{"id":"https://openalex.org/W2033761996","doi":"https://doi.org/10.1074/jbc.m110832200","title":"Oxidation of I\u03baB\u03b1 at Methionine 45 Is One Cause of Taurine Chloramine-induced Inhibition of NF-\u03baB Activation","display_name":"Oxidation of I\u03baB\u03b1 at Methionine 45 Is One Cause of Taurine Chloramine-induced Inhibition of NF-\u03baB Activation","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W2033761996","doi":"https://doi.org/10.1074/jbc.m110832200","mag":"2033761996","pmid":"https://pubmed.ncbi.nlm.nih.gov/11983684"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m110832200","doi":"https://doi.org/10.1074/jbc.m110832200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110832200","pdf_url":"http://www.jbc.org/article/S0021925819665695/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819665695/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083753767","display_name":"Atsuhiro Kanayama","orcid":"https://orcid.org/0009-0002-2250-1503","observed_orcids":["https://orcid.org/0009-0002-2250-1503"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuhiro Kanayama","raw_affiliation_strings":["Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058632940","display_name":"Jun\u2010ichiro Inoue","orcid":"https://orcid.org/0000-0001-6389-7036","observed_orcids":["https://orcid.org/0000-0001-6389-7036"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun-ichiro Inoue","raw_affiliation_strings":["Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083361633","display_name":"Yoshioko Sugita-Konishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshioko Sugita-Konishi","raw_affiliation_strings":["**Department of Biomedical Food Research, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"**Department of Biomedical Food Research, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan","institution_ids":["https://openalex.org/I4210086300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024068935","display_name":"Makoto Shimizu","orcid":"https://orcid.org/0000-0003-0467-9594","observed_orcids":["https://orcid.org/0000-0003-0467-9594"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Shimizu","raw_affiliation_strings":["Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016833897","display_name":"Yusei Miyamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yusei Miyamoto","raw_affiliation_strings":["Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016833897"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.2679,"has_fulltext":true,"cited_by_count":149,"citation_normalized_percentile":{"value":0.93108253,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"277","issue":"27","first_page":"24049","last_page":"24056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/taurine-chloramine","display_name":"taurine chloramine","score":0.843999981880188},{"id":"https://openalex.org/keywords/ikappabalpha","display_name":"I\u03baB\u03b1","score":0.8299999833106995},{"id":"https://openalex.org/keywords/methionine-oxidation","display_name":"methionine oxidation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.7839999794960022},{"id":"https://openalex.org/keywords/ikappab-kinase","display_name":"I\u03baB kinase","score":0.8970000147819519},{"id":"https://openalex.org/keywords/protein-oxidation","display_name":"protein oxidation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9490000009536743},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8450000286102295},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9350000023841858},{"id":"https://openalex.org/keywords/inflammation-reduction","display_name":"inflammation reduction","score":0.5709999799728394},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.781000018119812},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6776558756828308},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6302667856216431},{"id":"https://openalex.org/C2779701627","wikidata":"https://www.wikidata.org/wiki/Q207051","display_name":"Taurine","level":3,"score":0.5466409921646118},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.5035342574119568},{"id":"https://openalex.org/C2779730028","wikidata":"https://www.wikidata.org/wiki/Q15325101","display_name":"I\u03baB\u03b1","level":4,"score":0.4676976203918457},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.45843276381492615},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4361407160758972},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.4223713278770447},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3909503221511841},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.3199692964553833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19385787844657898},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.16831716895103455},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.14727145433425903},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013654","descriptor_name":"Taurine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013654","descriptor_name":"Taurine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015345","descriptor_name":"Oligonucleotide Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m110832200","doi":"https://doi.org/10.1074/jbc.m110832200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110832200","pdf_url":"http://www.jbc.org/article/S0021925819665695/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11983684","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11983684","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m110832200","doi":"https://doi.org/10.1074/jbc.m110832200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110832200","pdf_url":"http://www.jbc.org/article/S0021925819665695/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2033761996.pdf","grobid_xml":"https://content.openalex.org/works/W2033761996.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W97463538","https://openalex.org/W622716335","https://openalex.org/W989016558","https://openalex.org/W1509729044","https://openalex.org/W1548089074","https://openalex.org/W1775749144","https://openalex.org/W1958167223","https://openalex.org/W1981398931","https://openalex.org/W1998763047","https://openalex.org/W2010917922","https://openalex.org/W2016730049","https://openalex.org/W2018571781","https://openalex.org/W2021191809","https://openalex.org/W2023877008","https://openalex.org/W2024449277","https://openalex.org/W2042537047","https://openalex.org/W2046703464","https://openalex.org/W2051914105","https://openalex.org/W2057093252","https://openalex.org/W2060804489","https://openalex.org/W2064664882","https://openalex.org/W2070853191","https://openalex.org/W2075836508","https://openalex.org/W2077799657","https://openalex.org/W2085837280","https://openalex.org/W2093551079","https://openalex.org/W2095019663","https://openalex.org/W2127167914","https://openalex.org/W2134598541","https://openalex.org/W2135110724","https://openalex.org/W2144838215","https://openalex.org/W2177909750","https://openalex.org/W2411875378","https://openalex.org/W2414094150","https://openalex.org/W4230901874","https://openalex.org/W7098235620"],"related_works":["https://openalex.org/W2088532361","https://openalex.org/W2144838215","https://openalex.org/W2116161116","https://openalex.org/W188636114","https://openalex.org/W1985408494","https://openalex.org/W2050993447","https://openalex.org/W610618952","https://openalex.org/W2000302315","https://openalex.org/W65571157","https://openalex.org/W3041441972"],"abstract_inverted_index":{"A":[0,95,159],"band":[1,70,109,161],"shift":[2,71,110,162],"of":[3,43,72,84,97,146,156],"IkappaBalpha":[4,73,98,147],"was":[5,101,130,163],"observed":[6,164],"in":[7,116,134,200],"Western":[8],"blots":[9],"with":[10,14,137,172,185],"Jurkat":[11],"cells":[12,135,167],"treated":[13,171],"1":[15,21],"mm":[16],"taurine":[17,188,193],"chloramine":[18],"(TauCl)":[19],"for":[20,177],"h.":[22],"TauCl":[23,36,65,92,112],"treatment":[24,113],"inhibited":[25],"tumor":[26],"necrosis":[27],"factor":[28,32],"alpha":[29],"(TNFalpha)-initiated":[30],"nuclear":[31],"kappaB":[33],"(NF-kappaB)":[34],"activation.":[35,158],"did":[37,52,105],"not":[38,106,131],"inhibit":[39,53],"either":[40],"the":[41,69,153],"upstream":[42],"IkappaB":[44],"kinase":[45],"(IKK)":[46],"activation":[47,55],"or":[48],"IKK":[49,58],"itself":[50],"but":[51],"NF-kappaB":[54,157],"induced":[56],"by":[57],"overexpression.":[59],"Deletion":[60],"experiments":[61],"showed":[62],"that":[63,91,126,143],"a":[64,85,108,122,149],"modification":[66],"site":[67],"causing":[68],"is":[74,148],"Met45.":[75,94],"High":[76],"performance":[77],"liquid":[78],"chromatography":[79],"and":[80,114],"mass":[81],"spectrometry":[82],"analyses":[83],"small":[86],"peptide":[87],"containing":[88],"Met45":[89,100,144],"revealed":[90,125],"oxidizes":[93],"mutant":[96],"whose":[99],"converted":[102],"to":[103,118],"alanine":[104],"generate":[107],"upon":[111],"degraded":[115],"response":[117],"TNFalpha":[119],"stimulation.":[120],"However,":[121],"reporter":[123],"assay":[124],"NF-kappaB-dependent":[127],"luciferase":[128],"expression":[129],"fully":[132],"recovered":[133],"transfected":[136],"this":[138],"mutant.":[139],"These":[140],"results":[141],"indicate":[142],"oxidation":[145],"molecular":[150],"mechanism":[151],"underlying":[152],"TauCl-induced":[154],"inhibition":[155],"similar":[160],"when":[165],"HL-60":[166],"expressing":[168],"myeloperoxidase":[169],"were":[170,183],"100":[173],"microm":[174],"hydrogen":[175],"peroxide":[176],"5":[178],"min.":[179],"When":[180],"rat":[181],"neutrophils":[182],"incubated":[184],"bacteria,":[186],"intracellular":[187],"decreased":[189],"interleukin-8":[190],"production.":[191],"Therefore,":[192],"may":[194],"help":[195],"suppress":[196],"excessive":[197],"inflammatory":[198],"reaction":[199],"neutrophils.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
