{"id":"https://openalex.org/W2033703236","doi":"https://doi.org/10.1167/iovs.08-3193","title":"Oxidative Stress-Mediated Induction of MMP-1 and MMP-3 in Human RPE Cells","display_name":"Oxidative Stress-Mediated Induction of MMP-1 and MMP-3 in Human RPE Cells","publication_year":2009,"publication_date":"2009-11-01","ids":{"openalex":"https://openalex.org/W2033703236","doi":"https://doi.org/10.1167/iovs.08-3193","mag":"2033703236","pmid":"https://pubmed.ncbi.nlm.nih.gov/19516002"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.08-3193","doi":"https://doi.org/10.1167/iovs.08-3193","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.08-3193","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041342462","display_name":"Claudia Priglinger","orcid":"https://orcid.org/0000-0003-1847-3626","observed_orcids":["https://orcid.org/0000-0003-1847-3626"]},"institutions":[{"id":"https://openalex.org/I4210161393","display_name":"Gespag","ror":"https://ror.org/05rtd6p98","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210161393"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["AT","DE"],"is_corresponding":true,"raw_author_name":"Claudia S. Alge-Priglinger","raw_affiliation_strings":["From the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; the 2Department of Ophthalmology, Linz General Hospital, Linz, Austria; and the","Department of Ophthalmology, Linz General Hospital, Linz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; the 2Department of Ophthalmology, Linz General Hospital, Linz, Austria; and the","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Department of Ophthalmology, Linz General Hospital, Linz, Austria","institution_ids":["https://openalex.org/I4210161393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007253052","display_name":"Thomas Christian Kreutzer","orcid":"https://orcid.org/0000-0003-3684-8145","observed_orcids":["https://orcid.org/0000-0003-3684-8145"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas Kreutzer","raw_affiliation_strings":["From the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; the","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061726738","display_name":"Katja Obholzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Katja Obholzer","raw_affiliation_strings":["From the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; the","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075076772","display_name":"Armin Wolf","orcid":"https://orcid.org/0000-0002-6991-2214","observed_orcids":["https://orcid.org/0000-0002-6991-2214"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Armin Wolf","raw_affiliation_strings":["From the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; the","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064876381","display_name":"Martin Mempel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Martin Mempel","raw_affiliation_strings":["Department of Dermatology and Allergy, Technical University Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Allergy, Technical University Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051825660","display_name":"Marcus Kernt","orcid":"https://orcid.org/0000-0002-8390-5520","observed_orcids":["https://orcid.org/0000-0002-8390-5520"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Marcus Kernt","raw_affiliation_strings":["From the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; the","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038996603","display_name":"Anselm Kampik","orcid":"https://orcid.org/0000-0001-6801-7114","observed_orcids":["https://orcid.org/0000-0001-6801-7114"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Anselm Kampik","raw_affiliation_strings":["From the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; the","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083191480","display_name":"Siegfried Georg Priglinger","orcid":"https://orcid.org/0000-0002-5580-612X","observed_orcids":["https://orcid.org/0000-0002-5580-612X"]},"institutions":[{"id":"https://openalex.org/I4210161393","display_name":"Gespag","ror":"https://ror.org/05rtd6p98","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210161393"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["AT","DE"],"is_corresponding":true,"raw_author_name":"Siegfried G. Priglinger","raw_affiliation_strings":["From the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; the 2Department of Ophthalmology, Linz General Hospital, Linz, Austria; and the","Department of Ophthalmology, Linz General Hospital, Linz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; the 2Department of Ophthalmology, Linz General Hospital, Linz, Austria; and the","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Department of Ophthalmology, Linz General Hospital, Linz, Austria","institution_ids":["https://openalex.org/I4210161393"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007253052","https://openalex.org/A5038996603","https://openalex.org/A5041342462","https://openalex.org/A5051825660","https://openalex.org/A5061726738","https://openalex.org/A5064876381","https://openalex.org/A5075076772","https://openalex.org/A5083191480"],"corresponding_institution_ids":["https://openalex.org/I4210161393","https://openalex.org/I62916508","https://openalex.org/I8204097"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":3.1883,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.90346091,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"50","issue":"11","first_page":"5495","last_page":"5495"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.19529999792575836,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":1.0},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9679999947547913},{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.9150000214576721},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/bruch-s-membrane","display_name":"Bruch's membrane","score":0.9120000004768372},{"id":"https://openalex.org/keywords/type-i-collagen-degradation","display_name":"type I collagen degradation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8360000252723694},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9559999704360962},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.8550000190734863},{"id":"https://openalex.org/keywords/choroidal-neovascularization","display_name":"choroidal neovascularization","score":0.843999981880188},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.7450000047683716},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.7972214221954346},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7530828714370728},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.7371398210525513},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5723598599433899},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5377981662750244},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5195134878158569},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4549850523471832},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4451352059841156},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3848031163215637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3623211681842804},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.3220052719116211},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24697309732437134}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020781","descriptor_name":"Matrix Metalloproteinase 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D020781","descriptor_name":"Matrix Metalloproteinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D061965","descriptor_name":"Matrix Metalloproteinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1167/iovs.08-3193","doi":"https://doi.org/10.1167/iovs.08-3193","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.08-3193","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},{"id":"pmid:19516002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19516002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/978113","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/978113","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W13188211","https://openalex.org/W119546037","https://openalex.org/W1505132263","https://openalex.org/W1531139060","https://openalex.org/W1533267622","https://openalex.org/W1541399905","https://openalex.org/W1607763659","https://openalex.org/W1653551216","https://openalex.org/W1871154760","https://openalex.org/W1935587632","https://openalex.org/W1983729225","https://openalex.org/W1986010238","https://openalex.org/W1989948570","https://openalex.org/W1992981081","https://openalex.org/W1993936029","https://openalex.org/W1993963021","https://openalex.org/W1998487825","https://openalex.org/W2014481298","https://openalex.org/W2016272097","https://openalex.org/W2017009693","https://openalex.org/W2017215522","https://openalex.org/W2018642709","https://openalex.org/W2020866554","https://openalex.org/W2025124971","https://openalex.org/W2028065796","https://openalex.org/W2032181734","https://openalex.org/W2042082129","https://openalex.org/W2045292202","https://openalex.org/W2045403409","https://openalex.org/W2045601200","https://openalex.org/W2048636094","https://openalex.org/W2049086577","https://openalex.org/W2054746252","https://openalex.org/W2063641138","https://openalex.org/W2070082813","https://openalex.org/W2071359561","https://openalex.org/W2074141889","https://openalex.org/W2077123765","https://openalex.org/W2080600302","https://openalex.org/W2083769234","https://openalex.org/W2087530988","https://openalex.org/W2090554202","https://openalex.org/W2097708243","https://openalex.org/W2109623522","https://openalex.org/W2112564853","https://openalex.org/W2116670685","https://openalex.org/W2118679449","https://openalex.org/W2126376064","https://openalex.org/W2144839999","https://openalex.org/W2166321381","https://openalex.org/W2171003020","https://openalex.org/W2217612888","https://openalex.org/W2220195887","https://openalex.org/W2312259609","https://openalex.org/W2325814183","https://openalex.org/W2417015271"],"related_works":["https://openalex.org/W2036947311","https://openalex.org/W2986679095","https://openalex.org/W2991611632","https://openalex.org/W4312080426","https://openalex.org/W4380853165","https://openalex.org/W15330144","https://openalex.org/W7219294923","https://openalex.org/W2036009934","https://openalex.org/W3012203653","https://openalex.org/W2082325637"],"abstract_inverted_index":{"PURPOSE:":[0],"In":[1],"early":[2,257],"exudative":[3,258],"age-related":[4],"macular":[5],"degeneration":[6],"(AMD),":[7],"segmental":[8],"thinning":[9],"of":[10,17,51,66,83,111,147,158,170,180,256],"Bruch's":[11,67],"membrane":[12],"is":[13,28,238],"associated":[14,239],"with":[15,61,90,155,207,240],"ingrowth":[16],"choroidal":[18],"neovascularization":[19],"into":[20],"the":[21,40,44,49,81,91,222,235,254],"subretinal":[22],"space.":[23],"To":[24,79],"determine":[25],"whether":[26],"there":[27],"a":[29,208,212],"link":[30],"between":[31],"oxidative":[32,52,77,153,229],"stress":[33,53,132,154],"and":[34,56,99,106,135,149,161,219],"extracellular":[35],"matrix":[36],"(ECM)":[37],"degradation":[38,120,198],"by":[39,103,108,115,121,127,190,199,204,228],"retinal":[41,122,223],"pigment":[42,123,224],"epithelium,":[43],"present":[45],"study":[46],"focused":[47],"on":[48,54],"effect":[50],"MMP-1":[55,98,134,148,174,218],"MMP-3":[57,100,136,150,186,220],"expression,":[58,175],"two":[59],"enzymes":[60],"substrate":[62],"specificity":[63],"for":[64],"components":[65],"membrane.":[68],"METHODS:":[69],"Cultured":[70],"human":[71],"RPE":[72,200],"cells":[73,87,201],"were":[74,88,101],"exposed":[75],"to":[76,253],"stress.":[78,230],"investigate":[80],"role":[82],"signal":[84],"transduction":[85],"proteins,":[86],"pretreated":[89],"specific":[92],"inhibitors":[93],"SB202190":[94],"or":[95,211],"PD98059.":[96],"Secreted":[97],"detected":[102],"ELISA,":[104],"MMP-2,":[105],"MMP-9":[107,162],"zymography.":[109],"Expression":[110],"mRNA":[112,151,163],"was":[113,125,164,183,188,202],"determined":[114],"quantitative":[116],"real-time":[117],"RT-PCR.":[118],"ECM":[119],"epithelium":[124,225],"assessed":[126],"immunofluorescence":[128],"microscopy.":[129],"RESULTS:":[130],"Oxidative":[131,193],"increased":[133,241],"protein":[137],"release":[138],"but":[139],"reduced":[140,173,203],"MMP-2":[141,160],"activity.":[142],"Real-time":[143],"RT-PCR":[144],"disclosed":[145],"increases":[146],"after":[152],"no":[156],"modulation":[157],"TIMP-1.":[159],"slightly":[165],"enhanced.":[166],"PD98059,":[167],"an":[168,178,249],"inhibitor":[169,179],"ERK1/2,":[171],"markedly":[172],"whereas":[176],"SB202190,":[177],"p38":[181],"MAPK,":[182],"less":[184],"effective.":[185],"expression":[187],"attenuated":[189],"both":[191],"inhibitors.":[192],"stress-stimulated":[194],"type":[195,242],"I":[196,243],"collagen":[197,244],"simultaneous":[205],"treatment":[206],"synthetic":[209],"MMP-inhibitor":[210],"neutralizing":[213],"antibody":[214],"against":[215],"MMP-1.":[216],"CONCLUSIONS:":[217],"in":[221,234],"are":[226],"inducible":[227],"The":[231],"directional":[232],"shift":[233],"MMP-1,-3/TIMP-1":[236],"ratio":[237],"degradation.":[245],"This":[246],"may":[247],"be":[248],"important":[250],"mechanism":[251],"contributing":[252],"pathogenesis":[255],"AMD.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}