia.":[156],"This":[157],"relationship":[158],"persisted":[159],"at":[160,191,215,221,228],"year":[161,192,222,229],"(P=0.001)":[167],"(P=0.01)":[170],"groups.":[171,208,239],"followed":[175],"for":[176],"median":[178],"6":[180],"years,":[181],"fewer":[182],"occurred":[185],"improved":[189,219],"compared":[194],"those":[196,217],"without":[197],"such":[198],"(P=0.03)":[204],"(P=0.05)":[207],"3-4":[213],"baseline,":[216],"had":[224],"less":[225],"(P=0.0003)":[235],"(P=0.02)":[238],"CONCLUSIONS:":[240],"Reduced":[241],"(measured":[244],"randomization)":[250],"profound":[254],"virological":[255],"during":[257],"treatment":[259],"decreased":[265],"outcomes,":[270],"independent":[271],"treatment.":[274]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}