{"id":"https://openalex.org/W2033716824","doi":"https://doi.org/10.1111/j.1471-4159.1984.tb02684.x","title":"Hormones and Neurotransmitters Control Cyclic AMP Metabolism in Choroid Plexus Epithelial Cells","display_name":"Hormones and Neurotransmitters Control Cyclic AMP Metabolism in Choroid Plexus Epithelial Cells","publication_year":1984,"publication_date":"1984-02-01","ids":{"openalex":"https://openalex.org/W2033716824","doi":"https://doi.org/10.1111/j.1471-4159.1984.tb02684.x","mag":"2033716824","pmid":"https://pubmed.ncbi.nlm.nih.gov/6198461"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.1984.tb02684.x","doi":"https://doi.org/10.1111/j.1471-4159.1984.tb02684.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1984.tb02684.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028803906","display_name":"Richard B. Crook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard B. Crook","raw_affiliation_strings":["Departments of Neurology and Biochemistry and Biophysics, University of California, San Francisco, California, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Biochemistry and Biophysics, University of California, San Francisco, California, U.S.A","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044944532","display_name":"Michael B. Farber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Farber","raw_affiliation_strings":["Departments of Neurology and Biochemistry and Biophysics, University of California, San Francisco, California, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Biochemistry and Biophysics, University of California, San Francisco, California, U.S.A","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066991343","display_name":"Stanley B. Prusiner","orcid":"https://orcid.org/0000-0003-1955-5498","observed_orcids":["https://orcid.org/0000-0003-1955-5498"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley B. Prusiner","raw_affiliation_strings":["Departments of Neurology and Biochemistry and Biophysics, University of California, San Francisco, California, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Biochemistry and Biophysics, University of California, San Francisco, California, U.S.A","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028803906"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":4.247,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.93939716,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"42","issue":"2","first_page":"340","last_page":"350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/choroid-plexus-epithelial-cells","display_name":"choroid plexus epithelial cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cyclic-amp-metabolism","display_name":"cyclic AMP metabolism","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cholera-toxin","display_name":"cholera toxin","score":0.7409999966621399},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.968999981880188},{"id":"https://openalex.org/keywords/prostaglandin-e1","display_name":"prostaglandin E1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.996999979019165},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":1.0},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.6639999747276306},{"id":"https://openalex.org/keywords/diphenhydramine","display_name":"diphenhydramine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/metiamide","display_name":"metiamide","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hormone-receptors","display_name":"hormone receptors","score":0.5019999742507935},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-production","display_name":"cerebrospinal fluid production","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.7964690923690796},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7476128935813904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7380701303482056},{"id":"https://openalex.org/C2776538271","wikidata":"https://www.wikidata.org/wiki/Q926250","display_name":"Choroid plexus","level":3,"score":0.6245015263557434},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5454611778259277},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4738224744796753},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.4572848677635193},{"id":"https://openalex.org/C2777198256","wikidata":"https://www.wikidata.org/wiki/Q4860325","display_name":"Prostaglandin E","level":2,"score":0.45559975504875183},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.4406149983406067},{"id":"https://openalex.org/C2779837120","wikidata":"https://www.wikidata.org/wiki/Q579348","display_name":"Prostaglandin E1","level":2,"score":0.43207675218582153},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42141464352607727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.400905579328537},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24629321694374084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17376282811164856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1416020691394806},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002831","descriptor_name":"Choroid Plexus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015056","descriptor_name":"1-Methyl-3-isobutylxanthine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.1984.tb02684.x","doi":"https://doi.org/10.1111/j.1471-4159.1984.tb02684.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1984.tb02684.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:6198461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6198461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W173393522","https://openalex.org/W622893658","https://openalex.org/W1510715764","https://openalex.org/W1518913349","https://openalex.org/W1555121428","https://openalex.org/W1775749144","https://openalex.org/W1898796296","https://openalex.org/W1969198649","https://openalex.org/W1978064025","https://openalex.org/W1979700521","https://openalex.org/W1980182029","https://openalex.org/W1983912620","https://openalex.org/W1984136894","https://openalex.org/W1984175759","https://openalex.org/W1988278859","https://openalex.org/W1988403106","https://openalex.org/W1992066360","https://openalex.org/W1993398213","https://openalex.org/W1996740012","https://openalex.org/W2004949747","https://openalex.org/W2023721239","https://openalex.org/W2024210337","https://openalex.org/W2027994501","https://openalex.org/W2028594746","https://openalex.org/W2029450533","https://openalex.org/W2032242639","https://openalex.org/W2034748546","https://openalex.org/W2037918689","https://openalex.org/W2039910426","https://openalex.org/W2048402218","https://openalex.org/W2050031563","https://openalex.org/W2053755284","https://openalex.org/W2055684364","https://openalex.org/W2071233611","https://openalex.org/W2074949244","https://openalex.org/W2077816523","https://openalex.org/W2079002943","https://openalex.org/W2083976364","https://openalex.org/W2085839596","https://openalex.org/W2102131116","https://openalex.org/W2107003838","https://openalex.org/W2117833280","https://openalex.org/W2124466449","https://openalex.org/W2136687006","https://openalex.org/W2160061090","https://openalex.org/W2190785305","https://openalex.org/W2331879894","https://openalex.org/W2341541642","https://openalex.org/W2414504366","https://openalex.org/W3001853319","https://openalex.org/W4300845805","https://openalex.org/W6657148684"],"related_works":["https://openalex.org/W2190785305","https://openalex.org/W2051932518","https://openalex.org/W2082418032","https://openalex.org/W2029450533","https://openalex.org/W2155894069","https://openalex.org/W2050360404","https://openalex.org/W2023721239","https://openalex.org/W2122934214","https://openalex.org/W2034740511","https://openalex.org/W42396258"],"abstract_inverted_index":{"The":[0,97],"choroid":[1,15,163,216],"plexus":[2,16,164],"is":[3],"a":[4,26,185,194],"major":[5],"site":[6],"of":[7,13,29,39,58,62,99,130,174,187,197,207,214],"CSF":[8],"production.":[9],"When":[10],"primary":[11],"cultures":[12],"bovine":[14],"epithelial":[17,212],"cells":[18,40,213],"were":[19,74],"exposed":[20],"to":[21,41,71,80,183],"1":[22,35],"micrograms/ml":[23],"cholera":[24],"toxin,":[25],"50-fold":[27],"increase":[28],"intracellular":[30,59,189],"cyclic":[31,60,94,100,126,143,175,190,208],"AMP":[32,95,101,127,144,176,191,209],"was":[33,181],"found":[34,182],"h":[36],"later.":[37],"Exposure":[38],"10(-5)":[42,49,53],"M":[43,46,50,54],"isoproterenol,":[44,131,168],"10(-4)":[45],"prostaglandin":[47,132,169],"E1,":[48,133,170],"histamine,":[51,134],"and":[52,66,88,115,135,171],"serotonin":[55,136,150],"caused":[56],"increases":[57],"concentrations":[61],"100-,":[63],"50-,":[64],"20-,":[65],"4-fold,":[67],"respectively.":[68],"From":[69],"5":[70],"15":[72],"min":[73],"required":[75],"for":[76,167,204],"these":[77],"maximal":[78],"responses":[79,139],"occur.":[81],"Many":[82],"other":[83],"molecules":[84],"including":[85],"prolactin,":[86],"vasopressin,":[87],"corticotropin":[89],"did":[90],"not":[91],"alter":[92],"cellular":[93],"levels.":[96],"accumulation":[98,145],"could":[102],"be":[103,184],"inhibited":[104,109,117,124,151],"by":[105,142],"specific":[106],"antagonists:":[107],"propranolol":[108],"the":[110,118,152,178,188,215],"isoproterenol-mediated":[111],"stimulation":[112],"while":[113],"diphenhydramine":[114,123],"metiamide":[116],"histamine":[119,153],"response.":[120,154],"In":[121],"addition,":[122],"serotonin-dependent":[125],"accumulation.":[128],"Combinations":[129],"elicited":[137],"additive":[138],"as":[140],"measured":[141],"with":[146],"one":[147],"exception,":[148],"i.e.,":[149],"Our":[155,199],"findings":[156],"suggest":[157],"that":[158],"distinct":[159],"receptor":[160],"sites":[161],"on":[162],"epithelia":[165],"exist":[166],"histamine.":[172],"Efflux":[173],"into":[177],"extracellular":[179],"medium":[180],"function":[186],"levels":[192],"over":[193],"wide":[195],"range":[196],"concentrations.":[198],"studies":[200],"provide":[201],"direct":[202],"evidence":[203],"hormonal":[205],"regulation":[206],"metabolism":[210],"in":[211],"plexus.":[217]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}