{"id":"https://openalex.org/W2033735546","doi":"https://doi.org/10.1016/s0022-1759(03)00251-5","title":"Di-diabody: a novel tetravalent bispecific antibody molecule by design","display_name":"Di-diabody: a novel tetravalent bispecific antibody molecule by design","publication_year":2003,"publication_date":"2003-07-22","ids":{"openalex":"https://openalex.org/W2033735546","doi":"https://doi.org/10.1016/s0022-1759(03)00251-5","mag":"2033735546","pmid":"https://pubmed.ncbi.nlm.nih.gov/12969563"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-1759(03)00251-5","doi":"https://doi.org/10.1016/s0022-1759(03)00251-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-1759(03)00251-5","pdf_url":null,"source":{"id":"https://openalex.org/S201669150","display_name":"Journal of Immunological Methods","issn_l":"0022-1759","issn":["0022-1759","1872-7905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunological Methods","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101478993","display_name":"Dan Lu","orcid":"https://orcid.org/0000-0003-4718-3564","observed_orcids":["https://orcid.org/0000-0003-4718-3564"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Lu","raw_affiliation_strings":["Department of Antibody Technology, ImClone Systems Incorporated, New York, NY 10014, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Antibody Technology, ImClone Systems Incorporated, New York, NY 10014, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011301983","display_name":"Xenia Jimenez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xenia Jimenez","raw_affiliation_strings":["Department of Molecular and Cell Biology, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA","Department of Molecular and Cell Biology, ImClone Systems Inc., 180 Varick Street, New York, NY 10014, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular and Cell Biology, ImClone Systems Inc., 180 Varick Street, New York, NY 10014, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106133524","display_name":"Haifan Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haifan Zhang","raw_affiliation_strings":["Department of Antibody Technology, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Antibody Technology, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Amanda Atkins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda Atkins","raw_affiliation_strings":["Department of Antibody Technology, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Antibody Technology, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Laura Brennan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Brennan","raw_affiliation_strings":["Department of Molecular and Cell Biology, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA","Department of Molecular and Cell Biology, ImClone Systems Inc., 180 Varick Street, New York, NY 10014, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular and Cell Biology, ImClone Systems Inc., 180 Varick Street, New York, NY 10014, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079048970","display_name":"Paul J. Balderes","orcid":"https://orcid.org/0009-0008-4919-0390","observed_orcids":["https://orcid.org/0009-0008-4919-0390"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Balderes","raw_affiliation_strings":["Department of Protein Chemistry, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA","Department of Protein Chemistry, ImClone Systems Inc., 180 Varick Street, New York, NY 10014, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Chemistry, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Protein Chemistry, ImClone Systems Inc., 180 Varick Street, New York, NY 10014, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059035410","display_name":"Peter B\u00f6hlen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Bohlen","raw_affiliation_strings":["Department of Research, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA","Department of Research, ImClone Systems Inc., 180 Varick Street, New York, NY 10014, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Research, ImClone Systems Inc., 180 Varick Street, New York, NY 10014, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109922991","display_name":"Larry Witte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larry Witte","raw_affiliation_strings":["Department of Molecular and Cell Biology, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA","Department of Molecular and Cell Biology, ImClone Systems Inc., 180 Varick Street, New York, NY 10014, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular and Cell Biology, ImClone Systems Inc., 180 Varick Street, New York, NY 10014, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102120005","display_name":"Zhenping Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zhenping Zhu","raw_affiliation_strings":["Department of Antibody Technology, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Antibody Technology, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5102120005"],"corresponding_institution_ids":[],"apc_list":{"value":2970,"currency":"USD","value_usd":2970},"apc_paid":null,"fwci":1.038,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.74293817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"279","issue":"1-2","first_page":"219","last_page":"232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.6200000047683716},{"id":"https://openalex.org/keywords/diabodies","display_name":"diabodies","score":0.9179999828338623},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor-receptor","display_name":"vascular endothelial growth factor receptor","score":0.7620000243186951},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.7149999737739563},{"id":"https://openalex.org/keywords/antibody-dimerization","display_name":"antibody dimerization","score":0.6600000262260437},{"id":"https://openalex.org/keywords/recombinant-antibody-production","display_name":"recombinant antibody production","score":0.7979999780654907},{"id":"https://openalex.org/keywords/antibody-stability","display_name":"antibody stability","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.855816662311554},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6458810567855835},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6263830661773682},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5736380815505981},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5539599061012268},{"id":"https://openalex.org/C74884574","wikidata":"https://www.wikidata.org/wiki/Q171407","display_name":"Divalent","level":2,"score":0.5470690131187439},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.438326358795166},{"id":"https://openalex.org/C2909223937","wikidata":"https://www.wikidata.org/wiki/Q909628","display_name":"Immunoglobulin Fab Fragments","level":5,"score":0.42840901017189026},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4215962290763855},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.41988325119018555},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.41849592328071594},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3926781713962555},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3890003561973572},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3262903094291687},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.19692739844322205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.105460524559021},{"id":"https://openalex.org/C85630698","wikidata":"https://www.wikidata.org/wiki/Q3826179","display_name":"Complementarity determining region","level":4,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043925","descriptor_name":"Angiogenesis Inducing Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-1759(03)00251-5","doi":"https://doi.org/10.1016/s0022-1759(03)00251-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-1759(03)00251-5","pdf_url":null,"source":{"id":"https://openalex.org/S201669150","display_name":"Journal of Immunological Methods","issn_l":"0022-1759","issn":["0022-1759","1872-7905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunological Methods","raw_type":"journal-article"},{"id":"pmid:12969563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12969563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunological methods","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7703999876976013,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W10594096","https://openalex.org/W1485875137","https://openalex.org/W1517969155","https://openalex.org/W1546278532","https://openalex.org/W1592045168","https://openalex.org/W1959801065","https://openalex.org/W1970053353","https://openalex.org/W1975097310","https://openalex.org/W1982058902","https://openalex.org/W1983447668","https://openalex.org/W1984344157","https://openalex.org/W1985031636","https://openalex.org/W1988655450","https://openalex.org/W1996808366","https://openalex.org/W1996820981","https://openalex.org/W2001483547","https://openalex.org/W2003052374","https://openalex.org/W2006974596","https://openalex.org/W2010934866","https://openalex.org/W2012719421","https://openalex.org/W2018227703","https://openalex.org/W2033689496","https://openalex.org/W2035154199","https://openalex.org/W2035181064","https://openalex.org/W2044035096","https://openalex.org/W2053428753","https://openalex.org/W2060609324","https://openalex.org/W2065307898","https://openalex.org/W2069402857","https://openalex.org/W2074598941","https://openalex.org/W2079876729","https://openalex.org/W2081327537","https://openalex.org/W2081732271","https://openalex.org/W2085025484","https://openalex.org/W2085317767","https://openalex.org/W2086146164","https://openalex.org/W2100525694","https://openalex.org/W2107386887","https://openalex.org/W2110466399","https://openalex.org/W2111823261","https://openalex.org/W2123386346","https://openalex.org/W2143477049","https://openalex.org/W2150361111","https://openalex.org/W2166777850","https://openalex.org/W6681213273"],"related_works":["https://openalex.org/W2416416983","https://openalex.org/W2025779348","https://openalex.org/W2931445906","https://openalex.org/W2005969425","https://openalex.org/W1996808366","https://openalex.org/W2085317767","https://openalex.org/W2005110237","https://openalex.org/W1993046790","https://openalex.org/W2053428753","https://openalex.org/W2246431659"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
