{"id":"https://openalex.org/W2033704607","doi":"https://doi.org/10.4330/wjc.v5.i7.261","title":"Berberine behind the thriller of marked symptomatic bradycardia","display_name":"Berberine behind the thriller of marked symptomatic bradycardia","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2033704607","doi":"https://doi.org/10.4330/wjc.v5.i7.261","mag":"2033704607","pmid":"https://pubmed.ncbi.nlm.nih.gov/23888197","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3722425"},"language":"en","primary_location":{"id":"doi:10.4330/wjc.v5.i7.261","doi":"https://doi.org/10.4330/wjc.v5.i7.261","is_oa":true,"landing_page_url":"https://doi.org/10.4330/wjc.v5.i7.261","pdf_url":"https://www.wjgnet.com/1949-8462/full/v5/i7/261.htm","source":{"id":"https://openalex.org/S78385471","display_name":"World Journal of Cardiology","issn_l":"1949-8462","issn":["1949-8462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.wjgnet.com/1949-8462/full/v5/i7/261.htm","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028249939","display_name":"Margherita Cannillo","orcid":"https://orcid.org/0009-0008-6579-9040","observed_orcids":["https://orcid.org/0009-0008-6579-9040"]},"institutions":[{"id":"https://openalex.org/I4210097265","display_name":"Azienda Ospedaliero Universitaria San Giovanni Battista","ror":"https://ror.org/00nrtez23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097265"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Margherita Cannillo","raw_affiliation_strings":["Margherita Cannillo, Simone Frea, Cristina Fornengo, Elisabetta Toso, Fiorenzo Gaita, Division of Cardiology, Cardiovascular Department, AOU S. Giovanni Battista di Torino and University of Torino, 10100 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Margherita Cannillo, Simone Frea, Cristina Fornengo, Elisabetta Toso, Fiorenzo Gaita, Division of Cardiology, Cardiovascular Department, AOU S. Giovanni Battista di Torino and University of Torino, 10100 Torino, Italy","institution_ids":["https://openalex.org/I4210097265","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154466783","display_name":"Simone Frea","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simone Frea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056449621","display_name":"Cristina Fornengo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristina Fornengo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070655404","display_name":"Elisabetta Toso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisabetta Toso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161545652","display_name":"Giancarlo Mercurio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giancarlo Mercurio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111998187","display_name":"Stefania Battista","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefania Battista","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5161517479","display_name":"Fiorenzo Gaita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fiorenzo Gaita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028249939"],"corresponding_institution_ids":["https://openalex.org/I4210097265","https://openalex.org/I55143463"],"apc_list":null,"apc_paid":null,"fwci":2.0791,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.83790449,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"5","issue":"7","first_page":"261","last_page":"261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.6039999723434448,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.6039999723434448,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.25290000438690186,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.039799999445676804,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/berberine","display_name":"berberine","score":1.0},{"id":"https://openalex.org/keywords/drug-induced-bradycardia","display_name":"drug-induced bradycardia","score":0.8230000138282776},{"id":"https://openalex.org/keywords/sinus-bradycardia","display_name":"sinus bradycardia","score":0.8379999995231628},{"id":"https://openalex.org/keywords/first-degree-atrioventricular-block","display_name":"first-degree atrioventricular block","score":0.9089999794960022},{"id":"https://openalex.org/keywords/chronotropic-incompetence","display_name":"chronotropic incompetence","score":0.753000020980835},{"id":"https://openalex.org/keywords/drug-induced-arrhythmia","display_name":"drug-induced arrhythmia","score":0.8109999895095825},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.5820000171661377},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.847000002861023},{"id":"https://openalex.org/keywords/holter-monitoring","display_name":"Holter monitoring","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9282495975494385},{"id":"https://openalex.org/C2780116568","wikidata":"https://www.wikidata.org/wiki/Q176525","display_name":"Berberine","level":2,"score":0.8833319544792175},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.649943470954895},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6062514781951904},{"id":"https://openalex.org/C2777495988","wikidata":"https://www.wikidata.org/wiki/Q217111","display_name":"Bradycardia","level":4,"score":0.5595479011535645},{"id":"https://openalex.org/C2781235965","wikidata":"https://www.wikidata.org/wiki/Q2995544","display_name":"Sinus bradycardia","level":5,"score":0.5008480548858643},{"id":"https://openalex.org/C2775914520","wikidata":"https://www.wikidata.org/wiki/Q12335414","display_name":"Sinus rhythm","level":3,"score":0.4839463531970978},{"id":"https://openalex.org/C2779210884","wikidata":"https://www.wikidata.org/wiki/Q6311817","display_name":"Junctional rhythm","level":2,"score":0.4569895267486572},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.4376836121082306},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39690613746643066},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.2747310400009155},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.21713075041770935},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.08186608552932739},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.4330/wjc.v5.i7.261","doi":"https://doi.org/10.4330/wjc.v5.i7.261","is_oa":true,"landing_page_url":"https://doi.org/10.4330/wjc.v5.i7.261","pdf_url":"https://www.wjgnet.com/1949-8462/full/v5/i7/261.htm","source":{"id":"https://openalex.org/S78385471","display_name":"World Journal of Cardiology","issn_l":"1949-8462","issn":["1949-8462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Cardiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2714989","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3722425","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23888197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23888197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of cardiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3722425","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3722425/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Cardiol","raw_type":"Text"},{"id":"pmh:oai:iris.unito.it:2318/147344","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/147344","pdf_url":"https://iris.unito.it/bitstream/2318/147344/1/Berberine%20behind%20the%20thriller%20of%20marked%20symptomatic%20bradycardia.pdf","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3145629918","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/71417X/201307/1003032757.html","pdf_url":null,"source":{"id":"https://openalex.org/S78385471","display_name":"World Journal of Cardiology","issn_l":"1949-8462","issn":["1949-8462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e16\u754c\u5fc3\u810f\u75c5\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248\uff08\u7535\u5b50\u7248\uff09","raw_type":null}],"best_oa_location":{"id":"doi:10.4330/wjc.v5.i7.261","doi":"https://doi.org/10.4330/wjc.v5.i7.261","is_oa":true,"landing_page_url":"https://doi.org/10.4330/wjc.v5.i7.261","pdf_url":"https://www.wjgnet.com/1949-8462/full/v5/i7/261.htm","source":{"id":"https://openalex.org/S78385471","display_name":"World Journal of Cardiology","issn_l":"1949-8462","issn":["1949-8462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2033704607.pdf","grobid_xml":"https://content.openalex.org/works/W2033704607.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1966909652","https://openalex.org/W1983112400","https://openalex.org/W1984933590","https://openalex.org/W1990454475","https://openalex.org/W1998202198","https://openalex.org/W2015973798","https://openalex.org/W2060830816","https://openalex.org/W2063518321","https://openalex.org/W2074005494","https://openalex.org/W2076359557","https://openalex.org/W2076524420","https://openalex.org/W2086508705","https://openalex.org/W2086709102","https://openalex.org/W2097434120","https://openalex.org/W2130575832","https://openalex.org/W2137843059","https://openalex.org/W2148313399","https://openalex.org/W2153423786","https://openalex.org/W2218955956","https://openalex.org/W2363752655","https://openalex.org/W2793292756"],"related_works":["https://openalex.org/W7197011484","https://openalex.org/W2063518321","https://openalex.org/W1020105534","https://openalex.org/W2086508705","https://openalex.org/W2978078590","https://openalex.org/W4200407443","https://openalex.org/W2053792416","https://openalex.org/W2085874421","https://openalex.org/W4409565986","https://openalex.org/W2387050867"],"abstract_inverted_index":{"Patients":[0],"with":[1],"chronic":[2],"aortic":[3],"dissections":[4],"are":[5],"at":[6],"high":[7],"risk":[8],"of":[9,25,43,54,93,95,110,120,161],"catheter-induced":[10],"complications.":[11],"We":[12,39],"report":[13,40,144],"a":[14,35,41,44,117,135,162],"Berberine":[15],"is":[16,140],"used":[17],"in":[18,104,154,158,176],"traditional":[19],"Chinese":[20],"medicine":[21],"for":[22,51],"the":[23,52,91,105,114,141,159,181],"treatment":[24],"congestive":[26],"heart":[27],"failure,":[28],"hypertension,":[29],"diabetes,":[30],"and":[31,33,56,77,90,101,122,184],"dyslipidaemia":[32],"has":[34],"good":[36,128],"safety":[37],"profile.":[38],"case":[42,143],"53-year-old":[45],"sportsman":[46],"referred":[47],"to":[48,64,180,193],"our":[49],"hospital":[50],"onset":[53],"fatigue":[55],"dyspnoea":[57],"upon":[58],"exertion":[59],"after":[60],"he":[61],"started":[62],"berberine":[63,148],"treat":[65],"hypercholesterolaemia.":[66],"An":[67,81,131],"electrocardiogram":[68,132],"showed":[69,85,127,134],"sinus":[70,102],"bradycardia":[71],"(45":[72],"bpm),":[73],"first-degree":[74],"atrioventricular":[75],"block,":[76],"competitive":[78,96],"junctional":[79,97],"rhythm.":[80],"ergometric":[82,124],"stress":[83,125],"test":[84,126],"slightly":[86],"reduced":[87],"chronotropic":[88,129],"competence":[89],"presence":[92],"runs":[94],"rhythm,":[98],"atrial":[99],"tachycardia,":[100],"pauses":[103],"recovery.":[106],"After":[107],"10":[108],"d":[109],"wash-out":[111],"from":[112],"berberine,":[113],"patient":[115],"experienced":[116],"complete":[118],"resolution":[119],"symptoms,":[121],"an":[123],"competence.":[130],"Holter":[133],"latent":[136],"hypervagotonic":[137,155,177],"state.":[138],"This":[139],"first":[142],"that":[145,147,164],"shows":[146],"could":[149,165,188],"present":[150],"certain":[151],"side":[152],"effects":[153],"people,":[156],"even":[157],"absence":[160],"situation":[163],"cause":[166],"drug":[167],"accumulation.":[168],"Therefore,":[169],"berberine's":[170],"use":[171],"should":[172],"be":[173],"carefully":[174],"weighed":[175],"people":[178],"due":[179],"drug's":[182],"bradycardic":[183],"antiarrhythmic":[185],"properties,":[186],"which":[187],"became":[189],"proarrhythmic,":[190],"exposing":[191],"patients":[192],"potential":[194],"health":[195],"risks.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}