{"id":"https://openalex.org/W2033754833","doi":"https://doi.org/10.2165/00002018-200225110-00004","title":"Benefits and Risks of Pharmacotherapy for Narcolepsy","display_name":"Benefits and Risks of Pharmacotherapy for Narcolepsy","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2033754833","doi":"https://doi.org/10.2165/00002018-200225110-00004","mag":"2033754833","pmid":"https://pubmed.ncbi.nlm.nih.gov/12222990"},"language":"en","primary_location":{"id":"doi:10.2165/00002018-200225110-00004","doi":"https://doi.org/10.2165/00002018-200225110-00004","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00002018-200225110-00004","pdf_url":null,"source":{"id":"https://openalex.org/S49488433","display_name":"Drug Safety","issn_l":"0114-5916","issn":["0114-5916","1179-1942"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Safety","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078557072","display_name":"Merrill M. Mitler","orcid":"https://orcid.org/0000-0002-7829-880X","observed_orcids":["https://orcid.org/0000-0002-7829-880X"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Merrill M. Mitler","raw_affiliation_strings":["Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA. mitler@scripps.edu","Department of Neuropharmacology,, The Scripps Research Institute,, La Jolla,, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA. mitler@scripps.edu","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Neuropharmacology,, The Scripps Research Institute,, La Jolla,, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110234410","display_name":"Roza Hayduk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roza Hayduk","raw_affiliation_strings":["Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA","Department of Neuropharmacology,, The Scripps Research Institute,, La Jolla,, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Neuropharmacology,, The Scripps Research Institute,, La Jolla,, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078557072"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.2858,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.32026144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"25","issue":"11","first_page":"791","last_page":"809"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/narcolepsy","display_name":"narcolepsy","score":1.0},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/modafinil","display_name":"modafinil","score":0.8769999742507935},{"id":"https://openalex.org/keywords/sodium-oxybate","display_name":"sodium oxybate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/psychostimulants","display_name":"psychostimulants","score":0.9089999794960022},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cataplexy","display_name":"cataplexy","score":0.9700000286102295},{"id":"https://openalex.org/keywords/excessive-daytime-sleepiness","display_name":"excessive daytime sleepiness","score":0.9750000238418579},{"id":"https://openalex.org/keywords/risk-benefit-assessment","display_name":"risk-benefit assessment","score":0.7509999871253967},{"id":"https://openalex.org/keywords/traffic-accidents","display_name":"traffic accidents","score":0.5740000009536743},{"id":"https://openalex.org/keywords/occupational-safety","display_name":"occupational safety","score":0.5270000100135803},{"id":"https://openalex.org/keywords/polysomnography","display_name":"polysomnography","score":0.7450000047683716},{"id":"https://openalex.org/keywords/multiple-sleep-latency-test","display_name":"multiple sleep latency test","score":0.7820000052452087},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2779494582","wikidata":"https://www.wikidata.org/wiki/Q189561","display_name":"Narcolepsy","level":3,"score":0.9738180637359619},{"id":"https://openalex.org/C2780163352","wikidata":"https://www.wikidata.org/wiki/Q944473","display_name":"Cataplexy","level":4,"score":0.9469231367111206},{"id":"https://openalex.org/C2780714222","wikidata":"https://www.wikidata.org/wiki/Q410441","display_name":"Modafinil","level":2,"score":0.890264630317688},{"id":"https://openalex.org/C2777133385","wikidata":"https://www.wikidata.org/wiki/Q486851","display_name":"Sleep paralysis","level":5,"score":0.7859890460968018},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7776756882667542},{"id":"https://openalex.org/C2781433485","wikidata":"https://www.wikidata.org/wiki/Q3144201","display_name":"Excessive daytime sleepiness","level":4,"score":0.6151115298271179},{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.5857475996017456},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.5605836510658264},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.5128307938575745},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.4626627266407013},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3727285861968994},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3565335273742676},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35121434926986694},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.28857263922691345},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.10813379287719727},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009290","descriptor_name":"Narcolepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009290","descriptor_name":"Narcolepsy","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D009290","descriptor_name":"Narcolepsy","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009290","descriptor_name":"Narcolepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2165/00002018-200225110-00004","doi":"https://doi.org/10.2165/00002018-200225110-00004","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00002018-200225110-00004","pdf_url":null,"source":{"id":"https://openalex.org/S49488433","display_name":"Drug Safety","issn_l":"0114-5916","issn":["0114-5916","1179-1942"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Safety","raw_type":"journal-article"},{"id":"pmid:12222990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12222990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug safety","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1655645242","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR000833","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8499994297","display_name":"NARCOLEPSY--MULTICENTER GENETIC AND FAMILY STUDY","funder_award_id":"R01NS037571","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W10873845","https://openalex.org/W24259209","https://openalex.org/W26111232","https://openalex.org/W37427538","https://openalex.org/W43053740","https://openalex.org/W44752123","https://openalex.org/W63471172","https://openalex.org/W78749887","https://openalex.org/W83603467","https://openalex.org/W112788469","https://openalex.org/W118116533","https://openalex.org/W580412617","https://openalex.org/W1490421201","https://openalex.org/W1519232679","https://openalex.org/W1521227715","https://openalex.org/W1538227282","https://openalex.org/W1554603143","https://openalex.org/W1808174417","https://openalex.org/W1865170399","https://openalex.org/W1973865770","https://openalex.org/W1974205580","https://openalex.org/W1977887519","https://openalex.org/W1982413389","https://openalex.org/W1983298714","https://openalex.org/W1985381738","https://openalex.org/W1990199913","https://openalex.org/W1997672805","https://openalex.org/W1997759379","https://openalex.org/W2006998897","https://openalex.org/W2007702485","https://openalex.org/W2007954852","https://openalex.org/W2013965517","https://openalex.org/W2016865305","https://openalex.org/W2019293768","https://openalex.org/W2020312260","https://openalex.org/W2024209529","https://openalex.org/W2031716644","https://openalex.org/W2035288859","https://openalex.org/W2040032939","https://openalex.org/W2040480454","https://openalex.org/W2049088920","https://openalex.org/W2049726998","https://openalex.org/W2051220203","https://openalex.org/W2052534401","https://openalex.org/W2060212263","https://openalex.org/W2060762262","https://openalex.org/W2061720038","https://openalex.org/W2066055512","https://openalex.org/W2067651484","https://openalex.org/W2070779251","https://openalex.org/W2072154498","https://openalex.org/W2073960829","https://openalex.org/W2074216166","https://openalex.org/W2083086230","https://openalex.org/W2086283225","https://openalex.org/W2086508456","https://openalex.org/W2087045789","https://openalex.org/W2089214977","https://openalex.org/W2111766101","https://openalex.org/W2130741672","https://openalex.org/W2154122353","https://openalex.org/W2157909194","https://openalex.org/W2162725175","https://openalex.org/W2169378022","https://openalex.org/W2213671166","https://openalex.org/W2315212772","https://openalex.org/W2318002795","https://openalex.org/W2337313447","https://openalex.org/W2346798935","https://openalex.org/W2394531688","https://openalex.org/W2395455653","https://openalex.org/W2397159289","https://openalex.org/W2398461622","https://openalex.org/W2400125656","https://openalex.org/W2405807915","https://openalex.org/W2409487943","https://openalex.org/W2412093045","https://openalex.org/W2414009862","https://openalex.org/W2419544619","https://openalex.org/W2436852462","https://openalex.org/W2478765828","https://openalex.org/W2551140411","https://openalex.org/W3025140791","https://openalex.org/W3112171551","https://openalex.org/W4233425579","https://openalex.org/W4238478934","https://openalex.org/W4248046254","https://openalex.org/W4248551691","https://openalex.org/W4250760906","https://openalex.org/W4255085174","https://openalex.org/W4285719527","https://openalex.org/W4290746517","https://openalex.org/W4299579025","https://openalex.org/W4407197727","https://openalex.org/W4407217914","https://openalex.org/W7125638685"],"related_works":["https://openalex.org/W43053740","https://openalex.org/W2515124545","https://openalex.org/W2071536043","https://openalex.org/W1994439753","https://openalex.org/W7052944890","https://openalex.org/W1999664103","https://openalex.org/W3043416388","https://openalex.org/W2003134712","https://openalex.org/W3134415109","https://openalex.org/W66840967"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}